Binglin Shen
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View article: Optical characterization of ocular collagen microstructure and anisotropy in animal and human eyes
Optical characterization of ocular collagen microstructure and anisotropy in animal and human eyes Open
Second-harmonic generation (SHG) microscopy enabled label-free, high-resolution visualization of ocular collagen structures in mouse, rabbit, and human pterygium tissues. Quantitative analyses using fast Fourier transform (FFT), gray-level…
View article: Pan-immune-inflammation value as a novel predictor of pathological response to neoadjuvant chemotherapy combined with anti-PD-1 therapy in esophageal squamous cell carcinoma: a multicenter real-world retrospective clinical study
Pan-immune-inflammation value as a novel predictor of pathological response to neoadjuvant chemotherapy combined with anti-PD-1 therapy in esophageal squamous cell carcinoma: a multicenter real-world retrospective clinical study Open
Background: Current biomarkers for predicting pathological response to neoadjuvant chemoimmunotherapy in esophageal squamous cell carcinoma (ESCC) remain limited. Objective: This study investigates the potential of the pan-immune-inflammat…
View article: Enhancing Therapeutic Response and Overcoming Resistance to Checkpoint Inhibitors in Ovarian Cancer through Cell Cycle Regulation
Enhancing Therapeutic Response and Overcoming Resistance to Checkpoint Inhibitors in Ovarian Cancer through Cell Cycle Regulation Open
Tumor cells invade normal surrounding tissues through continuous division. In this study, we hypothesized that cell cycle regulation changes the immune efficacy of ovarian cancer. To investigate this hypothesis, a Förster resonance energy …
View article: Composition Regulation of Potassium Sodium Niobate Thin Films through Post-Annealing under Alkali Element Atmospheres
Composition Regulation of Potassium Sodium Niobate Thin Films through Post-Annealing under Alkali Element Atmospheres Open
Amorphous potassium sodium niobate (KNN) films were synthesized at 300 °C through the radio frequency magnetron sputtering method and subsequently crystallized by post-annealing at 700 °C in various alkali element atmospheres (Na and K). T…
View article: Rapid, high-contrast, and steady volumetric imaging with Bessel-beam-based two-photon fluorescence microscopy
Rapid, high-contrast, and steady volumetric imaging with Bessel-beam-based two-photon fluorescence microscopy Open
We achieved rapid, high-contrast, and robust volumetric imaging of the vasculature in live mouse brains and transgenic zebrafish using our TPFM with a sidelobe-free Bessel beam.
View article: Surmounting photon limits and motion artifacts for biological dynamics imaging via dual-perspective self-supervised learning
Surmounting photon limits and motion artifacts for biological dynamics imaging via dual-perspective self-supervised learning Open
Visualizing rapid biological dynamics like neuronal signaling and microvascular flow is crucial yet challenging due to photon noise and motion artifacts. Here we present a deep learning framework for enhancing the spatiotemporal relations …
View article: Multidimensional quantitative characterization of basal cell carcinoma by spectral- and time-resolved two-photon microscopy
Multidimensional quantitative characterization of basal cell carcinoma by spectral- and time-resolved two-photon microscopy Open
Basal cell carcinoma (BCC) is a common type of skin cancer. Conventional approaches to BCC diagnosis often involve invasive histological examinations that can distort or even destroy information derived from the biomolecules in the sample.…
View article: Noninvasive Nonlinear Optical Computational Histology
Noninvasive Nonlinear Optical Computational Histology Open
Cancer remains a global health challenge, demanding early detection and accurate diagnosis for improved patient outcomes. An intelligent paradigm is introduced that elevates label‐free nonlinear optical imaging with contrastive patch‐wise …
View article: Public data for nonlinear optical computational histology
Public data for nonlinear optical computational histology Open
Experimental datasets for training and testing nonlinear optical computational histology (NOCH), which include label-free nonlinear optical data: stimulated Raman scattering (SRS) images of human brain tumors and multiphoton (MP) images of…
View article: Public data for nonlinear optical computational histology
Public data for nonlinear optical computational histology Open
Experimental datasets for training and testing nonlinear optical computational histology (NOCH), which include label-free nonlinear optical data: stimulated Raman scattering (SRS) images of human brain tumors and multiphoton (MP) images of…
View article: Evolving electromechanical properties of defect engineered Pb(Zr,Ti)O3-based piezoceramics
Evolving electromechanical properties of defect engineered Pb(Zr,Ti)O3-based piezoceramics Open
Chemical modification is the frequently-adopted strategy to enhance the electromechanical properties of piezoelectric ceramics. However, chemically modified piezoelectric materials will inevitably produce point defects, such as dopant ions…
View article: Synthetic dataset for dual-perspective self-supervised learning
Synthetic dataset for dual-perspective self-supervised learning Open
The synthetic Ca datasets for training and testing, including training dataset with bidirectional collinear scan (Ny = 2Nx) for MP-SSL, training dataset with normal scan (Ny = Nx) for TP-SSL, and testing data (Ny = Nx) If you use these dat…
View article: Experimental dataset for dual-perspective self-supervised learning
Experimental dataset for dual-perspective self-supervised learning Open
Experimental data for training and testing, including astrocyte data, rapid hemodynamic data (larger vessels), vascular data (smaller vessels), zebrafish cardiac data. Referring to our paper: Surmounting photon limits and motion artifacts …
View article: Synthetic dataset for dual-perspective self-supervised learning
Synthetic dataset for dual-perspective self-supervised learning Open
The synthetic Ca datasets for training and testing, including training dataset with bidirectional collinear scan (Ny = 2Nx) for MP-SSL, training dataset with normal scan (Ny = Nx) for TP-SSL, and testing data (Ny = Nx) If you use these dat…
View article: Experimental dataset for dual-perspective self-supervised learning
Experimental dataset for dual-perspective self-supervised learning Open
Experimental data for training and testing, including astrocyte data, rapid hemodynamic data (larger vessels), vascular data (smaller vessels), zebrafish cardiac data. If you use these data acquired using our imaging system, please cite th…
View article: Experimental dataset for dual-perspective self-supervised learning
Experimental dataset for dual-perspective self-supervised learning Open
Experimental data for training and testing, including astrocyte data, rapid hemodynamic data (larger vessels), vascular data (smaller vessels), zebrafish cardiac data. If you use these data acquired using our imaging system, please cite th…
View article: Piezoelectric Materials and Sensors for Structural Health Monitoring: Fundamental Aspects, Current Status, and Future Perspectives
Piezoelectric Materials and Sensors for Structural Health Monitoring: Fundamental Aspects, Current Status, and Future Perspectives Open
Structural health monitoring technology can assess the status and integrity of structures in real time by advanced sensors, evaluate the remaining life of structure, and make the maintenance decisions on the structures. Piezoelectric mater…
View article: DLAM train data
DLAM train data Open
The train dataset of ovarian cancer acquired using galvo-resonant scanning system and dual-axis galvo scanning system. If you use these data, please cite the corresponding work:Shen, B., Liu, S., Li, Y. et al. Deep learning autofluorescenc…
View article: Deep learning-based high-speed, large-field, and high-resolution multiphoton imaging
Deep learning-based high-speed, large-field, and high-resolution multiphoton imaging Open
Multiphoton microscopy is a formidable tool for the pathological analysis of tumors. The physical limitations of imaging systems and the low efficiencies inherent in nonlinear processes have prevented the simultaneous achievement of high i…
View article: Multidimensional quantitative characterization of the tumor microenvironment by multicontrast nonlinear microscopy
Multidimensional quantitative characterization of the tumor microenvironment by multicontrast nonlinear microscopy Open
Characterization of the microenvironment features of tumors, such as its microstructures, biomolecular metabolism, and functional dynamics, may provide essential pathologic information about the tumor, tumor margin, and adjacent normal tis…
View article: Super‐Multiplex Nonlinear Optical Imaging Unscrambles the Statistical Complexity of Cancer Subtypes and Tumor Microenvironment
Super‐Multiplex Nonlinear Optical Imaging Unscrambles the Statistical Complexity of Cancer Subtypes and Tumor Microenvironment Open
Label‐free nonlinear optical imaging (NLOI) has made tremendous inroads toward unscrambling the microcosmic complexity of cancers. However, harmonic and Raman microscopy offers throughput without redox information to reveal metabolic diffe…
View article: Picosecond evolution of pulsed and CW alkali vapor lasers: laser oscillation buildup
Picosecond evolution of pulsed and CW alkali vapor lasers: laser oscillation buildup Open
Investigation of the kinetic principle of a diode-pumped alkali vapor laser (DPAL) is key to achieve multifunctional DPALs. In this work, we propose a spatiotemporal model, which combines the time-dependent rate equations of population den…
View article: Label-free whole-colony imaging and metabolic analysis of metastatic pancreatic cancer by an autoregulating flexible optical system
Label-free whole-colony imaging and metabolic analysis of metastatic pancreatic cancer by an autoregulating flexible optical system Open
Cancer metastasis is a Gordian knot for tumor diagnosis and therapy. Many studies have demonstrated that metastatic processes are inevitably affected by the tumor microenvironment. Histopathology is used universally as the gold standard fo…
View article: Monitoring the endocytosis of bovine serum albumin based on the fluorescence lifetime of small squaraine dye in living cells
Monitoring the endocytosis of bovine serum albumin based on the fluorescence lifetime of small squaraine dye in living cells Open
Bovine serum albumin (BSA) has a wide range of physiological functions involving the binding, transportation, and delivery of fatty acids, porphyrins, bilirubin, steroids, etc. In the present study, we prepared a small squaraine dye (SD), …
View article: Implementation and application of FRET–FLIM technology
Implementation and application of FRET–FLIM technology Open
With the development of the new detection methods and the function of fluorescent molecule, researchers hope to further explore the internal mechanisms of organisms, monitor changes in the intracellular microenvironment, and dynamic proces…