Binyin Li
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View article: The China Alzheimer Report 2025
The China Alzheimer Report 2025 Open
With the sustained growth of the economy and significant changes in social demographics, the issue of elderly-related diseases has increasingly drawn attention, particularly. Alzheimer’s disease (AD), as a representative disease of neurode…
View article: Synaptic loss pattern is constrained by brain connectome and modulated by phosphorylated tau in Alzheimer’s disease
Synaptic loss pattern is constrained by brain connectome and modulated by phosphorylated tau in Alzheimer’s disease Open
Synaptic loss strongly correlates with cognitive impairment in Alzheimer's disease (AD), yet the mechanism linking its origin and pattern remain unclear. Given that connected brain regions share molecular and synaptic features, and patholo…
View article: Prediction of longitudinal synaptic loss in Alzheimer's disease using tau PET and plasma biomarkers
Prediction of longitudinal synaptic loss in Alzheimer's disease using tau PET and plasma biomarkers Open
INTRODUCTION We investigated the associations of longitudinal synaptic loss and cognitive decline with tau burden and plasma biomarkers in Alzheimer's disease (AD). METHODS Twenty cognitively impaired (CI) individuals and 16 healthy contro…
View article: Tau pathology is associated with postsynaptic metabotropic glutamate receptor 5 (mGluR5) in early Alzheimer's disease in a sex‐specific manner
Tau pathology is associated with postsynaptic metabotropic glutamate receptor 5 (mGluR5) in early Alzheimer's disease in a sex‐specific manner Open
INTRODUCTION To investigate the associations of metabotropic glutamate receptor 5 (mGluR5) with tau deposition and cognitive ability in patients with early Alzheimer's disease (AD). METHODS Twenty‐six cognitively impaired (CI) and 14 cogni…
View article: Choroid Plexus Free-Water Correlates with Glymphatic function and Neurodegeneration in Alzheimer’s Disease
Choroid Plexus Free-Water Correlates with Glymphatic function and Neurodegeneration in Alzheimer’s Disease Open
Free-water imaging of the choroid plexus (CP) is an index revealing components of the CP, which may improve the evaluation of Alzheimer's disease (AD). Our study evaluated free water fraction (FWf) of CP in 216 participants (133 Aβ+ partic…
View article: Synaptic loss pattern is associated with functional connectivity in Alzheimer’s disease
Synaptic loss pattern is associated with functional connectivity in Alzheimer’s disease Open
Background Synaptic loss is identified as a strong correlate of cognitive impairment in Alzheimer’s disease (AD). Pathological tau can induce direct toxicity to synapse and spread trans‐synaptically across connected neurons. Recent neuroim…
View article: Plasma Glial Fibrillary Acid Protein and Phosphorated Tau 181 Association with Presynaptic Density-Dependent Tau Pathology at <sup>18</sup>F-SynVesT-1 Brain PET Imaging
Plasma Glial Fibrillary Acid Protein and Phosphorated Tau 181 Association with Presynaptic Density-Dependent Tau Pathology at <sup>18</sup>F-SynVesT-1 Brain PET Imaging Open
Plasma phosphorylated tau 181 (p-tau-181) and glial fibrillary acidic protein (GFAP) have potential predictive value for identifying synaptic density as measured using 18 F-SynVesT-1 brain PET; the relationship of plasma p-tau-181 and GFAP…
View article: Choroid Plexus Free-Water Correlates with Glymphatic function in Alzheimer Disease: The RJNB-D Study
Choroid Plexus Free-Water Correlates with Glymphatic function in Alzheimer Disease: The RJNB-D Study Open
The free water imaging of choroid plexus (CP) may improve the evaluation of Alzheimer's disease (AD). Our study investigated the role of free water fraction (FWf) of CP in AD by including 216 participants (133 Aβ + participants and 83 Aβ- …
View article: <i>APOE</i> ε4 is associated with decreased synaptic density in cognitively impaired participants
<i>APOE</i> ε4 is associated with decreased synaptic density in cognitively impaired participants Open
INTRODUCTION We aimed to investigate the effect of apolipoprotein E4 ( APOE) ε4 on synaptic density in cognitively impaired (CI) participants. METHODS One hundred ten CI participants underwent amyloid positron emission tomography (PET) wit…
View article: Individuals from Memory Clinic were Associated with Severer Amyloid Deposition in the Chinese Population in Urban Cities
Individuals from Memory Clinic were Associated with Severer Amyloid Deposition in the Chinese Population in Urban Cities Open
Background Amyloid deposition is considered the initial pathology in Alzheimer’s disease (AD), investigation of amyloid pathology and the risk factor for amyloid pathology and cognitive declines in the Chinese population is critical for pe…
View article: Individuals from Memory Clinic were Associated with Severer Amyloid Deposition in the Chinese Population in Urban Cities
Individuals from Memory Clinic were Associated with Severer Amyloid Deposition in the Chinese Population in Urban Cities Open
Background Amyloid deposition is considered the initial pathology in Alzheimer’s disease (AD), investigation of amyloid pathology and the risk factor for amyloid pathology and cognitive declines in the Chinese population is critical for pe…
View article: Cortical gray to white matter signal intensity ratio as a sign of neurodegeneration and cognition independent of β‐amyloid in dementia
Cortical gray to white matter signal intensity ratio as a sign of neurodegeneration and cognition independent of β‐amyloid in dementia Open
Cortical gray to white matter signal intensity ratio (GWR) measured from T1‐weighted magnetic resonance (MR) images was associated with neurodegeneration and dementia. We characterized topological patterns of GWR during AD pathogenesis and…
View article: Relationship Between <i>FERMT2</i>, <i>CELF1</i>, <i>COPI</i>, <i>CHRNA2</i>, and <i>ABCA7</i> Genetic Polymorphisms and Alzheimer’s Disease Risk in the Southern Chinese Population
Relationship Between <i>FERMT2</i>, <i>CELF1</i>, <i>COPI</i>, <i>CHRNA2</i>, and <i>ABCA7</i> Genetic Polymorphisms and Alzheimer’s Disease Risk in the Southern Chinese Population Open
Background: Alzheimer’s disease (AD) is a multi-gene inherited disease, and apolipoprotein E ( APOE) ɛ4 is a strong risk factor. Other genetic factors are important but limited. Objective: This study aimed to investigate the relationship b…
View article: Editorial: Advanced neuroimage techniques for metabolic and blood flow assessment in cerebrovascular disease
Editorial: Advanced neuroimage techniques for metabolic and blood flow assessment in cerebrovascular disease Open
EDITORIAL article Front. Neurol., 06 July 2023Sec. Applied Neuroimaging Volume 14 - 2023 | https://doi.org/10.3389/fneur.2023.1238378
View article: Associations between Age and Cortical Thickness in Brain Regions Supporting Speech Motor Control
Associations between Age and Cortical Thickness in Brain Regions Supporting Speech Motor Control Open
Background Prior research has demonstrated consistent associations between age and cortical thickness, as well as longitudinal reductions in cortical thickness in older adults (e.g., Salat et al., 2004; Storsve et al., 2014). To date, the …
View article: Early changes of fecal short‐chain fatty acid levels in patients with mild cognitive impairments
Early changes of fecal short‐chain fatty acid levels in patients with mild cognitive impairments Open
Aims To compare the fecal levels of short‐chain fatty acids (SCFAs) in patients with mild cognitive impairment (MCI) and normal controls (NCs) and to examine whether fecal SCFAs could be used as the biomarker for the identification of pati…
View article: In vivo synaptic density loss correlates with impaired functional and related structural connectivity in Alzheimer’s disease
In vivo synaptic density loss correlates with impaired functional and related structural connectivity in Alzheimer’s disease Open
Synapse loss has been considered as a major pathological change in Alzheimer’s disease (AD). It remains unclear about whether and how synapse loss relates to functional and structural connectivity dysfunction in AD. We measured synaptic ve…
View article: The Switching Rates of Dynamic Functional Networks Differently Contribute to Cross-Sectional and Longitudinal Cognition in Mild Cognitive Impairment
The Switching Rates of Dynamic Functional Networks Differently Contribute to Cross-Sectional and Longitudinal Cognition in Mild Cognitive Impairment Open
Background: The relationship between switching rate of multilayer functional network and cognitive ability in mild cognitive impairment (MCI) and Alzheimers’ disease remains unclear. Methods: We followed up MCI patients for one year and an…
View article: Aberrant miR-339-5p/neuronatin signaling causes prodromal neuronal calcium dyshomeostasis in mutant presenilin mice
Aberrant miR-339-5p/neuronatin signaling causes prodromal neuronal calcium dyshomeostasis in mutant presenilin mice Open
Mushroom spine loss and calcium dyshomeostasis are early hallmark events of age-related neurodegeneration, such as Alzheimer's disease (AD), that are connected with neuronal hyperactivity in early pathology of cognitive brain areas. Howeve…
View article: Disrupted coupling between salience network segregation and glucose metabolism is associated with cognitive decline in Alzheimer's disease – A simultaneous resting-state FDG-PET/fMRI study
Disrupted coupling between salience network segregation and glucose metabolism is associated with cognitive decline in Alzheimer's disease – A simultaneous resting-state FDG-PET/fMRI study Open
The aberrant organization and functioning of three core neurocognitive networks (NCNs), i.e., default-mode network (DMN), central executive network (CEN), and salience network (SN), are among the prominent features in Alzheimer's disease (…
View article: Identifying individuals with Alzheimer's disease‐like brains based on structural imaging in the Human Connectome Project Aging cohort
Identifying individuals with Alzheimer's disease‐like brains based on structural imaging in the Human Connectome Project Aging cohort Open
Given the difficulty in factoring out typical age effects from subtle Alzheimer's disease (AD) effects on brain structure, identification of very early, as well as younger preclinical “at‐risk” individuals has unique challenges. We examine…