Explanipedia

Non-coding exon splicing orchestrates tissue-specific expression of two functionally distinct mitochondrial isoforms of Mitofusin 2 Open

Claudine David, Chloe Barsa, C. Evain, Annika Krüger, Marion Papin , et al. · 2025

In mammals, outer mitochondrial membrane fusion controls mitochondrial network morphology, promotes subcellular trafficking and ensures proper mitochondrial content mixing. This process is controlled by two homologous dynamin related prote…

Titin-dependent biomechanical feedback tailors sarcomeres to specialized muscle functions in insects Open

Vincent Loreau, Wouter Koolhaas, Eunice HoYee Chan, Paul de Boissier, Nicolas Brouilly , et al. · 2025

Sarcomeres are the universal contractile units of muscles that enable animals to move. Insect muscles display a remarkable functional diversity: they operate at extremely different contraction frequencies (ranging from ~1 to 1000 hertz) an…

mitoXplorer 3.0, a web tool for exploring mitochondrial dynamics in single-cell RNA-seq data Open

Margaux Haering, Andrea Del Bondio, Hélène Puccio, Bianca Habermann · 2024

Mitochondria are important eukaryotic organelles, best known for their function in ATP production and in cellular metabolism and signalling. It is widely accepted that their structure, composition and function differ across cell types. How…

MitoMAMMAL: a genome scale model of mammalian mitochondria predicts cardiac and BAT metabolism Open

Stephen P. Chapman, Theo Brunet, Arnaud Mourier, Bianca Habermann · 2024

Motivation Mitochondria are essential for cellular metabolism and are inherently flexible to allow correct function in a wide range of tissues. Consequently, dysregulated mitochondrial metabolism affects different tissues in different ways…

Author response: Integrative study of skeletal muscle mitochondrial dysfunction in a murine pancreatic cancer-induced cachexia model Open

Tristan Gicquel, Fabio Marchianò, Gabriela Reyes‐Castellanos, Stéphane Audebert, Luc Camoin , et al. · 2024

Mechanoresponsive regulation of myogenesis by the force-sensing transcriptional regulator Tono Open

Xu Zhang, Jerome Avellaneda, Maria L. Spletter, Sandra B. Lemke, Pierre Mangeol , et al. · 2024

MitoMAMMAL: a genome scale model of mammalian mitochondria predicts cardiac and BAT metabolism Open

Stephen P. Chapman, Theo Brunet, Arnaud Mourier, Bianca Habermann · 2024

Mitochondria perform several essential functions in order to maintain cellular homeostasis and mitochondrial metabolism is inherently flexible to allow correct function in a wide range of tissues. Dysregulated mitochondrial metabolism can …

Author Response: Integrative study of skeletal muscle mitochondrial dysfunction in a murine pancreatic cancer-induced cachexia model Open

Tristan Gicquel, Fabio Marchianò, Gabriela Reyes‐Castellanos, Stéphane Audebert, Luc Camoin , et al. · 2024

Pancreatic Ductal AdenoCarcinoma (PDAC), the most common pancreatic cancer, is a deadly cancer, often diagnosed late and resistant to current therapies. PDAC patients are frequently affected by cachexia characterized by muscle mass and str…

Integrative study of skeletal muscle mitochondrial dysfunction in a murine pancreatic cancer-induced cachexia model Open

Tristan Gicquel, Fabio Marchianò, Gabriela Reyes‐Castellanos, Stéphane Audebert, Luc Camoin , et al. · 2024

Aims Pancreatic Ductal AdenoCarcinoma (PDAC), the most common pancreatic cancer, is a deadly cancer, often diagnosed late and resistant to current therapies. PDAC patients are frequently affected by cachexia characterized by muscle mass an…

Mitoxplorer 3.0, a Web Tool for Exploring Mitochondrial Dynamics in Single-Cell Rna-Seq Data Open

Margaux Haering, Andrea Del Bondio, Bianca Habermann, Hélène Puccio · 2024

Fatty Acid Metabolism and The Oxidative Stress Response Support Bacterial Predation Open

Rikesh Jain, Nguyen-Hung Le, Lionel Bertaux, Jean Baudry, Jérôme Bibette , et al. · 2023

Despite growing awareness of their importance in soil ecology, the genetic and physiological traits of bacterial predators are still relatively poorly understood. In the course of a Myxococcus xanthus predator evolution experiment, we disc…

MechanoProDB: A Web Based Database for Exploring the Mechanical Properties of Proteins Open

Ismahene Mesbah, Bianca Habermann, Félix Rico · 2023

The mechanical stability of proteins is crucial for biological processes. To understand the mechanical functions of proteins, it is important to know the protein structure and mechanical properties. Protein mechanics is usually investigate…

Phasik: a Python package to identify system states in partially temporal networks Open

Maxime Lucas, Alex Townsend-Teague, Matteo Neri, Simone Poetto, Arthur J. Morris , et al. · 2023

Phasik is a Python library for analyzing the temporal structure of temporal and partially temporal networks.Temporal networks are used to model complex systems that consist of entities with time-varying interactions.This library provides m…

A mechanically regulated liquid-liquid phase separation of the transcriptional regulator Tono instructs muscle development Open

Xu Zhang, Jerome Avellaneda, Maria L. Spletter, Sandra B. Lemke, Pierre Mangeol , et al. · 2023

Muscle morphogenesis is a multi-step program, starting with myoblast fusion, followed by myotube-tendon attachment and sarcomere assembly, with subsequent sarcomere maturation, mitochondrial amplification and specialisation. The correct ch…

Mitochondrial dysfunction and calcium dysregulation in <i>COQ8A</i>-ataxia Purkinje neurons are rescued by CoQ10 treatment Open

Ioannis Manolaras, Andrea Del Bondio, Olivier Griso, Laurence Reutenauer, Aurélie Eisenmann , et al. · 2023

COQ8A-ataxia is a rare form of neurodegenerative disorder due to mutations in the COQ8A gene. The encoded mitochondrial protein is involved in the regulation of coenzyme Q10 biosynthesis. Previous studies on the constitutive Coq8a−/− mice …

Inferring cell cycle phases from a partially temporal network of protein interactions Open

Maxime Lucas, Arthur J. Morris, Alex Townsend-Teague, Laurent Tichit, Bianca Habermann , et al. · 2023

MitoMouse is a model reconstruction of murine mitochondrial metabolism Open

Stephen P. Chapman, Thibaut Molinié, Arnaud Mourier, Bianca Habermann · 2023

Mitochondria, apart from being the powerhouses of our cells, are key players in cellular metabolism and homeostasis. As a consequence, the core bioenergetics and metabolism of mitochondria are well studied considering the role that dysregu…

Integrative study of skeletal muscle mitochondrial dysfunction in a murine pancreatic cancer-induced cachexia model Open

Tristan Gicquel, Fabio Marchianò, Gabriela Reyes‐Castellanos, Stéphane Audebert, Luc Camoin , et al. · 2022

Aims Pancreatic Ductal AdenoCarcinoma (PDAC), the most common pancreatic cancer, is a deadly cancer, often diagnosed late and resistant to current therapies. PDAC patients are frequently affected by cachexia characterized by muscle mass an…

The evo-MOTiF pipeline and database for studying protein motif evolution in a structural context Open

Paul de Boissier, Nathanael Zweig, Bianca Habermann · 2022

Short linear motifs (SLiMs) in proteins are short functionally independent sequence stretches with a defined function and required for proteins to interact with their environment. Their functional importance makes it interesting to analyse…

Author response: Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers Open

Qiyan Mao, Achyuth Acharya, Alejandra Rodríguez‐delaRosa, Fabio Marchianò, Benoît Dehapiot , et al. · 2022

Reconstructing human Brown Fat developmental trajectory in vitro Open

Jyoti Rao, Jérome Chal, Fabio Marchianò, Chih‐Hao Wang, Ziad Al Tanoury , et al. · 2022

Brown adipocytes represent a specialized type of mammalian adipocytes able to uncouple nutrient catabolism from ATP generation to dissipate energy as heat. They play an important role in mammals, allowing non-shivering thermogenesis to reg…

The mitoXplorer 2.0 update: integrating and interpreting mitochondrial expression dynamics within a cellular context Open

Fabio Marchianò, Margaux Haering, Bianca Habermann · 2022

Mitochondria are subcellular organelles present in almost all eukaryotic cells, which play a central role in cellular metabolism. Different tissues, health and age conditions are characterised by a difference in mitochondrial structure and…

Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers Open

Qiyan Mao, Achyuth Acharya, Alejandra Rodríguez‐delaRosa, Fabio Marchianò, Benoît Dehapiot , et al. · 2021

Human muscle is a hierarchically organised tissue with its contractile cells called myofibers packed into large myofiber bundles. Each myofiber contains periodic myofibrils built by hundreds of contractile sarcomeres that generate large me…

Author response: A Tad-like apparatus is required for contact-dependent prey killing in predatory social bacteria Open

Sofiene Seef, Julien Herrou, Paul de Boissier, Lætitia My, Gaël Brasseur , et al. · 2021

Complete Genome Assembly of Myxococcus xanthus Strain DZ2 Using Long High-Fidelity (HiFi) Reads Generated with PacBio Technology Open

Rikesh Jain, Bianca Habermann, Tâm Mignot · 2021

Myxococcus xanthus is a Gram-negative social bacterium belonging to the order Myxococcales of the class Deltaproteobacteria . It is a facultative social predator found in soils across the globe and is thought to be crucial for the microbia…

Camk2a-Cre and Tshz3 Expression in Mouse Striatal Cholinergic Interneurons: Implications for Autism Spectrum Disorder Open

Xavier Caubit, Elise Arbeille, Dorian Chabbert, Florence Desprez, Imane Messak , et al. · 2021

Camk2a-Cre mice have been widely used to study the postnatal function of several genes in forebrain projection neurons, including cortical projection neurons (CPNs) and striatal medium-sized spiny neurons (MSNs). We linked heterozygous del…

Evolution of mechanisms controlling epithelial morphogenesis across animals: new insights from dissociation - reaggregation experiments in the sponge Oscarella lobularis Open

Amélie Vernale, Maria Mandela Prünster, Fabio Marchianò, Henry Debost, Nicolas Brouilly , et al. · 2021

Background: The ancestral presence of epithelia in Metazoa is no longer debated. Even though Porifera seem to be the best candidates to be the sister group to all other Metazoa, hardly anything is known about the proteins involved in the c…

Inferring cell cycle phases from a partially temporal network of protein interactions Open

Maxime Lucas, Arthur J. Morris, Alex Townsend-Teague, Laurent Tichit, Bianca Habermann , et al. · 2021

The temporal organisation of biological systems into phases and subphases is often crucial to their functioning. Identifying this multiscale organisation can yield insight into the underlying biological mechanisms at play. To date, however…

Evolution of mechanisms controlling epithelial morphogenesis across animals: new insights from dissociation - reaggregation experiments in the sponge Oscarella lobularis. Open

Amélie Vernale, Maria Mandela Prünster, Fabio Marchianò, Henry Debost, Nicolas Brouilly , et al. · 2021

Background: The ancestral presence of epithelia in Metazoa is no longer debated. Even though Porifera seem to be the best candidates to be the sister group to all other Metazoa, hardly anything is known about the proteins involved in the c…

BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulators Open

Olivier Castellanet, Fahmida Ahmad, Yaron Vinik, Gordon B. Mills, Bianca Habermann , et al. · 2021

Cell cycle regulators are frequently altered in Triple-Negative Breast Cancer (TNBC). Emerging agents targeting these signals offer the possibility to design new combinatorial therapies. However, preclinical models that recapitulate TNBC p…

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