Explanipedia

A longitudinal study on SARS-CoV-2 seroconversion, reinfection and neutralisation spanning several variant waves and vaccination campaigns, Heinsberg, Germany, April 2020 to November 2022 Open

Bianca Schulte, Enrico Richter, Antonia Büning, Maximilian Baum, A Breuer , et al. · 2024

Background Since its emergence in December 2019, over 700 million people worldwide have been infected with SARS-CoV-2 up to May 2024. While early rollout of mRNA vaccines against COVID-19 has saved many lives, there was increasing immune e…

Impaired humoral immunity to BQ.1.1 in convalescent and vaccinated patients Open

Felix Dewald, Martin Pirkl, Martha Paluschinski, Joachim Kühn, Carina Elsner , et al. · 2023

Determining SARS-CoV-2 immunity is critical to assess COVID-19 risk and the need for prevention and mitigation strategies. We measured SARS-CoV-2 Spike/Nucleocapsid seroprevalence and serum neutralizing activity against Wu01, BA.4/5 and BQ…

Analysis of fatality impact and seroprevalence surveys in a community sustaining a SARS-CoV-2 superspreading event Open

Enrico Richter, Dominik Liebl, Bianca Schulte, Nils Lehmann, Christine Fuhrmann , et al. · 2023

There is an ongoing debate on the COVID-19 infection fatality rate (IFR) and the impact of COVID-19 on overall population mortality. Here, we addressed these issues in a community in Germany with a major superspreader event analyzing death…

Impaired humoral immunity to BQ.1.1 in convalescent and vaccinated patients Open

Felix Dewald, Martin Pirkl, Elvin Ahmadov, Martha Paluschinski, Joachim Kühn , et al. · 2023

Determining SARS-CoV-2 immunity is critical to assess COVID-19 risk and the need for prevention and mitigation strategies. We measured SARS-CoV-2 Spike/Nucleocapsid seroprevalence and serum neutralizing activity against Wu01, BA.4/5 and BQ…

Persistent Maintenance of Intermediate Memory B Cells Following SARS-CoV-2 Infection and Vaccination Recall Response Open

Jernej Pušnik, Julia König, Karola Mai, Enrico Richter, Jasmin Zorn , et al. · 2022

To efficiently maintain immunity against SARS-CoV-2 infection, we must first determine the durability of the immune response following infection or vaccination. Here, we demonstrated that, unlike antibodies, virus-specific memory B cells p…

SARS-CoV-2 in Environmental Samples of Quarantined Households Open

Manuel Döhla, Bianca Schulte, Gero Wilbring, Beate M. Kümmerer, Christin Döhla , et al. · 2022

The role of environmental transmission of SARS-CoV-2 remains unclear. Thus, the aim of this study was to investigate whether viral contamination of air, wastewater, and surfaces in quarantined households result in a higher risk for exposed…

Dynamics, outcomes and prerequisites of the first SARS-CoV-2 superspreading event in Germany in February 2020: a cross-sectional epidemiological study Open

Lukas Wessendorf, Enrico Richter, Bianca Schulte, Ricarda Maria Schmithausen, Martin Exner , et al. · 2022

Objectives The first German SARS-CoV-2 outbreak was a superspreading event in Gangelt, North Rhine-Westphalia, during indoor carnival festivities called ‘Kappensitzung’ (15 February 2020). We determined SARS-CoV-2 RT-PCR positivity rate, S…

Front Cover: Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti‐SARS‐CoV‐2 Activity (ChemMedChem 5/2022) Open

Bianca Schulte, Maria König, Beate I. Escher, Sophie Wittenburg, Matic Proj , et al. · 2022

The Front Cover illustrates the natural product andrographolide, which modulates the abundance of the transcription factor NRF2, a substrate of the E3 ligase KEAP1. Previous studies identified that this drug possessed anti-SARS-CoV-2 activ…

Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti‐SARS‐CoV‐2 Activity Open

Bianca Schulte, Maria König, Beate I. Escher, Sophie Wittenburg, Matic Proj , et al. · 2022

Naturally occurring compounds represent a vast pool of pharmacologically active entities. One of such compounds is andrographolide, which is endowed with many beneficial properties, including the activity against severe acute respiratory s…

Analysis of Fatality Impact and Seroprevalence Surveys in a Community Sustaining a SARS-CoV-2 Superspreading Event Open

Enrico Richter, Dominik Liebl, Bianca Schulte, Nils Lehmann, Christine Fuhrmann , et al. · 2022

There is ongoing debate on the COVID-19 infection fatality rate (IFR) and the impact of COVID-19 on overall population mortality. Here, we addressed these issues in a community in Germany with a major superspreader event analyzing deaths o…

Persistent Maintenance of Atypical Memory B Cells Following SARS-CoV-2 Infection and Vaccination Recall Response Open

Jernej Pušnik, Julia König, Karola Mai, Enrico Richter, Jasmin Zorn , et al. · 2022

Analysis of the Dynamics, Outcome, and Prerequisites of the first German SARS-CoV-2 Superspreading Event Open

Lukas Wessendorf, Enrico Richter, Bianca Schulte, Ricarda Maria Schmithausen, Martin Exner , et al. · 2021

Background The beginning of the COVID-19 pandemic was shaped by superspreading events including large-scale outbreaks. In Germany the first SARS-CoV-2 outbreak was a superspreading event in a rural area during indoor carnival festivities i…

Correlation between a quantitative anti‐SARS‐CoV‐2 IgG ELISA and neutralization activity Open

Ramona Dolscheid‐Pommerich, Eva Bartok, Marcel Renn, Beate M. Kümmerer, Bianca Schulte , et al. · 2021

In the current COVID‐19 pandemic, a better understanding of the relationship between merely binding and functionally neutralizing antibodies is necessary to characterize protective antiviral immunity following infection or vaccination. Thi…

Case Report: Infection With SARS-CoV-2 in the Presence of High Levels of Vaccine-Induced Neutralizing Antibody Responses Open

Bianca Schulte, Benjamin Marx, Marek Korencak, Dorian Emmert, Souhaib Aldabbagh , et al. · 2021

We present a case of SARS-CoV-2 B.1. 525 infection in a healthcare worker despite the presence of highly neutralizing, multivariant-specific antibodies 7 weeks after full vaccination with the mRNA vaccine BNT162b2. We show that the virus r…

Memory B cells targeting SARS-CoV-2 spike protein and their dependence on CD4+ T cell help Open

Jernej Pušnik, Enrico Richter, Bianca Schulte, Ramona Dolscheid‐Pommerich, Christian Bode , et al. · 2021

Detectable SARS-CoV-2 RNAemia in Critically Ill Patients, but Not in Mild and Asymptomatic Infections Open

Enrico Richter, Doaa Al Arashi, Bianca Schulte, Christian Bode, Benjamin Marx , et al. · 2021

Background: The SARS-CoV-2 pandemic has challenged many of our current routine practices in the treatment and care of patients. Given the critical importance of blood donation and transfusion we analyzed 92 blood samples of i…

Smoking is Associated with Reduced Frequency of SARS-CoV-2 Infection Open

Bianca Schulte, Lukas Wessendorf, Nils Lehmann, Anika Hüsing, Karl-Heinz Jöckel , et al. · 2021

Supplementary Material for: Detectable SARS-CoV-2 RNAemia in Critically Ill Patients, but Not in Mild and Asymptomatic Infections Open

Elihu D. Richter, D. AlArashi, Bianca Schulte, Christian Bode, Benjamin Marx , et al. · 2021

Background: The SARS-CoV-2 pandemic has challenged many of our current routine practices in the treatment and care of patients. Given the critical importance of blood donation and transfusion we analyzed 92 blood samples of i…

Infection fatality rate of SARS-CoV2 in a super-spreading event in Germany Open

Hendrik Streeck, Bianca Schulte, Beate M. Kümmerer, Enrico Richter, Tobias Höller , et al. · 2020

Strategic Anti-SARS-CoV-2 Serology Testing in a Low Prevalence Setting: The COVID-19 Contact (CoCo) Study in Healthcare Professionals Open

Georg M. N. Behrens, Anne Cossmann, Metodi V. Stankov, Bianca Schulte, Hendrik Streeck , et al. · 2020

Strategic anti-SARS-CoV-2 serology testing in a low prevalence pandemic: The COVID-19 Contact (CoCo) Study in health care professionals Open

Georg M. N. Behrens, Anne Cossmann, Metodi V. Stankov, Bianca Schulte, Hendrik Streeck , et al. · 2020

Background Serology testing is explored for epidemiological research and to inform individuals after suspected infection. During the COVID-19 pandemic, frontline healthcare professionals (HCP) may be at particular risk for infection. No lo…

SARS-CoV-2 in environmental samples of quarantined households Open

Manuel Döhla, Gero Wilbring, Bianca Schulte, Beate M. Kümmerer, Christin Diegmann , et al. · 2020

The role of environmental transmission of SARS-CoV-2 remains unclear. Particularly the close contact of persons living together or cohabitating in domestic quarantine could result in high risk for exposure to the virus within the household…

Characteristic Temporary Loss of Taste and Olfactory Senses in SARS-CoV-2-positive-Individuals with Mild Symptoms Open

Ricarda Maria Schmithausen, Manuel Döhla, Heidrun Schößler, Christin Diegmann, Bianca Schulte , et al. · 2020

SARS-CoV-2 infection has been characterized as an upper and lower respiratory tract infection with symptoms ranging from sore throat, cough, headache, and fatigue to a severe respiratory syndrome that requires intensive care [1-7]. Althoug…

Infection fatality rate of SARS-CoV-2 infection in a German community with a super-spreading event Open

Hendrik Streeck, Bianca Schulte, Beate M. Kümmerer, Enrico Richter, Tobias Höller , et al. · 2020

The world faces an unprecedented SARS-CoV2 pandemic where many critical factors still remain unknown. The case fatality rates (CFR) reported in the context of the SARS-CoV-2 pandemic substantially differ between countries. For SARS-CoV-2 i…

Rapid point-of-care testing for SARS-CoV-2 in a community screening setting shows low sensitivity Open

Manuel Döhla, Christoph Boesecke, Bianca Schulte, Christin Diegmann, Esther Sib , et al. · 2020

Novel monoclonal antibodies to the SERINC5 HIV-1 restriction factor detect endogenous and virion-associated SERINC5 Open

Sebastian Molnar, Lindsay Wieczorek, Michelle Zemil, Bianca Schulte, Elizabeth J. Martinez , et al. · 2020

SERINC5 is a multi-pass transmembrane protein that is thought to play a role in serine incorporation during cellular membrane biosynthesis. This protein has also been identified as a human immunodeficiency virus Type 1 (HIV-1) restriction …

Modulation of Vaccine-Induced CD4 T Cell Functional Profiles by Changes in Components of HIV Vaccine Regimens in Humans Open

Franco Pissani, Bianca Schulte, Michael A. Eller, Bruce Schultz, Silvia Ratto‐Kim , et al. · 2018

Only one HIV-1 candidate vaccine strategy has shown protection, albeit marginally (31%), against HIV-1 acquisition, and correlates of protection suggested that a multifunctional CD4 T cell immune response may be important for this protecti…

Localization to detergent-resistant membranes and HIV-1 core entry inhibition correlate with HIV-1 restriction by SERINC5 Open

Bianca Schulte, Anastasia Selyutina, Silvana Opp, Alon Herschhorn, Joseph Sodroski , et al. · 2017

MxB Is Not Responsible for the Blocking of HIV-1 Infection Observed in Alpha Interferon-Treated Cells Open

Silvana Opp, Daniel Vieira, Bianca Schulte, Sumit K. Chanda, Felipe Diaz‐Griffero · 2015

MxB restricts HIV-1 infection by directly interacting with the HIV-1 core, which is made of viral capsid; however, the contribution of MxB to the HIV-1 restriction observed in alpha interferon (IFN-α)-treated human cells is unknown. To und…

Restriction of HIV-1 Requires the N-Terminal Region of MxB as a Capsid-Binding Motif but Not as a Nuclear Localization Signal Open

Bianca Schulte, Cindy Buffone, Silvana Opp, Francesca Di Nunzio, Daniel A. de Souza Aranha Vieira , et al. · 2015

The interferon alpha (IFN-α)-inducible restriction factor MxB blocks HIV-1 infection after reverse transcription but prior to integration. Fate-of-capsid experiments have correlated the ability of MxB to block HIV-1 infection with stabiliz…

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