Boying Xiao
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View article: Exploring a mutation-based signature to predict the benefits of immune checkpoint inhibitors in oncogene-addicted subsets of non-small cell lung cancer: a retrospective study
Exploring a mutation-based signature to predict the benefits of immune checkpoint inhibitors in oncogene-addicted subsets of non-small cell lung cancer: a retrospective study Open
The mutation-based signature established herein represents a robust biomarker for identifying patients with advanced NSCLCs who are most likely to benefit from ICB therapy, including those with targetable oncogene alterations.
View article: Acupuncture Therapy for Sciatica: An Overview of Systematic Reviews and Meta-Analysis
Acupuncture Therapy for Sciatica: An Overview of Systematic Reviews and Meta-Analysis Open
Although current evidence is limited by methodological flaws, publication bias, and poor reporting quality, acupuncture shows promising clinical potential for sciatica. High-quality, rigorously designed studies are needed to confirm its ef…
View article: Therapeutic efficacy and mechanisms of Xuebijing in Acinetobacter baumannii infection based on meta-analysis and integrated pharmacology approaches
Therapeutic efficacy and mechanisms of Xuebijing in Acinetobacter baumannii infection based on meta-analysis and integrated pharmacology approaches Open
Background Xuebijing (XBJ) is a traditional Chinese medicine widely used in China for managing sepsis, systemic inflammatory response syndrome, and multiple organ dysfunction secondary to severe infections. This study aimed to assess the t…
View article: Clinical efficacy and mechanistic insights of Xuebijing in hand, foot, and mouth disease: a meta-analysis with integrated pharmacological approaches
Clinical efficacy and mechanistic insights of Xuebijing in hand, foot, and mouth disease: a meta-analysis with integrated pharmacological approaches Open
Background: Hand, foot, and mouth disease (HFMD) is a viral infection, primarily caused by gastrointestinal viruses. Xuebijing (XBJ) injection, widely used in China for treating inflammatory conditions like sepsis, may offer therapeutic be…
View article: Deep learning–based assessment of missense variants in the <i>COG4</i> gene presented with bilateral congenital cataract
Deep learning–based assessment of missense variants in the <i>COG4</i> gene presented with bilateral congenital cataract Open
Objective We compared the protein structure and pathogenicity of clinically relevant variants of the COG4 gene with AlphaFold2 (AF2), Alpha Missense (AM), and ThermoMPNN for the first time. Methods and analysis The sequences of clinically …
View article: WCN23-0598 EFFECT OF TRADITIONAL CHINESE HEALTH EXERCISE ON SLEEP QUALITY IN PATIENTS WITH END-STAGE RENAL DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS
WCN23-0598 EFFECT OF TRADITIONAL CHINESE HEALTH EXERCISE ON SLEEP QUALITY IN PATIENTS WITH END-STAGE RENAL DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS Open
Due to the disease itself and the dialysis procedure, patients with end-stage renal disease (ESRD) are more likely to experience sleep disorders and other psychological pathologies than the general population. Except decreasing the quality…
View article: P1465: INITIAL SAFETY AND EFFICACY STUDY OF RM-001, AUTOLOGOUS HBG1/2 PROMOTER-MODIFIED CD34+ HEMATOPOIETIC STEM AND PROGENITOR CELLS, IN TRANSFUSION-DEPENDENT ΒETA-THALASSEMIA
P1465: INITIAL SAFETY AND EFFICACY STUDY OF RM-001, AUTOLOGOUS HBG1/2 PROMOTER-MODIFIED CD34+ HEMATOPOIETIC STEM AND PROGENITOR CELLS, IN TRANSFUSION-DEPENDENT ΒETA-THALASSEMIA Open
Background: Natural mutations that cause hereditary persistence of fetal hemoglobin (HPFH) alleviate the symptoms of β-thalassemia. It is now known that small natural deletions and mutations in the γ- globin gene (HBG1/HBG2) promoters disr…
View article: Systematic appraisal of guidelines for the diagnosis of pancreatic cancer
Systematic appraisal of guidelines for the diagnosis of pancreatic cancer Open
This review aimed at assessing current guidelines' methodological quality systematically for pancreatic cancer's diagnosis and to reveal the heterogeneity of the recommendations among the evaluated guidelines. A systematic search was condu…