Lan Huang
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View article: Unveiling the Genetic Mosaic of Pediatric AML: Insights from Southwest China
Unveiling the Genetic Mosaic of Pediatric AML: Insights from Southwest China Open
Background: Pediatric acute myeloid leukemia (pAML) is the second most common type of childhood leukemia, behind acute lymphoblastic leukemia. High-throughput technologies have enabled the identification of increasing molecular alterations…
View article: LENG8 mediates RNA nuclear retention and degradation in eukaryotes
LENG8 mediates RNA nuclear retention and degradation in eukaryotes Open
In eukaryotes, incompletely processed and misprocessed mRNAs as well as numerous noncoding RNAs are retained in the nucleus and often degraded. However, the mechanisms for this critical quality control pathway remain poorly understood. Her…
View article: Mass Spectrometry‐Based Proteomics Technologies to Define Endogenous Protein‐Protein Interactions and Their Applications to Cancer and Viral Infectious Diseases
Mass Spectrometry‐Based Proteomics Technologies to Define Endogenous Protein‐Protein Interactions and Their Applications to Cancer and Viral Infectious Diseases Open
An intricate network of protein assemblies and protein‐protein interactions (PPIs) underlies nearly every biological process in living systems. The organization of these cellular networks is highly dynamic and intimately tied to the genomi…
View article: Identification of a novel TOP2B::AFF2 fusion gene in B-cell acute lymphoblastic leukemia
Identification of a novel TOP2B::AFF2 fusion gene in B-cell acute lymphoblastic leukemia Open
Genetic alterations play a pivotal role in leukemic clonal transformation, significantly influencing disease pathogenesis and clinical outcomes. Here, we report a novel fusion gene and investigate its pathogenic role in acute lymphoblastic…
View article: Association between albumin corrected anion gap and in-hospital mortality in critically ill patients with chronic obstructive pulmonary disease
Association between albumin corrected anion gap and in-hospital mortality in critically ill patients with chronic obstructive pulmonary disease Open
Background: The relationship between albumin-corrected anion gap (ACAG) and in-hospital mortality in critically ill patients with COPD remains unclear. Objective: This study investigated the association between ACAG levels and the risk of …
View article: Ginsenoside reprogramming microglia through the FGF/FGFR1 inhibits post traumatic stress disorder
Ginsenoside reprogramming microglia through the FGF/FGFR1 inhibits post traumatic stress disorder Open
Post traumatic stress disorder (PTSD) is a serious and persistent mental diseases. Nowadays, Treatment of PTSD patients in clinical practice is mainly based on drug therapy accompanied by psychological therapy. However, the therapeutic eff…
View article: NEMF-mediated CAT-tailing defines distinct branches of translocation-associated quality control
NEMF-mediated CAT-tailing defines distinct branches of translocation-associated quality control Open
Ribosome stalling during co-translational translocation at the endoplasmic reticulum (ER) causes translocon clogging and impairs ER protein biogenesis. Mammalian cells resolve translocon clogging vial a poorly characterized translocation-a…
View article: Trioxane-based MS-cleavable Cross-linking Mass Spectrometry for Profiling Multimeric Interactions of Cellular Networks
Trioxane-based MS-cleavable Cross-linking Mass Spectrometry for Profiling Multimeric Interactions of Cellular Networks Open
Cross-linking mass spectrometry (XL-MS) is a powerful technology for mapping protein-protein interactions (PPIs) at the systems-level. By covalently connecting pairs of proximal residues, cross-linking reagents provide distance restraints …
View article: Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins
Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins Open
Understanding the normal function of the Huntingtin (HTT) protein is of significance in the design and implementation of therapeutic strategies for Huntington’s disease (HD). Expansion of the CAG repeat in the HTT gene, encoding an expande…
View article: Vasodilator Hydralazine Promotes Nanoparticle Penetration in Advanced Desmoplastic Tumors
Vasodilator Hydralazine Promotes Nanoparticle Penetration in Advanced Desmoplastic Tumors Open
Desmoplastic tumors are normally resistant to nanoparticle-based chemotherapy due to dense stroma and limited particle permeability inside the tumor. Herein, we reported that hydralazine (HDZ)- A n antihypertension vasodilator-would dramat…
View article: Mono-UFMylation promotes misfolding-associated secretion of α-synuclein
Mono-UFMylation promotes misfolding-associated secretion of α-synuclein Open
Stressed cells secret misfolded proteins lacking signaling sequence via an unconventional protein secretion (UcPS) pathway, but how misfolded proteins are targeted selectively in UcPS is unclear. Here, we report that misfolded UcPS clients…
View article: Abstract 1295 Application of Crosslinking-based technology in Quantitative Analysis of PHD2 Interactome
Abstract 1295 Application of Crosslinking-based technology in Quantitative Analysis of PHD2 Interactome Open
PHD2 is a major regulatory enzyme that targets hypoxia-inducible factor-1α (HIF-1α). Under normoxia, PHD2-mediated proline hydroxylation promotes the binding of pVHL binding towards HIF-1α that allows its polyubiquitylation and subsequent …
View article: Pyruvate kinase deficiency and PKLR gene mutations: Insights from molecular dynamics simulation analysis
Pyruvate kinase deficiency and PKLR gene mutations: Insights from molecular dynamics simulation analysis Open
Pyruvate kinase deficiency is a rare hereditary erythrocyte enzyme disease caused by mutations in the pyruvate kinase liver and red blood cell gene. The clinical presentations of pyruvate kinase deficiency are significantly heterogeneous, …
View article: DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples
DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples Open
Protein-protein interactions (PPIs) are fundamental to understanding biological systems as protein complexes are the active molecular modules critical for carrying out cellular functions. Dysfunctional PPIs have been associated with variou…
View article: Meeting Report on the 3rd Chinese American Society for Mass Spectrometry Conference—Advancing Biological and Pharmaceutical Mass Spectrometry
Meeting Report on the 3rd Chinese American Society for Mass Spectrometry Conference—Advancing Biological and Pharmaceutical Mass Spectrometry Open
Following the highly successful Chinese American Society for Mass Spectrometry (CASMS) conferences in the previous 2 years, the 3rd CASMS Conference was held virtually on August 28–31, 2023, using the Gather.Town platform to bring together…
View article: Computational Characterization of Undifferentially Expressed Genes with Altered Transcription Regulation in Lung Cancer
Computational Characterization of Undifferentially Expressed Genes with Altered Transcription Regulation in Lung Cancer Open
A transcriptome profiles the expression levels of genes in cells and has accumulated a huge amount of public data. Most of the existing biomarker-related studies investigated the differential expression of individual transcriptomic feature…
View article: Lipid-anchored proteasomes control membrane protein homeostasis
Lipid-anchored proteasomes control membrane protein homeostasis Open
Protein degradation in eukaryotic cells is mainly carried out by the 26 S proteasome, a macromolecular complex not only present in the cytosol and nucleus but also associated with various membranes. How proteasomes are anchored to the memb…
View article: Proximity Labeling Expansion Microscopy (PL-ExM) resolves structure of the interactome
Proximity Labeling Expansion Microscopy (PL-ExM) resolves structure of the interactome Open
Elucidating the spatial relationships within the protein interactome is pivotal to understanding the organization and regulation of protein-protein interactions. However, capturing the 3D architecture of the interactome presents a dual cha…
View article: 732 Immune activation with plinabulin enhances anti-tumor response combining radiation with immune checkpoint blockade
732 Immune activation with plinabulin enhances anti-tumor response combining radiation with immune checkpoint blockade Open
Background Plinabulin is a selective immunomodulating microtubule-binding agent that exerts direct anti-cancer activity as a single agent, as well as enhancing the immune response, primarily by inducing dendritic cell (DC) maturation and T…
View article: Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target
Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target Open
Safely expanding indications for cellular therapies has been challenging given a lack of highly cancer-specific surface markers. Here we explore the hypothesis that tumor cells express cancer-specific surface protein conformations that are…
View article: Efficient plant genome engineering using a probiotic sourced CRISPR-Cas9 system
Efficient plant genome engineering using a probiotic sourced CRISPR-Cas9 system Open
Among CRISPR-Cas genome editing systems, Streptococcus pyogenes Cas9 (SpCas9), sourced from a human pathogen, is the most widely used. Here, through in silico data mining, we have established an efficient plant genome engineering system us…
View article: Real-World Impact of Prophylactic Growth Factor Use on Timing of Febrile Neutropenia and Infection After High-Risk Chemotherapy
Real-World Impact of Prophylactic Growth Factor Use on Timing of Febrile Neutropenia and Infection After High-Risk Chemotherapy Open
Background: Prophylactic growth-factor therapy with granulocyte colony-stimulating factor (G-CSF) reduces the risk of febrile neutropenia (FN) in patients with breast cancer initiating myelosuppressive chemotherapy. However, little is know…
View article: The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress
The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress Open
The Hippo pathway is known for its crucial involvement in development, regeneration, organ size control, and cancer. While energy stress is known to activate the Hippo pathway and inhibit its effector YAP, the precise role of the Hippo pat…