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View article: Zingerone alleviates inflammatory pain by reducing the intrinsic excitability of anterior cingulate cortex neurons in a mice model
Zingerone alleviates inflammatory pain by reducing the intrinsic excitability of anterior cingulate cortex neurons in a mice model Open
Background Zingiber officinale Roscoe has been shown to possess analgesic properties. Zingerone (ZO), a bioactive compound derived from Zingiber officinale Roscoe, exhibits a range of pharmacological effects, including anti-inflammatory, a…
View article: Spatiotemporal formation of glands in plants is modulated by MYB-like transcription factors
Spatiotemporal formation of glands in plants is modulated by MYB-like transcription factors Open
About one third of vascular plants develop glandular trichomes, which produce defensive compounds that repel herbivores and act as a natural biofactory for important pharmaceuticals such as artemisinin and cannabinoids. However, only a few…
View article: Noggin Combined With Human Dental Pulp Stem Cells to Promote Skeletal Muscle Regeneration
Noggin Combined With Human Dental Pulp Stem Cells to Promote Skeletal Muscle Regeneration Open
A proper source of stem cells is key to muscle injury repair. Dental pulp stem cells (DPSCs) are an ideal source for the treatment of muscle injuries due to their high proliferative and differentiation capacities. However, the current myog…
View article: The tooth movement efficiency of different orthodontic thermoplastics for clear aligners: study protocol for a randomized controlled clinical trial
The tooth movement efficiency of different orthodontic thermoplastics for clear aligners: study protocol for a randomized controlled clinical trial Open
Introduction : With regard to the esthetics and comfort of orthodontic treatment, the requirement for removable clear aligners (CAs) is increasing. Unlike conventional fixed orthodontic appliances, CAs were made of thermoplastic film by th…
View article: Role of TRPC6 in periodontal tissue reconstruction mediated by appropriate stress
Role of TRPC6 in periodontal tissue reconstruction mediated by appropriate stress Open
Introduction The basis of orthodontic tooth movement (OTM) is the reconstruction of periodontal tissue under stress. Increasing the speed of OTM has always been the focus of attention. Objectives Periodontal ligament stem cells (PDLSCs) ar…
View article: High-Fat Diet-Induced Mitochondrial Dysfunction Promotes Genioglossus Injury – A Potential Mechanism for Obstructive Sleep Apnea with Obesity
High-Fat Diet-Induced Mitochondrial Dysfunction Promotes Genioglossus Injury – A Potential Mechanism for Obstructive Sleep Apnea with Obesity Open
Our findings suggest that a HFD caused genioglossus injury in obese mice. The mitochondrial dysfunction and the accompanying oxidative stress were involved in the genioglossus injury, which may provide potential therapeutic targets for OSA…
View article: Role of transient receptor potential channel 6 in the osteogenesis of periodontal ligament cells
Role of transient receptor potential channel 6 in the osteogenesis of periodontal ligament cells Open
Transient receptor potential channel 6 (TRPC6) is a receptor-operated Ca2+ channel that plays an important role in Ca2+ influx in the majority of non-excitable cells and influences calcium signalling and cellular responses. Therefore, the …
View article: Noggin Combined With Dental Pulp Stem Cells Repair Muscle Injury Through Smad/Pax7 Signaling Pathway
Noggin Combined With Dental Pulp Stem Cells Repair Muscle Injury Through Smad/Pax7 Signaling Pathway Open
Background: A proper stem cell source is key to muscle injury repair. Dental pulp stem cells (DPSCs) are an available source for the treatment of muscle injury due to their high reproductive and differential activities. However, the applic…
View article: HIF-1α activator DMOG inhibits alveolar bone resorption in murine periodontitis by regulating macrophage polarization
HIF-1α activator DMOG inhibits alveolar bone resorption in murine periodontitis by regulating macrophage polarization Open
Periodontitis is initiated by serious and sustained bacterial infection and ultimately results in chronic immune-mediated inflammation, tissue destruction, and bone loss. The pathogenesis of periodontitis remains unclear. Host immunologica…