Bingbing Yuan
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View article: High‐throughput CRISPR screen of GWAS risk loci in human microglia reveals novel risk genes for Alzheimer's disease and multiple sclerosis
High‐throughput CRISPR screen of GWAS risk loci in human microglia reveals novel risk genes for Alzheimer's disease and multiple sclerosis Open
Background Alzheimer's (AD) and other neurological diseases (NDs) cause substantial health‐related and economic burdens, but progress toward preventative or ameliorative treatments has been limited. Genome‐wide association studies (GWAS) h…
View article: Inflammation awakens dormant cancer cells by modulating the epithelial–mesenchymal phenotypic state
Inflammation awakens dormant cancer cells by modulating the epithelial–mesenchymal phenotypic state Open
The awakening of dormant disseminated cancer cells appears to be responsible for the clinical relapses of patients whose primary tumors have been successfully cured months and even years earlier. In the present study, we demonstrate that d…
View article: Functional genomic dissection of MS risk loci reveals convergence of cis and trans gene regulatory mechanisms in microglia
Functional genomic dissection of MS risk loci reveals convergence of cis and trans gene regulatory mechanisms in microglia Open
Summary Neurological diseases (NDs) are a major source of unmet medical need, and translational insights have been hampered by complex underlying pathophysiologies and limitations of experimental models. Noncoding single nucleotide polymor…
View article: Epigenomics and single cell CRISPR screening to investigate the risk‐modifying role of microglia in Alzheimer’s disease and multiple sclerosis
Epigenomics and single cell CRISPR screening to investigate the risk‐modifying role of microglia in Alzheimer’s disease and multiple sclerosis Open
Background Alzheimer’s disease (AD) and other neurodegenerative diseases (NDs) cause substantial health‐related and economic burdens, but progress towards preventative or ameliorative treatments has been limited. Genome‐wide association st…
View article: The A53T Mutation in α-Synuclein Enhances Proinflammatory Activation in Human Microglia Upon Inflammatory Stimulus
The A53T Mutation in α-Synuclein Enhances Proinflammatory Activation in Human Microglia Upon Inflammatory Stimulus Open
Our results indicate that A53T mutant human microglia display cell autonomous phenotypes that may worsen neuronal damage in early-onset PD.
View article: Chronic activation of a negative engram induces behavioral and cellular abnormalities
Chronic activation of a negative engram induces behavioral and cellular abnormalities Open
Negative memories engage a brain and body-wide stress response in humans that can alter cognition and behavior. Prolonged stress responses induce maladaptive cellular, circuit, and systems-level changes that can lead to pathological brain …
View article: Author response: Chronic activation of a negative engram induces behavioral and cellular abnormalities
Author response: Chronic activation of a negative engram induces behavioral and cellular abnormalities Open
Negative memories engage a brain and body-wide stress response in humans that can alter cognition and behavior. Prolonged stress responses induce maladaptive cellular, circuit, and systems-level changes that can lead to pathological brain …
View article: Chronic activation of a negative engram induces behavioral and cellular abnormalities
Chronic activation of a negative engram induces behavioral and cellular abnormalities Open
Negative memories engage a brain and body-wide stress response in humans that can alter cognition and behavior. Prolonged stress responses induce maladaptive cellular, circuit, and systems-level changes that can lead to pathological brain …
View article: Reviewer #2 (Public Review): Chronic activation of a negative engram induces behavioral and cellular abnormalities
Reviewer #2 (Public Review): Chronic activation of a negative engram induces behavioral and cellular abnormalities Open
Negative memories engage a brain and body-wide stress response in humans that can alter cognition and behavior. Prolonged stress responses induce maladaptive cellular, circuit, and systems-level changes that can lead to pathological brain …
View article: Reviewer #1 (Public Review): Chronic activation of a negative engram induces behavioral and cellular abnormalities
Reviewer #1 (Public Review): Chronic activation of a negative engram induces behavioral and cellular abnormalities Open
Negative memories engage a brain and body-wide stress response in humans that can alter cognition and behavior. Prolonged stress responses induce maladaptive cellular, circuit, and systems-level changes that can lead to pathological brain …
View article: Chronic activation of a negative engram induces behavioral and cellular abnormalities
Chronic activation of a negative engram induces behavioral and cellular abnormalities Open
Negative memories engage a brain and body-wide stress response in humans that can alter cognition and behavior. Prolonged stress responses induce maladaptive cellular, circuit, and systems-level changes that can lead to pathological brain …
View article: Reviewer #3 (Public Review): Chronic activation of a negative engram induces behavioral and cellular abnormalities
Reviewer #3 (Public Review): Chronic activation of a negative engram induces behavioral and cellular abnormalities Open
Negative memories engage a brain and body-wide stress response in humans that can alter cognition and behavior. Prolonged stress responses induce maladaptive cellular, circuit, and systems-level changes that can lead to pathological brain …
View article: Chronic activation of a negative engram induces behavioral and cellular abnormalities
Chronic activation of a negative engram induces behavioral and cellular abnormalities Open
Negative memories engage a brain and body-wide stress response in humans that can alter cognition and behavior. Prolonged stress responses induce maladaptive cellular, circuit, and systems-level changes that can lead to pathological brain …
View article: Chronic activation of a negative engram induces behavioral and cellular abnormalities
Chronic activation of a negative engram induces behavioral and cellular abnormalities Open
Negative memories engage a brain and body-wide stress response in humans that can alter cognition and behavior. Prolonged stress responses induce maladaptive cellular, circuit, and systems-level changes that can lead to pathological brain …
View article: The A53T mutation in α-synuclein enhances pro-inflammatory activation in human microglia
The A53T mutation in α-synuclein enhances pro-inflammatory activation in human microglia Open
Parkinson’s disease (PD) is characterized by the aggregation of α-synuclein into Lewy bodies and Lewy neurites in the brain. Microglia-driven neuroinflammation may contribute to neuronal death in PD, however the exact role of microglia rem…
View article: Fragile X syndrome patient-derived neurons developing in the mouse brain show <i>FMR1</i> -dependent phenotypes
Fragile X syndrome patient-derived neurons developing in the mouse brain show <i>FMR1</i> -dependent phenotypes Open
Abnormal neuronal development in Fragile X syndrome (FXS) is poorly understood. Data on FXS patients remain scarce and FXS animal models have failed to yield successful therapies. In vitro models do not fully recapitulate the morphology an…
View article: Hippocampal cells multiplex positive and negative engrams
Hippocampal cells multiplex positive and negative engrams Open
The hippocampus is involved in processing a variety of mnemonic computations specifically the spatiotemporal components and emotional dimensions of contextual memory. 1–3 Recent studies have demonstrated vast structural and functional hete…
View article: Human-mouse chimeric Fragile X syndrome model reveals FMR1-dependent neuronal phenotypes
Human-mouse chimeric Fragile X syndrome model reveals FMR1-dependent neuronal phenotypes Open
Abnormal neuronal development in Fragile X syndrome (FXS) is poorly understood. Data on FXS patients remain scarce and FXS animal models have failed to yield successful therapies. In vitro models do not fully recapitulate the morphology an…
View article: Phosphocholine accumulation and PHOSPHO1 depletion promote adipose tissue thermogenesis
Phosphocholine accumulation and PHOSPHO1 depletion promote adipose tissue thermogenesis Open
Phosphocholine phosphatase-1 (PHOSPHO1) is a phosphocholine phosphatase that catalyzes the hydrolysis of phosphocholine (PC) to choline. Here we demonstrate that the PHOSPHO1 transcript is highly enriched in mature brown adipose tissue (BA…
View article: Efficient derivation of microglia-like cells from human pluripotent stem cells
Efficient derivation of microglia-like cells from human pluripotent stem cells Open
Microglia, the only lifelong resident immune cells of the central nervous system (CNS), are highly specialized macrophages that have been recognized to have a crucial role in neurodegenerative diseases such as Alzheimer's, Parkinson's and …
View article: MERAV: a tool for comparing gene expression across human tissues and cell types
MERAV: a tool for comparing gene expression across human tissues and cell types Open
The oncogenic transformation of normal cells into malignant, rapidly proliferating cells requires major alterations in cell physiology. For example, the transformed cells remodel their metabolic processes to supply the additional demand fo…