Bohao Zheng
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View article: Inhibition of P2X7 receptor in satellite glial cells contributes to electroacupuncture's analgesia in rats with CFA-induced inflammatory pain
Inhibition of P2X7 receptor in satellite glial cells contributes to electroacupuncture's analgesia in rats with CFA-induced inflammatory pain Open
Background Accumulating evidence highlights the anti-inflammatory and analgesic effects of electroacupuncture (EA), yet the underlying mechanisms remain poorly understood. The P2X7 purinergic receptor (P2X7R), located in the peripheral and…
View article: Complete response in a patient with metastatic metaplastic breast cancer treated with immune checkpoint inhibitor and chemotherapy: A case report and a review of the literature
Complete response in a patient with metastatic metaplastic breast cancer treated with immune checkpoint inhibitor and chemotherapy: A case report and a review of the literature Open
Metaplastic breast cancer (MpBC) is a rare subtype of breast cancer characterized by poor prognosis and lack of treatment guidance. It is notably resistant to conventional chemotherapy. Currently, immunotherapy is becoming a promising opti…
View article: Fasting inhibits glycolysis and migration/invasion in gallbladder cancer via PCBP2/ANGPTL4 signaling
Fasting inhibits glycolysis and migration/invasion in gallbladder cancer via PCBP2/ANGPTL4 signaling Open
Gallbladder cancer (GBC) is a biliary tract cancer with a poor prognosis. Consistent evidence suggests that fasting has extensive antitumor effects in various cancers and influences levels of poly (rC)-binding protein 2 (PCBP2). However, w…
View article: Evaluation of Sound Touch Elastography in Diagnosing Nonalcoholic Fatty Liver Disease
Evaluation of Sound Touch Elastography in Diagnosing Nonalcoholic Fatty Liver Disease Open
[Objective] We aimed to evaluate the effectiveness of sound touch elastography (STE) in diagnosing nonalcoholic fatty liver disease (NAFLD). [Methods] A total of 58 patients with nonalcoholic fatty liver (NAFL) and 37 with nonalcoholic ste…
View article: The aberrant expression of CD39 is associated with the dismal outcome of patients with cholangiocarcinoma
The aberrant expression of CD39 is associated with the dismal outcome of patients with cholangiocarcinoma Open
Purpose To investigate the biological function and the underlying mechanism of CD39 in cholangiocarcinoma. Methods Quantitative reverse transcription PCR (RT-qPCR), western blot (WB), and immunohistochemistry staining was used to evaluate …
View article: Ginsenoside RK3 inhibits glioblastoma by modulating macrophage M2 polarization via the PPARG/CCL2 axis
Ginsenoside RK3 inhibits glioblastoma by modulating macrophage M2 polarization via the PPARG/CCL2 axis Open
This study innovatively highlights the dual mechanism of ginsenoside RK3 in glioblastoma treatment: it impedes tumor progression by modulating the PPARG/CCL2 pathway and enhances the efficacy of temozolomide. Our research underscores the p…
View article: Human <scp>TCR</scp> repertoire in cancer
Human <span>TCR</span> repertoire in cancer Open
Background T cells, the “superstar” of the immune system, play a crucial role in antitumor immunity. T‐cell receptors (TCR) are crucial molecules that enable T cells to identify antigens and start immunological responses. The body has evol…
View article: Ferroptosis: a novel strategy to overcome chemoresistance in gynecological malignancies
Ferroptosis: a novel strategy to overcome chemoresistance in gynecological malignancies Open
Ferroptosis is an iron-dependent form of cell death, distinct from apoptosis, necrosis, and autophagy, and is characterized by altered iron homeostasis, reduced defense against oxidative stress, and increased lipid peroxidation. Extensive …
View article: Exosomal microRNAs in hepatocellular carcinoma, rising research filed in hepatocellular carcinoma
Exosomal microRNAs in hepatocellular carcinoma, rising research filed in hepatocellular carcinoma Open
In this editorial we comment on the review by Wang et al published in the recent issue of the World Journal of Gastroenterology in 2023. Small extracellular vesicles (exosomes) play important roles in the tumor microenvironment. In this re…
View article: Fasting-induced RNF152 resensitizes gallbladder cancer cells to gemcitabine by inhibiting mTORC1-mediated glycolysis
Fasting-induced RNF152 resensitizes gallbladder cancer cells to gemcitabine by inhibiting mTORC1-mediated glycolysis Open
Abnormal mTORC1 activation by the lysosomal Ragulator complex has been implicated in cancer and glycolytic metabolism associated with drug resistance. Fasting upregulates RNF152 and mediates the metabolic status of cells. We report that RN…
View article: Understanding endometriosis from an immunomicroenvironmental perspective
Understanding endometriosis from an immunomicroenvironmental perspective Open
Endometriosis, a heterogeneous, inflammatory, and estrogen-dependent gynecological disease defined by the presence and growth of endometrial tissues outside the lining of the uterus, affects approximately 5–10% of reproductive-age women, c…
View article: Fasting-induced RNF152 re-sensitizes gallbladder cancer cells to gemcitabine by inhibiting mTORC1-mediated glycolysis
Fasting-induced RNF152 re-sensitizes gallbladder cancer cells to gemcitabine by inhibiting mTORC1-mediated glycolysis Open
Accumulating evidence indicates that the lysosomal Ragulator complex is essential for the full activation of the mechanistic target of rapamycin complex 1 (mTORC1). Abnormal mTORC1 activation has been implicated in cancer and glycolytic me…
View article: [Latest Findings on the Function of Immune Metabolism in Tumor Immunity].
[Latest Findings on the Function of Immune Metabolism in Tumor Immunity]. Open
Metabolic reprogramming, an important hallmark of cancer, helps cancer achieve rapid proliferation. Metabolic changes in tumors regulate multiple metabolic pathways of immune cells, thereby suppressing antitumor immunity. Recent studies ha…
View article: Genomic feature and potential therapeutic target for cholangiocarcinoma
Genomic feature and potential therapeutic target for cholangiocarcinoma Open
Background: The genomic feature of biliary tract carcinoma (BTC) has been characterized, but limited studies focus on the potential therapeutic target for cholangiocarcinoma patients. Methods: 43 BTC patients were enrolled in this retrospe…
View article: Analysis of immunotherapeutic response-related signatures in esophageal squamous-cell carcinoma
Analysis of immunotherapeutic response-related signatures in esophageal squamous-cell carcinoma Open
Background Esophageal squamous cell carcinoma (ESCC) is one of the most common and lethal malignant diseases. Immunotherapy has been widely studied and has exhibited potential in ESCC treatment. However, there are only a portion of ESCC pa…
View article: Research hotspots and trends of biodegradable magnesium and its alloys
Research hotspots and trends of biodegradable magnesium and its alloys Open
With the increasing demand for innovative therapies, biodegradable magnesium has attracted more and more attention, which could avoid secondary surgery and reduce complications. Until now, plenty of researchers take part in the research & …
View article: The clinical and prognostic factors for biliary neuroendocrine neoplasm: a study based on the SEER database
The clinical and prognostic factors for biliary neuroendocrine neoplasm: a study based on the SEER database Open
Background In this study, we aimed at elucidating the postoperative survival and prognostic factors in patients with biliary neuroendocrine neoplasm (NEN). Methods Cases of biliary system NEN and adenocarcinoma from 1975 to 2016 were extra…
View article: Acetylation stabilizes stathmin1 and promotes its activity contributing to gallbladder cancer metastasis
Acetylation stabilizes stathmin1 and promotes its activity contributing to gallbladder cancer metastasis Open
Gallbladder cancer is the most common biliary tract malignant tumor with highly metastatic characters and poor prognosis. However, the underlying mechanism remains unclear. Stathmin1 is ubiquitous phosphoprotein, regulating microtubule sta…
View article: The crosstalk between reactive oxygen species and noncoding RNAs: from cancer code to drug role
The crosstalk between reactive oxygen species and noncoding RNAs: from cancer code to drug role Open
Oxidative stress (OS), characterized by the excessive accumulation of reactive oxygen species (ROS), is an emerging hallmark of cancer. Tumorigenesis and development driven by ROS require an aberrant redox homeostasis, that activates onco-…
View article: Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy
Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy Open
Cellular metabolism constitutes a fundamental process in biology. During tumor initiation and progression, each cellular component in the cancerous niche undergoes dramatic metabolic reprogramming, adapting to a challenging microenvironmen…
View article: Biliverdin reductase B impairs cholangiocarcinoma cell motility by inhibiting the Notch/Snail signaling pathway
Biliverdin reductase B impairs cholangiocarcinoma cell motility by inhibiting the Notch/Snail signaling pathway Open
Cholangiocarcinoma (CCA) is one of the most lethal types of solid tumors worldwide. Lymph node metastasis is common in the early stage, which is associated with recurrence and reduced survival time after CCA resection. The molecular pathog…