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View article: Prospective associations between nicotine type and the continuation of youth e-cigarette use
Prospective associations between nicotine type and the continuation of youth e-cigarette use Open
Our findings suggest that, when it comes to predicting the continuation of vaping among youth who have already initiated, nicotine type (i.e., the ratio of R- and S-isomers) may play a critical role. It is encouraging that R/S nicotine may…
Dual pandemic of firearm injury and COVID-19 in Central and Southeastern Ohio: An interrupted time series analysis Open
BACKGROUND Firearm injuries increased as the United States faced the onset and first two years of the COVID-19 pandemic, a phenomenon some refer to as the “dual pandemic.” Across the country, evidence suggests regional firearm injury rates…
View article: Longitudinal analysis of e-cigarette and cannabis dual use in an Ohio sample of adolescents and young adults
Longitudinal analysis of e-cigarette and cannabis dual use in an Ohio sample of adolescents and young adults Open
Adolescents and young adults (AYA) who vape e-cigarettes are likely to use cannabis ("dual use"), but little research has examined factors influencing future use pattern-. Using longitudinal data from 551 Ohio AYA (aged 15-24) who reported…
Case Report: Sliding gouty tophi: a case of dynamic ultrasound diagnosis of carpal tunnel syndrome Open
Carpal tunnel syndrome (CTS) caused by gouty tophi is a rare clinical condition. In this case, ultrasonography clearly identified gouty tophi deposited within the superficial flexor tendon of the right middle finger, resulting in tendon th…
View article: Differentiable NMS via Sinkhorn Matching for End-to-End Fabric Defect Detection
Differentiable NMS via Sinkhorn Matching for End-to-End Fabric Defect Detection Open
Fabric defect detection confronts two fundamental challenges. First, conventional non-maximum suppression disrupts gradient flow, which hinders genuine end-to-end learning. Second, acquiring pixel-level annotations at industrial scale is p…
M‐Learning for Individual Treatment Rule With Survival Outcomes Open
Individualized treatment rules (ITRs) tailor treatments to individuals based on their unique characteristics to optimize clinical outcomes and resource allocation. Current approaches use outcome modeling or propensity score weighting to co…
Substation Inspection Safety Risk Identification Based on Synthetic Data and Spatiotemporal Action Detection Open
During substation inspection, operators are often exposed to hazardous working environments. It is necessary to use visual sensors to determine work status and perform action detection to distinguish between normal and dangerous actions in…
View article: Mass resection as a candidate treatment for uterine PEComas of uncertain malignant potential: a case report and literature review
Mass resection as a candidate treatment for uterine PEComas of uncertain malignant potential: a case report and literature review Open
Background Perivascular epithelioid cell tumours (PEComas) occurring in the uterus are rare, with surgery being the most recommended primary treatment for malignant cases. This study aims to provide clinical guidance on the clinicopatholog…
Matching‐Assisted Power Prior for Incorporating Real‐World Data in Randomized Clinical Trial Analysis Open
Leveraging external data information to supplement randomized clinical trials has been a popular topic in recent years, especially for medical device and drug discovery. In rare diseases, it is very challenging to recruit patients and run …
View article: A Matched Design for Causal Inference With Survey Data: Evaluation of Medical Marijuana Legalization in Kentucky and Tennessee
A Matched Design for Causal Inference With Survey Data: Evaluation of Medical Marijuana Legalization in Kentucky and Tennessee Open
A concern surrounding marijuana legalization is that driving after marijuana use may become more prevalent. Survey data are valuable for estimating policy effects, however their observational nature and unequal sampling probabilities creat…
Causal Inference with Complex Surveys: A Unified Perspective on Sample Selection and Exposure Selection Open
Probability surveys are a major source of population representative data for policy research and program evaluation. However, the data come with the added complications of being observational and selected with unequal probabilities. Propen…
Impact of COVID-19 pandemic on traumatic brain injury emergency department visits, interfacility transfer and mortality in the United States, 2016–2020: a cross-sectional study Open
Objective The aim of this study was to determine how the COVID-19 pandemic affected patient demographics, injury mechanisms, interhospital transfers and mortality of patients with traumatic brain injuries (TBIs) treated in US emergency dep…
View article: Nicotine information disclosed online by e-cigarette brands popular with young people
Nicotine information disclosed online by e-cigarette brands popular with young people Open
Overall, these results suggest that the e-cigarette industry is not fully informing its consumers about the nicotine in their products. Given that nicotine form and type have implications for e-cigarette addiction potential, these findings…
View article: Demographic and Behavioral Differences Between Adolescents and Young Adults Who Use E-Cigarettes at Low and High Frequency
Demographic and Behavioral Differences Between Adolescents and Young Adults Who Use E-Cigarettes at Low and High Frequency Open
Background: Among adolescents and young adults (AYAs), “current use” of electronic cigarettes (e-cigarettes) is commonly defined as any use in the past 30 days. However, few studies have examined differences among those within this broad c…
The Association Between the License Fee Increase and the Density of Tobacco Retailers in California—A Segmented Interrupted Time-Series Analysis by Income and Race/Ethnicity Open
Introduction On May 9, 2016, the State of California passed a law to increase the licensing fee for tobacco retailers from a one-time-only fee of $100 to an annual fee of $265, effective on June 9, 2016. This study investigates the associa…
View article: Data from ALK Inhibitor PF02341066 (Crizotinib) Increases Sensitivity to Radiation in Non–Small Cell Lung Cancer Expressing EML4-ALK
Data from ALK Inhibitor PF02341066 (Crizotinib) Increases Sensitivity to Radiation in Non–Small Cell Lung Cancer Expressing EML4-ALK Open
Crizotinib (PF02341066) is a tyrosine kinase inhibitor of anaplastic lymphoma kinase (ALK) that has been shown to selectively inhibit growth of cancer cells that harbor the EML4-ALK fusion found in a subset of patients with non–small cell …
View article: Supplmentary Figures 1-3 from ALK Inhibitor PF02341066 (Crizotinib) Increases Sensitivity to Radiation in Non–Small Cell Lung Cancer Expressing EML4-ALK
Supplmentary Figures 1-3 from ALK Inhibitor PF02341066 (Crizotinib) Increases Sensitivity to Radiation in Non–Small Cell Lung Cancer Expressing EML4-ALK Open
PDF File - 501K, PF02341066 is well tolerated in female athymic nude mice.
View article: Data from ALK Inhibitor PF02341066 (Crizotinib) Increases Sensitivity to Radiation in Non–Small Cell Lung Cancer Expressing EML4-ALK
Data from ALK Inhibitor PF02341066 (Crizotinib) Increases Sensitivity to Radiation in Non–Small Cell Lung Cancer Expressing EML4-ALK Open
Crizotinib (PF02341066) is a tyrosine kinase inhibitor of anaplastic lymphoma kinase (ALK) that has been shown to selectively inhibit growth of cancer cells that harbor the EML4-ALK fusion found in a subset of patients with non–small cell …