Explanipedia

The Landscape of Noncoding RNAs in Cardiovascular Aging and Diseases Open

Hua Zhu, Bingchuan Geng, Deqiang Li, Ruili Xie, Timothy Powlik , et al. · 2025

Macrophage regulated cell death: implications and mechanisms in organ transplantation Open

Jun Hou, Chenghao Li, Li Geng, Wai Yen Yim, Bingchuan Geng , et al. · 2025

Organ transplantation is a critical treatment for end-stage organ failure, but long-term graft survival remains suboptimal due to ischemia-reperfusion injury (IRI) and transplant rejection. The immune microenvironment, especially macrophag…

Navigating the Landscape of Translational Medicine of Calcific Aortic Valve Disease Open

Xingyu Qian, Li Xu, Bingchuan Geng, Fei Li, Nianguo Dong · 2025

Circadian immune system in solid organ transplantation: a review article Open

Wai Yen Yim, Chenghao Li, Fuqiang Tong, Jun Hou, Yuqi Chen , et al. · 2025

The innate and adaptive immune systems are intricately regulated by the circadian clock machinery. Recent clinical investigations have shed light on the influence of timing in organ procurement and transplantation on graft survival. In thi…

Neutrophil pyroptosis regulates corneal wound healing and post‐injury neovascularisation Open

Peng Chen, Zhentao Zhang, L. Sakai, Y. Xu, Shanzhi Wang , et al. · 2024

Rationale The cornea is a unique structure that maintains its clarity by remaining avascular. Corneal injuries can lead to neovascularisation (CNV) and fibrosis and are the third most common cause of blindness worldwide. Objective Corneal …

FOXO1 regulates RUNX2 ubiquitination through SMURF2 in calcific aortic valve disease Open

Chen Jiang, Dingyi Yao, Zongtao Liu, Yidan Zheng, Ming Chen , et al. · 2024

Prime Editing in vivo: Correcting the Leptin Receptor of db/db Mice Open

Kyung Lee, Yanping Xu, Bingchuan Geng, Jong Soo Kim, Natalie Kellon , et al. · 2024

Genetic diseases can be caused by monogenic diseases, which result from a single gene mutation in the DNA sequence. Many innovative approaches have been developed to cure monogenic genetic diseases, namely by genome editing. A specific typ…

Prime editing‐mediated correction of the leptin receptor in muscle cells of db/db mice Open

Kyung Eun Lee, Yanping Xu, Bingchuan Geng, Jong Soo Kim, Natalie Kellon , et al. · 2024

Genetic diseases can be caused by monogenic diseases, which result from a single gene mutation in the DNA sequence. Many innovative approaches have been developed to cure monogenic genetic diseases, namely by genome editing. A specific typ…

Is Time Scheduling Important? An Analysis of Donor Heart Cross-clamp Times During Heart Transplantation Open

Doug A. Gouchoe, Asvin M. Ganapathi, Ervin Y. Cui, Matthew C. Henn, Wai Yen Yim , et al. · 2024

Background. Outcomes in heart transplantation are affected by a variety of variables and patient factors. However, the impact of circadian rhythms, gene expression, and transcription remain underexplored. We thus evaluated the potential ro…

Platelet membrane-coated alterbrassicene A nanoparticle inhibits calcification of the aortic valve by suppressing phosphorylation P65 NF-κB Open

Bingchuan Geng, Xing Chen, Jiangyang Chi, Fengli Li, Wai Yen Yim , et al. · 2023

Rationale: Calcific aortic valve disease (CAVD) is a leading cause of cardiovascular mortality and morbidity with increasing prevalence and incidence. The pathobiology of CAVD involves valvular fibrocalcification, and osteogenic and…

Neutrophil Pyroptosis Regulates Corneal Wound Healing and Post-Injury Neovascularization Open

Peng Chen, Shanzhi Wang, Kyung Eun Lee, Bingchuan Geng, Jong-Soo Kim , et al. · 2023

Platelet Membrane-Coated Alterbrassicene a Nanoparticle Inhibits Calcification of the Aortic Valve by Suppressing Phosphorylation P65 NF-κB Open

Bingchuan Geng, Xing Chen, Jiangyang Chi, Fengli Li, Wai Yen Yim , et al. · 2023

MG53 Inhibits Necroptosis Through Ubiquitination-Dependent RIPK1 Degradation for Cardiac Protection Following Ischemia/Reperfusion Injury Open

Qiang Wang, Ki Ho Park, Bingchuan Geng, Peng Chen, Chunlin Yang , et al. · 2022

Rationale While reactive oxygen species (ROS) has been recognized as one of the main causes of cardiac injury following myocardial infarction, the clinical application of antioxidants has shown limited effects on protecting hearts against …

Ubiquitin Carboxyl-Terminal Hydrolase L1 of Cardiomyocytes Promotes Macroautophagy and Proteostasis and Protects Against Post-myocardial Infarction Cardiac Remodeling and Heart Failure Open

Penglong Wu, Yifan Li, Mingqi Cai, Bo Ye, Bingchuan Geng , et al. · 2022

Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a deubiquitinase known to play essential roles in the nervous tissue. Myocardial upregulation of UCHL1 was observed in human dilated cardiomyopathy and several animal models of heart dise…

UCHL1 protects against ischemic heart injury via activating HIF-1α signal pathway Open

Bingchuan Geng, Xiaoliang Wang, Ki Ho Park, Kyung Eun Lee, Jong-Soo Kim , et al. · 2022

Ubiquitin carboxyl-terminal esterase L1 (UCHL1) has been thought to be a neuron specific protein and shown to play critical roles in Parkinson's Disease and stroke via de-ubiquiting and stabilizing key pathological proteins, such as α-synu…

Global, Regional and National Incidence, Mortality, and Disability-Adjusted Life-Years of Non-Rheumatic Valvular Heart Disease and Trend Analysis from 1990 to 2019: Results from the Global Burden of Disease Study 2019 Open

Kan Wang, Bingchuan Geng, Chen Jiang, Qiannan Guo, Hongwen Lan , et al. · 2022

Serp-1 Promotes Corneal Wound Healing by Facilitating Re-epithelialization and Inhibiting Fibrosis and Angiogenesis Open

Brent Ju, Oscar Guo, Dathe Benissan‐Messan, McKinley H. Shawver, Peng Chen , et al. · 2021

Purpose: Chemical corneal injuries carry a high morbidity and commonly lead to visual impairment. Here, we investigate the role of Serp-1, a serine protease inhibitor, in corneal wound healing. Methods: An alkaline-induced corneal injury w…

Recombinant Human MG53 Protein Protects Against Alkaline-Induced Corneal Injuries in Mice Open

Oscar Guo, Brent Ju, McKinley H. Shawver, Bingchuan Geng, Siqi Wei , et al. · 2021

Introduction The current study was designed to test the potential role of recombinant human MG53 (rhMG53) protein on protecting against alkaline-induced corneal injury in mice. Materials and Methods A round filter paper with 2-mm diameter …

Cavin3 Suppresses Breast Cancer Metastasis via Inhibiting AKT Pathway Open

Xin An, Xi Lin, Anli Yang, Qiwei Jiang, Bingchuan Geng , et al. · 2020

Cavin3 expression is significantly lower in BC and is correlated with distant metastasis and worse survival. Cavin3 functions as a metastasis suppressor via inhibiting the AKT pathway, suggesting cavin3 as a potential prognostic bio…

A simple, quick, and efficient CRISPR/Cas9 genome editing method for human induced pluripotent stem cells Open

Bingchuan Geng, Kyoung-Han Choi, Shanzhi Wang, Peng Chen, Xiudi Pan , et al. · 2020

Diabetes inhibits corneal epithelial cell migration and tight junction formation in mice and human via increasing ROS and impairing Akt signaling Open

Qiwei Jiang, Denis Kaili, Jonaye Freeman, Chong-yang Lei, Bingchuan Geng , et al. · 2019

MG53 promotes corneal wound healing and mitigates fibrotic remodeling in rodents Open

Heather L. Chandler, Tao Tan, Chunlin Yang, Anne J. Gemensky‐Metzler, Rita F. Wehrman , et al. · 2019

Limited prognostic value of myocardial viability assessment in patients with coronary artery diseases and severe left ventricular dysfunction Open

Yihua Liu, Yefan Jiang, Xiaoxi Yang, Bingchuan Geng, Yi Liu , et al. · 2018

Myocardial viability assessment using ¹⁸FDG-PET is of limited prognostic value in patients with CAD and severe LV dysfunction. In patients with substantial myocardial scar burden despite the existence of considerable hibernating…

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