Bing Gu
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View article: A point-of-care testing device for monkeypox virus integrating recombinase polymerase amplification and lateral flow assay
A point-of-care testing device for monkeypox virus integrating recombinase polymerase amplification and lateral flow assay Open
This compact, portable POCT kit, requiring no professional operation or precision instruments, offers a promising solution for on-site and home self-testing. Its high sensitivity and specificity, coupled with the capacity to swiftly adapt …
View article: Development of Surface Enhanced Raman Spectra coupled with Machine Learning Analysis for Differentiation of Closely Related Species within Enterobacter cloacae Complex
Development of Surface Enhanced Raman Spectra coupled with Machine Learning Analysis for Differentiation of Closely Related Species within Enterobacter cloacae Complex Open
Background Enterobacter cloacae complex (ECC) is an important nosocomial pathogen and consists of multiple similar species. The taxonomy of ECC has been consecutively updated, adding to its identification difficulty. Methods A total of 92 …
View article: A multi-center study for colorectal cancer early detection in high-risk disease patients using cell-free fragmentomics assay
A multi-center study for colorectal cancer early detection in high-risk disease patients using cell-free fragmentomics assay Open
This multi-center study underscores a significant advancement in liquid biopsy technology, offering a highly accurate and non-invasive approach for early CRC detection and differentiation of advanced colorectal adenomas.
View article: PKD1-tau disulfide linkage promotes tau phosphorylation and tau accumulation in a tauopathy mouse model
PKD1-tau disulfide linkage promotes tau phosphorylation and tau accumulation in a tauopathy mouse model Open
Abnormal accumulation of the microtubule-interacting protein tau is a characteristic feature of numerous neurodegenerative disorders, including Alzheimer’s disease (AD). Oxidative stress, a pivotal factor in neurodegeneration, contributes …
View article: B‐EPIC: A Transformer‐Based Language Model for Decoding B Cell Immunodominance Patterns
B‐EPIC: A Transformer‐Based Language Model for Decoding B Cell Immunodominance Patterns Open
Vaccine development for pathogens has faced significant challenges, contributing to a public health burden. B‐cell epitope (BCE) prediction is a crucial process in vaccine development, but is hindered by limited efficiency and accuracy. To…
View article: Multilevel regulation of c-di-GMP biosynthesis by cAMP signaling increases Shigella sonnei fitness and pathogenicity in response to bile salts
Multilevel regulation of c-di-GMP biosynthesis by cAMP signaling increases Shigella sonnei fitness and pathogenicity in response to bile salts Open
It was previously demonstrated that intestinal pathogens have evolved different mechanisms to enhance their infection and colonization in the intestines of hosts. However, it is unclear how Shigella effectively survives in the presence of …
View article: <i>Lactiplantibacillus plantarum</i> strain 84-3 and <i>Staphylococcus aureus</i> phages alleviate type 2-diabetes-induced <i>S. aureus</i> and BCAAs increases by PI3K/AKT/GLUT4 signaling pathway
<i>Lactiplantibacillus plantarum</i> strain 84-3 and <i>Staphylococcus aureus</i> phages alleviate type 2-diabetes-induced <i>S. aureus</i> and BCAAs increases by PI3K/AKT/GLUT4 signaling pathway Open
Epidemiological studies have indicated that branched-chain amino acids (BCAAs) increased and gut microbiota disordered in type 2 diabetes mellitus (T2DM). This study aimed to investigate the mechanism of Lactiplantibacillus plantarum strai…
View article: Exponential convergence of the local diabatic representation for nonadiabatic models
Exponential convergence of the local diabatic representation for nonadiabatic models Open
The discrete variable local diabatic representation (LDR) provides a divergence-free framework for exact conical intersection dynamics simulation. In this work, we investigate the convergence with respect to the number of "nuclear" grid po…
View article: A Dynamic Analysis of Cross-Category Innovation in Digital Platform Ecosystems with Network Effects
A Dynamic Analysis of Cross-Category Innovation in Digital Platform Ecosystems with Network Effects Open
Cross-category innovation in digital platform ecosystems is increasingly pivotal for competitive reconfiguration, and the value it generates for users primarily stems from the benefits of network effects. By extending the spatial competiti…
View article: Comprehensive Pan‐Cancer Analysis of <scp>TRNT1</scp> as a Potential Biomarker for Breast Cancer
Comprehensive Pan‐Cancer Analysis of <span>TRNT1</span> as a Potential Biomarker for Breast Cancer Open
TRNT1, an RNA nucleotide transferase, plays a critical role in cellular processes and may be involved in cancer. However, its role in cancer has not been fully explored. This study aims to explore the potential significance of TRNT1 in can…
View article: Optimizing Laboratory Diagnostics Education: Research on the Doctor-Patient-Technician Integrated Teaching Model Based on Medical STEM Concepts
Optimizing Laboratory Diagnostics Education: Research on the Doctor-Patient-Technician Integrated Teaching Model Based on Medical STEM Concepts Open
Objectives This study aims to reform and optimize laboratory diagnostics education by developing an innovative teaching model based on M-STEM (Medical Science, Technology, Engineering, and Mathematics). Methods Students majoring in clinica…
View article: Mercaptophenylboronic Acid‐Mediated Nanozyme Immunochromatographic Assay for Simultaneous Detection of Respiratory Bacteria and Virus (Adv. Sci. 31/2025)
Mercaptophenylboronic Acid‐Mediated Nanozyme Immunochromatographic Assay for Simultaneous Detection of Respiratory Bacteria and Virus (Adv. Sci. 31/2025) Open
View article: Age-dependent effects of H2S on post-traumatic stress disorder in adolescent and adult mice
Age-dependent effects of H2S on post-traumatic stress disorder in adolescent and adult mice Open
Background Among people with post-traumatic stress disorder (PTSD), there is an increased prevalence of age-related diseases. However, the biological mechanisms underlying this phenomenon remain incompletely understood. Methods The express…
View article: Cross-Category Innovation Strategy and Evolution of Digital Platform Ecosystems: A Technology-Driven Perspective
Cross-Category Innovation Strategy and Evolution of Digital Platform Ecosystems: A Technology-Driven Perspective Open
Digital platform ecosystems confront critical management challenges as they overcome path dependence amid rapid technological change. This study explores cross-category innovation as a key strategic action, using a longitudinal case study …
View article: Cross-Category Innovation Strategy and Evolution of Digital Platform Ecosystems: A Technology-Driven Perspective
Cross-Category Innovation Strategy and Evolution of Digital Platform Ecosystems: A Technology-Driven Perspective Open
Digital platform ecosystems confront critical management challenges as they overcome path dependence amid rapid technological change. This study explores cross-category innovation as a key strategic action, using a longitudinal case study …
View article: Integrated plasma and vegetation proteomic characterization of infective endocarditis for early diagnosis and treatment
Integrated plasma and vegetation proteomic characterization of infective endocarditis for early diagnosis and treatment Open
View article: A cell-cell communication signal from <i>Enterobacter cloacae</i> interfering with the signaling systems and virulence in <i>Shigella sonnei</i>
A cell-cell communication signal from <i>Enterobacter cloacae</i> interfering with the signaling systems and virulence in <i>Shigella sonnei</i> Open
Quorum sensing (QS) is widely utilized by both bacteria and fungi to mediate cell-cell communication. Previous studies have demonstrated that the indole derivative indole-3-ethanol (also known as tryptophol) controls morphogenesis as a QS …
View article: Mercaptophenylboronic Acid‐Mediated Nanozyme Immunochromatographic Assay for Simultaneous Detection of Respiratory Bacteria and Virus
Mercaptophenylboronic Acid‐Mediated Nanozyme Immunochromatographic Assay for Simultaneous Detection of Respiratory Bacteria and Virus Open
Rapid, sensitive, and accurate detection of respiratory pathogens is essential yet challenging. Here, this study presents a universal nanozyme immunochromatographic assay (ICA) that utilizes the broad binding capacity of 4‐mercaptophenylbo…
View article: Fluorescence Color Gradient Immunochromatographic Assay for Highly‐Sensitive, Quantitative, and Simultaneous Detection of Small‐Molecule Pollutants
Fluorescence Color Gradient Immunochromatographic Assay for Highly‐Sensitive, Quantitative, and Simultaneous Detection of Small‐Molecule Pollutants Open
Rapid on‐site screening of small‐molecule pollutants in complex samples is essential but remains unachieved. In this study, we introduce a universal fluorescence color gradient immunochromatographic assay (FCGICA) utilizing dual‐signal sup…
View article: Risk factors associated with Helicobacter pylori infection in the urban population of China: A nationwide, multi-center, cross-sectional study
Risk factors associated with Helicobacter pylori infection in the urban population of China: A nationwide, multi-center, cross-sectional study Open
Our findings highlight the importance of promoting a healthy lifestyle and improving the understanding of H. pylori in reducing the infection rate of the bacterial pathogen in the urban Chinese population.
View article: Electropositive Magnetic Fluorescent Nanoprobe‐Mediated Immunochromatographic Assay for the Ultrasensitive and Simultaneous Detection of Bacteria (Adv. Sci. 12/2025)
Electropositive Magnetic Fluorescent Nanoprobe‐Mediated Immunochromatographic Assay for the Ultrasensitive and Simultaneous Detection of Bacteria (Adv. Sci. 12/2025) Open
Immunochromatographic Assay for Bacteria Detection
View article: Chemoenzymatic Synthesis of <i>tert</i> ‐Butyl ((3 <i>R</i> , 6 <i>R</i> )‐6‐methyl‐piperidin‐3‐yl)carbamate: A Key Intermediate in Orexin Receptor Antagonist and IRAK4 Inhibitor
Chemoenzymatic Synthesis of <i>tert</i> ‐Butyl ((3 <i>R</i> , 6 <i>R</i> )‐6‐methyl‐piperidin‐3‐yl)carbamate: A Key Intermediate in Orexin Receptor Antagonist and IRAK4 Inhibitor Open
tert ‐Butyl ((3 R ,6 R )‐6‐methylpiperidin‐3‐yl)carbamate is a pivotal pharmaceutical intermediate and active pharmacophore in drug synthesis, encompassing applications in orexin receptor antagonist and IRAK4 inhibitor. To date, a simple a…
View article: An experimental study on the lytic bacteriophage MSP15 with wide-spectrum targeting methicillin-resistant Staphylococcus aureus
An experimental study on the lytic bacteriophage MSP15 with wide-spectrum targeting methicillin-resistant Staphylococcus aureus Open
Lytic bacteriophages with a wide spectrum can become an auxiliary approach for treating MRSA infection.
View article: Electropositive Magnetic Fluorescent Nanoprobe‐Mediated Immunochromatographic Assay for the Ultrasensitive and Simultaneous Detection of Bacteria
Electropositive Magnetic Fluorescent Nanoprobe‐Mediated Immunochromatographic Assay for the Ultrasensitive and Simultaneous Detection of Bacteria Open
Immunochromatographic assays (ICAs) provide simple and rapid strategies for bacterial diagnosis but still suffer from the problems of low sensitivity and high dependency on paired antibodies. Herein, the broad‐spectrum capture and detectio…
View article: Path-ordered linked product approximation to the global electronic overlap matrix
Path-ordered linked product approximation to the global electronic overlap matrix Open
The global many-electron wave function overlap matrix accounts for all effects beyond the Born-Oppenheimer approximation in the discrete variable local diabatic representation, a numerically exact framework for modeling nonadiabatic conica…
View article: Nanoengineered magneto-fluorescent lateral flow immunoassay enabling point-of-care talaromycosis diagnosis via ultra-sensitive Hsp30 detection
Nanoengineered magneto-fluorescent lateral flow immunoassay enabling point-of-care talaromycosis diagnosis via ultra-sensitive Hsp30 detection Open
View article: GlycoPro: A High-Throughput Sample-Processing Platform for Multi-Glycosylation-Omics Analysis
GlycoPro: A High-Throughput Sample-Processing Platform for Multi-Glycosylation-Omics Analysis Open
View article: Regional Variation, Lifestyle Determinants, and Household Clustering of Helicobacter pylori in Coastal Southern China: A Multicenter, Population-Based Cross-Sectional Study
Regional Variation, Lifestyle Determinants, and Household Clustering of Helicobacter pylori in Coastal Southern China: A Multicenter, Population-Based Cross-Sectional Study Open
View article: Development of a droplet digital PCR method for the detection of Ureaplasma urealyticum
Development of a droplet digital PCR method for the detection of Ureaplasma urealyticum Open
Our data indicated that ddPCR detection technology has the characteristics of absolute quantification, high stability, high specificity and high sensitivity of UU. It can promote the accurate detection of UU, providing a more scientific ba…
View article: Comparative evaluation of BacT/ALERT VIRTUO and BACTEC FX400 blood culture systems for the detection of bloodstream infections
Comparative evaluation of BacT/ALERT VIRTUO and BACTEC FX400 blood culture systems for the detection of bloodstream infections Open
Bloodstream infections (BSI) pose significant threats to patient health, necessitating timely and accurate diagnostics to reduce mortality and morbidity. This study aimed to evaluate the clinical performance of the BacT/ALERT VIRTUO blood …