Bin Zhou
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View article: Serum response factor targets Cyr61 to facilitate chronic progression after ischemic acute kidney injury through renal tubular epithelial–myofibroblast transdifferentiation
Serum response factor targets Cyr61 to facilitate chronic progression after ischemic acute kidney injury through renal tubular epithelial–myofibroblast transdifferentiation Open
Objectives To explore the regulation and function of serum response factor (SRF)/cysteine-rich protein 61 (Cyr61) pathway in renal tubular epithelial–myofibroblast transdifferentiation (EMyT) in the chronic progression after ischemic acute…
View article: Contribution of Gli1 <sup>+</sup> Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury
Contribution of Gli1 <sup>+</sup> Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury Open
Adventitial stem cells (ASCs), identified by Gli1 expression, have been proposed as key contributors to the vascular smooth muscle cell (SMC) population during atherosclerosis development. However, their precise role remains a subject of d…
View article: Distinct populations of vascular smooth muscle and sinoatrial progenitors are localized adjacent to pro-epicardium
Distinct populations of vascular smooth muscle and sinoatrial progenitors are localized adjacent to pro-epicardium Open
The developmental potential of cells adjacent to pro-epicardial (PE) cells (pro-EpiCs) that also express pro-EpiC markers is unknown. We apply single-cell mRNA deep sequencing paired with RNAScope validation, bioinformatic analysis, and li…
View article: Targeting lysozyme 2 in remote endocardial zones promotes rapid cardiac repair after injury
Targeting lysozyme 2 in remote endocardial zones promotes rapid cardiac repair after injury Open
The adult mammalian heart lacks the capacity to regenerate after injury, leading to heart failure. While most of the research focused on the cardiomyocyte proliferation around the infarct zones, a new study (Fan et al., Cell Stem Cell 32(1…
View article: Unraveling the Interactive Role of Mitochondrial Dysfunction in Promoting Macrophage Polarization in Pulmonary Fibrosis
Unraveling the Interactive Role of Mitochondrial Dysfunction in Promoting Macrophage Polarization in Pulmonary Fibrosis Open
Pulmonary fibrosis (PF) is a chronic, irreversible interstitial lung disease. There is no effective treatment or drug that can completely cure this disease. The pathogenesis is still unclear. In recent years, several scholars have reported…
View article: Associations between triglyceride-glucose-related indices and all-cause and cardiovascular mortality among individuals with atrial fibrillation and metabolic syndrome: a cohort study of the UK biobank
Associations between triglyceride-glucose-related indices and all-cause and cardiovascular mortality among individuals with atrial fibrillation and metabolic syndrome: a cohort study of the UK biobank Open
This study demonstrateed the prognostic value of TyG-related indices in individuals with AF and MetS. These indices may serve as practical surrogate markers for risk stratification and the prevention of adverse outcomes.
View article: NSUN2 promotes leukemogenesis by ferritin heavy chain 1-mediated anti-ferroptosis and enhancing global protein synthesis in an m5C-dependent manner in B-acute lymphoblastic leukemia
NSUN2 promotes leukemogenesis by ferritin heavy chain 1-mediated anti-ferroptosis and enhancing global protein synthesis in an m5C-dependent manner in B-acute lymphoblastic leukemia Open
Our results demonstrate that NSUN2 facilitates leukemogenesis by increasing FTH1 expression and enhancing global protein synthesis in an m5C-dependent manner. Targeting NSUN2 might provide a promising therapeutic strategy for B-ALL.
View article: Cell Fate Determination and Lineage Tracing: Technological Evolution and Multidimensional Applications
Cell Fate Determination and Lineage Tracing: Technological Evolution and Multidimensional Applications Open
Cell fate determination is a fundamental process in multicellular development. In multicellular organisms, cells display plasticity in their fate, allowing them to revert to prior states or adopt alternative differentiation pathways, there…
View article: Sympathetic Activation Promotes Kidney Fibrosis in Mice via Macrophage‐Derived N2ICD‐Enriched Extracellular Vesicles
Sympathetic Activation Promotes Kidney Fibrosis in Mice via Macrophage‐Derived N2ICD‐Enriched Extracellular Vesicles Open
Persistent overactivation of the renal sympathetic nervous system drives kidney inflammation and fibrosis. Macrophages contribute to fibrogenesis by secreting various pro‐fibrogenic mediators. However, whether the sympathetic nervous syste…
View article: Topological phase transition induced by modulating unit cells in photonic Lieb lattice
Topological phase transition induced by modulating unit cells in photonic Lieb lattice Open
Topological photonics was embarked from realizing the first-order chiral state in gyromagnetic media, but its higher-order states were mostly studied in dielectric lattice instead. In this paper we theoretically unveil a hierarchy of topol…
View article: Ginsenoside Rb1 attenuates age-associated cognitive impairment by modulating oxidative stress and the SIRT1/eNOS/NO axis
Ginsenoside Rb1 attenuates age-associated cognitive impairment by modulating oxidative stress and the SIRT1/eNOS/NO axis Open
Rb1 modulates the SIRT1/eNOS/NO axis, which is linked to reducing oxidative stress and inflammatory reactions, hence delaying the aging process in mice.
View article: Visualizing Vascular Bone Marrow Niche Alterations in Diabetes
Visualizing Vascular Bone Marrow Niche Alterations in Diabetes Open
BACKGROUND: Diabetes is characterized by chronic hyperglycemia that leads to systemic vascular complications. Hyperglycemia impairs endothelial function and promotes vascular inflammation, resulting in leukocytosis, altered hematopoiesis, …
View article: PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice
PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice Open
Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease characterized by the excessive accumulation of activated myofibroblasts that deposit extracellular matrix (ECM) protein, leading to progressive scar formation a…
View article: Regulation of heart regeneration by LSD1 through suppressing CEND1
Regulation of heart regeneration by LSD1 through suppressing CEND1 Open
Rationale: Improving heart regeneration through reactivating cardiomyocyte proliferation holds a great potential for repairing diseased hearts. We recently reported that LSD1-dependent epigenetic repression of Cend1 transcription is prereq…
View article: Hedgehog-interacting protein orchestrates alveologenesis and protects against bronchopulmonary dysplasia and emphysema
Hedgehog-interacting protein orchestrates alveologenesis and protects against bronchopulmonary dysplasia and emphysema Open
Most of the lung’s gas-exchange surface forms during alveologenesis and its disruption causes bronchopulmonary dysplasia (BPD) in infants, characterized by alveolar simplification and myofibroblast accumulation. BPD also increases the risk…
Resistance to anti-LAG-3 plus anti-PD-1 therapy in head and neck cancer is mediated by Sox9+ tumor cells interaction with Fpr1+ neutrophils Open
Relatlimab and nivolumab combination therapy shows significant efficacy in treating various types of cancer. Current research on the molecular mechanisms of this treatment is abundant, but in-depth investigations into post-treatment resist…
View article: Ductal or Ngn3+ cells do not contribute to adult pancreatic islet beta-cell neogenesis in homeostasis
Ductal or Ngn3+ cells do not contribute to adult pancreatic islet beta-cell neogenesis in homeostasis Open
The adult pancreatic ducts have long been proposed to contain rare progenitors, some of which expressing Ngn3, that generate new beta cells in endocrine-islet homeostasis. Due to their postulated rarity and the lack of definitive markers, …
View article: Dual genetic tracing demonstrates the heterogeneous differentiation and function of neuromesodermal progenitors in vivo
Dual genetic tracing demonstrates the heterogeneous differentiation and function of neuromesodermal progenitors in vivo Open
In recent decades, the traditional paradigm of three distinct germ layers formed during gastrulation has been revised with the identification of neuromesodermal progenitors (NMPs). These progenitors emerge during gastrulation and contribut…
View article: Risk factors associated with Helicobacter pylori infection in the urban population of China: A nationwide, multi-center, cross-sectional study
Risk factors associated with Helicobacter pylori infection in the urban population of China: A nationwide, multi-center, cross-sectional study Open
Our findings highlight the importance of promoting a healthy lifestyle and improving the understanding of H. pylori in reducing the infection rate of the bacterial pathogen in the urban Chinese population.
Tunneling nanotube–like structures regulate distant cellular interactions during heart formation Open
In the developing mammalian heart, the endocardium and the myocardium are separated by so-called cardiac jelly. Communication between the endocardium and the myocardium is essential for cardiac morphogenesis. How membrane-localized recepto…
View article: Protocol for the in vivo tracing of alveolar type I cells from mice using two distinct dual recombinase-mediated genetic approaches
Protocol for the in vivo tracing of alveolar type I cells from mice using two distinct dual recombinase-mediated genetic approaches Open
Revealing the origins of alveolar epithelial stem cells is crucial for preventing and treating lung diseases. Here, we present a protocol for tracing alveolar type I (AT1) cells from mice in vivo using two distinct dual recombinase-mediate…
View article: High glycemic variability serves as an independent risk factor for postoperative infection-related complications in patients undergoing radical surgery for gastric, colon, and rectal cancer
High glycemic variability serves as an independent risk factor for postoperative infection-related complications in patients undergoing radical surgery for gastric, colon, and rectal cancer Open
Patients with gastrointestinal surgery have a higher incidence of infection-related complications than the rest of those who undergo clean cut surgery. It can lead to a worse prognosis for patients. This study aimed to assess the associati…
View article: Tumor-initiating cells escape tumor immunity via CCL8 from tumor-associated macrophages in mice
Tumor-initiating cells escape tumor immunity via CCL8 from tumor-associated macrophages in mice Open
Tumor-initiating cells (TICs) play a key role in cancer progression and immune escape. However, how TICs evade immune elimination remains poorly characterized. Combining single-cell RNA-Seq (scRNA-Seq), dual-recombinase-based lineage traci…