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View article: RNA structure modulates Cas13 activity and enables mismatch detection
RNA structure modulates Cas13 activity and enables mismatch detection Open
Cas13 is activated by the hybridization of a CRISPR RNA to a complementary single-stranded RNA protospacer in a target RNA. While Cas13 is not activated by double-stranded RNA in vitro, it robustly targets RNA in cellular environments wher…
View article: APOBEC3A deaminates CTG hairpin loops to promote fragility and instability of expanded CAG/CTG repeats
APOBEC3A deaminates CTG hairpin loops to promote fragility and instability of expanded CAG/CTG repeats Open
CAG/CTG repeats are prone to expansion, causing several inherited human diseases. The initiating sources of DNA damage which lead to inaccurate repair of the repeat tract to cause expansions are not fully understood. Expansion-prone CAG/CT…
View article: Mucus mediated protection against acute colitis in adiponectin deficient mice
Mucus mediated protection against acute colitis in adiponectin deficient mice Open