Bilal E. Kerman
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View article: Development of Potent, Selective cPLA2 Inhibitors for Targeting Neuroinflammation in Alzheimer’s Disease and Other Neurodegenerative Disorders
Development of Potent, Selective cPLA2 Inhibitors for Targeting Neuroinflammation in Alzheimer’s Disease and Other Neurodegenerative Disorders Open
Chronic neuroinflammation plays a key role in the progression of Alzheimer’s disease (AD), and the cytosolic calcium-dependent phospholipase A2 (cPLA 2 ) enzyme is a critical mediator of inflammatory lipid signaling pathways. Here we inves…
View article: PreventE4: A Double-Blind Placebo Controlled Clinical Trial Testing High Dose DHA in APOE ε4 Carriers Before the Onset of Dementia
PreventE4: A Double-Blind Placebo Controlled Clinical Trial Testing High Dose DHA in APOE ε4 Carriers Before the Onset of Dementia Open
View article: Increased cerebrospinal fluid and plasma apoE glycosylation is associated with reduced levels of Alzheimer’s disease biomarkers
Increased cerebrospinal fluid and plasma apoE glycosylation is associated with reduced levels of Alzheimer’s disease biomarkers Open
The apolipoprotein E ( APOE ) ε4 allele is the strongest genetic risk factor for Alzheimer’s disease (AD). ApoE is glycosylated with an O-linked Core-1 sialylated glycan at several sites, yet the impact and function of this glycosylation o…
View article: Novel mechanisms of cytosolic phospholipase A2 beta in neurodegeneration and cognitive impairments of Alzheimer’s disease
Novel mechanisms of cytosolic phospholipase A2 beta in neurodegeneration and cognitive impairments of Alzheimer’s disease Open
Background Synaptic loss predicts cognitive decline in Alzheimer’s disease (AD). However, the critical disease modifying molecular mechanisms of synaptic failure remain elusive. Animal studies implicate the increased activation of cytosoli…
View article: Single cell nuclei transcriptomics of human brains identify a role for homeostatic microglia in cellular senescence in Alzheimer’s disease
Single cell nuclei transcriptomics of human brains identify a role for homeostatic microglia in cellular senescence in Alzheimer’s disease Open
Background Cellular senescence is a hallmark of aging and has been implicated in several neurodegenerative diseases including Alzheimer’s disease (AD). Senescence cells undergo changes in gene expression and metabolism and can exhibit a so…
View article: Studying APOE Aggregation in Live Cells and Human Neurons
Studying APOE Aggregation in Live Cells and Human Neurons Open
Background Human Apolipoprotein (APOE) has three isoforms, ε2 , ε3 , and ε4 among which ε4 ( APOE4 ) confers the highest risk for late‐onset Alzheimer’s disease (AD). APOE4 is also the most prone to aggregate among APOE isoforms. Current e…
View article: Microglia States are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer’s Disease
Microglia States are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer’s Disease Open
Cellular senescence is a major contributor to aging-related degenerative diseases, including Alzheimer’s disease (AD) but much less is known on the key cell types and pathways driving mechanisms of senescence in the brain. We hypothesized …
View article: Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD
Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD Open
View article: ABCA1 Deficiency Impairs Endosomal-Lysosomal Trafficking of Glutamate Receptors in the Brain
ABCA1 Deficiency Impairs Endosomal-Lysosomal Trafficking of Glutamate Receptors in the Brain Open
View article: Can the gut microbiome inform the effects of omega-3 fatty acid supplementation trials on cognition?
Can the gut microbiome inform the effects of omega-3 fatty acid supplementation trials on cognition? Open
Purpose of review Most omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation clinical trials report inconsistent or null findings on measures of cognition or Alzheimer's disease (AD) with a relatively large variability in the respo…
View article: Mechanisms of reduced Apolipoprotein E4 lipidation in iPSC‐derived astrocytes
Mechanisms of reduced Apolipoprotein E4 lipidation in iPSC‐derived astrocytes Open
Background Carrying the apolipoprotein E ε4 (APOE4) allele is the highest known genetic risk factor for late‐onset Alzheimer’s disease (LOAD). Although how APOE4 leads to LOAD is not known, dysregulated endo‐lysosomal trafficking and lipid…
View article: Manipulation of Dietary DHA does not Alter DHA Brain Uptake Kinetics in Mice Despite Changing Brain and Plasma DHA Levelsvs
Manipulation of Dietary DHA does not Alter DHA Brain Uptake Kinetics in Mice Despite Changing Brain and Plasma DHA Levelsvs Open
Background Increased brain docosahexaenoic acid (DHA) uptake reflects a compensatory mechanism for maintaining brain DHA homeostasis and can be captured through PET‐MRI scan uptake studies using radiolabeled DHA. It has been previously sho…
View article: Cholesterol accumulation promotes ABCA1 degradation in astrocytes via Caveolin‐1 mediated endocytosis in ApoE4
Cholesterol accumulation promotes ABCA1 degradation in astrocytes via Caveolin‐1 mediated endocytosis in ApoE4 Open
Background Apolipoprotein E4 (ApoE4) dysregulates cholesterol metabolism in the brain promoting the accumulation of lipid droplets, synaptic dysfunction and associates with a greater Alzheimer’s disease risk. We previously demonstrated tha…
View article: Identification of protein–protein interaction bridges for multiple sclerosis
Identification of protein–protein interaction bridges for multiple sclerosis Open
Motivation Identifying and prioritizing disease-related proteins is an important scientific problem to develop proper treatments. Network science has become an important discipline to prioritize such proteins. Multiple sclerosis, an autoim…
View article: Hexokinase 1b is a novel target for Non–small-cell lung cancer
Hexokinase 1b is a novel target for Non–small-cell lung cancer Open
SUMMARY Deregulation of glycolysis is common in non-small cell lung cancer (NSCLC). Hexokinase (HK) enzymes catalyze the phosphoryl-group-transfer in glucose metabolism. There are a very few studies that have begun to reveal the connection…
View article: Effect Of The ABCA1 Agonist CS-6253 On Amyloid β And Lipoproteins Metabolism In Cynomolgus Monkeys.
Effect Of The ABCA1 Agonist CS-6253 On Amyloid β And Lipoproteins Metabolism In Cynomolgus Monkeys. Open
Background: Inducing brain ATP binding cassette 1 (ABCA1) activity in Alzheimer’s disease (AD) mouse models is associated with improvement in AD pathology. The purpose of this study was to investigate the effects of the ABCA1 agonist pepti…
View article: Supplement : Abstract Proceedings of the 7th INTERNATIONAL CONGRESS of THE MOLECULAR BIOLOGY ASSOCIATION of TURKEY
Supplement : Abstract Proceedings of the 7th INTERNATIONAL CONGRESS of THE MOLECULAR BIOLOGY ASSOCIATION of TURKEY Open
The annual MolBiyoKon congress is organized by the Molecular Biology Association of Turkey and is one of the primary and noteworthy international conferences in the field of molecular biology in Turkey.The congress aims to bring together s…
View article: Author Index
Author Index Open
View article: Front Matter: Volume 10887
Front Matter: Volume 10887 Open
View article: Author response: Species-specific maturation profiles of human, chimpanzee and bonobo neural cells
Author response: Species-specific maturation profiles of human, chimpanzee and bonobo neural cells Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Comparative analyses of neuronal phenotype…
View article: NextGen Voices: Quality mentoring
NextGen Voices: Quality mentoring Open
peer reviewed
View article: DeepMQ: A Deep Learning Approach Based Myelin Quantification in Microscopic Fluorescence Images
DeepMQ: A Deep Learning Approach Based Myelin Quantification in Microscopic Fluorescence Images Open
Oligodendrocytes wrap around the axons and form the myelin. Myelin facilitates rapid neural signal transmission. Any damage to myelin disrupts neuronal communication leading to neurological diseases such as multiple sclerosis (MS). There i…
View article: Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice
Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice Open
Apart from its potent antioxidant property, recent studies have revealed that melatonin promotes PI3K/Akt phosphorylation following focal cerebral ischemia (FCI) in mice. However, it is not clear (i) whether increased PI3K/Akt phosphorylat…
View article: Myelin disorders and stem cells: as therapies and models
Myelin disorders and stem cells: as therapies and models Open
Myelin disorders burden millions of people around the world, yet existing therapies are inadequate to cure them. Current remedies commonly treat the symptoms with minimal to no effect on the actual cause of the disorder. The basis and/or t…
View article: Primate-Specific ORF0 Contributes to Retrotransposon-Mediated Diversity
Primate-Specific ORF0 Contributes to Retrotransposon-Mediated Diversity Open
View article: <i>In vitro</i> myelin formation using embryonic stem cells
<i>In vitro</i> myelin formation using embryonic stem cells Open
Myelination in the central nervous system is the process by which oligodendrocytes form myelin sheaths around the axons of neurons. Myelination enables neurons to transmit information more quickly and more efficiently and allows for more c…