Bianca E. Teal
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View article: Autophagy prevents graft failure during murine graft-versus-host disease
Autophagy prevents graft failure during murine graft-versus-host disease Open
Autophagy is an intracellular survival process that has established roles in the long-term survival and function of hematopoietic stem cells (HSC). We investigated the contribution of autophagy to HSC fitness during allogeneic transplantat…
View article: CSF-1–dependant donor-derived macrophages mediate chronic graft-versus-host disease
CSF-1–dependant donor-derived macrophages mediate chronic graft-versus-host disease Open
Chronic GVHD (cGVHD) is the major cause of late, nonrelapse death following stem cell transplantation and characteristically develops in organs such as skin and lung. Here, we used multiple murine models of cGVHD to investigate the contrib…
View article: Th17 plasticity and transition toward a pathogenic cytokine signature are regulated by cyclosporine after allogeneic SCT
Th17 plasticity and transition toward a pathogenic cytokine signature are regulated by cyclosporine after allogeneic SCT Open
Key Points Th17 cells differentiate early after allo-SCT in both mouse and man and display a high degree of cytokine plasticity. IL-12/IL-23 drives further differentiation of Th17 toward an inflammatory phenotype that is inhibited by cyclo…
View article: Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease
Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease Open
Regulatory T cells (Tregs) play a crucial role in the maintenance of peripheral tolerance. Quantitative and/or qualitative defects in Tregs result in diseases such as autoimmunity, allergy, malignancy, and graft-versus-host disease (GVHD),…
View article: Corruption of dendritic cell antigen presentation during acute GVHD leads to regulatory T-cell failure and chronic GVHD
Corruption of dendritic cell antigen presentation during acute GVHD leads to regulatory T-cell failure and chronic GVHD Open
Key Points Acute GVHD leads to defective MHC class II antigen presentation by donor DC, leading to a failure of peripheral Treg homeostasis. Impaired Treg homeostasis results in chronic GVHD directly and can be alleviated by adoptive Treg …