Bikui Zhang
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View article: Practical utility of meropenem therapeutic drug monitoring: a systematic review of evidence for clinical application
Practical utility of meropenem therapeutic drug monitoring: a systematic review of evidence for clinical application Open
Background and purpose Therapeutic Drug Monitoring (TDM) is advocated to optimize antibiotic therapy, yet its efficacy remains debated. This systematic review and meta-analysis evaluates TDM’s impact on meropenem therapy, focusing on treat…
View article: Therapeutic drug monitoring of biologics in inflammatory bowel disease: An evidence-based multidisciplinary guideline
Therapeutic drug monitoring of biologics in inflammatory bowel disease: An evidence-based multidisciplinary guideline Open
View article: The pharmacy graduate global competence evaluation scale (PGGCES): a nationwide study in China
The pharmacy graduate global competence evaluation scale (PGGCES): a nationwide study in China Open
To improve GC, universities should prioritize enhancing students' global competence through reading foreign language materials and interacting with international scholars in daily teaching. Additionally, under resource-limited conditions, …
View article: A practice guideline for therapeutic drug monitoring of mycophenolic acid for solid organ transplants
A practice guideline for therapeutic drug monitoring of mycophenolic acid for solid organ transplants Open
Mycophenolic acid (MPA), the active moiety of both mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (EC-MPS), serves as a primary immunosuppressant for maintaining solid organ transplants. Therapeutic drug monitoring (TD…
View article: Predictive value of the combined triglyceride-glucose and frailty index for cardiovascular disease and stroke in two prospective cohorts
Predictive value of the combined triglyceride-glucose and frailty index for cardiovascular disease and stroke in two prospective cohorts Open
Background The triglyceride-glucose (TyG) index is a validated surrogate for insulin resistance, while frailty reflects cumulative physiological decline. The combined impact of TyG-Frailty Index (TyGFI) has not been adequately explored. Th…
View article: Predictive Value of the Combined TyG and FI Index for Cardiovascular Disease and Stroke in two prospective cohorts
Predictive Value of the Combined TyG and FI Index for Cardiovascular Disease and Stroke in two prospective cohorts Open
Background The triglyceride-glucose (TyG) index is a validated surrogate for insulin resistance, while frailty reflects cumulative physiological decline. The combined impact of TyG-Frailty Index (TyGFI) has not been adequately explored. Th…
View article: Population pharmacokinetics and dosing optimization of teicoplanin in renal transplant patients
Population pharmacokinetics and dosing optimization of teicoplanin in renal transplant patients Open
The objectives of this study were to investigate the population pharmacokinetic (PK) characteristics of teicoplanin in renal transplant patients and to provide recommendations for optimal teicoplanin dosing regimens. A total of 99 renal tr…
View article: Corrigendum: Population dynamics analysis of the interaction between tacrolimus and voriconazole in renal transplant recipients
Corrigendum: Population dynamics analysis of the interaction between tacrolimus and voriconazole in renal transplant recipients Open
[This corrects the article DOI: 10.3389/fphar.2024.1502097.].
View article: Akkermansia muciniphila ameliorates olanzapine-induced metabolic dysfunction-associated steatotic liver disease via PGRMC1/SIRT1/FOXO1 signaling pathway
Akkermansia muciniphila ameliorates olanzapine-induced metabolic dysfunction-associated steatotic liver disease via PGRMC1/SIRT1/FOXO1 signaling pathway Open
Akkermansia muciniphila (AKK), classified as “lean bacteria,” has emerged as a promising candidate for ameliorating metabolic disorders, including obesity, diabetes, and liver disease. In this study, we investigated the therapeutic potenti…
View article: Evaluating the influence MRSA Co-infection on 28-day mortality among sepsis patients: insights from the MIMIC-IV database
Evaluating the influence MRSA Co-infection on 28-day mortality among sepsis patients: insights from the MIMIC-IV database Open
Background Sepsis remains a leading cause of mortality in intensive care units (ICUs), with methicillin-resistant Staphylococcus aureus (MRSA) infections presenting significant treatment challenges. The impact of MRSA co-infection on sepsi…
View article: A preliminary exploration of liver microsomes and PBPK to uncover the impact of CYP3A4/5 and CYP2C19 on tacrolimus and voriconazole drug-drug interactions
A preliminary exploration of liver microsomes and PBPK to uncover the impact of CYP3A4/5 and CYP2C19 on tacrolimus and voriconazole drug-drug interactions Open
View article: Unmasking MRSA antibiotic resistance: the impact of environment, pollution, and healthcare quality—a nationwide exploration in China: a comprehensive analysis spanning 2014 to 2021 in mainland China
Unmasking MRSA antibiotic resistance: the impact of environment, pollution, and healthcare quality—a nationwide exploration in China: a comprehensive analysis spanning 2014 to 2021 in mainland China Open
Background The rise of antibiotic resistance has become a critical global health concern, resulting in numerous fatalities annually. Among resistant pathogens, methicillin-resistant Staphylococcus aureus (MRSA) poses a particularly severe …
View article: Population dynamics analysis of the interaction between tacrolimus and voriconazole in renal transplant recipients
Population dynamics analysis of the interaction between tacrolimus and voriconazole in renal transplant recipients Open
Background The concurrent administration of tacrolimus and voriconazole in kidney transplant recipients can lead to drug interactions, potentially resulting in severe adverse reactions. This study aimed to establish a robust population pha…
View article: Epidemiology and Risk Factors of Carbapenem Resistance Among Gram-Negative Pathogens: A Two-Phase Clinical and Microbiological Study
Epidemiology and Risk Factors of Carbapenem Resistance Among Gram-Negative Pathogens: A Two-Phase Clinical and Microbiological Study Open
View article: Voriconazole Adjustment for Liver Dysfunction (VALID): From Population Pharmacokinetic Model to the Real-World
Voriconazole Adjustment for Liver Dysfunction (VALID): From Population Pharmacokinetic Model to the Real-World Open
Objective Liver dysfunction affects drug metabolism, including voriconazole, used for treating fungal infections. This study evaluated the effectiveness and safety of a voriconazole dosing regimen adjusted for liver dysfunction (VALID) com…
View article: Higher Depressive Symptom Burden is Associated with Elevated Liver Disease Risk: Longitudinal Evidence from Two National Aging Cohorts
Higher Depressive Symptom Burden is Associated with Elevated Liver Disease Risk: Longitudinal Evidence from Two National Aging Cohorts Open
View article: Optimizing mathematical models for the efficacy and precise regimens of meropenem in RICU patients: a real-world prospective study
Optimizing mathematical models for the efficacy and precise regimens of meropenem in RICU patients: a real-world prospective study Open
Background It is inadequate to direct evaluation of meropenem pharmacokinetic targets and clinical efficacy. This study aimed to investigate the predictors of meropenem clinical effectiveness and to optimize dosing regimens precisely in th…
View article: Integration of genomics, clinical characteristics and baseline biological profiles to predict the risk of liver injury induced by high-dose methotrexate
Integration of genomics, clinical characteristics and baseline biological profiles to predict the risk of liver injury induced by high-dose methotrexate Open
Background High-dose methotrexate (HD-MTX) is commonly employed in the treatment of malignant tumors in children and young adults due to its distinctive therapeutic efficacy. Nonetheless, the systemic exposure to MTX often results in liver…
View article: Role for the F-box proteins in heart diseases
Role for the F-box proteins in heart diseases Open
The maintenance of cardiac homeostasis necessitates proper protein turnover, which is regulated by the ubiquitin-proteasome system. F-box proteins are one type of E3 ubiquitin ligases, and accumulating evidence suggests that dysregulation …
View article: Harnessing Tumor Cell‐Derived Exosomes for Immune Rejection Management in Corneal Transplantation
Harnessing Tumor Cell‐Derived Exosomes for Immune Rejection Management in Corneal Transplantation Open
Transplantation remains the definitive treatment for end‐stage organ failures, but its efficacy is frequently compromised by immune rejection. This study introduces a novel strategy by utilizing tumor‐derived exosomes from B16‐F10 melanoma…
View article: Parthenolide alleviates doxorubicin-induced cardiotoxicity via regulation of Cyp1a1 and Nppa and suppression of NLRP3 inflammasome
Parthenolide alleviates doxorubicin-induced cardiotoxicity via regulation of Cyp1a1 and Nppa and suppression of NLRP3 inflammasome Open
A combination administration of PTL effectively inhibited Dox-induced cytotoxicity as well as cardiomyocyte apoptosis in H9c2 cells. PTL also exerts a protective effect on Dox-induced cardiac injury by improving myocardial function, histol…
View article: Individualized dosing parameters for tacrolimus in the presence of voriconazole: a real-world PopPK study
Individualized dosing parameters for tacrolimus in the presence of voriconazole: a real-world PopPK study Open
Objectives Significant increase in tacrolimus exposure was observed during co-administration with voriconazole, and no population pharmacokinetic model exists for tacrolimus in renal transplant recipients receiving voriconazole. To achieve…
View article: Sustainable Implementation of Physician-Pharmacist Collaborative Clinics for Diabetes Management in Primary Healthcare Centers: A Qualitative Study
Sustainable Implementation of Physician-Pharmacist Collaborative Clinics for Diabetes Management in Primary Healthcare Centers: A Qualitative Study Open
View article: Combination of UGT1A1 polymorphism and baseline plasma bilirubin levels in predicting the risk of antipsychotic-induced dyslipidemia in schizophrenia patients
Combination of UGT1A1 polymorphism and baseline plasma bilirubin levels in predicting the risk of antipsychotic-induced dyslipidemia in schizophrenia patients Open
The prolonged usage of atypical antipsychotic drugs (AAPD) among individuals with schizophrenia often leads to metabolic side effects such as dyslipidemia. These effects not only limit one’s selection of AAPD but also significantly reduce …
View article: Improving Survival in Sepsis: Optimizing Treatment Duration with Polymyxin-B Immobilized Hemoperfusion—A Comprehensive Network Meta-Analysis
Improving Survival in Sepsis: Optimizing Treatment Duration with Polymyxin-B Immobilized Hemoperfusion—A Comprehensive Network Meta-Analysis Open
Background and objectives: Sepsis and septic shock are critical health emergencies with high morbidity and mortality rates, often triggered by infections. The study investigates Polymyxin B-immobilized fiber column hemoperfusion (PMX-HP) a…
View article: Exploring the causes of the prevalence of vancomycin-resistant Enterococcus faecalis
Exploring the causes of the prevalence of vancomycin-resistant Enterococcus faecalis Open
Background Bacterial drug resistance represents a significant global concern, with vancomycin-resistant Enterococcus faecalis posing a particularly grave threat to contemporary healthcare systems. This study aims to reveal the reasons for …
View article: Unraveling the Mysteries Behind Resistance and Mortality in China's Carbapenem-Resistant Bacteria
Unraveling the Mysteries Behind Resistance and Mortality in China's Carbapenem-Resistant Bacteria Open
Background: The current situation of bacterial resistance is severe. This study aimed to investigate the relationship between four Gram-negative bacteria and the environment, diet, and mortality. Methods: Data for this study were sourced f…
View article: Environmental factors influencing the development and spread of resistance in erythromycin-resistant streptococcus pneumoniae
Environmental factors influencing the development and spread of resistance in erythromycin-resistant streptococcus pneumoniae Open
Background: Bacterial drug resistance is becoming increasingly serious,This study aims to investigate the relationship between the resistance rate of erythromycin-resistant Streptococcus pneumoniae and reasons for the epidemic under comple…
View article: Pre-treatment risk predictors of valproic acid-induced dyslipidemia in pediatric patients with epilepsy
Pre-treatment risk predictors of valproic acid-induced dyslipidemia in pediatric patients with epilepsy Open
Background: Valproic acid (VPA) stands as one of the most frequently prescribed medications in children with newly diagnosed epilepsy. Despite its infrequent adverse effects within therapeutic range, prolonged VPA usage may result in metab…
View article: CircAkap7: A novel circular RNA with a role in Doxorubicin-induced cardiotoxicity
CircAkap7: A novel circular RNA with a role in Doxorubicin-induced cardiotoxicity Open