Bindu Chandrasekharan
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View article: Microbiota-dependent Formylated Peptide Receptor (Fpr1/2) Signaling Regulates Enteric Nervous System Development and Gastrointestinal Motility in Mice
Microbiota-dependent Formylated Peptide Receptor (Fpr1/2) Signaling Regulates Enteric Nervous System Development and Gastrointestinal Motility in Mice Open
View article: Corrigendum to: Intracolonic Neuropeptide Y Y1 Receptor Inhibition Attenuates Intestinal Inflammation in Murine Colitis and Cytokine Release in IBD Biopsies
Corrigendum to: Intracolonic Neuropeptide Y Y1 Receptor Inhibition Attenuates Intestinal Inflammation in Murine Colitis and Cytokine Release in IBD Biopsies Open
View article: Intracolonic Neuropeptide Y Y1 Receptor Inhibition Attenuates Intestinal Inflammation in Murine Colitis and Cytokine Release in IBD Biopsies
Intracolonic Neuropeptide Y Y1 Receptor Inhibition Attenuates Intestinal Inflammation in Murine Colitis and Cytokine Release in IBD Biopsies Open
We have demonstrated that neuropeptide Y (NPY) can regulate pro-inflammatory signaling in the gut via cross-talk with the pro-inflammatory cytokine tumor necrosis factor (TNF). Here, we investigated if selective blocking of NPY receptors, …
View article: Imaging the Gut with "CLARITY"
Imaging the Gut with "CLARITY" Open
CLARITY (Clear Lipid-exchanged Acrylamide-hybridized Rigid Imaging compatible Tissue hYdrogel) has recently evolved as a valuable technique involving acrylamide embedding to delipidate tissue (without sectioning) and to preserve the 3-D ti…
View article: Cu/Zn Superoxide Dismutase (Sod1) regulates the canonical Wnt signaling pathway
Cu/Zn Superoxide Dismutase (Sod1) regulates the canonical Wnt signaling pathway Open
View article: Gut-Resident Lactobacilli Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury
Gut-Resident Lactobacilli Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury Open
View article: Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced Apoptosis
Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced Apoptosis Open
View article: Initiation of Parkinson’s disease from gut to brain by δ-secretase
Initiation of Parkinson’s disease from gut to brain by δ-secretase Open
View article: Interactions Between Commensal Bacteria and Enteric Neurons, via FPR1 Induction of ROS, Increase Gastrointestinal Motility in Mice
Interactions Between Commensal Bacteria and Enteric Neurons, via FPR1 Induction of ROS, Increase Gastrointestinal Motility in Mice Open
View article: Gut Resident <i>Lactobacilli</i> Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury
Gut Resident <i>Lactobacilli</i> Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury Open
View article: Hydro-Cy3-Mediated Detection of Reactive Oxygen Species In Vitro and In Vivo
Hydro-Cy3-Mediated Detection of Reactive Oxygen Species In Vitro and In Vivo Open
View article: Extra-mitochondrial Cu/Zn superoxide dismutase (Sod1) is dispensable for protection against oxidative stress but mediates peroxide signaling in Saccharomyces cerevisiae
Extra-mitochondrial Cu/Zn superoxide dismutase (Sod1) is dispensable for protection against oxidative stress but mediates peroxide signaling in Saccharomyces cerevisiae Open
Cu/Zn Superoxide Dismutase (Sod1) is a highly conserved and abundant metalloenzyme that catalyzes the disproportionation of superoxide radicals into hydrogen peroxide and molecular oxygen. As a consequence, Sod1 serves dual roles in oxidat…
View article: Neuropeptide Y (NPY) promotes inflammation-induced tumorigenesis by enhancing epithelial cell proliferation
Neuropeptide Y (NPY) promotes inflammation-induced tumorigenesis by enhancing epithelial cell proliferation Open
We have demonstrated that neuropeptide Y (NPY), abundantly produced by enteric neurons, is an important regulator of intestinal inflammation. However, the role of NPY in the progression of chronic inflammation to tumorigenesis is unknown. …
View article: Heme dynamics and trafficking factors revealed by genetically encoded fluorescent heme sensors
Heme dynamics and trafficking factors revealed by genetically encoded fluorescent heme sensors Open
Significance All heme-dependent functions require the mobilization of labile heme (LH), of which there is little understanding of its nature and dynamics. To probe LH pools, we developed genetically encoded fluorescent heme sensors and dep…