Binghui Zeng
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View article: A Spatially Resolved Atlas of Alternative Polyadenylation Across 18 Human Tissues and 76 Disease States
A Spatially Resolved Atlas of Alternative Polyadenylation Across 18 Human Tissues and 76 Disease States Open
Alternative polyadenylation (APA) is a key regulator of gene expression and cellular dynamics, yet systematic investigations of spatially resolved APA across diverse human tissues remain limited. Here, we developed SpatialAPA ( https://git…
View article: Molecular Biological Comparison of Pulp Stem Cells from Supernumerary Teeth, Permanent Teeth, and Deciduous Teeth for Endodontic Regeneration
Molecular Biological Comparison of Pulp Stem Cells from Supernumerary Teeth, Permanent Teeth, and Deciduous Teeth for Endodontic Regeneration Open
Supernumerary tooth-derived pulp stem cells (SNTSCs) hold promise for endodontic regeneration, yet little is known about the similarities and diversities of SNTSCs relative to other dental-derived mesenchymal stem cells. Herein, we compare…
View article: Seroprevalence of Getah virus in pigs in Southeast China determined with a recombinant Cap protein-based indirect ELISA
Seroprevalence of Getah virus in pigs in Southeast China determined with a recombinant Cap protein-based indirect ELISA Open
Getah virus (GETV) is a mosquito-borne virus with a broad host range, including mosquitoes and various animals such as pigs, horses, goats, cattle, boars, and blue foxes. In pigs, GETV can cause fever, abortion and reproductive disorders i…
View article: Development of a space-compatible packaging system for an integrated monolithic ultra-stable optical reference
Development of a space-compatible packaging system for an integrated monolithic ultra-stable optical reference Open
We report the development of a space-compatible packaging system for an integrated monolithic ultra-stable optical reference toward China’s next-generation geodesy mission with low orbit satellite-to-satellite tracking. Building on our pre…
View article: Black phosphorus quantum dot-modified ADSCs as a novel therapeutic for periodontitis bone loss coupling of osteogenesis and osteoimmunomodulation
Black phosphorus quantum dot-modified ADSCs as a novel therapeutic for periodontitis bone loss coupling of osteogenesis and osteoimmunomodulation Open
Alveolar bone defect repair remains a persistent clinical challenge for periodontitis treatment. The use of peripheral functional seed cells is a hot topic in periodontitis. Herein, we explored the cellular behaviors and osteogenic ability…
View article: Black phosphorus quantum dots pretreated ADSCs promotes bone regeneration coupling of osteogenesis and osteoimmunomodulation
Black phosphorus quantum dots pretreated ADSCs promotes bone regeneration coupling of osteogenesis and osteoimmunomodulation Open
Adipose-derived mesenchymal stem cells (ADSCs) are ideal candidates for regenerative therapy to promote the critical bone defects repair due to their good accessibility, multi-potency capacity and paracrine functions. However, the limited …
View article: Enamel Structure Defects in Kdf1 Missense Mutation Knock-in Mice
Enamel Structure Defects in Kdf1 Missense Mutation Knock-in Mice Open
The Keratinocyte differentiation factor 1 (KDF1) is reported to take part in tooth formation in humans, but the dental phenotype of Kdf1 mutant mice has not been understood. Additionally, the role of the KDF1 gene in dental hard tissue dev…
View article: EPHB4 Regulates the Proliferation and Metastasis of Oral Squamous Cell Carcinoma through the HMGB1/NF-κB Signalling Pathway: Erratum
EPHB4 Regulates the Proliferation and Metastasis of Oral Squamous Cell Carcinoma through the HMGB1/NF-κB Signalling Pathway: Erratum Open
[This corrects the article DOI: 10.7150/jca.59331.].
View article: Two Novel Mutations in Ectodysplasin-A Identified in Syndromic Tooth Agenesis
Two Novel Mutations in Ectodysplasin-A Identified in Syndromic Tooth Agenesis Open
Anodontia, EDA, WNT 10A, Whole exome sequencing, Odontogenesis.
View article: Association of miR-155 and MIR155HG polymorphisms with cancer risk
Association of miR-155 and MIR155HG polymorphisms with cancer risk Open
Background: Analysis of emerging data shows that miRNAs, including miR-155, play important roles in tumorigenesis. Several studies have indicated that miR-155 and MIR155HG polymorphisms may be related to cancer risk, but the association wa…
View article: COVID19db: a comprehensive database platform to discover potential drugs and targets of COVID-19 at whole transcriptomic scale
COVID19db: a comprehensive database platform to discover potential drugs and targets of COVID-19 at whole transcriptomic scale Open
Many open access transcriptomic data of coronavirus disease 2019 (COVID-19) were generated, they have great heterogeneity and are difficult to analyze. To utilize these invaluable data for better understanding of COVID-19, additional softw…
View article: circMine: a comprehensive database to integrate, analyze and visualize human disease–related circRNA transcriptome
circMine: a comprehensive database to integrate, analyze and visualize human disease–related circRNA transcriptome Open
Many circRNA transcriptome data were deposited in public resources, but these data show great heterogeneity. Researchers without bioinformatics skills have difficulty in investigating these invaluable data or their own data. Here, we speci…
View article: Effect of magnetic graphene oxide on cellular behaviors and osteogenesis under a moderate static magnetic field
Effect of magnetic graphene oxide on cellular behaviors and osteogenesis under a moderate static magnetic field Open
The biological behaviors of magnetic graphene oxide (MGO) in a static magnetic field (SMF) are unknown. The current study is to investigate the cellular behaviors, osteogenesis and the mechanism in BMSCs treated with MGO combined with an S…
View article: CanImmunother: a manually curated database for identification of cancer immunotherapies associating with biomarkers, targets, and clinical effects
CanImmunother: a manually curated database for identification of cancer immunotherapies associating with biomarkers, targets, and clinical effects Open
As immunotherapy is evolving into an essential armamentarium against cancers, numerous translational studies associated with relevant biomarkers, targets, and clinical effects have been reported in recent years. However, a large amount of …
View article: EPHB4 Regulates the Proliferation and Metastasis of Oral Squamous Cell Carcinoma through the HMGB1/NF-κB Signalling Pathway
EPHB4 Regulates the Proliferation and Metastasis of Oral Squamous Cell Carcinoma through the HMGB1/NF-κB Signalling Pathway Open
Background: Malignant proliferation and cervical lymphatic metastasis restrict the prognosis of oral squamous cell carcinoma (OSCC). Erythropoietin-producing human hepatocellular B4 (EPHB4) regulates a series of tumour functions involving …
View article: ncRNAVar: A Manually Curated Database for Identification of Noncoding RNA Variants Associated with Human Diseases
ncRNAVar: A Manually Curated Database for Identification of Noncoding RNA Variants Associated with Human Diseases Open
While variants of noncoding RNAs (ncRNAs) have been experimentally validated as a new class of biomarkers and drug targets, the discovery and interpretation of relationships between ncRNA variants and human diseases become important and ch…
View article: piRPheno: a manually curated database to prioritize and analyze human disease related piRNAs
piRPheno: a manually curated database to prioritize and analyze human disease related piRNAs Open
Many studies have uncovered that piRNAs (PIWI-interacting RNA) are associated with a broad range of diseases and might be a novel type of biomarkers and targets for precision medicine. However, public resource of high-quality curated human…
View article: Upregulation of Circular RNA circATRNL1 to Sensitize Oral Squamous Cell Carcinoma to Irradiation
Upregulation of Circular RNA circATRNL1 to Sensitize Oral Squamous Cell Carcinoma to Irradiation Open
Accumulating evidence has demonstrated that circular RNAs (circRNAs) play important roles in regulating gene expression involved in tumor development. However, the role of circRNAs in modulating the radiosensitivity of oral squamous cell c…
View article: LncRNA GAS5 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition in oral squamous cell carcinoma by regulating the miR-21/PTEN axis
LncRNA GAS5 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition in oral squamous cell carcinoma by regulating the miR-21/PTEN axis Open
Growth-arrest-specific transcript 5 (GAS5) functions as a tumor suppressor in a variety of cancers. GAS5 has been reported to be down-regulated in oral squamous cell carcinoma (OSCC). The aim of this study was to investigate the mechanisms…
View article: Novel <i>ANO5</i> mutation c.1067G>T (p.C356F) identified by whole genome sequencing in a big family with atypical gnathodiaphyseal dysplasia
Novel <i>ANO5</i> mutation c.1067G>T (p.C356F) identified by whole genome sequencing in a big family with atypical gnathodiaphyseal dysplasia Open
Background Gnathodiaphyseal dysplasia (GDD) is a rare skeletal disorder that has not been well studied. Methods Sanger sequencing, whole‐genome sequencing (WGS), and bioinformatics and structural modeling analyses were performed. Results A…
View article: Novel EDA or EDAR Mutations Identified in Patients with X-Linked Hypohidrotic Ectodermal Dysplasia or Non-Syndromic Tooth Agenesis
Novel EDA or EDAR Mutations Identified in Patients with X-Linked Hypohidrotic Ectodermal Dysplasia or Non-Syndromic Tooth Agenesis Open
Both X-linked hypohidrotic ectodermal dysplasia (XLHED) and non-syndromic tooth agenesis (NSTA) result in symptoms of congenital tooth loss. This study investigated genetic causes in two families with XLHED and four families with NSTA. We …
View article: Cellular behaviours of bone marrow‐derived mesenchymal stem cells towards pristine graphene oxide nanosheets
Cellular behaviours of bone marrow‐derived mesenchymal stem cells towards pristine graphene oxide nanosheets Open
Objectives Graphene oxide ( GO ), the derivative of graphene with unique properties, has attracted much attention for applications in dental implants. The aim of this study was, by two biomimetic cell culture methods, to investigate the qu…
View article: Downregulation of miR-222 Induces Apoptosis and Cellular Migration in Adenoid Cystic Carcinoma Cells
Downregulation of miR-222 Induces Apoptosis and Cellular Migration in Adenoid Cystic Carcinoma Cells Open
Previous studies have shown that miR-222 targets the p53 upregulated modulator of apoptosis (PUMA) to regulate cell biological behavior in some human malignancies. We hypothesized that there was a negative regulation, which might induce ap…
View article: miR-222 knockdown suppresses epithelial-to-mesenchymal transitionin human oral squamous cell carcinoma.
miR-222 knockdown suppresses epithelial-to-mesenchymal transitionin human oral squamous cell carcinoma. Open
Tumor metastasis is the main cause of death in patients with oral squamous cell carcinoma (OSCC). Epithelial-to-mesenchymal transition (EMT) is potentially associated with metastasis and histological grading in OSCC. Therefore, the discove…
View article: Eight Mutations of Three Genes (EDA, EDAR, and WNT10A) Identified in Seven Hypohidrotic Ectodermal Dysplasia Patients
Eight Mutations of Three Genes (EDA, EDAR, and WNT10A) Identified in Seven Hypohidrotic Ectodermal Dysplasia Patients Open
Hypohidrotic ectodermal dysplasia (HED) is characterized by abnormal development of the teeth, hair, and sweat glands. Ectodysplasin A (EDA), Ectodysplasin A receptor (EDAR), and EDAR-associated death domain (EDARADD) are candidate genes f…
View article: Novel <i><scp>EDA</scp></i> mutation in X‐linked hypohidrotic ectodermal dysplasia and genotype–phenotype correlation
Novel <i><span>EDA</span></i> mutation in X‐linked hypohidrotic ectodermal dysplasia and genotype–phenotype correlation Open
Objectives X‐linked hypohidrotic ectodermal dysplasia ( XLHED ) is characterized by abnormalities of hair, teeth, and sweat glands, while non‐syndromic hypodontia ( NSH ) affects only teeth. Mutations in Ectodysplasin A ( EDA ) underlie bo…