Bifa Fan
YOU?
Author Swipe
View article: Patient Version of Guideline for Fibromyalgia (2025 Edition)
Patient Version of Guideline for Fibromyalgia (2025 Edition) Open
Objective To develop an evidence‐based patient version of guideline (PVG) for fibromyalgia, aiming to improve patients’ understanding of disease symptoms and therapeutic options and to enhance their self‐management abilities. Methods Follo…
View article: Chinese Expert Consensus on Percutaneous Balloon Compression for Trigeminal Neuralgia (2022)
Chinese Expert Consensus on Percutaneous Balloon Compression for Trigeminal Neuralgia (2022) Open
Percutaneous balloon compression (PBC) is recognized as a simple, safe, and effective intervention for trigeminal neuralgia (TN) and has been widely adopted in clinical practice across China. However, variations in its application exist am…
View article: Rising global burden of migraine among adolescents and young adults: a 30-year analysis (1990–2021)
Rising global burden of migraine among adolescents and young adults: a 30-year analysis (1990–2021) Open
Background Migraine significantly impacts the physical and mental health of adolescents and young adults (AYA, aged 10–24 years). This study aims to assess global trends in migraine incidence, prevalence, and DALYs in this age group from 1…
View article: Mendelian Randomization Analysis Reveal the Role of Circulating Inflammatory Proteins in Mediating Functional Brain Networks and Peripheral Neuropathic Pain Effects
Mendelian Randomization Analysis Reveal the Role of Circulating Inflammatory Proteins in Mediating Functional Brain Networks and Peripheral Neuropathic Pain Effects Open
Objective : The perception of pain is thought to arise from the integration of information between multiple brain regions. Data from observational studies indicates that dysfunction of brain resting‐state functional networks is present in …
View article: Efficacy of continuous epidural anesthetics and steroids infusion for management of acute herpes zoster and postherpetic neuralgia: a retrospective study
Efficacy of continuous epidural anesthetics and steroids infusion for management of acute herpes zoster and postherpetic neuralgia: a retrospective study Open
Background Herpes zoster (HZ), caused by the reactivation of the varicella-zoster virus, frequently leads to postherpetic neuralgia (PHN), a debilitating neuropathic pain condition. Current treatments for acute HZ and PHN prevention remain…
View article: Causal effect of body mass index on herpes zoster and postherpetic neuralgia: A Mendelian randomization study
Causal effect of body mass index on herpes zoster and postherpetic neuralgia: A Mendelian randomization study Open
Although observational studies have reported the relationship between body mass index (BMI), herpes zoster (HZ), and postherpetic neuralgia (PHN), the impacts of BMI on the incidence of HZ and PHN are still controversial. Our study aimed t…
View article: 10 kHz spinal cord stimulation vs. traditional low-frequency spinal cord stimulation for the treatment of diabetes peripheral neuropathic pain: study protocol for a multi-center randomized controlled clinical trial
10 kHz spinal cord stimulation vs. traditional low-frequency spinal cord stimulation for the treatment of diabetes peripheral neuropathic pain: study protocol for a multi-center randomized controlled clinical trial Open
Background Diabetic peripheral neuropathic pain (DPNP), affecting ~50% of diabetes patients, imposes major burdens on quality of life and healthcare systems, while current therapies including pharmacotherapy and conventional spinal cord st…
View article: Development and Validation of a Machine Learning-Based Risk Prediction Model for Low Back Pain in Middle-Aged and Elderly Chinese: A SHAP-Interpretable Longitudinal Cohort Study
Development and Validation of a Machine Learning-Based Risk Prediction Model for Low Back Pain in Middle-Aged and Elderly Chinese: A SHAP-Interpretable Longitudinal Cohort Study Open
Background Low back pain is one of the most common diseases among middle-aged and elderly people in China. Therefore, it is necessary to explore a risk prediction model for low back pain in middle-aged and elderly individuals. Methods This…
View article: Real-world study on adverse events of central muscle relaxants in the treatment of cervicogenic headache based on the U.S. FAERS database
Real-world study on adverse events of central muscle relaxants in the treatment of cervicogenic headache based on the U.S. FAERS database Open
Background: Central muscle relaxants are widely used in the treatment of cervicogenic headache, which can inhibit the excessive excitation of the central nervous system, relieve neck muscle spasms, and thereby reduce pain and discomfort. H…
View article: Effects of Transcutaneous Electrical Acustimulation on Patients with Fibromyalgia Syndrome: Study Protocol of a Randomized, Double-Blind, Sham-Controlled Trial
Effects of Transcutaneous Electrical Acustimulation on Patients with Fibromyalgia Syndrome: Study Protocol of a Randomized, Double-Blind, Sham-Controlled Trial Open
http://itmctr.ccebtcm.org.cn/ identifier ITMCTR2024000638.
View article: Prevalence of depressive symptoms in middle-aged and elderly outpatient patients with chronic pain in three cities and provinces of China
Prevalence of depressive symptoms in middle-aged and elderly outpatient patients with chronic pain in three cities and provinces of China Open
Background: Chronic pain and depression are closely related, significantly impacting patients' quality of life. Notably, large-scale cross-sectional studies on chronic pain patients are scarce in China. This study examined depressive sympt…
View article: Efficacy and safety of interferon-alpha 1b injection into the intervertebral foramen with ultrasonic guidance in patients with postherpetic neuralgia: study protocol for a randomized, double-blind, placebo-controlled, multicenter clinical trial
Efficacy and safety of interferon-alpha 1b injection into the intervertebral foramen with ultrasonic guidance in patients with postherpetic neuralgia: study protocol for a randomized, double-blind, placebo-controlled, multicenter clinical trial Open
Purpose Postherpetic neuralgia (PHN) is a type of refractory neuropathic pain that causes significant suffering, disability, economic loss, and medical burden. In this study, we aim to evaluate the efficacy and safety of interferon (IFN)-α…
View article: Global, regional, and national burden of migraine, 1990-2021: a systematic analysis from the global burden of disease study 2021
Global, regional, and national burden of migraine, 1990-2021: a systematic analysis from the global burden of disease study 2021 Open
Background: Migraine is a prevalent and disabling neurovascular disorder that poses a significant public health challenge worldwide. Currently, there is a lack of comprehensive analysis regarding the global disease burden and evolving tren…
View article: Real-world study of adverse events associated with triptan use in migraine treatment based on the U.S. Food and Drug Administration (FDA) adverse event reporting system (FAERS) database
Real-world study of adverse events associated with triptan use in migraine treatment based on the U.S. Food and Drug Administration (FDA) adverse event reporting system (FAERS) database Open
Analyses have demonstrated that AEs are present in a range of systems, including cardiac, nervous, gastrointestinal, and musculoskeletal disorders. It should be noted, however, that the incidence and signal intensity of these AEs vary depe…
View article: Collagenase Chemonucleolysis for Treating Cervical Disc Herniation: An Exploratory, Single-Arm, Open-Label, Multicenter Clinical Trial
Collagenase Chemonucleolysis for Treating Cervical Disc Herniation: An Exploratory, Single-Arm, Open-Label, Multicenter Clinical Trial Open
The trial was registered on www.Chictr.org.cn (ChiCTR2200063043).
View article: The evolving landscape of neuromodulation for pain care
The evolving landscape of neuromodulation for pain care Open
Here, we present five different insights on the use of neuromodulation strategies for effective pain management in clinical practice. Experts briefly illustrate the various techniques available and the complexities involved in evaluating t…
View article: The <scp>PATCH</scp> trial: 5% lidocaine‐medicated plaster for trigeminal neuralgia—Results of a multicentric, enriched enrollment, randomized withdrawal, double‐blind, vehicle‐controlled, parallel‐group study
The <span>PATCH</span> trial: 5% lidocaine‐medicated plaster for trigeminal neuralgia—Results of a multicentric, enriched enrollment, randomized withdrawal, double‐blind, vehicle‐controlled, parallel‐group study Open
Objective To explore the efficacy and safety of 5% lidocaine‐medicated plaster (LMP) in patients with trigeminal neuralgia (TN). Background TN is an excruciatingly painful type of neuropathic facial pain. Anti‐epileptics are the first‐line…
View article: Genetics of causal relationships between circulating inflammatory proteins and postherpetic neuralgia: a bidirectional Mendelian randomization study
Genetics of causal relationships between circulating inflammatory proteins and postherpetic neuralgia: a bidirectional Mendelian randomization study Open
Objective According to data from several observational studies, there is a strong association between circulating inflammatory cytokines and postherpetic neuralgia (PHN), but it is not clear whether this association is causal or confoundin…
View article: ABCB1 genetic polymorphisms affect opioid requirement by altering function of the intestinal P-glycoprotein
ABCB1 genetic polymorphisms affect opioid requirement by altering function of the intestinal P-glycoprotein Open
The association between polymorphisms of the human ATP binding cassette subfamily B member 1 (ABCB1) gene and opioid response has attracted intense attention recently. As the ABCB1 gene encodes for the transporter P-glycoprotein in the bra…
View article: Circadian changes of autonomic function in patients with zoster‐associated pain: A heart rate variability analysis
Circadian changes of autonomic function in patients with zoster‐associated pain: A heart rate variability analysis Open
Objective To investigate the circadian changes of the autonomic function in patients with zoster‐associated pain (ZAP). Methods A total of 37 patients with ZAP from April 2022 to October 2022 were enrolled as the observation group, and 37 …
View article: Glutamatergic neurons in the paraventricular nucleus of the hypothalamus participate in the regulation of visceral pain induced by pancreatic cancer in mice
Glutamatergic neurons in the paraventricular nucleus of the hypothalamus participate in the regulation of visceral pain induced by pancreatic cancer in mice Open
Glutamatergic neurons in the PVN participate in the regulation of visceral pain induced by pancreatic cancer in mice, providing new insights for the discovery of effective targets for the treatment of pancreatic cancer visceral pain.
View article: Neuroinflammation in the paraventricular nucleus of the hypothalamus precipitates visceral pain induced by pancreatic cancer in mice
Neuroinflammation in the paraventricular nucleus of the hypothalamus precipitates visceral pain induced by pancreatic cancer in mice Open
This study found that PVN microglia and astrocytes were involved in regulating PCVP. Our results suggest that targeting glia may be a potential approach for alleviating visceral pain in patients with pancreatic cancer.
View article: Inhibition of GABAergic neurons in the paraventricular nucleus of the hypothalamus precipitates visceral pain induced by pancreatic cancer in mice
Inhibition of GABAergic neurons in the paraventricular nucleus of the hypothalamus precipitates visceral pain induced by pancreatic cancer in mice Open
GABAergic neurons located in PVN play a crucial role in precipitating visceral pain induced by pancreatic cancer in mice, thereby offering novel insights for identifying effective targets to treat pancreatic cancer-related visceral pain.
View article: Multidisciplinary Guidelines for the Rational Use of Topical Non-Steroidal Anti-Inflammatory Drugs for Musculoskeletal Pain (2022)
Multidisciplinary Guidelines for the Rational Use of Topical Non-Steroidal Anti-Inflammatory Drugs for Musculoskeletal Pain (2022) Open
(1) Background: Topical non-steroidal anti-inflammatory drugs (NSAIDs) are one of the primary drugs for treating musculoskeletal pain. However, there are currently no evidence-based recommendations about drug selection, drug administration…
View article: Pain Physicians’ Attitudes and Experiences Regarding Clinical Pharmacy Services in China: A National Cross-Sectional Survey
Pain Physicians’ Attitudes and Experiences Regarding Clinical Pharmacy Services in China: A National Cross-Sectional Survey Open
Pain physicians in China had positive perceptions and high expectations, but relatively low experiences regarding clinical pharmacy services. Expanding clinical pharmacist pain management credentialing and increasing pain physicians' expos…
View article: Comparison of external system and implanted system in intrathecal therapy for refractory cancer pain in China: A retrospective study
Comparison of external system and implanted system in intrathecal therapy for refractory cancer pain in China: A retrospective study Open
Introduction Intrathecal therapy (ITT) via an implanted system was demonstrated for the treatment of refractory cancer pain for decades. Recently, the dissemination of ITT is enhanced in an external system way in Asia for a lower implantat…
View article: Short-term spinal cord stimulation is an effective therapeutic approach for herpetic-related neuralgia—A Chinese nationwide expert consensus
Short-term spinal cord stimulation is an effective therapeutic approach for herpetic-related neuralgia—A Chinese nationwide expert consensus Open
Purpose Short-term spinal cord stimulation (st-SCS) has been widely used to treat herpetic-related neuralgia (HN) in China for several years, but is still heavily debated as it has no strong evidence in clinical application. Therefore, a q…
View article: Diagnosis and Treatment of Five Pain-Related Conditions in Urban China: A Population-Based Cross-Sectional National Health and Wellness Survey
Diagnosis and Treatment of Five Pain-Related Conditions in Urban China: A Population-Based Cross-Sectional National Health and Wellness Survey Open
Our study highlights the importance of raising awareness for pain management as well as education and training for healthcare providers and patients.