Bilian Ke
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Longitudinal Study of Changes in Retinal Curvature and its Relationship With Myopia Shift in Chinese Children Open
RC changes are closely linked to myopia shift. Longitudinal monitoring of RC can serve as a quantitative measure for assessing morphological changes associated with myopia shift in children.
Extracellular Matrix Stiffness Modulates Myopia Scleral Remodeling Through Integrin/F-Actin/YAP Axis Open
Our results suggest that the integrin α1β1-F-actin-YAP-COL1A1 axis constitutes a vital regulatory mechanism intrinsically associated with the pathogenesis of myopia.
Change in three‐dimensional choroidal vessel network after <span>AR</span> device assisted 1‐hour visual task in <span>2D</span>/<span>3D</span> mode in young healthy subjects Open
Purpose The purpose of the study was to investigate the changes of choroidal blood perfusion in different layers and quadrants and its possible related factors after 1 h visual task by augmented reality (AR) device in two‐dimensional (2D) …
View article: Perfluorohexyloctane Eye Drops for Dry Eye Disease Associated With Meibomian Gland Dysfunction in Chinese Patients
Perfluorohexyloctane Eye Drops for Dry Eye Disease Associated With Meibomian Gland Dysfunction in Chinese Patients Open
Importance Meibomian gland dysfunction (MGD) is a leading cause of evaporative dry eye disease (DED). Medical and surgical management for DED is limited; therefore, new treatment options are sought. Objective To evaluate the efficacy and s…
View article: Combination Therapy of 0.1% Fluorometholone and 0.05% Azelastine in Eyes with Severe Allergic Conjunctival Diseases: A Randomized Controlled Trial
Combination Therapy of 0.1% Fluorometholone and 0.05% Azelastine in Eyes with Severe Allergic Conjunctival Diseases: A Randomized Controlled Trial Open
This study sought to evaluate the efficacy of the isolated use of fluorometholone compared with the combined use of azelastine and fluorometholone for the treatment of severe allergic conjunctival disease (ACD). One hundred and eleven pati…
Changes in Dimensions and Functions of Crystalline Lens in High Myopia Using CASIA2 Optical Coherence Tomography Open
Introduction: Crystalline lens is the major dioptric component and varies with refractive status. In this study, we aim to evaluate the changes of dimensions and functions of crystalline lens in high myopia (HM) and its correlated variable…
View article: Combination of 0.05% Azelastine and 0.1% Tacrolimus Eye Drops in Children With Vernal Keratoconjunctivitis: A Prospective Study
Combination of 0.05% Azelastine and 0.1% Tacrolimus Eye Drops in Children With Vernal Keratoconjunctivitis: A Prospective Study Open
Aims: To compare the efficacy of the combination of 0. 05% azelastine and 0.1% tacrolimus eye drops with 0.1% tacrolimus monotherapy in pediatric patients with vernal keratoconjunctivitis (VKC). Methods: Prospective study. Seventy-six pati…
Clinical Characteristics of Paracentral Acute Middle Maculopathy in Eyes with Retinal Vascular Occlusion Diseases in Chinese Patients Open
Aim. To investigate the incidence and clinical characteristics of paracentral acute middle maculopathy (PAMM) and its relationship with prominent middle limiting membrane (p-MLM) sign in eyes with retinal artery occlusion (RAO) or retinal …
Alternative Flicker Glass: A New Anti-Suppression Approach to the Treatment of Anisometropic Amblyopia Open
Introduction: Amblyopia always presents with monocular and binocular dysfunction. In this study, we aim to investigate the efficacy of alternative occlusion using liquid crystal glasses versus continuous occlusion therapy using traditional…
Transient reduction in the retinal microvascular network following implantation surgery of implantable collamer lens: An OCT angiography study. Open
Retinal microvascular density was decreased postoperatively and then recovered toward the baseline level after 3 months. ICL surgery may have a transient influence on the retinal microvascular network without affecting visual function.
Comparative proteome analysis of form-deprivation myopia in sclera with iTRAQ-based quantitative proteomics. Open
Proteomics and bioinformatics results can be helpful for identifying proteins and providing new insights for better understanding of the molecular mechanism underlying scleral remodeling. These results revealed that the proteins associated…
Transient Alteration of Retinal Microvasculature after Refractive Surgery Open
Purpose: The purpose of this study was to determine the retinal microvasculature in myopic patients after refractive surgery. Methods: Thirty-six right eyes of 36 patients who undertook femtosecond laser-assisted laser in situ keratomileus…
Endoplasmic Reticulum Stress Regulates Scleral Remodeling in a Guinea Pig Model of Form-Deprivation Myopia Open
Purpose . This study aimed to investigate the role of endoplasmic reticulum (ER) stress in scleral remodeling in a guinea pig model of form-deprivation myopia (FDM). Methods . Guinea pigs were form deprived to induce myopia. ER ultrastruct…
The Role of the RhoA/ROCK Signaling Pathway in Mechanical Strain-Induced Scleral Myofibroblast Differentiation Open
Mechanical strain activated RhoA signaling and scleral myofibroblast differentiation. Strain also mediated myofibroblast differentiation via the RhoA/ROCK2-MRTF-A/SRF pathway. These findings provided evidence for a mechanical strain-induce…
Involvement of ciliary neurotrophic factor in early diabetic retinal neuropathy in streptozotocin-induced diabetic rats Open
Our study suggests that early diabetic retinal neuropathy involves the reduced expression of CNTF and can be ameliorated by an exogenous supply of this neurotrophin.
Post-LASIK exacerbation of granular corneal dystrophy type 2 in members of a chinese family Open
PurposeThe post-LASIK exacerbation of corneal dystrophy, otherwise asymptomatic, is almost exclusively associated with the TGFBI gene mutations at codon 124 in exon 4 and codon 555 in exon 12. It is our intention to demonstrate that the pr…
The Relationship Between High-Order Aberration and Anterior Ocular Biometry During Accommodation in Young Healthy Adults Open
HOA components altered during step-controlled accommodative stimuli. Ciliary muscle first contracted during stepwise accommodation, which may directly contribute to the reduction of spherical aberration (SA). The lens morphology was then a…
Interaction between Corneal and Internal Ocular Aberrations Induced by Orthokeratology and Its Influential Factors Open
Purpose . To investigate the interaction between corneal, internal, and total wavefront aberrations (WAs) and their influential factors during orthokeratology (OK) treatment in Chinese adolescents. Methods . Thirty teenagers (eyes) were en…
Wavefront Derived Refraction and Full Eye Biometry in Pseudophakic Eyes Open
The combined system is capable of measuring full eye biometry and refraction with good repeatability. The system is suitable for future investigation of pseudoaccommodation in the pseudophakic eye.
Expression of Wnt/<i>β</i>-Catenin Signaling Pathway and Its Regulatory Role in Type I Collagen with TGF-<i>β</i>1 in Scleral Fibroblasts from an Experimentally Induced Myopia Guinea Pig Model Open
Background . To investigate Wnt/ β -catenin signaling pathway expression and its regulation of type I collagen by TGF- β 1 in scleral fibroblasts from form-deprivation myopia (FDM) guinea pig model. Methods . Wnt isoforms were examined usi…