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View article: Signature Construction Associated with Tumor-Infiltrating Macrophages Identifies IRF8 as a Novel Biomarker for Immunotherapy in Advanced Gastric Cancer
Signature Construction Associated with Tumor-Infiltrating Macrophages Identifies IRF8 as a Novel Biomarker for Immunotherapy in Advanced Gastric Cancer Open
Advanced gastric cancer (AGC) is characterized by poor prognosis and limited responsiveness to immunotherapy. Tumor-associated macrophages (TAMs) play a pivotal role in cancer progression and therapeutic outcomes. In this study, we develop…
View article: Comparison of pegaspargase with concurrent radiation <i>vs</i>. P-GEMOX with sequential radiation in early-stage NK/T-cell lymphoma
Comparison of pegaspargase with concurrent radiation <i>vs</i>. P-GEMOX with sequential radiation in early-stage NK/T-cell lymphoma Open
P+CCRT is associated with comparable clinical outcomes compared to P-GEMOX + SERT in early-stage NKTCL, with comparable adverse events. Additionally, P+CCRT offers the benefit of a more streamlined treatment regimen with a shorter cycle. G…
View article: Phase II study of pegaspargase, etoposide, gemcitabine (PEG) followed by involved-field radiation therapy in early-stage extranodal natural killer/T-cell lymphoma
Phase II study of pegaspargase, etoposide, gemcitabine (PEG) followed by involved-field radiation therapy in early-stage extranodal natural killer/T-cell lymphoma Open
PEG followed by IFRT is a safe and effective initial therapy for early-stage ENKTL, demonstrating impressive PFS and OS rates. This promising approach warrants further validation in a randomized controlled trial (Registered at Clinicaltria…
View article: Phase II Study of Peg-Asparaginase, Etoposide, Gemcitabine (PEG) Followed by Involved- Field Radiation Therapy in Early-Stage Extranodal Natural Killer/T-Cell Lymphoma
Phase II Study of Peg-Asparaginase, Etoposide, Gemcitabine (PEG) Followed by Involved- Field Radiation Therapy in Early-Stage Extranodal Natural Killer/T-Cell Lymphoma Open
Background The prognosis of extra-nodal NK-/T-cell lymphoma (ENKTL) is poor and the best therapy controversial. We studied safety and efficacy of a new combined modality therapy. Methods Phase-2 study of peg-asparaginase, etoposide and gem…
View article: Lipid profile as a novel prognostic predictor for patients with acute myeloid leukemia
Lipid profile as a novel prognostic predictor for patients with acute myeloid leukemia Open
Purpose This study investigated the relationship between serum lipid levels and clinical outcomes in acute myeloid leukemia (AML) by establishing a predictive risk classification model. Method A total of 214 AML patients who were pathologi…
View article: Integrated assessment of the clinical and biological value of ferroptosis-related genes in multiple myeloma
Integrated assessment of the clinical and biological value of ferroptosis-related genes in multiple myeloma Open
Background Ferroptosis is an iron-dependent mode of cell death that could be induced by erastin and exert antitumor effects. However, the clinical and biological roles of ferroptosis-related gene (FRG) signature and the therapeutic value o…
View article: CircKIF4A Is a Prognostic Factor and Modulator of Natural Killer/T-Cell Lymphoma Progression
CircKIF4A Is a Prognostic Factor and Modulator of Natural Killer/T-Cell Lymphoma Progression Open
Background: Natural killer/T-cell lymphoma (NKTL) is difficult to treat. Circular RNAs (circ RNAs) have been implicated in tumorigenesis. However, the function of circKIF4A in NKTL has not been investigated. Methods: QPCR analysis was used…
View article: Integrative analysis identifies CXCL11 as an immune-related prognostic biomarker correlated with cell proliferation and immune infiltration in multiple myeloma microenvironment
Integrative analysis identifies CXCL11 as an immune-related prognostic biomarker correlated with cell proliferation and immune infiltration in multiple myeloma microenvironment Open
Purpose The interaction between tumor cells and tumor microenvironment (TME) has an important impact on progression and prognosis of multiple myeloma (MM), and has been proven to be promising therapeutic targets. This study intended to exp…
View article: Integrative Analysis of a Pyroptosis-Related Signature of Clinical and Biological Value in Multiple Myeloma
Integrative Analysis of a Pyroptosis-Related Signature of Clinical and Biological Value in Multiple Myeloma Open
Purpose Pyroptosis is an inflammation-based programmed cell death that holds great potential as a novel cancer therapeutic target in patients with multiple myeloma (MM). However, thus far, the function of pyroptosis-related genes (PRGs) in…
View article: Simulation Analysis and Experiment of Instantaneous Temperature Field for Grinding Face Gear with A Grinding Worm
Simulation Analysis and Experiment of Instantaneous Temperature Field for Grinding Face Gear with A Grinding Worm Open
In this paper, a transient temperature calculation model for simulating grinding face gear with a grinding worm is proposed. Firstly, according to the principle of differential geometry, the equations for determining contact arc length and…
View article: Inflammation-based Glasgow prognostic score as an independent prognostic factor in patients with angioimmunoblastic T-cell lymphoma
Inflammation-based Glasgow prognostic score as an independent prognostic factor in patients with angioimmunoblastic T-cell lymphoma Open
Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive form of peripheral T-cell lymphoma (PIT) associated with poor prognosis. It is characterized by lymph node enlargement, B symptoms (unexplained recurrent fevers (often above 38°C),…