Bikash Medhi
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View article: Comparative Evaluation of Peppermint Oil, Lignocaine Gel, and Ice as Topical Anesthetics for Intraoral Injections in Children: A Randomized Controlled Trial
Comparative Evaluation of Peppermint Oil, Lignocaine Gel, and Ice as Topical Anesthetics for Intraoral Injections in Children: A Randomized Controlled Trial Open
Sharma D, Bhat M, Khairwa A, et al. Comparative Evaluation of Peppermint Oil, Lignocaine Gel, and Ice as Topical Anesthetics for Intraoral Injections in Children: A Randomized Controlled Trial. Int J Clin Pediatr Dent 2025;18(10):11…
View article: Ethnomedicine in Question: A Study among Rabhas of Assam
Ethnomedicine in Question: A Study among Rabhas of Assam Open
View article: A novel modulator of the Axin/β-Catenin interaction to restore EAAT2 expression in alzheimer’s disease: an in-silico and in-vitro approach
A novel modulator of the Axin/β-Catenin interaction to restore EAAT2 expression in alzheimer’s disease: an in-silico and in-vitro approach Open
Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by synaptic dysfunction and neuronal loss, with glutamate excitotoxicity playing a central role in its pathology. The astrocytic glutamate transporter EAAT2, respo…
View article: Sex/gender differences in clinical pharmacology: A perspective from the IUPHAR World Smart Medication Day 2025
Sex/gender differences in clinical pharmacology: A perspective from the IUPHAR World Smart Medication Day 2025 Open
View article: Increasing early phase clinical trials capacity in India
Increasing early phase clinical trials capacity in India Open
The Indian Council for Medical Research has established the ICMR-Network for Phase 1 Clinical Trials. Here we describe identification of the need to establish the Network and further elaborate on its vision, governance, and operational asp…
View article: Over-the-counter drug development in developing countries
Over-the-counter drug development in developing countries Open
View article: Genetic Association in the Pathophysiology of Degenerative Cervical Disc Disease: Defining Roles?
Genetic Association in the Pathophysiology of Degenerative Cervical Disc Disease: Defining Roles? Open
Degenerative cervical myelopathy (DCM), encompassing cervical spondylotic myelopathy and posterior longitudinal ligament ossification, is now being documented frequently and significantly burdening the health care systems. The pathogenesis…
View article: Adenylyl Cyclase Activator: Forskolin Mediates <scp>CREB</scp> ser133 Phosphorylation in the Hippocampus, Alleviates Autism‐Like Deficits in a Valproic Acid Model of Wistar Rats
Adenylyl Cyclase Activator: Forskolin Mediates <span>CREB</span> ser133 Phosphorylation in the Hippocampus, Alleviates Autism‐Like Deficits in a Valproic Acid Model of Wistar Rats Open
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by social deficits, restricted interest, and repetitive behaviors. The prevalence is higher in males (4:1). FDA‐approved drugs, Aripiprazole, and risper…
View article: Prescribing trends of fixed-dose combination of domperidone and proton-pump inhibitor across tertiary care centers in India, is the combination rational?
Prescribing trends of fixed-dose combination of domperidone and proton-pump inhibitor across tertiary care centers in India, is the combination rational? Open
BACKGROUND: There have been concerns over the rationality of prescribing practices of fixed-dose combinations (FDCs) available in India. The FDC of domperidone and pantoprazole recently emerged as a top-selling product at Janaushadhi Kendr…
View article: A Prospective Comparative Study of Laparoscopic Common Bile Duct Exploration and Endoscopic Retrograde Cholangiopancreatography for Managing Common Bile Duct Calculi
A Prospective Comparative Study of Laparoscopic Common Bile Duct Exploration and Endoscopic Retrograde Cholangiopancreatography for Managing Common Bile Duct Calculi Open
View article: A Retrospective Risk-Factor Analysis of Patients Presenting With Peripheral Vascular Disease in a Tertiary Care Hospital in North-East India
A Retrospective Risk-Factor Analysis of Patients Presenting With Peripheral Vascular Disease in a Tertiary Care Hospital in North-East India Open
Background Peripheral vascular disease (PVD) encompasses both upper and lower limb diseases affecting veins and arteries. This study focuses on peripheral arterial disease (PAD) due to its higher morbidity and mortality rates related to ca…
View article: Potential application of the wolly mouse in future research
Potential application of the wolly mouse in future research Open
View article: Authors’ response
Authors’ response Open
View article: Metallic nanoparticles in malaria treatment: advances in therapeutics, diagnostics, and future prospects
Metallic nanoparticles in malaria treatment: advances in therapeutics, diagnostics, and future prospects Open
Malaria remains one of the causes of extreme mortality in southern Africa and Southeast Asia. Despite extreme efforts to control and eliminate malaria, the appearance of drug-resistant parasites and their spread is a major concern. In this…
View article: ANTI-PLASMODIAL EFFECT OF NICOTINAMIDE- VITAMIN B3 AGAINST CHLOROQUINE RESISTANT MALARIA IN AN IN VIVO MODEL
ANTI-PLASMODIAL EFFECT OF NICOTINAMIDE- VITAMIN B3 AGAINST CHLOROQUINE RESISTANT MALARIA IN AN IN VIVO MODEL Open
Nicotinamide (NICO), an amide derivative of nicotinic acid, used in high doses for four decades, has shown antimicrobial and potential anti-malarial activity in vitro. However, its antiplasmodial effects in drug-resistant in vivo models we…
View article: Recommendations for India-specific multiple micronutrient supplement through expert consultation
Recommendations for India-specific multiple micronutrient supplement through expert consultation Open
Background & objectives Reducing maternal anaemia and enhancing feto-maternal health to achieve desired birth outcomes is a major health concern in India. Micronutrient deficiencies during pregnancy may impact fetal growth and neonatal out…
View article: Metformin alleviates reactive gliosis and neurodegeneration, improving cognitive deficit in a rat model of temporal lobe epilepsy
Metformin alleviates reactive gliosis and neurodegeneration, improving cognitive deficit in a rat model of temporal lobe epilepsy Open
Cognitive impairment is a prevalent co-morbidity associated with epilepsy. Emerging studies indicate that neuroinflammation could be a possible link between epilepsy and its comorbidities, including cognitive impairment. In this context, t…
View article: Advancing pediatric drug development in South Asia: Current landscape and vision for the future
Advancing pediatric drug development in South Asia: Current landscape and vision for the future Open
The manuscript summarizes the outcomes of a one-day conference by the South Asian College of American College of Clinical Pharmacology (SAC-ACCP) in July 2023, at Bhopal. The theme of the conference was “Advancing pediatric drug developmen…
View article: Unlocking the Therapeutic Potential: Sitagliptin’s Multifaceted Approach in Drug-Resistant Epilepsy through a Novel Mechanism Inhibiting Protein Kinase C-γ and a Long-Term Potentiation Pathway
Unlocking the Therapeutic Potential: Sitagliptin’s Multifaceted Approach in Drug-Resistant Epilepsy through a Novel Mechanism Inhibiting Protein Kinase C-γ and a Long-Term Potentiation Pathway Open
Drug-resistant epilepsy is a prominent challenge in chronic neurological disorders. Valproate, commonly used to treat epilepsy, can fail due to various side effects and interactions, necessitating the exploration of alternative treatments.…
View article: A randomised controlled trial to evaluate the effectiveness of a culture and disease-specific, patient-centric multi-component tobacco cessation intervention package for the patients attending non-communicable disease clinics in Punjab, India
A randomised controlled trial to evaluate the effectiveness of a culture and disease-specific, patient-centric multi-component tobacco cessation intervention package for the patients attending non-communicable disease clinics in Punjab, India Open
Strengthening existing health systems is crucial for offering cessation support in the resource-restraint setting of LMICs to assist in quitting sustainably.
View article: Therapeutic Drug Monitoring of Levetiracetam in Different Trimesters of Pregnant Women with Epilepsy in a Tertiary Care Center: A Prospective Study
Therapeutic Drug Monitoring of Levetiracetam in Different Trimesters of Pregnant Women with Epilepsy in a Tertiary Care Center: A Prospective Study Open
Background: Levetiracetam is the most commonly used antiepileptic drug in pregnant women due to its low teratogenic risk profile, favorable pharmacokinetic characteristics, and safety profile. Serum levels of levetiracetam vary in epilepsy…
View article: Prescription-based cost analysis of medicines for cardiovascular risk factors at Indian Council of Medical Research-Rational Use of Medicine Centre Hospitals of India
Prescription-based cost analysis of medicines for cardiovascular risk factors at Indian Council of Medical Research-Rational Use of Medicine Centre Hospitals of India Open
OBJECTIVES: India has taken several initiatives to provide health care to its population while keeping the related expenditure minimum. Since cardiovascular diseases are the most prevalent chronic conditions, in the present study, we aimed…
View article: Disrupting Maternal Behavior and Inducing Cannibalism Due to Valproic Acid: An Unexplored Insight
Disrupting Maternal Behavior and Inducing Cannibalism Due to Valproic Acid: An Unexplored Insight Open
Introduction: Valproic acid (VPA) is the most widely used chemical to develop the preclinical model of autism spectrum disorder (ASD). However, in addition to inducing autism, it causes different teratogenic effects like teeth malformation…
View article: Evaluation of prescriptions from tertiary care hospitals across India for deviations from treatment guidelines & their potential consequences
Evaluation of prescriptions from tertiary care hospitals across India for deviations from treatment guidelines & their potential consequences Open
Background & objectives: Irrational prescribing practices have major consequences on patient safety and also increase the economic burden. Real-life examples of impact of irrational prescription have potential to improve prescribing practi…
View article: The pivotal role of artificial intelligence in enhancing experimental animal model research: A machine learning perspective
The pivotal role of artificial intelligence in enhancing experimental animal model research: A machine learning perspective Open
Artificial intelligence (AI) refers to a computer imitating "intellectual processes characteristic of humans, such as the ability to reason, discover meaning, generalize, or learn from past experience."[1] Machine learning (ML) is a core a…
View article: A systematic review for the development of Alzheimer’s disease in in vitro models: a focus on different inducing agents
A systematic review for the development of Alzheimer’s disease in in vitro models: a focus on different inducing agents Open
Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease and is associated with dementia. Presently, various chemical and environmental agents are used to induce in-vitro models of Alzheimer disease to investigate …
View article: Antiparasitic effect of Farnesol against Leishmania major: A rationale from in vitro and in silico investigations
Antiparasitic effect of Farnesol against Leishmania major: A rationale from in vitro and in silico investigations Open
Leishmaniasis is a vector-borne parasitic infection caused by the infective bite of female Phlebotomine sandflies. Treatment of leishmaniasis by conventional synthetic compounds is met by challenges pertaining to adverse effects which call…
View article: Neuroprotective potential of erucic acid via inhibition of N2a cell lines and rotenone induced Parkinson’s disease rat model
Neuroprotective potential of erucic acid via inhibition of N2a cell lines and rotenone induced Parkinson’s disease rat model Open
OBJECTIVE: The objective of this study was to investigate the potential for erucic acid (EA), an omega-9 monounsaturated fatty acid, to act as a neuroprotective agent. MATERIALS AND METHODS: In this study, EA was investigated against N2a c…
View article: In silico and In vitro Antibacterial Activity of Essential oil of Eucalyptus globulus Labill
In silico and In vitro Antibacterial Activity of Essential oil of Eucalyptus globulus Labill Open
Eucalyptus globulus Labill. Traditionally used as disinfectant, fumigant, insect repellent, it is also used to cure asthma, bronchitis, arthritis, boils etc. The current research is focused on to study the in vitro and in silico antibacter…
View article: Space medicine
Space medicine Open
Introduction Space medicine may be defined as: "The practice of all aspects of preventive medicine including screening, health-care delivery, and maintaining human performance in the extreme environment of space and preserving the long-ter…