Billy W. Loo
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View article: High-speed proton therapy within a short breath-hold
High-speed proton therapy within a short breath-hold Open
Proton therapy provides superior dose conformity compared with photon radiotherapy, concentrating radiation within the tumor while sparing adjacent healthy tissue. This advantage has been most effectively realized for static tumors in anat…
View article: Translating FLASH to the clinic: treatment planning system for a FLASH-compatible dose delivery using a novel x-ray UHDR machine
Translating FLASH to the clinic: treatment planning system for a FLASH-compatible dose delivery using a novel x-ray UHDR machine Open
Objective. To develop and validate a treatment planning system (TPS) for a novel x-ray ultra-high dose rate (UHDR) system and compare its performance with conventional volumetric modulated arc therapy (VMAT).
Approach. A TPS was develo…
View article: Non-invasive Reversible Software-based Configuration of a Clinically Used Linear Accelerator for Preclinical Electron FLASH Radiobiology
Non-invasive Reversible Software-based Configuration of a Clinically Used Linear Accelerator for Preclinical Electron FLASH Radiobiology Open
Configuring clinical linear accelerators (linacs) for ultra-high dose rate (UHDR) electron experiments typically requires invasive hardware manipulation and/or irreversible manufacturer modifications, limiting broader implementation. We pr…
View article: Figures S1-S8 from Integrating ctDNA Analysis and Radiomics for Dynamic Risk Assessment in Localized Lung Cancer
Figures S1-S8 from Integrating ctDNA Analysis and Radiomics for Dynamic Risk Assessment in Localized Lung Cancer Open
Figures showing the CONSORT diagram, clonal hematopoiesis prevalence, the SNV score model, mid-chemoradiation ctDNA analysis, radiomic model robustness, pre-chemoradiation prognostic factors, association of clonal hematopoiesis with outcom…
View article: Data from Integrating ctDNA Analysis and Radiomics for Dynamic Risk Assessment in Localized Lung Cancer
Data from Integrating ctDNA Analysis and Radiomics for Dynamic Risk Assessment in Localized Lung Cancer Open
The complementarity and clinical utility of combining liquid biopsies and radiomic image analysis has not been demonstrated. ctDNA minimal residual disease after chemoradiotherapy (CRT) for non–small cell lung cancer (NSCLC) is highly prog…
View article: Table S1-S10 from Integrating ctDNA Analysis and Radiomics for Dynamic Risk Assessment in Localized Lung Cancer
Table S1-S10 from Integrating ctDNA Analysis and Radiomics for Dynamic Risk Assessment in Localized Lung Cancer Open
Anonymized clinical and demographic data, cell-free DNA metrics, somatic mutation data, radiomic, biological, and molecular metrics, and CIRI-LCRT predicted progression-free survival.
View article: Modification of the microstructure of the CERN- CLEAR-VHEE beam at the picosecond scale modifies ZFE morphogenesis but has no impact on hydrogen peroxide production
Modification of the microstructure of the CERN- CLEAR-VHEE beam at the picosecond scale modifies ZFE morphogenesis but has no impact on hydrogen peroxide production Open
Our findings suggest that scanning strategies employing high intensity beamlets may be optimal for the clinical implementation of FLASH radiotherapy. These insights are pivotal for guiding the development of future FLASH protocols in radia…
View article: Integrating ctDNA Analysis and Radiomics for Dynamic Risk Assessment in Localized Lung Cancer
Integrating ctDNA Analysis and Radiomics for Dynamic Risk Assessment in Localized Lung Cancer Open
The complementarity and clinical utility of combining liquid biopsies and radiomic image analysis has not been demonstrated. ctDNA minimal residual disease after chemoradiotherapy (CRT) for non–small cell lung cancer (NSCLC) is highly prog…
View article: Effectiveness of FLASH vs. Conventional Dose Rate Radiotherapy in a Model of Orthotopic, Murine Breast Cancer
Effectiveness of FLASH vs. Conventional Dose Rate Radiotherapy in a Model of Orthotopic, Murine Breast Cancer Open
Introduction: Radiotherapy is effective for breast cancer treatment but often causes undesirable side effects that impair quality of life. Ultra-high dose rate radiotherapy (FLASH) has shown reduced normal tissue toxicity while achieving c…
View article: Rapid Sterilization of Clinical Apheresis Blood Products Using Ultra-High Dose Rate Radiation
Rapid Sterilization of Clinical Apheresis Blood Products Using Ultra-High Dose Rate Radiation Open
Blood products, including apheresis platelets and plasma, are essential for medical use but pose risks of bacterial contamination and viral transmission. Platelets are prone to bacterial growth due to their storage conditions, while plasma…
View article: Modification of the microstructure of the CERN- CLEAR-VHEE beam at the picosecond scale modifies ZFE morphogenesis but has no impact on hydrogen peroxide production
Modification of the microstructure of the CERN- CLEAR-VHEE beam at the picosecond scale modifies ZFE morphogenesis but has no impact on hydrogen peroxide production Open
FLASH has emerged as a significant breakthrough for the future of radiation oncology, as it reduces complications while preserving the tumor killing efficacy. To define the beam parameters for future clinical translation, Very High Energy …
View article: Effectiveness of FLASH vs conventional dose rate radiotherapy in a model of orthotopic, murine breast cancer
Effectiveness of FLASH vs conventional dose rate radiotherapy in a model of orthotopic, murine breast cancer Open
Purpose Radiotherapy is an effective breast cancer treatment that enhances local tumor control and prolongs overall survival yet is associated with undesirable side effects which can impair quality of life. Ultra-high dose rate radiotherap…
View article: Rapid Sterilization of Clinical Apheresis Blood Products using Ultra-High Dose Rate Radiation
Rapid Sterilization of Clinical Apheresis Blood Products using Ultra-High Dose Rate Radiation Open
BACKGROUND AND OBJECTIVES Apheresis platelets products and plasma are essential for medical interventions, but both still have inherent risks associated with contamination and viral transmission. Platelet products are vulnerable to bacteri…
View article: AVATAR 2.0: next level communication systems for radiotherapy through face-to-face video, biofeedback, translation, and audiovisual immersion
AVATAR 2.0: next level communication systems for radiotherapy through face-to-face video, biofeedback, translation, and audiovisual immersion Open
Purpose This paper discusses an advanced version of our audiovisual-assisted therapeutic ambience in radiotherapy (AVATAR) radiolucent display systems designed for pediatric radiotherapy, enabling anesthesia-free treatments, video communic…
View article: Primary Results of NRG-RTOG1106/ECOG-ACRIN 6697: A Randomized Phase II Trial of Individualized Adaptive (chemo)Radiotherapy Using Midtreatment <sup>18</sup> F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Stage III Non–Small Cell Lung Cancer
Primary Results of NRG-RTOG1106/ECOG-ACRIN 6697: A Randomized Phase II Trial of Individualized Adaptive (chemo)Radiotherapy Using Midtreatment <sup>18</sup> F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Stage III Non–Small Cell Lung Cancer Open
PURPOSE NRG-RTOG0617 demonstrated a detrimental effect of uniform high-dose radiation in stage III non–small cell lung cancer. NRG-RTOG1106/ECOG-ACRIN6697 (ClinicalTrials.gov identifier: NCT01507428 ), a randomized phase II trial, studied …
View article: Dosimetric calibration of anatomy‐specific ultra‐high dose rate electron irradiation platform for preclinical FLASH radiobiology experiments
Dosimetric calibration of anatomy‐specific ultra‐high dose rate electron irradiation platform for preclinical FLASH radiobiology experiments Open
Background FLASH radiation therapy (RT) offers a promising avenue for the broadening of the therapeutic index. However, to leverage the full potential of FLASH in the clinical setting, an improved understanding of the biological principles…
View article: Discordance in acute gastrointestinal toxicity between synchrotron-based proton and linac-based electron ultra-high dose rate irradiation
Discordance in acute gastrointestinal toxicity between synchrotron-based proton and linac-based electron ultra-high dose rate irradiation Open
Purpose Proton FLASH has been investigated using cyclotron and synchrocyclotron beamlines but not synchrotron beamlines. We evaluated the impact of dose rate (ultra-high [UHDR] vs. conventional [CONV]) and beam configuration (shoot-through…
View article: Integrating Audiovisual Immersion Into Pediatric Radiation Therapy Across Multiple Centers: Methodology, Timeliness, and Cost of the Audiovisual-Assisted Therapeutic Ambience in Radiation Therapy Prospective Multi-Institutional Trial
Integrating Audiovisual Immersion Into Pediatric Radiation Therapy Across Multiple Centers: Methodology, Timeliness, and Cost of the Audiovisual-Assisted Therapeutic Ambience in Radiation Therapy Prospective Multi-Institutional Trial Open
This report elaborates on the methodology and timeline of trial conception and development using data from a previously published supportive care study combining video immersion with radiation therapy among 10 cooperating pediatric oncolog…
View article: Effectiveness of Radiation Therapy for Low- to Intermediate-Grade Neuroendocrine Tumors
Effectiveness of Radiation Therapy for Low- to Intermediate-Grade Neuroendocrine Tumors Open
Surgery is the primary treatment for localized neuroendocrine tumors (NETs). Grade 1-2 NETs traditionally have been considered radioresistant due to their indolent nature but data regarding a role for radiation therapy (RT) are limited to …
View article: Redefining FLASH RT: the impact of mean dose rate and dose per pulse in the gastrointestinal tract
Redefining FLASH RT: the impact of mean dose rate and dose per pulse in the gastrointestinal tract Open
Background The understanding of how varying radiation beam parameter settings affect the induction and magnitude of the FLASH effect remains limited. Purpose We sought to evaluate how the magnitude of radiation-induced gastrointestinal (GI…
View article: Mesothelioma: Pleural, Version 1.2024
Mesothelioma: Pleural, Version 1.2024 Open
Mesothelioma is a rare cancer that originates from the mesothelial surfaces of the pleura and other sites, and is estimated to occur in approximately 3,500 people in the United States annually. Pleural mesothelioma is the most common type …
View article: A multi-institutional study to investigate the sparing effect after whole brain electron FLASH in mice: Reproducibility and temporal evolution of functional, electrophysiological, and neurogenic endpoints
A multi-institutional study to investigate the sparing effect after whole brain electron FLASH in mice: Reproducibility and temporal evolution of functional, electrophysiological, and neurogenic endpoints Open
Purpose Ultra-high dose-rate radiotherapy (FLASH) has been shown to mitigate normal tissue toxicities associated with conventional dose rate radiotherapy (CONV) without compromising tumor killing in preclinical models. A prominent challeng…
View article: Dosimetric calibration of an anatomically specific ultra-high dose rate electron irradiation platform for preclinical FLASH radiobiology experiments
Dosimetric calibration of an anatomically specific ultra-high dose rate electron irradiation platform for preclinical FLASH radiobiology experiments Open
We characterized the dosimetric properties of a clinical linear accelerator configured to deliver ultra-high dose rate (UHDR) irradiation to mice and cell-culture FLASH radiobiology experiments. UHDR electron beams were controlled by a mic…
View article: Predicting Adverse Cardiac Events After Radiotherapy for Locally Advanced Non–Small Cell Lung Cancer
Predicting Adverse Cardiac Events After Radiotherapy for Locally Advanced Non–Small Cell Lung Cancer Open
Adverse cardiac events associated with radiation occur in more than 20% of patients undergoing thoracic radiotherapy within a median time of <2 years. The present findings provide further evidence to support significant associations betwee…