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View article: ADAR1 editing is necessary for only a small subset of cytosolic dsRNAs to evade MDA5-mediated autoimmunity
ADAR1 editing is necessary for only a small subset of cytosolic dsRNAs to evade MDA5-mediated autoimmunity Open
Endogenous long double-stranded RNAs (dsRNAs), which are not edited by the RNA editing enzyme ADAR1, may activate the antiviral dsRNA receptor MDA5 to trigger interferon-mediated immune responses. Among the large number of endogenous long …
View article: ADAR1p150 RNA binding, independent of A-to-I RNA editing, buffers immunogenicity from the tonic type I IFN induced transcriptome <i>in vivo</i>
ADAR1p150 RNA binding, independent of A-to-I RNA editing, buffers immunogenicity from the tonic type I IFN induced transcriptome <i>in vivo</i> Open
ADAR1 edits adenosine to inosine (A-to-I) in double-stranded RNA to prevent MDA5 sensing of cellular transcripts, its key physiological role. However, editing-independent functions of ADAR1 remain poorly understood. Using a series of Adar1…
View article: Stereo-random oligonucleotides enable efficient recruitment of ADAR in vitro and in vivo
Stereo-random oligonucleotides enable efficient recruitment of ADAR in vitro and in vivo Open
Site-directed RNA editing is a promising and potentially safer alternative to genome editing. Previous methods have been developed that recruit the endogenously and ubiquitously expressed ADAR enzymes to initiate site-specific A-to-I edits…
View article: Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of the RNA sensor MDA5 in atherosclerosis
Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of the RNA sensor MDA5 in atherosclerosis Open
Although genetic risk in coronary artery disease (CAD) is linked to changes in gene expression, recent discoveries have revealed a major role for A-to-I RNA editing in CAD. ADAR1 edits immunogenic double-stranded RNA (dsRNA), preventing ac…
View article: A highly conserved A-to-I RNA editing event within the glutamate-gated chloride channel GluClα is necessary for olfactory-based behaviors in <i>Drosophila</i>
A highly conserved A-to-I RNA editing event within the glutamate-gated chloride channel GluClα is necessary for olfactory-based behaviors in <i>Drosophila</i> Open
A-to-I RNA editing is a cellular mechanism that generates transcriptomic and proteomic diversity, which is essential for neuronal and immune functions. It involves the conversion of specific adenosines in RNA molecules to inosines, which a…
View article: Smooth muscle expression of RNA editing enzyme <i>ADAR1</i> controls activation of RNA sensor MDA5 in atherosclerosis
Smooth muscle expression of RNA editing enzyme <i>ADAR1</i> controls activation of RNA sensor MDA5 in atherosclerosis Open
Mapping the genomic architecture of complex disease has been predicated on the understanding that genetic variants influence disease risk through modifying gene expression. However, recent discoveries have revealed that a significant burde…
View article: Multifaceted roles of RNA editing enzyme ADAR1 in innate immunity
Multifaceted roles of RNA editing enzyme ADAR1 in innate immunity Open
Innate immunity must be tightly regulated to enable sensitive pathogen detection while averting autoimmunity triggered by pathogen-like host molecules. A hallmark of viral infection, double-stranded RNAs (dsRNAs) are also abundantly encode…
View article: <scp>A‐to‐I RNA</scp> editing by <scp>ADAR</scp> and its therapeutic applications: From viral infections to cancer immunotherapy
<span>A‐to‐I RNA</span> editing by <span>ADAR</span> and its therapeutic applications: From viral infections to cancer immunotherapy Open
ADAR deaminases catalyze adenosine‐to‐inosine (A‐to‐I) editing on double‐stranded RNA (dsRNA) substrates that regulate an umbrella of biological processes. One of the two catalytically active ADAR enzymes, ADAR1, plays a major role in inna…
View article: A highly conserved A-to-I RNA editing event within the glutamate-gated chloride channel GluClα is necessary for olfactory-based behaviors in<i>Drosophila</i>
A highly conserved A-to-I RNA editing event within the glutamate-gated chloride channel GluClα is necessary for olfactory-based behaviors in<i>Drosophila</i> Open
A-to-I RNA editing is an important cellular process that modifies genomically encoded information during transcription, to generate various RNA isoforms from a single DNA sequence. It involves the conversion of specific adenosines in the R…
View article: ADAR1p150 Prevents MDA5 and PKR Activation via Distinct Mechanisms to Avert Fatal Autoinflammation
ADAR1p150 Prevents MDA5 and PKR Activation via Distinct Mechanisms to Avert Fatal Autoinflammation Open
Summary Effective immunity requires the innate immune system to distinguish foreign (non-self) nucleic acids from cellular (self) nucleic acids. Cellular double-stranded RNAs (dsRNAs) are edited by the RNA editing enzyme ADAR1 to prevent t…
View article: Ablation of Adar1 in myeloid cells imprints a global antiviral state in the lung and heightens early immunity against SARS-CoV-2
Ablation of Adar1 in myeloid cells imprints a global antiviral state in the lung and heightens early immunity against SARS-CoV-2 Open
Under normal homeostatic conditions, self-double-stranded RNA (self-dsRNA) is modified by adenosine deaminase acting on RNA 1 (ADAR1) to prevent the induction of a type I interferon-mediated inflammatory cascade. Antigen-presenting cells (…
View article: A Small Subset of Cytosolic dsRNAs Must Be Edited by ADAR1 to Evade MDA5-Mediated Autoimmunity
A Small Subset of Cytosolic dsRNAs Must Be Edited by ADAR1 to Evade MDA5-Mediated Autoimmunity Open
The innate immune system detects viral infection via pattern recognition receptors and induces defense reactions such as production of type I interferon 1 . One such receptor, MDA5, is activated upon the recognition of double-stranded RNAs…
View article: Developmentally regulated alternate 3′ end cleavage of nascent transcripts controls dynamic changes in protein expression in an adult stem cell lineage
Developmentally regulated alternate 3′ end cleavage of nascent transcripts controls dynamic changes in protein expression in an adult stem cell lineage Open
Alternative polyadenylation (APA) generates transcript isoforms that differ in the position of the 3′ cleavage site, resulting in the production of mRNA isoforms with different length 3′ UTRs. Although widespread, the role of APA in the bi…
View article: Learning <i>cis</i>-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis
Learning <i>cis</i>-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis Open
Adenosine-to-inosine (A-to-I) RNA editing catalyzed by ADAR enzymes occurs in double-stranded RNAs (dsRNAs). How the RNA sequence and structure (i.e., the cis -regulation) determine the editing efficiency and specificity is poorly understo…
View article: Unbiased identification of <i>trans</i> regulators of ADAR and A-to-I RNA editing
Unbiased identification of <i>trans</i> regulators of ADAR and A-to-I RNA editing Open
Adenosine-to-Inosine RNA editing is catalyzed by ADAR enzymes that deaminate adenosine to inosine. While many RNA editing sites are known, few trans regulators have been identified. We perform BioID followed by mass-spectrometry to identif…
View article: Zinc finger RNA binding protein Zn72D regulates ADAR-mediated RNA editing in neurons
Zinc finger RNA binding protein Zn72D regulates ADAR-mediated RNA editing in neurons Open
Adenosine-to-inosine RNA editing, catalyzed by ADAR enzymes, alters RNA sequences from those encoded by DNA. These editing events are dynamically regulated, but few trans regulators of ADARs are known in vivo . Here, we screen RNA binding …
View article: Illuminating spatial A-to-I RNA editing signatures within the <i>Drosophila</i> brain
Illuminating spatial A-to-I RNA editing signatures within the <i>Drosophila</i> brain Open
Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by ADAR enzymes, is a ubiquitous mechanism that generates transcriptomic diversity. This process is particularly important for proper neuronal function; however, little is known about ho…
View article: Dynamic landscape and genetic regulation of RNA editing in schizophrenia
Dynamic landscape and genetic regulation of RNA editing in schizophrenia Open
RNA editing is vital for neurodevelopment and the maintenance of normal neuronal function. We surveyed the global landscape and genetic regulation of RNA editing across several hundred schizophrenia and control postmortem brain samples fro…