Binbin Gu
YOU?
Author Swipe
View article: Comparison of endoscopic and laparoscopic resection of gastric gastrointestinal stromal tumors: A propensity score-matched study
Comparison of endoscopic and laparoscopic resection of gastric gastrointestinal stromal tumors: A propensity score-matched study Open
BACKGROUND Endoscopic resection (ER) and laparoscopic resection (LR) have been widely used for the treatment of non-metastatic gastric gastrointestinal stromal tumors (gGISTs) (2-5 cm), but there are no selection criteria for their applica…
View article: Two Sesterterpene Synthases from <i>Lentzea atacamensis</i> Demonstrate the Role of Conformational Variability in Terpene Biosynthesis
Two Sesterterpene Synthases from <i>Lentzea atacamensis</i> Demonstrate the Role of Conformational Variability in Terpene Biosynthesis Open
Mining of two multiproduct sesterterpene synthases from Lentzea atacamensis resulted in the identification of the synthases for lentzeadiene (LaLDS) and atacamatriene (LaATS). The main product of LaLDS (lentzeadiene) is a new compound, whi…
View article: CCDC 2294797: Experimental Crystal Structure Determination
CCDC 2294797: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2294796: Experimental Crystal Structure Determination
CCDC 2294796: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Subrutilane—A Hexacyclic Sesterterpene from <i>Streptomyces subrutilus</i>
Subrutilane—A Hexacyclic Sesterterpene from <i>Streptomyces subrutilus</i> Open
Mining of a terpene synthase from Streptomyces subrutilus resulted in the identification of the hexacyclic sesterterpene subrutilane, besides eight pentacyclic side products. Subrutilane represents the first case of a saturated sesterterpe…
View article: Functions of enzyme domains in 2-methylisoborneol biosynthesis and enzymatic synthesis of non-natural analogs
Functions of enzyme domains in 2-methylisoborneol biosynthesis and enzymatic synthesis of non-natural analogs Open
Two aspects of the biosynthesis of the non-canonical terpene synthase for 2-methylisoborneol have been studied. Several 2-methylisoborneol synthases have a proline-rich N-terminal domain of unknown function. The results presented here demo…
View article: Functional characterisation of twelve terpene synthases from actinobacteria
Functional characterisation of twelve terpene synthases from actinobacteria Open
Fifteen type I terpene synthase homologs from diverse actinobacteria that were selected based on a phylogenetic analysis of more than 4000 amino acid sequences were investigated for their products. For four enzymes with functions not previ…
View article: Ruptenes: A Family of Terpene Analogs Give Insight into Cyclisation Mechanisms by Cascade Disruption
Ruptenes: A Family of Terpene Analogs Give Insight into Cyclisation Mechanisms by Cascade Disruption Open
The terpenoid substrate analogs (7 R )‐6,7‐dihydrogeranylgeranyl diphosphate (6,7‐dihydro‐GGPP) and (7 R )‐6,7‐dihydrogeranylfarnesyl diphosphate (6,7‐dihydro‐GFPP) were synthesised from ( S )‐citronellol and enzymatically converted with n…
View article: Functional Characterisation of Highly Conserved and Structurally Prominent Residues of 2‐Methylisoborneol Synthase
Functional Characterisation of Highly Conserved and Structurally Prominent Residues of 2‐Methylisoborneol Synthase Open
2‐Methylisoborneol is a widespread musty odourant that is produced by many bacteria including actinomycetes, cyanobacteria and myxobacteria. Two 2‐methylisoborneol synthases (MIBS) that are phylogenetically distant to the known enzyme from…
View article: Association of <i>KMT2C/D</i> loss‐of‐function variants with response to immune checkpoint blockades in colorectal cancer
Association of <i>KMT2C/D</i> loss‐of‐function variants with response to immune checkpoint blockades in colorectal cancer Open
Immune checkpoint inhibitors (ICIs) have become important treatment strategies, yet responses vary among patients and predictive biomarkers are urgently needed. Mutations in KMT2C and KMT2D lead to increased levels of genomic instability. …
View article: A Computer-Assisted Diagnosis System for the Detection of Chronic Gastritis in Endoscopic Images Using A Novel Convolution and Relative Self-Attention Parallel Network
A Computer-Assisted Diagnosis System for the Detection of Chronic Gastritis in Endoscopic Images Using A Novel Convolution and Relative Self-Attention Parallel Network Open
Chronic gastritis mainly includes chronic non-atrophic gastritis (CNAG), autoimmune gastritis (AIG), and type B gastritis. Early detection of AIG and type B gastritis will help identify high-risk groups for gastric cancer and prevent the d…
View article: Mechanistic Characterisation and Engineering of Sesterviolene Synthase from <i>Streptomyces violens</i>
Mechanistic Characterisation and Engineering of Sesterviolene Synthase from <i>Streptomyces violens</i> Open
The sesterviolene synthase from Streptomyces violens was identified and represents the second known sesterterpene synthase from bacteria. Isotopic labelling experiments in conjunction with DFT calculations were performed that provided deta…
View article: The stereochemical course of 2-methylisoborneol biosynthesis
The stereochemical course of 2-methylisoborneol biosynthesis Open
Both enantiomers of 2-methyllinalyl diphosphate (2-Me-LPP) were synthesized enantioselectively using Sharpless epoxidation as a key step and purification of enantiomerically enriched intermediates through HPLC separation on a chiral statio…
View article: Distribution characteristics and clinical significance of circulating CD8 + CD28 - regulatory T cells in the peripheral blood of patients with pulmonary tuberculosis
Distribution characteristics and clinical significance of circulating CD8 + CD28 - regulatory T cells in the peripheral blood of patients with pulmonary tuberculosis Open
Background: Regulatory T cells (Treg cells) in the peripheral blood of patients with pulmonary tuberculosis (PTB) may be closely related to the progression of PTB. In this study, the distribution characteristics and clinical importance of …
View article: High Versatility of IPP and DMAPP Methyltransferases Enables Synthesis of C<sub>6</sub>, C<sub>7</sub> and C<sub>8</sub> Terpenoid Building Blocks
High Versatility of IPP and DMAPP Methyltransferases Enables Synthesis of C<sub>6</sub>, C<sub>7</sub> and C<sub>8</sub> Terpenoid Building Blocks Open
The natural substance class of terpenoids covers an extremely wide range of different structures, although their building block repertoire is limited to the C 5 compounds DMAPP and IPP. This study aims at the characterization of methyltran…
View article: Ninety-four thousand-case retrospective study on antibacterial drug resistance of <i>Helicobacter pylori</i>
Ninety-four thousand-case retrospective study on antibacterial drug resistance of <i>Helicobacter pylori</i> Open
BACKGROUND: The resistance rate to antibacterial drugs is the key inhibitor of Helicobacter pylori (H. pylori) eradication treatment. AIM: To evaluate the prevalence and drug resistance of H. pylori based on big data. METHODS: Gastric muco…
View article: Transplantation of acellularized dermis matrix (ADM) plus fully covered metal stent to prevent stricture after circumferential endoscopic submucosal dissection of early esophageal cancer (with video)
Transplantation of acellularized dermis matrix (ADM) plus fully covered metal stent to prevent stricture after circumferential endoscopic submucosal dissection of early esophageal cancer (with video) Open
This study was performed to assess the efficacy and safe method of relieving the severity of esophageal stricture after ESD through transplantation of ADM.
View article: Prediction of Re-positivity for Coronavirus Nucleic Acid Among COVID-19 Patients in the Recovery Phase
Prediction of Re-positivity for Coronavirus Nucleic Acid Among COVID-19 Patients in the Recovery Phase Open
Background and Objectives: Although the pathogenesis and treatment of coronavirus disease 2019 (COVID-19) have been gradually revealed, the risk for re-emergence of coronavirus nucleic acids in recovered patients remains poorly understood.…
View article: Isoliquiritigenin Suppressed Esophageal Squamous Carcinoma Growth by Blocking EGFR Activation and Inducing Cell Cycle Arrest
Isoliquiritigenin Suppressed Esophageal Squamous Carcinoma Growth by Blocking EGFR Activation and Inducing Cell Cycle Arrest Open
Isoliquiritigenin (ILQ) is a natural product isolated from licorice root which has served as traditional Chinese medicine for a long time. Recently, the antitumor effects of ILQ have been widely studied in various cancers, but the role and…
View article: lncRNA‑CCHE1 is involved in migration and invasion but not in proliferation of pancreatic adenocarcinoma cells possibly by interacting with ROCK1
lncRNA‑CCHE1 is involved in migration and invasion but not in proliferation of pancreatic adenocarcinoma cells possibly by interacting with ROCK1 Open
Cervical carcinoma high-expressed long non-coding RNA (lncRNA) 1 (lncRNA-CCHE1) serves an oncogenic role in cervical and liver cancer. The present study aimed to explore the role of CCHE1 in pancreatic adenocarcinoma. CCHE1 expression was …
View article: Ochrasperfloroid, an ochratoxin–ergosteroid heterodimer with inhibition of IL-6 and NO production from <i>Aspergillus flocculosus</i> 16D-1
Ochrasperfloroid, an ochratoxin–ergosteroid heterodimer with inhibition of IL-6 and NO production from <i>Aspergillus flocculosus</i> 16D-1 Open
A novel ochratoxin–ergosteroid heterodimer, ochrasperfloroid (1), together with a known mycotoxin, ochratoxin A (2), were isolated from the sponge-derived fungus Aspergillus flocculosus 16D-1.
View article: New Anti-inflammatory Cyclopeptides From a Sponge-Derived Fungus Aspergillus violaceofuscus
New Anti-inflammatory Cyclopeptides From a Sponge-Derived Fungus Aspergillus violaceofuscus Open
Three new cyclic peptides including a cyclic tetrapeptide (1), an aspochracin-type cyclic tripeptide sclerotiotide L (2) and a diketopiperazine dimer (3), have been isolated from the ethyl acetate extract of a marine sponge-derived fungus …
View article: Sesquiterpene Quinones/Hydroquinones from the Marine Sponge <i>Spongia pertusa</i> Esper
Sesquiterpene Quinones/Hydroquinones from the Marine Sponge <i>Spongia pertusa</i> Esper Open
Nine new sesquiterpene quinones/hydroquinones (1-7, 10, and 12), three solvent-generated artifacts (8, 9, and 11), and three known compounds, 5-epi-smenospongine (13), smenospongine (14), and smenospongiadine (15), were isolated from the m…