Ji Bao
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View article: Comparative profiling of 72 quinoa varieties reveals superior nutritional quality, bio-active petrochemicals, and sensory acceptability for functional leafy vegetable applications
Comparative profiling of 72 quinoa varieties reveals superior nutritional quality, bio-active petrochemicals, and sensory acceptability for functional leafy vegetable applications Open
View article: Large Language Model Evaluation in Traditional Chinese Medicine for Stroke: Quantitative Benchmarking Study
Large Language Model Evaluation in Traditional Chinese Medicine for Stroke: Quantitative Benchmarking Study Open
Background The application of large language models (LLMs) in medicine is rapidly advancing. However, evaluating LLM capabilities in specialized domains such as traditional Chinese medicine (TCM), which possesses a unique theoretical syste…
View article: The irreplaceable role of pathology for the clinical translation of patient-derived organoids in precision medicine
The irreplaceable role of pathology for the clinical translation of patient-derived organoids in precision medicine Open
View article: Effect of Prompt Engineering and Retrieval Augmentation on ChatGPT-4 Diagnostic Accuracy for Congenital Ear Deformities: a Paired Clinical Image Study (Preprint)
Effect of Prompt Engineering and Retrieval Augmentation on ChatGPT-4 Diagnostic Accuracy for Congenital Ear Deformities: a Paired Clinical Image Study (Preprint) Open
BACKGROUND The generation of clinical diagnoses from image data is a cornerstone of medical image analysis. ChatGPT-4, a large multimodal model capable of processing both text and image inputs (e.g., dermatoscopic, histologic, and radiogr…
View article: Interpretable AI-assisted diagnosis of papillary thyroid cancer cytopathology using graph neural networks and knowledge graphs
Interpretable AI-assisted diagnosis of papillary thyroid cancer cytopathology using graph neural networks and knowledge graphs Open
View article: Efficacy of bleomycin and sirolimus in inhibiting CD31+ endothelial cell proliferation in noninvoluting congenital hemangiomas
Efficacy of bleomycin and sirolimus in inhibiting CD31+ endothelial cell proliferation in noninvoluting congenital hemangiomas Open
Objective Congenital hemangiomas are rare vascular anomalies that manifest at birth. Noninvoluting congenital hemangiomas present significant clinical challenges due to their persistence and associated complications. The mechanisms underly…
View article: Precisely Targeted Nanoparticles for CRISPR-Cas9 Delivery in Clinical Applications
Precisely Targeted Nanoparticles for CRISPR-Cas9 Delivery in Clinical Applications Open
Clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR-Cas9), an emerging gene-editing technology, has recently gained rapidly increasing attention. However, the lack of efficient delivery vectors to …
View article: Post-pericardiectomy ECMO for constrictive pericarditis: a case series and literature review
Post-pericardiectomy ECMO for constrictive pericarditis: a case series and literature review Open
VA-ECMO might be effective for refractory LCOS after pericardiectomy in patients with constrictive pericarditis, and could improve survival rates.
View article: Test-time Controllable Image Generation by Explicit Spatial Constraint Enforcement
Test-time Controllable Image Generation by Explicit Spatial Constraint Enforcement Open
Recent text-to-image generation favors various forms of spatial conditions, e.g., masks, bounding boxes, and key points. However, the majority of the prior art requires form-specific annotations to fine-tune the original model, leading to …
View article: Poly(ionic liquids)-based hydrogels: Integrating moisturizing and antibacterial functions for wound healing applications
Poly(ionic liquids)-based hydrogels: Integrating moisturizing and antibacterial functions for wound healing applications Open
View article: Thyrotoxic periodic Paralysis With hypoxemia: A case report and a comprehensive review
Thyrotoxic periodic Paralysis With hypoxemia: A case report and a comprehensive review Open
Hyperthyroidism is linked to several muscle disorders, including thyrotoxic myopathy, myasthenia gravis, and periodic paralysis. Thyrotoxic periodic paralysis (TPP) is a rare and potentially life-threatening neuromuscular condition that pr…
View article: Lung dECM matrikine-based hydrogel reverses bleomycin-induced pulmonary fibrosis by suppressing M2 macrophage polarization
Lung dECM matrikine-based hydrogel reverses bleomycin-induced pulmonary fibrosis by suppressing M2 macrophage polarization Open
Background. Recent studies have shown promising results using decellularized extracellular matrix (dECM) matrikines-based hydrogel as attractive strategies for preventing and alleviating fibrosis. Methods & Results. Porcine lung decellular…
View article: Aligned fibrous scaffolds promote directional migration of breast cancer cells via caveolin-1/YAP-mediated mechanosensing
Aligned fibrous scaffolds promote directional migration of breast cancer cells via caveolin-1/YAP-mediated mechanosensing Open
View article: Utilizing decellularized bio-membranes to optimize histopathological embedding of small tissues
Utilizing decellularized bio-membranes to optimize histopathological embedding of small tissues Open
View article: Targeted Integration of siRNA against Porcine Cytomegalovirus (PCMV) Enhances the Resistance of Porcine Cells to PCMV
Targeted Integration of siRNA against Porcine Cytomegalovirus (PCMV) Enhances the Resistance of Porcine Cells to PCMV Open
In the world’s first pig-to-human cardiac cytomegalovirus (PCMV), xenotransplant and elevated levels of porcine key factors contributing to patient mortality were considered. This has renewed attention on PCMV, a virus widely prevalent in …
View article: Targeted Integration of siRNA against Porcine Cytomegalovirus (PCMV) Enhances the Resistance of Porcine Cells to PCMV
Targeted Integration of siRNA against Porcine Cytomegalovirus (PCMV) Enhances the Resistance of Porcine Cells to PCMV Open
In the world's first pig-to-human cardiac xenotransplant, the elevated levels of porcine cytomeg-alovirus (PCMV) are considered key factors contributing to patient mortality. This has renewed attention to PCMV, a virus widely prevalent in …
View article: One-step in vivo gene knock-out in porcine embryos using recombinant adeno-associated viruses
One-step in vivo gene knock-out in porcine embryos using recombinant adeno-associated viruses Open
Introduction: Gene-edited pigs have become prominent models for studying human disease mechanisms, gene therapy, and xenotransplantation. CRISPR (clustered regularly interspaced short palindromic repeats)/CRISPR-associated 9 (CRISPR/Cas9) …
View article: Construction and applications of the EOMA spheroid model of Kaposiform hemangioendothelioma
Construction and applications of the EOMA spheroid model of Kaposiform hemangioendothelioma Open
Background Kaposiform hemangioendothelioma (KHE) is a rare intermediate vascular tumor with unclear pathogenesis. Recently, three dimensional (3D) cell spheroids and organoids have played an indispensable role in the study of many diseases…
View article: Cyclic Nucleotide-Gated Channels Gene Family in Quinoa: Functional Analysis and Stress-Responsive Roles
Cyclic Nucleotide-Gated Channels Gene Family in Quinoa: Functional Analysis and Stress-Responsive Roles Open
View article: Aligned Fibrous Scaffolds Promote Directional Migration of Breast Cancer Cells Via Caveolin-1/Yap-Mediated Mechanosensing
Aligned Fibrous Scaffolds Promote Directional Migration of Breast Cancer Cells Via Caveolin-1/Yap-Mediated Mechanosensing Open
View article: Tissue-specific micropattern array chips fabricated via decellularized ECM for 3D cell culture
Tissue-specific micropattern array chips fabricated via decellularized ECM for 3D cell culture Open
Multicellular three-dimensional (3D) in vitro models, such as cell spheroids and organoids, can significantly improve the viability, histomorphology, genotype stability, function and drug metabolism of cells [1], [2], [3]. In general, seve…
View article: The prevention strategies of swine viruses related to xenotransplantation
The prevention strategies of swine viruses related to xenotransplantation Open
View article: Pig-to-Human xenotransplantation: Moving toward organ customization
Pig-to-Human xenotransplantation: Moving toward organ customization Open
View article: The CRISPR/Cas9 System Delivered by Extracellular Vesicles
The CRISPR/Cas9 System Delivered by Extracellular Vesicles Open
Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein (Cas) systems can precisely manipulate DNA sequences to change the characteristics of cells and organs, which has potential in the mechanistic rese…
View article: Artificial intelligence applications in pathological diagnosis of gastric cancer
Artificial intelligence applications in pathological diagnosis of gastric cancer Open
Globally, gastric cancer is the third leading cause of death from tumors. Prevention and individualized treatment are considered to be the best options for reducing the mortality rate of gastric cancer. Artificial intelligence (AI) technol…
View article: Three-Dimensional Microtumor Formation of Infantile Hemangioma-Derived Endothelial Cells for Mechanistic Exploration and Drug Screening
Three-Dimensional Microtumor Formation of Infantile Hemangioma-Derived Endothelial Cells for Mechanistic Exploration and Drug Screening Open
Infantile hemangioma (IH) is the most prevalent type of vascular tumor in infants. The pathophysiology of IH is unknown. The tissue structure and physiology of two-dimensional cell cultures differ greatly from those in vivo, and spontaneou…
View article: Autoclaving pHEMA-Based Hydrogels Immersed in Deionized Water has No Effect on Physicochemical Properties and Cell Behaviors
Autoclaving pHEMA-Based Hydrogels Immersed in Deionized Water has No Effect on Physicochemical Properties and Cell Behaviors Open
Hydrogels based on poly-(2-hydroxyethyl methacrylate) (pHEMA) have been widely used as biomaterials in tissue engineering due to their biocompatibility, hydrophilicity, and low friction coefficient. The terminal sterilization of hydrogels …
View article: Linked PDF of Table of Contents
Linked PDF of Table of Contents Open
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View article: Application of deep learning to identify ductal carcinoma in situ and microinvasion of the breast using ultrasound imaging
Application of deep learning to identify ductal carcinoma in situ and microinvasion of the breast using ultrasound imaging Open
Deep learning can be used to identify MIC of breast DCIS from ultrasound images. Models based on Inception-v3 can provide automated detection of DCIS with MIC from ultrasound images.
View article: Kidney ECM Pregel Nanoarchitectonics for Microarrays to Accelerate Harvesting Gene-Edited Porcine Primary Monoclonal Spheres
Kidney ECM Pregel Nanoarchitectonics for Microarrays to Accelerate Harvesting Gene-Edited Porcine Primary Monoclonal Spheres Open
One of the key steps of using CRISPR/Cas9 to obtain gene-edited cells used in generating gene-edited animals combined with somatic cell nuclear transplantation (SCNT) is to harvest monoclonal cells with genetic modifications. However, prim…