Bijar Ghafouri
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View article: Effects on Blood Markers for Stress, Metabolism and Inflammation in Nurses Working Quick Returns (<11h Between Shifts) – and Experimental Field Study
Effects on Blood Markers for Stress, Metabolism and Inflammation in Nurses Working Quick Returns (<11h Between Shifts) – and Experimental Field Study Open
View article: The relationship between inflammatory markers in cerebrospinal fluid in healthy controls and in patients with severe essential tremor before and after deep brain stimulation
The relationship between inflammatory markers in cerebrospinal fluid in healthy controls and in patients with severe essential tremor before and after deep brain stimulation Open
Objective: Essential tremor (ET) is the most common movement disorder, with a prevalence of approximately 5 % in individuals over 65 years old. The pathophysiology behind ET is still largely unknown but emerging evidence indicates that ET …
View article: System-wide targeted analysis of oxylipins and lipoproteins in chronic peripheral neuropathic pain-an explorative study.
System-wide targeted analysis of oxylipins and lipoproteins in chronic peripheral neuropathic pain-an explorative study. Open
These results present a previously unexplored network of integrated alterations of lipoproteins, octadecanoids, and cytokines in patients suffering from NeuP, indicative of deviant immuno-protective functioning across several biological sy…
View article: Effects of acute alcohol administration on endocannabinoids and relation to subjective effects
Effects of acute alcohol administration on endocannabinoids and relation to subjective effects Open
Rationale Harmful alcohol use remains a significant global public health challenge. Examining variability in the acute subjective effects of alcohol and related neurobiological mechanisms may advance the understanding of susceptibility to …
View article: Surface microdialysis to monitor hepatic metabolism in liver surgery
Surface microdialysis to monitor hepatic metabolism in liver surgery Open
View article: Investigation of endocannabinoids in plasma and their correlation with physical fitness and resting state functional connectivity of the periaqueductal grey in women with fibromyalgia: An exploratory secondary study
Investigation of endocannabinoids in plasma and their correlation with physical fitness and resting state functional connectivity of the periaqueductal grey in women with fibromyalgia: An exploratory secondary study Open
Objectives The endocannabinoid system is a neuromodulatory system linked to pain, distress, and physical activity. The endocannabinoids (eCBs) arachidonoylethanolamide (AEA) and 2-arachidonoylglycerol are known to activate the cannabinoid …
View article: The diurnal pattern of cytokines, chemokines and growth factors in human saliva—a pilot study
The diurnal pattern of cytokines, chemokines and growth factors in human saliva—a pilot study Open
Background Understanding of possible periodicity of cytokines, chemokines and growth factors is of great interest and provide valuable information for research into pathophysiological mechanism of inflammatory disease and chronic pain. Sig…
View article: A New IL-6-Inducing Mechanism in Cancer with New Therapeutic Possibilities
A New IL-6-Inducing Mechanism in Cancer with New Therapeutic Possibilities Open
Background: Interleukin-6 is dysregulated in multiple pathological conditions, e.g., cancer and inflammatory diseases. Aim: To investigate new mechanisms for the regulation of pathological IL-6 production. Methods: PBMCs (peripheral blood …
View article: Exploring emotional well-being, spiritual, religious and personal beliefs and telomere length in chronic pain patients—A pilot study with cross-sectional design
Exploring emotional well-being, spiritual, religious and personal beliefs and telomere length in chronic pain patients—A pilot study with cross-sectional design Open
Living with chronic pain is associated with substantial suffering and high societal costs. Patient reported outcomes (PROM’s) and cellular ageing should be considered in pain management. The aim of this study was to explore correlations of…
View article: A New IL-6 Inducing Mechanism in Cancer with new Therapeutic Possibilities
A New IL-6 Inducing Mechanism in Cancer with new Therapeutic Possibilities Open
Background: Interleukin-6 is dysregulated in multiple pathological conditions, e.g. cancer and inflammatory diseases. Aim: To investigate new mechanisms for regulation of pathological IL-6 production. Methods: PBMC produce interleukin-6 (I…
View article: The use of a protein network analysis to explore the complexity of early skin inflammation after oronasal mask application- A pilot study
The use of a protein network analysis to explore the complexity of early skin inflammation after oronasal mask application- A pilot study Open
View article: Parotid saliva and blood biomarkers in juvenile idiopathic arthritis in relation to temporomandibular joint magnetic resonance imaging findings
Parotid saliva and blood biomarkers in juvenile idiopathic arthritis in relation to temporomandibular joint magnetic resonance imaging findings Open
Background Juvenile idiopathic arthritis (JIA) often affects the temporomandibular joint (TMJ) caused by an abnormal immune system that includes overactive inflammatory processes. Salivary biomarkers may be a powerful tool that can help es…
View article: Eating habits and the desire to eat healthier among patients with chronic pain: a registry-based study
Eating habits and the desire to eat healthier among patients with chronic pain: a registry-based study Open
View article: Pain and the biochemistry of fibromyalgia: patterns of peripheral cytokines and chemokines contribute to the differentiation between fibromyalgia and controls and are associated with pain, fat infiltration and content
Pain and the biochemistry of fibromyalgia: patterns of peripheral cytokines and chemokines contribute to the differentiation between fibromyalgia and controls and are associated with pain, fat infiltration and content Open
Objectives This explorative study analyses interrelationships between peripheral compounds in saliva, plasma, and muscles together with body composition variables in healthy subjects and in fibromyalgia patients (FM). There is a need to be…
View article: Neck and shoulder pain and inflammatory biomarkers in plasma among forklift truck operators – A case–control study
Neck and shoulder pain and inflammatory biomarkers in plasma among forklift truck operators – A case–control study Open
Objectives The aim of this study was to investigate a panel of inflammatory biomarkers in plasma from forklift truck operators (FLTOs) and healthy controls, and their relation to neck pain characteristics. Methods From employees in a wareh…
View article: Cerebrospinal Fluid Metabolomics Identified Ongoing Analgesic Medication in Neuropathic Pain Patients
Cerebrospinal Fluid Metabolomics Identified Ongoing Analgesic Medication in Neuropathic Pain Patients Open
Background: Cerebrospinal fluid (CSF) can reasonably be hypothesized to mirror central nervous system pathophysiology in chronic pain conditions. Metabolites are small organic molecules with a low molecular weight. They are the downstream …
View article: Serum levels of endocannabinoids and related lipids in painful vs painless diabetic neuropathy: results from the Pain in Neuropathy Study
Serum levels of endocannabinoids and related lipids in painful vs painless diabetic neuropathy: results from the Pain in Neuropathy Study Open
N-arachidonoylethanolamine (also known as anandamide) and 2-arachidonoylglycerol are activators of the cannabinoid receptors. The endocannabinoid system also includes structurally and functionally related lipid mediators that do not target…
View article: Altered levels of transthyretin in human cerebral microdialysate after subarachnoid haemorrhage using proteomics; a descriptive pilot study
Altered levels of transthyretin in human cerebral microdialysate after subarachnoid haemorrhage using proteomics; a descriptive pilot study Open
View article: AB0039 EXPRESSION OF INFLAMMATORY MARKERS IN PATIENTS WITH PAINFUL KNEE OSTEOARTHRITIS: A MULTIVARIATE ANALYSIS OF PRESURGICAL SERUM SAMPLES
AB0039 EXPRESSION OF INFLAMMATORY MARKERS IN PATIENTS WITH PAINFUL KNEE OSTEOARTHRITIS: A MULTIVARIATE ANALYSIS OF PRESURGICAL SERUM SAMPLES Open
View article: Consequences of Acute Stress and Alcohol Exposure on the Endo-cannabinoid System in Healthy Humans
Consequences of Acute Stress and Alcohol Exposure on the Endo-cannabinoid System in Healthy Humans Open
View article: Resilience to substance use disorder following childhood maltreatment: association with peripheral biomarkers of endocannabinoid function and neural indices of emotion regulation
Resilience to substance use disorder following childhood maltreatment: association with peripheral biomarkers of endocannabinoid function and neural indices of emotion regulation Open
View article: Cognitive and mental fatigue in chronic pain: cognitive functions, emotional aspects, biomarkers and neuronal correlates—protocol for a descriptive cross-sectional study
Cognitive and mental fatigue in chronic pain: cognitive functions, emotional aspects, biomarkers and neuronal correlates—protocol for a descriptive cross-sectional study Open
Introduction Chronic pain (CP) is one of the most frequently presenting conditions in health care and many patients with CP report mental fatigue and a decline in cognitive functioning. However, the underlying mechanisms are still unknown.…
View article: The Vastus Lateralis Muscle Interstitium Proteome Changes after an Acute Nociception in Patients with Fibromyalgia Compared to Healthy Subjects—A Microdialysis Study
The Vastus Lateralis Muscle Interstitium Proteome Changes after an Acute Nociception in Patients with Fibromyalgia Compared to Healthy Subjects—A Microdialysis Study Open
Fibromyalgia (FM) is a complex disorder and a clinical challenge to diagnose and treat. Microdialysis is a valuable tool that has been used to investigate the interstitial proteins and metabolites of muscle in patients with fibromyalgia. T…
View article: An investigation of metabolome in blood in patients with chronic peripheral, posttraumatic/postsurgical neuropathic pain
An investigation of metabolome in blood in patients with chronic peripheral, posttraumatic/postsurgical neuropathic pain Open
Neuropathic pain (NP) is a chronic pain condition resulting from a lesion or disease in the somatosensory nervous system. The aim of this study was to investigate the metabolome in plasma from patients with chronic peripheral, posttraumati…
View article: Biomarkers Associated with Complex Regional Pain Syndrome in Humans: Protocol for a Systematic Review
Biomarkers Associated with Complex Regional Pain Syndrome in Humans: Protocol for a Systematic Review Open
Review question / Objective: The aim of this systematic review is to explore the pathophysiology of complex regional pain syndrome and what differs between healthy c o n t r o l s a n d p a t i e n t s w i t h C R P S concerning biomarkers…
View article: Plasma proteins from several components of the immune system differentiate chronic widespread pain patients from healthy controls – an exploratory case-control study combining targeted and non-targeted protein identification
Plasma proteins from several components of the immune system differentiate chronic widespread pain patients from healthy controls – an exploratory case-control study combining targeted and non-targeted protein identification Open
Chronic widespread pain (CWP), including fibromyalgia (FM), is characterized by generalized musculoskeletal pain and hyperalgesia. Plasma proteins from proteomics (non-targeted) and from targeted inflammatory panels (cytokines/chemokines) …
View article: Swedish Chronic Pain Biobank: protocol for a multicentre registry and biomarker project
Swedish Chronic Pain Biobank: protocol for a multicentre registry and biomarker project Open
Introduction About 20% of the adult population have chronic pain, often associated with psychological distress, sick leave and poor health. There are large variations in the clinical picture. A biopsychosocial approach is used in investiga…
View article: Fibromyalgia in women: association of inflammatory plasma proteins, muscle blood flow, and metabolism with body mass index and pain characteristics
Fibromyalgia in women: association of inflammatory plasma proteins, muscle blood flow, and metabolism with body mass index and pain characteristics Open
Introduction: Obesity is a common comorbidity in fibromyalgia (FM). Both FM and obesity have been connected to low-grade inflammation, although it is possible that previously reported inflammatory alterations in FM primarily may be linked …
View article: Differences in plasma lipoprotein profiles between patients with chronic peripheral neuropathic pain and healthy controls: an exploratory pilot study
Differences in plasma lipoprotein profiles between patients with chronic peripheral neuropathic pain and healthy controls: an exploratory pilot study Open
Introduction: Little is still known about the underlying mechanisms that drive and maintain neuropathic pain (NeuP). Recently, lipids have been implicated as endogenous proalgesic ligands affecting onset and maintenance of pain; however, i…
View article: Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables
Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables Open
Obesity has a negative influence on FM symptomatology and increases the risk for other serious conditions. Hence, obesity, dietary habits, and physical activity should be considered when developing clinical management plans for patients wi…