Bibo Li
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View article: Enhancing pharmacokinetic properties of Chikusetsusaponin IVa via modification of polyethylenimine/poly(lactic-co-glycolic acid) nanoparticles for sustained drug delivery
Enhancing pharmacokinetic properties of Chikusetsusaponin IVa via modification of polyethylenimine/poly(lactic-co-glycolic acid) nanoparticles for sustained drug delivery Open
Distinguishing pharmacokinetic enhancements of novel drug delivery systems from conventional formulations is critical for optimizing therapeutic outcomes of poorly soluble drugs like Chikusetsusaponin IVa (CHIVA), which suffers from low aq…
View article: Synthesis and biological evaluation of orally active anti-Trypanosoma agents
Synthesis and biological evaluation of orally active anti-Trypanosoma agents Open
In previous studies, we developed anti-trypanosome tubulin inhibitors with promising in vitro selectivity and activity against Human African Trypanosomiasis (HAT). However, for such agents, oral activity is crucial. This study focused on f…
View article: Unwrap RAP1’s Mystery at Kinetoplastid Telomeres
Unwrap RAP1’s Mystery at Kinetoplastid Telomeres Open
Although located at the chromosome end, telomeres are an essential chromosome component that helps maintain genome integrity and chromosome stability from protozoa to mammals. The role of telomere proteins in chromosome end protection is c…
View article: Telomere maintenance in African trypanosomes
Telomere maintenance in African trypanosomes Open
Telomere maintenance is essential for genome integrity and chromosome stability in eukaryotic cells harboring linear chromosomes, as telomere forms a specialized structure to mask the natural chromosome ends from DNA damage repair machiner…
View article: Exploring the digesta- and mucosa-associated microbial community dynamics in the rumen and hindgut of goats from birth to adult
Exploring the digesta- and mucosa-associated microbial community dynamics in the rumen and hindgut of goats from birth to adult Open
Recently, the relationship between the goat host and its gastrointestinal microbiome has emerged as a hallmark of host-microbiota symbiosis, which was indispensable for the proper physiological function that convert the plant biomass to li…
View article: Proteomic analysis defines the interactome of telomerase in the protozoan parasite, Trypanosoma brucei
Proteomic analysis defines the interactome of telomerase in the protozoan parasite, Trypanosoma brucei Open
Telomerase is a ribonucleoprotein enzyme responsible for maintaining the telomeric end of the chromosome. The telomerase enzyme requires two main components to function: the telomerase reverse transcriptase (TERT) and the telomerase RNA (T…
View article: Unlocking phenotypic plasticity provides novel insights for immunity and personalized therapy in lung adenocarcinoma
Unlocking phenotypic plasticity provides novel insights for immunity and personalized therapy in lung adenocarcinoma Open
Background: Unlocking phenotype plasticity (UPP) has been shown to have an essential role in the mechanism of tumor development and therapeutic response. However, the clinical significance of unlocking phenotypic plasticity in patients wit…
View article: NF-κB-Activated lncRNACASC9 Promotes Bladder Cancer Progression by Regulating the TK1 Expression
NF-κB-Activated lncRNACASC9 Promotes Bladder Cancer Progression by Regulating the TK1 Expression Open
Long noncoding RNAs (lncRNA) are involved in cancer development, but the roles of most lncRNAs are undocumented. In this study, we identified lncRNAs that were abnormally expressed in bladder cancer. We found that lncRNACASC9 plays an impo…
View article: Unlocking Phenotypic Plasticity Provides Novels Insights for Immunity and Personalized Therapy in Lung Adenocarcinoma
Unlocking Phenotypic Plasticity Provides Novels Insights for Immunity and Personalized Therapy in Lung Adenocarcinoma Open
Background Unlocking phenotype plasticity (UPP) has been shown to have an essential role in the mechanism of tumor development and therapeutic response. However, the clinical significance of unlocking phenotypic plasticity in patients with…
View article: Assessment of Sexual Outcomes in Patients Undergoing Thulium Laser Prostate Surgery for Management of Benign Prostate Hyperplasia: A Systematic Review and Meta-analysis
Assessment of Sexual Outcomes in Patients Undergoing Thulium Laser Prostate Surgery for Management of Benign Prostate Hyperplasia: A Systematic Review and Meta-analysis Open
Background Thulium laser (Tm:YAG) prostate surgery is a safe and effective procedure with low morbidity and comparable clinical outcomes to those of transurethral resection of the prostate (TURP). However, the sexual function outcomes (ere…
View article: POLIE suppresses telomerase-mediated telomere G-strand extension and helps ensure proper telomere C-strand synthesis in trypanosomes
POLIE suppresses telomerase-mediated telomere G-strand extension and helps ensure proper telomere C-strand synthesis in trypanosomes Open
Trypanosoma brucei causes human African trypanosomiasis and sequentially expresses distinct VSGs, its major surface antigen, to achieve host immune evasion. VSGs are monoallelically expressed from subtelomeric loci, and telomere proteins r…
View article: In vivo Architecture of the Telomerase RNA Catalytic Core in Trypanosoma brucei
In vivo Architecture of the Telomerase RNA Catalytic Core in Trypanosoma brucei Open
This dataset describes the RNA SHAPE (NAI) and DMS reactivities obtained for the catalytic core and Helix IV domain of Telomerase RNA from pathogen Trypanosoma brucei which causes African sleeping sickness. This study was conducted on both…
View article: <i>In vivo</i> architecture of the telomerase RNA catalytic core in <i>Trypanosoma brucei</i>
<i>In vivo</i> architecture of the telomerase RNA catalytic core in <i>Trypanosoma brucei</i> Open
Telomerase is a unique ribonucleoprotein (RNP) reverse transcriptase that utilizes its cognate RNA molecule as a template for telomere DNA repeat synthesis. Telomerase contains the reverse transcriptase protein, TERT and the template RNA, …
View article: miR-219-5p targets TBXT and inhibits breast cancer cell EMT and cell migration and invasion
miR-219-5p targets TBXT and inhibits breast cancer cell EMT and cell migration and invasion Open
miR-219-5p has been reported to act as either a tumor suppressor or a tumor promoter in different cancers by targeting different genes. In the present study, we demonstrated that miR-219-5p negatively regulated the expression of TBXT, a kn…
View article: Regulation of Antigenic Variation by Trypanosoma brucei Telomere Proteins Depends on Their Unique DNA Binding Activities
Regulation of Antigenic Variation by Trypanosoma brucei Telomere Proteins Depends on Their Unique DNA Binding Activities Open
Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, Variant Surface Glycoprotein (VSG), to evade the host immune response. Such antigenic variation is a key pathogenesis mechanism that …
View article: Keeping Balance Between Genetic Stability and Plasticity at the Telomere and Subtelomere of Trypanosoma brucei
Keeping Balance Between Genetic Stability and Plasticity at the Telomere and Subtelomere of Trypanosoma brucei Open
Telomeres, the nucleoprotein complexes at chromosome ends, are well-known for their essential roles in genome integrity and chromosome stability. Yet, telomeres and subtelomeres are frequently less stable than chromosome internal regions. …
View article: Role of NRP1 in Bladder Cancer Pathogenesis and Progression
Role of NRP1 in Bladder Cancer Pathogenesis and Progression Open
Bladder urothelial carcinoma (BC) is a fatal invasive malignancy and the most common malignancy of the urinary system. In the current study, we investigated the function and mechanisms of Neuropilin-1 (NRP1), the co-receptor for vascular e…
View article: Pharmacokinetic study of an anti‐trypanosome agent with different formulations and administration routes in mice by HPLC–MS/MS
Pharmacokinetic study of an anti‐trypanosome agent with different formulations and administration routes in mice by HPLC–MS/MS Open
Previously compound 12 showed great anti‐trypanosome activity without toxicity in an in vivo study. In the current study, a sensitive and rapid high‐performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) method was develop…
View article: <i>Trypanosoma brucei</i>PolIE suppresses telomere recombination
<i>Trypanosoma brucei</i>PolIE suppresses telomere recombination Open
Telomeres are essential for genome integrity and stability. In T. brucei that causes human African trypanosomiasis, the telomere structure and telomere proteins also influence the virulence of the parasite, as its major surface antigen inv…
View article: <i>Tb</i>TRF suppresses the TERRA level and regulates the cell cycle-dependent TERRA foci number with a TERRA binding activity in its C-terminal Myb domain
<i>Tb</i>TRF suppresses the TERRA level and regulates the cell cycle-dependent TERRA foci number with a TERRA binding activity in its C-terminal Myb domain Open
Telomere repeat-containing RNA (TERRA) has been identified in multiple organisms including Trypanosoma brucei, a protozoan parasite that causes human African trypanosomiasis. T. brucei regularly switches its major surface antigen, VSG, to …
View article: <i>Tb</i> RAP1 has an unusual duplex DNA binding activity required for its telomere localization and VSG silencing
<i>Tb</i> RAP1 has an unusual duplex DNA binding activity required for its telomere localization and VSG silencing Open
The electrostatics-based dsDNA binding activity in Tb RAP1 NLS can be diminished by phosphorylation of NLS-adjacent S residues.
View article: Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis
Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis Open
Hypertrophic scars (HSs) are a type of pathological scar which are induced by surgery, burn injuries or trauma during the healing process. Due to the high recurrence rates and strong invasive properties, HSs have become a major clinical is…
View article: Trypanosoma brucei RAP1 Has Essential Functional Domains That Are Required for Different Protein Interactions
Trypanosoma brucei RAP1 Has Essential Functional Domains That Are Required for Different Protein Interactions Open
Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, VSG, to evade the host immune response. VSGs are expressed from subtelomeres in a monoallelic fashion. Tb RAP1, a telomere protein, i…
View article: The NRP1 gene regulates proliferation, apoptosis, migration, and invasion in T24 and 5637 bladder cancer cells
The NRP1 gene regulates proliferation, apoptosis, migration, and invasion in T24 and 5637 bladder cancer cells Open
Background Bladder urothelial carcinoma (BC) is a fatal invasive malignancy and the most common malignancy of the urinary system. In the current study, we investigate the function and mechanisms of Neuropilin-1 (NRP1), the co-receptor for …