Bing Zhai
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View article: Dual-modal photoacoustic and ultrasound imaging for early diagnosis of ovarian torsion and evaluation of long-term tissue hypoxia
Dual-modal photoacoustic and ultrasound imaging for early diagnosis of ovarian torsion and evaluation of long-term tissue hypoxia Open
Ovarian torsion (OT), a critical gynecological emergency caused by ovarian twisting and vascular compromise, risks necrosis without prompt intervention. This study evaluated dual-modal photoacoustic/ultrasound imaging for early detection a…
View article: First Report of Colletotrichum kahawae Causing Anthracnose on Buckwheat (Fagopyrum tataricum) in China and Biological Characterization of the Pathogen
First Report of Colletotrichum kahawae Causing Anthracnose on Buckwheat (Fagopyrum tataricum) in China and Biological Characterization of the Pathogen Open
Buckwheat (Fagopyrum tataricum) is native to Yunnan, China, and as a miscellaneous grain crop with high nutritional value, it has received increased attention from farmers and enterprises in recent years. In June 2024, we observed severe a…
View article: Small pangenome of <i>Candida parapsilosis</i> reflects overall low intraspecific diversity
Small pangenome of <i>Candida parapsilosis</i> reflects overall low intraspecific diversity Open
Candida parapsilosis is an opportunistic yeast pathogen that can cause life-threatening infections in immunocompromised humans. Whole-genome sequencing studies of the species have demonstrated remarkably low diversity, with strains typical…
View article: Small pangenome of <i>Candida parapsilosis</i> reflects overall low intraspecific diversity
Small pangenome of <i>Candida parapsilosis</i> reflects overall low intraspecific diversity Open
Candida parapsilosis is an opportunistic yeast pathogen that can cause life-threatening infections in immunocompromised humans. Whole genome sequencing (WGS) studies of the species have demonstrated remarkably low diversity, with strains t…
View article: Mechanism and Efficacy of Etanercept in Treating Autoimmune-like Manifestations of Coronavirus Disease 2019 in elderly individuals
Mechanism and Efficacy of Etanercept in Treating Autoimmune-like Manifestations of Coronavirus Disease 2019 in elderly individuals Open
During the COVID-19 pandemic, extensive research focused on universal treatments, but few studies addressed treatment regimens for elderly patients. This study aimed to evaluate the effects of etanercept, a TNF inhibitor, in elderly indivi…
View article: Identification of Epinastine as CD96/PVR inhibitor for cancer immunotherapy
Identification of Epinastine as CD96/PVR inhibitor for cancer immunotherapy Open
View article: Antifungal heteroresistance causes prophylaxis failure and facilitates breakthrough Candida parapsilosis infections
Antifungal heteroresistance causes prophylaxis failure and facilitates breakthrough Candida parapsilosis infections Open
Breakthrough fungal infections in patients on antimicrobial prophylaxis during allogeneic hematopoietic cell transplantation (allo-HCT) represent a major and often unexplained cause of morbidity and mortality. Candida parapsilosis is a com…
View article: Oral bacteria relative abundance in faeces increases due to gut microbiota depletion and is linked with patient outcomes
Oral bacteria relative abundance in faeces increases due to gut microbiota depletion and is linked with patient outcomes Open
View article: The mycobiome: interactions with host and implications in diseases
The mycobiome: interactions with host and implications in diseases Open
Over the past decade, our understanding of the composition and function of the human mucosal surface-associated fungal community (i.e. the mycobiome) has rapidly expanded. Fungi colonize at various sites of the mucosal surface at birth and…
View article: Worldwide emergence of fluconazole-resistant Candida parapsilosis: current framework and future research roadmap
Worldwide emergence of fluconazole-resistant Candida parapsilosis: current framework and future research roadmap Open
View article: Relative enrichment of oral bacteria in feces indicates loss of intestinal commensals with implications for host health
Relative enrichment of oral bacteria in feces indicates loss of intestinal commensals with implications for host health Open
High relative abundance of oral bacteria in the gut is considered abnormal and has been linked to intestinal disorders. However, this reported association has two alternate explanations: ectopic oral bacteria may increase in absolute numbe…
View article: A High Fraction of Oral Bacteria in the Feces Indicates Gut Microbiota Depletion with Implications for Human Health
A High Fraction of Oral Bacteria in the Feces Indicates Gut Microbiota Depletion with Implications for Human Health Open
The increased relative abundance of oral bacteria detected in fecal samples has been associated with intestinal diseases and digestive disorders. This observation raises two competing hypotheses: either oral bacteria invade the gut bacteri…
View article: Profiling the Fungal Microbiome after Fecal Microbiota Transplantation for Graft-versus-Host Disease: Insights from a Phase 1 Interventional Study
Profiling the Fungal Microbiome after Fecal Microbiota Transplantation for Graft-versus-Host Disease: Insights from a Phase 1 Interventional Study Open
View article: Systematic Analysis of Copy Number Variations in the Pathogenic Yeast Candida parapsilosis Identifies a Gene Amplification in <i>RTA3</i> That is Associated with Drug Resistance
Systematic Analysis of Copy Number Variations in the Pathogenic Yeast Candida parapsilosis Identifies a Gene Amplification in <i>RTA3</i> That is Associated with Drug Resistance Open
Copy number variations (CNVs) are an important source of genomic diversity that have been associated with drug resistance. We identify two unusual CNVs in the human fungal pathogen Candida parapsilosis .
View article: The dominoes fall after long-term antibiotic exposure
The dominoes fall after long-term antibiotic exposure Open
View article: Echinocandin heteroresistance causes prophylaxis failure and facilitates breakthrough<i>Candida parapsilosis</i>infection
Echinocandin heteroresistance causes prophylaxis failure and facilitates breakthrough<i>Candida parapsilosis</i>infection Open
Breakthrough infections of patients on antimicrobial prophylaxis represent a significant and often unexplained cause of morbidity. Here, we reveal that in high-risk patients on micafungin prophylaxis heteroresistance – the presence of a ph…
View article: Oral Bacteria in Feces Reflect Loss of Intestinal Bacteria
Oral Bacteria in Feces Reflect Loss of Intestinal Bacteria Open
View article: Resistance to miltefosine results from amplification of the <i>RTA3</i> floppase or inactivation of flippases in <i>Candida parapsilosis</i>
Resistance to miltefosine results from amplification of the <i>RTA3</i> floppase or inactivation of flippases in <i>Candida parapsilosis</i> Open
Flippases and floppases are two classes of proteins that have opposing functions in the maintenance of lipid asymmetry of the plasma membrane. Flippases translocate lipids from the exoplasmic leaflet to the cytosolic leaflet, and floppases…
View article: Customization of a DADA2-based pipeline for fungal internal transcribed spacer 1 (ITS1) amplicon data sets
Customization of a DADA2-based pipeline for fungal internal transcribed spacer 1 (ITS1) amplicon data sets Open
Identification and analysis of fungal communities commonly rely on internal transcribed spacer-based (ITS-based) amplicon sequencing. There is no gold standard used to infer and classify fungal constituents since methodologies have been ad…
View article: Haematopoietic cell transplantation outcomes are linked to intestinal mycobiota dynamics and an expansion of Candida parapsilosis complex species
Haematopoietic cell transplantation outcomes are linked to intestinal mycobiota dynamics and an expansion of Candida parapsilosis complex species Open
View article: Identification of a novel <i>Candida metapsilosis</i> isolate reveals multiple hybridization events
Identification of a novel <i>Candida metapsilosis</i> isolate reveals multiple hybridization events Open
Candida metapsilosis is a member of the Candida parapsilosis species complex, a group of opportunistic human pathogens. Of all the members of this complex, C. metapsilosis is the least virulent, and accounts for a small proportion of invas…
View article: Intestinal fungal dynamics and linkage to hematopoietic cell transplantation outcomes
Intestinal fungal dynamics and linkage to hematopoietic cell transplantation outcomes Open
Allogeneic hematopoietic cell transplantation (allo-HCT) induces profound shifts in the intestinal bacterial microbiota. The dynamics of intestinal fungi and their impact on clinical outcomes have not yet been integrated into a model of mi…
View article: Customization of a <i>dada2</i>-based pipeline for fungal Internal Transcribed Spacer 1 (ITS 1) amplicon datasets
Customization of a <i>dada2</i>-based pipeline for fungal Internal Transcribed Spacer 1 (ITS 1) amplicon datasets Open
Identification and analysis of fungal communities commonly rely on internal transcribed spacer (ITS)-based amplicon sequencing. Currently, there is no gold standard to infer and classify fungal constituents, in part since methodologies hav…
View article: Identification of a novel <i>Candida metapsilosis</i> isolate suggests ongoing hybridization.
Identification of a novel <i>Candida metapsilosis</i> isolate suggests ongoing hybridization. Open
Candida metapsilosis is a member of the C. parapsilosis species complex, a group of opportunistic human pathogens. Of all the members of this complex, C. metapsilosis is the least virulent, and accounts for a small proportion of invasive C…
View article: <i>Candida albicans</i> Isolates 529L and CHN1 Exhibit Stable Colonization of the Murine Gastrointestinal Tract
<i>Candida albicans</i> Isolates 529L and CHN1 Exhibit Stable Colonization of the Murine Gastrointestinal Tract Open
Candida albicans is a pathobiont that colonizes multiple niches in the body including the gastrointestinal (GI) tract, but is also responsible for both mucosal and systemic infections. Despite its prevalence as a human commensal, the murin…
View article: Gm40600 promotes CD4<sup>+</sup> T‐cell responses by interacting with Ahnak
Gm40600 promotes CD4<sup>+</sup> T‐cell responses by interacting with Ahnak Open
It is important to characterize novel proteins involved in T‐ and B‐cell responses. Our previous study demonstrated that a novel protein, Mus musculus Gm40600, reduced the proliferation of Mus musculus plasmablast (PB)‐like SP 2/0 cells an…
View article: Exploring Candida auris in its habitat
Exploring Candida auris in its habitat Open
View article: Adjuvant-free peptide vaccine targeting Clec9a on dendritic cells can induce robust antitumor immune response through Syk/IL-21 axis
Adjuvant-free peptide vaccine targeting Clec9a on dendritic cells can induce robust antitumor immune response through Syk/IL-21 axis Open
Dendritic cells (DCs) can process the antigens of cancer vaccine and thus stimulate the CD8+ T cells to recognize and kill the tumor cells that express these antigens. However, lack of promising carriers for presenting the antig…
View article: Mycobiota dysbiosis and gastric tumorigenesis
Mycobiota dysbiosis and gastric tumorigenesis Open
The gastrointestinal tract contains a vast and diverse microbial reservoir composed of bacteria, fungi, and viruses that contribute positively to human health. There is growing evidence that perturbation of the normal microbiota can promot…
View article: CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System
CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System Open
Candida is the most common human fungal pathogen and causes systemic infections that require neutrophils for effective host defense. Humans deficient in the C-type lectin pathway adaptor protein CARD9 develop spontaneous fungal disease tha…