Bing Xiong
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View article: Who is a Better Matchmaker? Human vs. Algorithmic Judge Assignment in a High-Stakes Startup Competition
Who is a Better Matchmaker? Human vs. Algorithmic Judge Assignment in a High-Stakes Startup Competition Open
There is growing interest in applying artificial intelligence (AI) to automate and support complex decision-making tasks. However, it remains unclear how algorithms compare to human judgment in contexts requiring semantic understanding and…
View article: Application of PBL in combination with the SP teaching method in the clinical teaching of orthopedics and traumatology
Application of PBL in combination with the SP teaching method in the clinical teaching of orthopedics and traumatology Open
The combined PBL and SP teaching method was found to be superior to traditional LBL in improving the clinical skills and self-learning abilities of orthopedic residents. This approach enhances student engagement, clinical thinking, and ove…
View article: A Bibliometric Analysis of Translator’s Style in Translation Studies: A Chinese Perspective (1980–2022)
A Bibliometric Analysis of Translator’s Style in Translation Studies: A Chinese Perspective (1980–2022) Open
The undeniable presence of translators has stimulated a growing interest in issues such as translator’s voice by Theo Hermans and translator’s style by Mona Baker. For a long time, existing research in China has exclusively explored transl…
View article: The Cryo-EM structure of TRPC1 and TRPC5 heterotetramer
The Cryo-EM structure of TRPC1 and TRPC5 heterotetramer Open
Ion channel heteromers display distinct electrophysiological and ligand-binding properties, allowing precise modulation of cellular functions in specific tissues. Among the TRPC subtypes, the TRPC1/4/5 heteromers are the most abundant isof…
View article: Structural mechanism of human HCN1 hyperpolarization-activated channel inhibition by ivabradine
Structural mechanism of human HCN1 hyperpolarization-activated channel inhibition by ivabradine Open
The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play a crucial role in regulating neuronal excitability. Despite growing evidence supporting the therapeutic potential of HCN1 inhibition in treating neurological disor…
View article: Remodeling tumor‐associated macrophage for anti‐cancer effects by rational design of irreversible inhibition of mitogen‐activated protein kinase‐activated protein kinase 2
Remodeling tumor‐associated macrophage for anti‐cancer effects by rational design of irreversible inhibition of mitogen‐activated protein kinase‐activated protein kinase 2 Open
Mitogen‐activated protein kinase‐activated protein kinase 2 (MK2) emerges as a pivotal target in developing anti‐cancer therapies. The limitations of ATP‐competitive inhibitors, due to insufficient potency and selectivity, underscore the u…
View article: Cryo-EM structure of human HCN3 channel and its regulation by cAMP
Cryo-EM structure of human HCN3 channel and its regulation by cAMP Open
HCN channels are important for regulating heart rhythm and nerve activity and have been studied as potential drug targets for treating depression, arrhythmia, nerve pain, and epilepsy. Despite possessing unique pharmacological properties, …
View article: Establishing and Validation of the VBV Score for Assessing Lung Ground-Glass Nodules based on High-Resolution Computed Tomography
Establishing and Validation of the VBV Score for Assessing Lung Ground-Glass Nodules based on High-Resolution Computed Tomography Open
Background The widespread utilization of chest High-resolution Computed Tomography (HRCT) has prompted detection of pulmonary ground-glass nodules (GGNs) in otherwise asymptomatic individuals. We aimed to establish a simple clinical risk s…
View article: Constructing Chinese Cultural Identity Internationally in Translated Political Discourse: A Corpus Analysis of the English Versions of President Xi Jinping’s International Addresses
Constructing Chinese Cultural Identity Internationally in Translated Political Discourse: A Corpus Analysis of the English Versions of President Xi Jinping’s International Addresses Open
Political discourse is generally assumed to deal with politics, on issues such as policies, power and ideology; however, it also involves cultural issues, thus playing a role in cultural transmission and cultural identity construction. The…
View article: Discovery of 1<i>H</i>-Imidazo[4,5-<i>b</i>]pyridine Derivatives as Potent and Selective BET Inhibitors for the Management of Neuropathic Pain
Discovery of 1<i>H</i>-Imidazo[4,5-<i>b</i>]pyridine Derivatives as Potent and Selective BET Inhibitors for the Management of Neuropathic Pain Open
Neuropathic pain (NP) is an intolerable pain syndrome that arises from continuous inflammation and excitability after nerve injury. Only a few NP therapeutics are currently available, and all of them do not provide adequate pain relief. He…
View article: Data from Preclinical Evaluation of SCC244 (Glumetinib), a Novel, Potent, and Highly Selective Inhibitor of c-Met in MET-dependent Cancer Models
Data from Preclinical Evaluation of SCC244 (Glumetinib), a Novel, Potent, and Highly Selective Inhibitor of c-Met in MET-dependent Cancer Models Open
Because the receptor tyrosine kinase c-Met plays a critical role in tumor growth, metastasis, tumor angiogenesis, and drug resistance, the c-Met axis represents an attractive therapeutic target. Herein, we report the first preclinical char…
View article: Screening and optimization of phage display cyclic peptides against the WDR5 WBM site
Screening and optimization of phage display cyclic peptides against the WDR5 WBM site Open
We reported two improved screenings based on the phage display technique to discover novel peptidic inhibitors against the WDR5 WBM site, and the optimized cyclic peptide CYC3 was acquired, which could be subjected to further biological ev…
View article: Design, synthesis and biological evaluation of 4-aminoquinoline derivatives as receptor-interacting protein kinase 2 (RIPK2) inhibitors
Design, synthesis and biological evaluation of 4-aminoquinoline derivatives as receptor-interacting protein kinase 2 (RIPK2) inhibitors Open
Receptor-interacting protein kinase 2 (RIPK2) is an essential protein kinase mediating signal transduction by NOD1 and NOD2, which play an important role in regulating immune signalling. In this study, we designed and synthesised a novel s…
View article: Discovery of Novel <i>N</i>-(5-(Pyridin-3-yl)-1<i>H</i>-indazol-3-yl)benzamide Derivatives as Potent Cyclin-Dependent Kinase 7 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease
Discovery of Novel <i>N</i>-(5-(Pyridin-3-yl)-1<i>H</i>-indazol-3-yl)benzamide Derivatives as Potent Cyclin-Dependent Kinase 7 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease Open
Recent evidence suggests that CDK7 is a novel potential drug target for autosomal dominant polycystic kidney disease (ADPKD) treatment. Herein, on the basis of structural analysis, a hit compound 3 with a novel scaffold was designed and su…
View article: Development of a series of quinazoline-2,5-diamine derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors
Development of a series of quinazoline-2,5-diamine derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors Open
Hematopoietic progenitor kinase 1 (HPK1) is a serine/threonine kinase that serves as the negative regulator of multiple immune signaling pathways. Genetic studies using HPK1 knockout and kinase-dead mice suggested that inhibiting HPK1 eith…