Bina Srivastava
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View article: Clinical and parasitological efficacy of artesunate and sulfadoxine-pyrimethamine (AS+SP) for the treatment of uncomplicated falciparum malaria in different transmission settings in India
Clinical and parasitological efficacy of artesunate and sulfadoxine-pyrimethamine (AS+SP) for the treatment of uncomplicated falciparum malaria in different transmission settings in India Open
Background & objectives: In 2010, artesunate and sulfadoxine-pyrimethamine (AS+SP) were adopted as the first-line artemisinin based combination therapy for treatment of uncomplicated Plasmodium falciparum malaria in India. Continuous thera…
View article: Contribution of Travelers to <i>Plasmodium Vivax</i> Malaria in South West Delhi, India: Cross-Sectional Survey
Contribution of Travelers to <i>Plasmodium Vivax</i> Malaria in South West Delhi, India: Cross-Sectional Survey Open
Background India is committed to malaria elimination by the year 2030. According to the classification of malaria endemicity, the National Capital Territory of Delhi falls under category 1, with an annual parasite incidence of <1, and was …
View article: Genotyping of paired clinical isolates using<i>PvCSP, PvMSP3</i>α<i>, PvMSP3</i>β and exploring STRs to differentiate between relapse and reinfection in<i>P. vivax</i>
Genotyping of paired clinical isolates using<i>PvCSP, PvMSP3</i>α<i>, PvMSP3</i>β and exploring STRs to differentiate between relapse and reinfection in<i>P. vivax</i> Open
The challenge of eliminating Vivax malaria is due to the relapses caused by hypnozoites. Despite several attempts to identify molecular markers to differentiate between relapse and new infection, a reliable marker has not yet been establis…
View article: Malaria Slide Bank to Strengthen and Improve the Quality of Malaria Diagnosis: A National Slide Repository in India
Malaria Slide Bank to Strengthen and Improve the Quality of Malaria Diagnosis: A National Slide Repository in India Open
Malaria elimination is one of the top health care priorities in India, necessitating accessible and accurate diagnosis for effective treatment. A malaria slide bank in India is a collection of quality-controlled malaria-positive and -negat…
View article: Outcome assessment of the implementation of Mass Drug Administration against lymphatic filariasis in Kalaburagi (Gulbarga) Karnataka, India: A cross-sectional survey
Outcome assessment of the implementation of Mass Drug Administration against lymphatic filariasis in Kalaburagi (Gulbarga) Karnataka, India: A cross-sectional survey Open
Background & objectives: Mass Drug Administration (MDA) of Di-Ethyl Carbamazine and Albendazole is an effective strategy recommended by the World Health Organization to prevent transmission and eliminate lymphatic filariasis. Under the Nat…
View article: Benefits of Lot Testing to Improve the Quality of Malaria Rapid Diagnostic Tests in India
Benefits of Lot Testing to Improve the Quality of Malaria Rapid Diagnostic Tests in India Open
Since 2010, malaria rapid diagnostic tests (RDTs) are widely used to detect malaria. The Indian Council of Medical Research–National Institute of Malaria Research performed lot testing (LT) according to WHO procedures since 2016. Lot testi…
View article: Artemisinin-based combination therapy successfully treated two hyperparasitaemic Plasmodium falciparum cases
Artemisinin-based combination therapy successfully treated two hyperparasitaemic Plasmodium falciparum cases Open
Hyperparasitaemia is an important event in the cascade of Plasmodium falciparum severe malaria (SM), and may also lead to SM associated complications and death, if left untreated. Here, we report two hyperparasitaemic patients with no life…
View article: Quality assurance of malaria rapid diagnostic tests
Quality assurance of malaria rapid diagnostic tests Open
Background & objectives: India targets malaria elimination by 2030 in a phased manner, so malaria’s assured diagnosis is crucial. Introduction of rapid diagnostic kits in India in 2010 has revolutionized malaria surveillance. The storage t…
View article: A case report of late treatment failure in Plasmodium falciparum malaria in a traveler from the Democratic Republic of the Congo to India
A case report of late treatment failure in Plasmodium falciparum malaria in a traveler from the Democratic Republic of the Congo to India Open
A young male returned from the Democratic Republic of the Congo (DRC) to India after four months during his official work. Within a week of his arrival, he developed a high-grade fever with nausea and was hospitalized in a private hospital…
View article: Seasonal Distribution and Trend Analysis of Urban Malaria Prevalence in a Malaria Clinic, South Delhi, India, between 2012 and 2019
Seasonal Distribution and Trend Analysis of Urban Malaria Prevalence in a Malaria Clinic, South Delhi, India, between 2012 and 2019 Open
It is important to study the recent malaria incidence trends in urban areas resulting from rapid urbanization that can lead to changes in environmental conditions for malaria. This retrospective study assessed trends in malaria patients, t…
View article: The case report of a non-resident Indian with Plasmodium ovale curtisi from Kerala, India
The case report of a non-resident Indian with Plasmodium ovale curtisi from Kerala, India Open
India’s target of malaria elimination by 2030 may not be achieved solely by detecting Plasmodium falciparum and P. vivax , the two common Plasmodium species causing infections in humans. Sporadic reports have been documented on other Plasm…
View article: Comparative Assessment of Diagnostic Performance of Cytochrome Oxidase Multiplex PCR and 18S rRNA Nested PCR
Comparative Assessment of Diagnostic Performance of Cytochrome Oxidase Multiplex PCR and 18S rRNA Nested PCR Open
Malaria elimination and control require prompt and accurate diagnosis for treatment plan. Since microscopy and rapid diagnostic test (RDT) are not sensitive particularly for diagnosing low parasitemia, highly sensitive diagnostic tools are…
View article: The case report of a non-resident Indian with Plasmodium ovale curtisi from Kerala
The case report of a non-resident Indian with Plasmodium ovale curtisi from Kerala Open
View article: A Study on The Depression and Life Satisfaction among Married Employed and Unemployed Women
A Study on The Depression and Life Satisfaction among Married Employed and Unemployed Women Open
Gender role-related expectations need to be understood closely in order to understand various psychological issues women in our society face. It’s like discriminations labourers face during division of labour. The purpose of this paper is …
View article: Nonrandomized Controlled Trial of Artesunate plus Sulfadoxine-Pyrimethamine with or without Primaquine for Preventing Posttreatment Circulation of Plasmodium falciparum Gametocytes
Nonrandomized Controlled Trial of Artesunate plus Sulfadoxine-Pyrimethamine with or without Primaquine for Preventing Posttreatment Circulation of Plasmodium falciparum Gametocytes Open
Artemisinin combination therapies eliminate immature Plasmodium falciparum gametocytes but not mature gametocytes, which may persist for up to 1 month posttreatment. A single dose of primaquine, which is inexpensive and effective against m…
View article: Delayed haemolysis after treatment with intravenous artesunate in patients with severe malaria in India
Delayed haemolysis after treatment with intravenous artesunate in patients with severe malaria in India Open
View article: Efficacy and safety of fixed dose combination of arterolane maleate and piperaquine phosphate in comparison with chloroquine phosphate in children with acute uncomplicated Plasmodium vivax malaria: A phase III, randomised, multicentric study
Efficacy and safety of fixed dose combination of arterolane maleate and piperaquine phosphate in comparison with chloroquine phosphate in children with acute uncomplicated Plasmodium vivax malaria: A phase III, randomised, multicentric study Open
The efficacy and safety of FDC of arterolane maleate and piperaquine phosphate was found to be comparable to chloroquine for treatment of uncomplicated P. vivax malaria in pediatric patients.
View article: A Simple and Cost-Effective Freeze-Thaw Based Method for Plasmodium DNA Extraction from Dried Blood Spot
A Simple and Cost-Effective Freeze-Thaw Based Method for Plasmodium DNA Extraction from Dried Blood Spot Open
Background: Available DNA isolation methods for Plasmodium involve numerous processing steps, adding to the cost and conferring risk of contamination. Here we devise a simple and cost-effective method for direct extraction of Plasmodium DN…
View article: Efficacy of two artemisinin-based combinations for the treatment of malaria in pregnancy in India: a randomized controlled trial
Efficacy of two artemisinin-based combinations for the treatment of malaria in pregnancy in India: a randomized controlled trial Open
View article: An epidemiological study of dengue and its coinfections in Delhi
An epidemiological study of dengue and its coinfections in Delhi Open
Delhi being hyperendemic, the occurrence of concurrent infections with multiple DENV serotypes has become a frequent finding. The study emphasizes the need of epidemiological and entomological surveillance to monitor trends in dengue distr…
View article: Emerging polymorphisms in falciparum Kelch 13 gene in Northeastern region of India
Emerging polymorphisms in falciparum Kelch 13 gene in Northeastern region of India Open
This is the first study to document the presence of F446I NS mutation in the k13 propeller region from Changlang district, Arunachal Pradesh, a site adjoining the Indo-Myanmar border region, where this mutation is highly prevalent. In addi…
View article: In vitro sensitivity pattern of chloroquine and artemisinin in Plasmodium falciparum
In vitro sensitivity pattern of chloroquine and artemisinin in Plasmodium falciparum Open
Artemisinin (ART) and its derivatives form the mainstay of antimalarial therapy. Emergence of resistance to them poses a potential threat to future malaria control and elimination on a global level. It is important to know the mechanism of…
View article: Comparison of the safety and efficacy of fixed-dose combination of arterolane maleate and piperaquine phosphate with chloroquine in acute, uncomplicated Plasmodium vivax malaria: a phase III, multicentric, open-label study
Comparison of the safety and efficacy of fixed-dose combination of arterolane maleate and piperaquine phosphate with chloroquine in acute, uncomplicated Plasmodium vivax malaria: a phase III, multicentric, open-label study Open
View article: Monitoring the efficacy of antimalarial medicines in India via sentinel sites: Outcomes and risk factors for treatment failure
Monitoring the efficacy of antimalarial medicines in India via sentinel sites: Outcomes and risk factors for treatment failure Open
Till 2012, India's national antimalarial drug resistance monitoring system proved highly efficacious and safe towards first-line antimalarials used in the country, except in Northeastern region where a decline in efficacy of AS+SP has been…
View article: Computer-vision-based technology for fast, accurate and cost effective diagnosis of malaria
Computer-vision-based technology for fast, accurate and cost effective diagnosis of malaria Open
The ability of the device to detect parasitaemia as compared with microscopy, was within 50% in 71.3% of cases and demonstrated a correlation coefficient of 0.89.
View article: Surveillance of Artemisinin Resistance in Plasmodium falciparum in India Using the kelch13 Molecular Marker
Surveillance of Artemisinin Resistance in Plasmodium falciparum in India Using the kelch13 Molecular Marker Open
Malaria treatment in Southeast Asia is threatened with the emergence of artemisinin-resistant Plasmodium falciparum . Genome association studies have strongly linked a locus on P. falciparum chromosome 13 to artemisinin resistance, and rec…
View article: The footprints of relapsing malaria in southwest Delhi, India
The footprints of relapsing malaria in southwest Delhi, India Open
The study showed presence of persistent P. vivax malaria with strains causing both frequent and long latency recurrences (probable relapses) in southwest Delhi. This highlights the need to evaluate primaquine regimens against both these st…