Bianca N. Mason
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View article: PAR2 activation in the dura causes acute behavioral responses and priming to glyceryl trinitrate in a mouse migraine model
PAR2 activation in the dura causes acute behavioral responses and priming to glyceryl trinitrate in a mouse migraine model Open
Background Migraine is a severely debilitating disorder that affects millions of people worldwide. Studies have indicated that activation of protease-activated receptor-2 (PAR2) in the dura mater causes headache responses in preclinical mo…
View article: Prolactin signaling modulates stress‐induced behavioral responses in a preclinical mouse model of migraine
Prolactin signaling modulates stress‐induced behavioral responses in a preclinical mouse model of migraine Open
Objective The aim of this study was to determine if prolactin signaling modulates stress‐induced behavioral responses in a preclinical migraine model. Background Migraine is one of the most complex and prevalent disorders. The involvement …
View article: Correction to: CGRP induces migraine-like symptoms in mice during both the active and inactive phases
Correction to: CGRP induces migraine-like symptoms in mice during both the active and inactive phases Open
View article: Investigating Migraine-Like Behavior using Light Aversion in Mice
Investigating Migraine-Like Behavior using Light Aversion in Mice Open
Migraine is a complex neurological disorder characterized by headache and sensory abnormalities, such as hypersensitivity to light, observed as photophobia. Whilst it is impossible to confirm that a mouse is experiencing migraine, light av…
View article: Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache Open
The cranial meninges, comprised of the dura mater, arachnoid, and pia mater, are thought to primarily serve structural functions for the nervous system. For example, they protect the brain from the skull and anchor/organize the vascular an…
View article: CGRP induces migraine-like symptoms in mice during both the active and inactive phases
CGRP induces migraine-like symptoms in mice during both the active and inactive phases Open
View article: PACAP Induces Light Aversion in Mice by an Inheritable Mechanism Independent of CGRP
PACAP Induces Light Aversion in Mice by an Inheritable Mechanism Independent of CGRP Open
The neuropeptides CGRP (calcitonin gene-related peptide) and PACAP (pituitary adenylate cyclase-activating polypeptide) have emerged as mediators of migraine, yet the potential overlap of their mechanisms remains unknown. Infusion of PACAP…
View article: Meningeal <scp>CGRP</scp> ‐Prolactin Interaction Evokes Female‐Specific Migraine Behavior
Meningeal <span>CGRP</span> ‐Prolactin Interaction Evokes Female‐Specific Migraine Behavior Open
Objective Migraine is three times more common in women. CGRP plays a critical role in migraine pathology and causes female‐specific behavioral responses upon meningeal application. These effects are likely mediated through interactions of …
View article: PACAP induces light aversion in mice by an inheritable mechanism independent of CGRP
PACAP induces light aversion in mice by an inheritable mechanism independent of CGRP Open
The neuropeptides CGRP and PACAP have emerged as mediators of migraine, yet the potential overlap of their mechanisms remains unknown. Infusion of PACAP, like CGRP, can cause migraine in people, and both peptides share similar vasodilatory…
View article: Vascular actions of peripheral CGRP in migraine-like photophobia in mice
Vascular actions of peripheral CGRP in migraine-like photophobia in mice Open
Background Calcitonin gene-related peptide is recognized as a key player in migraine, yet the mechanisms and sites of calcitonin gene-related peptide action remain unknown. The efficacy of calcitonin gene-related peptide-blocking antibodie…
View article: Repetitive stress in mice causes migraine-like behaviors and calcitonin gene-related peptide-dependent hyperalgesic priming to a migraine trigger
Repetitive stress in mice causes migraine-like behaviors and calcitonin gene-related peptide-dependent hyperalgesic priming to a migraine trigger Open
Migraine is one of the most disabling disorders worldwide but the underlying mechanisms are poorly understood. Stress is consistently reported as a common trigger of migraine attacks. Here, we show that repeated stress in mice causes migra…
View article: Vascular Contributions to Migraine: Time to Revisit?
Vascular Contributions to Migraine: Time to Revisit? Open
Migraine is one of the most prevalent and disabling neurovascular disorders worldwide. However, despite the increase in awareness and research, the understanding of migraine pathophysiology and treatment options remain limited. For centuri…
View article: Increased receptor activity-modifying protein 1 in the nervous system is sufficient to protect against autonomic dysregulation and hypertension
Increased receptor activity-modifying protein 1 in the nervous system is sufficient to protect against autonomic dysregulation and hypertension Open
Calcitonin gene-related peptide (CGRP) can cause migraines, yet it is also a potent vasodilator that protects against hypertension. Given the emerging role of CGRP-targeted antibodies for migraine prevention, an important question is wheth…
View article: (142) Immediate and delayed effects of peripherally administered CGRP in mice
(142) Immediate and delayed effects of peripherally administered CGRP in mice Open
View article: (141) Peripheral CGRP sites of action: examination of the vasculature in migraine-like photophobia
(141) Peripheral CGRP sites of action: examination of the vasculature in migraine-like photophobia Open
View article: CGRP receptor activity in mice with global expression of human receptor activity modifying protein 1
CGRP receptor activity in mice with global expression of human receptor activity modifying protein 1 Open
Background and Purpose CGRP is a potent vasodilator and nociceptive neuropeptide linked to migraine. CGRP receptors are heterodimers of receptor activity modifying protein 1 (RAMP1) and either calcitonin receptor‐like receptor (CLR; forms …
View article: Induction of Migraine-Like Photophobic Behavior in Mice by Both Peripheral and Central CGRP Mechanisms
Induction of Migraine-Like Photophobic Behavior in Mice by Both Peripheral and Central CGRP Mechanisms Open
The neuropeptide calcitonin gene-related peptide (CGRP) is a key player in migraine. Although migraine can be treated using CGRP antagonists that act peripherally, the relevant sites of CGRP action remain unknown. To address the role of CG…