Sang‐Bing Tsai
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View article: Pre- or post-CAR-T allogeneic hematopoietic cell transplant provides relapse-free survival benefit for R/R Philadelphia negative B-cell acute lymphoblastic leukemia (B-ALL) successfully treated with brexucabtagene autoleucel in the real world
Pre- or post-CAR-T allogeneic hematopoietic cell transplant provides relapse-free survival benefit for R/R Philadelphia negative B-cell acute lymphoblastic leukemia (B-ALL) successfully treated with brexucabtagene autoleucel in the real world Open
Introduction: Brexucabtagene autoleucel (Brexu-cel) is a CD19-targeted chimeric antigen receptor (CAR-)T cell therapy approved for treatment of relapsed/refractory (r/r) B-ALL. Brexu-cel's approval was founded on data from the ZUMA-3 trial…
View article: CAR HEMATOTOX independently predicts outcomes after CD19 CAR-T therapy for acute lymphoblastic leukemia
CAR HEMATOTOX independently predicts outcomes after CD19 CAR-T therapy for acute lymphoblastic leukemia Open
CAR-T treatment for B-cell acute lymphoblastic leukemia (ALL) induces high initial response rates, but most patients relapse. Low disease burden (often defined as < 5% blasts in the bone marrow) is associated with better outcomes. CAR-H…
View article: The Application of AI Customer Service
The Application of AI Customer Service Open
The widespread adoption of AI-powered customer service systems has transformed how users engage with digital platforms. However, understanding how users form satisfaction and trust toward these systems remains a major challenge, especially…
View article: Successful Allogeneic Stem Cell Transplant for Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia After Pneumonectomy for Pulmonary Mucormycosis: A Case Report and Review of the Literature
Successful Allogeneic Stem Cell Transplant for Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia After Pneumonectomy for Pulmonary Mucormycosis: A Case Report and Review of the Literature Open
The incidence of relapsed Philadelphia chromosome‐negative acute lymphoblastic leukemia in adults is estimated to be 40%–50%. Allogeneic stem cell transplantation can improve survival in relapsed acute lymphoblastic leukemia; however, impa…
View article: Design of an Enterprise Public Opinion Monitoring System Based on Natural Language Processing
Design of an Enterprise Public Opinion Monitoring System Based on Natural Language Processing Open
The widespread influence of social media and online discourse has made enterprise public opinion monitoring essential, yet existing sentiment analysis models struggle with sarcasm detection, multimodal sentiment integration, and high-risk …
View article: Outcomes of brexucabtagene autoleucel in patients with relapsed/refractory acute lymphoblastic leukemia with CNS involvement
Outcomes of brexucabtagene autoleucel in patients with relapsed/refractory acute lymphoblastic leukemia with CNS involvement Open
Patients with relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) with central nervous system (CNS) involvement (CNS B-ALL) have poor outcomes and were frequently excluded from CD19-targeting chimeric antigen receptor (CA…
View article: Deep Learning-Based User Information Behavior Mining and Personalized Recommendation Optimization
Deep Learning-Based User Information Behavior Mining and Personalized Recommendation Optimization Open
Personalized recommendation systems have become crucial for enhancing user experience and driving engagement in various online platforms. However, existing methods face challenges in accurately modeling high-order user-item relationships, …
View article: Supply Chain Management in the Digital Economy
Supply Chain Management in the Digital Economy Open
Supply chain management (SCM) is pivotal in orchestrating the flow of goods and services from suppliers to consumers, fundamentally shaping business operations worldwide. However, traditional SCM faces significant limitations, such as inef…
View article: Global Digital Transformation and New Venture Resilience
Global Digital Transformation and New Venture Resilience Open
In the new situation of building an entrepreneurial ecosystem, faced with the global multi-agent competition of the system, how new ventures should integrate with the system, isomorphism, and use their own advantages to cultivate new ventu…
View article: NGS MRD Negativity on Day 28 after Brexu Cel in Adults with R/R ALL Is Associated with Favorable Progression Free Survival
NGS MRD Negativity on Day 28 after Brexu Cel in Adults with R/R ALL Is Associated with Favorable Progression Free Survival Open
Introduction: Brexucabtagene autoleucel (brexu cel) is a CD19-targeted chimeric antigen receptor (CAR) T cell therapy approved for the treatment of adults with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL). Some patients (pt…
View article: Patrol Security Game: Defending Against Adversary with Freedom in Attack Timing, Location, and Duration
Patrol Security Game: Defending Against Adversary with Freedom in Attack Timing, Location, and Duration Open
We explored the Patrol Security Game (PSG), a robotic patrolling problem modeled as an extensive-form Stackelberg game, where the attacker determines the timing, location, and duration of their attack. Our objective is to devise a patrolli…
View article: Improved Clinical Outcomes with Appropriate Meropenem De-escalation in Patients with Febrile Neutropenia
Improved Clinical Outcomes with Appropriate Meropenem De-escalation in Patients with Febrile Neutropenia Open
Introduction: Antibiotic stewardship is a critical aspect of managing cancer patients with febrile neutropenia (FN) to limit the development of drug-resistant organisms and minimize adverse drug effects. Thus, it has been recommended that …
View article: Impact of prior inotuzumab ozogamicin treatment on brexucabtagene autoleucel outcomes in adults with B-cell ALL
Impact of prior inotuzumab ozogamicin treatment on brexucabtagene autoleucel outcomes in adults with B-cell ALL Open
The effect of prior inotuzumab ozogamicin (InO) treatment on brexucabtagene autoleucel (brexu-cel) outcomes remains unclear in adults with acute lymphoblastic leukemia (ALL). We conducted a retrospective multicenter analysis of 189 patient…
View article: Impact of Generative AI on Enterprise Performance in China
Impact of Generative AI on Enterprise Performance in China Open
This study examines the impact of generative artificial intelligence (GAI) on Chinese enterprises. 320 participants completed electronic surveys, revealing a positive relationship between GAI and corporate performance. Managerial relations…
View article: Text Mining-Based Study on Consumer Satisfaction in the Mobile Phone Market
Text Mining-Based Study on Consumer Satisfaction in the Mobile Phone Market Open
In the current context of rapid technological advancement, smartphones have become an indispensable part of people's daily lives. This has led to an increasing focus on the satisfaction of consumers with smartphone products, as understandi…
View article: Clinical Practice Guideline: Age‐Related Hearing Loss
Clinical Practice Guideline: Age‐Related Hearing Loss Open
Objective Age‐related hearing loss (ARHL) is a prevalent but often underdiagnosed and undertreated condition among individuals aged 50 and above. It is associated with various sociodemographic factors and health risks including dementia, d…
View article: Clinical Practice Guideline: Age‐Related Hearing Loss Executive Summary
Clinical Practice Guideline: Age‐Related Hearing Loss Executive Summary Open
Objective Age‐related hearing loss (ARHL) is a prevalent but often underdiagnosed and undertreated condition among individuals aged 50 and above. It is associated with various sociodemographic factors and health risks including dementia, d…
View article: Plain Language Summary: Age‐Related Hearing Loss
Plain Language Summary: Age‐Related Hearing Loss Open
The plain language summary explains age‐related hearing loss to patients, families, and care partners. The summary is for any patient aged 50 years and older, families, and care partners. It is based on the 2024 “Clinical Practice Guidelin…
View article: Forecasting Post-Epidemic Air Passenger Flow Among Hub Cities in China Based on PLS and GA-SVR Model
Forecasting Post-Epidemic Air Passenger Flow Among Hub Cities in China Based on PLS and GA-SVR Model Open
For stakeholders and companies involved in civil aviation to plan and make wise decisions, accurate estimates of air passenger flow are necessary. The conclusions drawn from this model serve as an invaluable resource for pertinent choices.…
View article: Financialization, Heterogeneous EnvironmentalRegulation, and Corporate Green Innovation:Evidence from China
Financialization, Heterogeneous EnvironmentalRegulation, and Corporate Green Innovation:Evidence from China Open
Along with the promotion of China's green development strategy and the policy of financial services to the real economy, how financialization affects corporate green innovation becomes an urgent issue to be explored.Using Chinese A-share l…
View article: How Manufacturing Companies Can Improve Their Competitiveness
How Manufacturing Companies Can Improve Their Competitiveness Open
As the global market continues to evolve and competition escalates, the business environment becomes increasingly competitive. How manufacturing companies improve their competitiveness has always been a topic of great concern. Service tran…
View article: Busulfan, melphalan and carfilzomib high‐dose chemotherapy and autologous haematopoietic stem cell transplantation in multiple myeloma
Busulfan, melphalan and carfilzomib high‐dose chemotherapy and autologous haematopoietic stem cell transplantation in multiple myeloma Open
Summary The standard of care for fit, newly diagnosed multiple myeloma patients includes induction therapy followed by consolidative high‐dose chemotherapy with melphalan and autologous stem cell transplant (AHSCT). Intensified preparative…
View article: The Impact of Social Determinants of Health on Brexucabtagene Autoleucel Outcomes in Adults with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia
The Impact of Social Determinants of Health on Brexucabtagene Autoleucel Outcomes in Adults with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia Open
Background Brexucabtagene autoleucel (brexu-cel) is an autologous anti-CD19 chimeric antigen receptor (CAR-T) cell therapy that recently received U.S. FDA approval as the first CAR-T cell therapy for adults with relapsed/refractory (r/r) B…