Bingjie Zhou
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View article: Galvanic catalyst boosts efficient electrolytic hydrogen production from liquid organic hydrogen carriers
Galvanic catalyst boosts efficient electrolytic hydrogen production from liquid organic hydrogen carriers Open
View article: The Impact of Family Cohesion and Adaptability on Depressive Symptoms in Adolescents with Depression: A Cross-sectional Study in China
The Impact of Family Cohesion and Adaptability on Depressive Symptoms in Adolescents with Depression: A Cross-sectional Study in China Open
Background Adolescent depression is increasingly prevalent in China, yet studies examining depressive symptoms through the lens of family cohesion and adaptability remain limited. This study explores the association between family cohesion…
View article: Lanthanum Hydroxide-Modified Zeolite as Adsorbents for Efficient Ammonia Nitrogen and Phosphate Removal and its Application in Sludge Fermentation Liquid
Lanthanum Hydroxide-Modified Zeolite as Adsorbents for Efficient Ammonia Nitrogen and Phosphate Removal and its Application in Sludge Fermentation Liquid Open
View article: Pyoluteorin-deficient Pseudomonas protegens improves cooperation with Bacillus velezensis, biofilm formation, co-colonizing, and reshapes rhizosphere microbiome
Pyoluteorin-deficient Pseudomonas protegens improves cooperation with Bacillus velezensis, biofilm formation, co-colonizing, and reshapes rhizosphere microbiome Open
Plant-beneficial Pseudomonas and Bacillus have been extensively studied and applied in biocontrol of plant diseases. However, there is less known about their interaction within two-strain synthetic communities (SynCom). Our study revealed …
View article: Possible Mechanism of Sucrose and Trehalose-6-Phosphate in Regulating the Secondary Flower on the Strong Upright Spring Shoots of Blueberry Planted in Greenhouse
Possible Mechanism of Sucrose and Trehalose-6-Phosphate in Regulating the Secondary Flower on the Strong Upright Spring Shoots of Blueberry Planted in Greenhouse Open
Secondary flowering is the phenomenon in which a tree blooms twice or more times a year. Along with the development of blueberry (Vaccinium corymbosum L.) fruits in spring, a large number of secondary flowers on the strong upright spring s…
View article: Development of a Human B7-H3-Specific Antibody with Activity against Colorectal Cancer Cells through a Synthetic Nanobody Library
Development of a Human B7-H3-Specific Antibody with Activity against Colorectal Cancer Cells through a Synthetic Nanobody Library Open
Nanobodies have emerged as promising tools in biomedicine due to their single-chain structure and inherent stability. They generally have convex paratopes, which potentially prefer different epitope sites in an antigen compared to traditio…
View article: A human antibody derived from original SARS-CoV-2 infection effectively neutralizes omicron
A human antibody derived from original SARS-CoV-2 infection effectively neutralizes omicron Open
View article: Lanthanum Hydroxide-Modified Zeolite as Adsorbents for Efficient Ammonia Nitrogen and Phosphate Removal and its Application in Sludge Fermentation Liquid
Lanthanum Hydroxide-Modified Zeolite as Adsorbents for Efficient Ammonia Nitrogen and Phosphate Removal and its Application in Sludge Fermentation Liquid Open
View article: Characteristics of Humification, Functional Enzymes and Bacterial Community Metabolism During Manganese Dioxide-Added Composting of Municipal Sludge
Characteristics of Humification, Functional Enzymes and Bacterial Community Metabolism During Manganese Dioxide-Added Composting of Municipal Sludge Open
View article: Impacts of Nitrilotriacetic Acid-Assisted Addition on Magnetite-Amended Composting of Municipal Sludge: Hydroxyl Radical, Humification and Bacterial Community Response
Impacts of Nitrilotriacetic Acid-Assisted Addition on Magnetite-Amended Composting of Municipal Sludge: Hydroxyl Radical, Humification and Bacterial Community Response Open
View article: Whole genome sequencing in high-grade cervical intraepithelial neoplasia patients from different ethnic groups in China
Whole genome sequencing in high-grade cervical intraepithelial neoplasia patients from different ethnic groups in China Open
Cervical cancer (CC) is the fourth most common cancer in women worldwide. It develops through precancerous lesions (cervical intraepithelial neoplasia (CIN), graded from low-grade (CIN1) to high-grade (CIN2-3)). It is well established that…
View article: Antibody-mediated spike activation promotes cell-cell transmission of SARS-CoV-2
Antibody-mediated spike activation promotes cell-cell transmission of SARS-CoV-2 Open
The COVID pandemic fueled by emerging SARS-CoV-2 new variants of concern remains a major global health concern, and the constantly emerging mutations present challenges to current therapeutics. The spike glycoprotein is not only essential …
View article: Heat-Denatured Lysozyme is a Novel Potential Non-alcoholic Disinfectant Against Respiratory Virus
Heat-Denatured Lysozyme is a Novel Potential Non-alcoholic Disinfectant Against Respiratory Virus Open
View article: A Spike-destructing human antibody effectively neutralizes Omicron-included SARS-CoV-2 variants with therapeutic efficacy
A Spike-destructing human antibody effectively neutralizes Omicron-included SARS-CoV-2 variants with therapeutic efficacy Open
Neutralizing antibodies (nAbs) are important assets to fight COVID-19, but most existing nAbs lose the activities against Omicron subvariants. Here, we report a human monoclonal antibody (Ab08) isolated from a convalescent patient infected…
View article: Molecular characterization of SPL gene family during flower morphogenesis and regulation in blueberry
Molecular characterization of SPL gene family during flower morphogenesis and regulation in blueberry Open
The SPL gene is a plant-specific transcription factor involved in the regulation of plant growth and development, which have been identified in woody plants. The process of floral bud differentiation affects the timing of flowering and fru…
View article: Construction and stable gene expression of AGR2xPD1 bi-specific antibody that enhances attachment between T-Cells and lung tumor cells, suppress tumor cell migration and promoting CD8 expression in cytotoxic T-cells
Construction and stable gene expression of AGR2xPD1 bi-specific antibody that enhances attachment between T-Cells and lung tumor cells, suppress tumor cell migration and promoting CD8 expression in cytotoxic T-cells Open
View article: Glycine Substitution of Residues with Unfavored Dihedral Angles Improves Protein Thermostability
Glycine Substitution of Residues with Unfavored Dihedral Angles Improves Protein Thermostability Open
Single mutations that can substantially enhance stability are highly desirable for protein engineering. However, it is generally rare for this kind of mutant to emerge from directed evolution experiments. This study used computational appr…
View article: Author Correction: A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection
Author Correction: A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection Open
View article: Structural Characterization of a Neutralizing Nanobody With Broad Activity Against SARS-CoV-2 Variants
Structural Characterization of a Neutralizing Nanobody With Broad Activity Against SARS-CoV-2 Variants Open
SARS-CoV-2 and its variants, such as the Omicron continue to threaten public health. The virus recognizes the host cell by attaching its Spike (S) receptor-binding domain (RBD) to the host receptor, ACE2. Therefore, RBD is a primary target…
View article: Isolation, characterization, and structure-based engineering of a neutralizing nanobody against SARS-CoV-2
Isolation, characterization, and structure-based engineering of a neutralizing nanobody against SARS-CoV-2 Open
View article: Charged Residue Implantation Improves the Affinity of a Cross-Reactive Dengue Virus Antibody
Charged Residue Implantation Improves the Affinity of a Cross-Reactive Dengue Virus Antibody Open
Dengue virus (DENV) has four serotypes that complicate vaccine development. Envelope protein domain III (EDIII) of DENV is a promising target for therapeutic antibody development. One EDIII-specific antibody, dubbed 1A1D-2, cross-reacts wi…
View article: Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein
Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein Open
The emergence of multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern threatens the efficacy of currently approved vaccines and authorized therapeutic monoclonal antibodies (MAbs). It is hence important…
View article: SARS-CoV-2 spike engagement of ACE2 primes S2′ site cleavage and fusion initiation
SARS-CoV-2 spike engagement of ACE2 primes S2′ site cleavage and fusion initiation Open
Significance The SARS-CoV-2 spike protein is responsible for host receptor recognition, membrane fusion, and viral infection. Understanding the cellular and inhibiting the molecular mechanisms of spike-driven viral entry is a research prio…
View article: Enhancing Methane Conversion by Modification of Zn States in Co-Reaction of MTA
Enhancing Methane Conversion by Modification of Zn States in Co-Reaction of MTA Open
Limited by harsh reaction conditions, the activation and utilization of methane were regarded as holy grail reaction. Co-reaction with methanol, successfully realizing mild conversion below 450 °C, provides practical strategies for methane…
View article: Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody
Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody Open
View article: A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection
A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection Open
View article: Discovery of nanobodies against SARS-CoV-2 and an uncommon neutralizing mechanism
Discovery of nanobodies against SARS-CoV-2 and an uncommon neutralizing mechanism Open
SARS-CoV-2 and its variants continue to threaten public health. The virus recognizes the host cell by attaching its Spike receptor-binding domain (RBD) to the host receptor ACE2. Therefore, RBD is a primary target for neutralizing antibodi…
View article: A high-affinity RBD-targeting nanobody improves fusion partner’s potency against SARS-CoV-2
A high-affinity RBD-targeting nanobody improves fusion partner’s potency against SARS-CoV-2 Open
A key step to the SARS-CoV-2 infection is the attachment of its Spike receptor-binding domain (S RBD) to the host receptor ACE2. Considerable research has been devoted to the development of neutralizing antibodies, including llama-derived …
View article: The SARS-CoV-2 envelope and membrane proteins modulate maturation and retention of the spike protein, allowing assembly of virus-like particles
The SARS-CoV-2 envelope and membrane proteins modulate maturation and retention of the spike protein, allowing assembly of virus-like particles Open
View article: Cloning, Expression, Purification, and Characterization of Soluble Bioactive Recombinant Human Anterior Gradient Homolog 2 - DsRed Monomer Protein in Escherichia coli
Cloning, Expression, Purification, and Characterization of Soluble Bioactive Recombinant Human Anterior Gradient Homolog 2 - DsRed Monomer Protein in Escherichia coli Open
Anterior gradient homolog 2, Red fluorescent protein, Recombinant expression, Escherichia coliAnterior gradient 2 (AGR2), initially discovered as an estrogen-responsive gene in breast cancer cell lines, is a developmentally regulated gene …