Bingwei Ma
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View article: Efficient derivation of immortalized, isogenic cell lines from genetically defined murine hepatoblastomas
Efficient derivation of immortalized, isogenic cell lines from genetically defined murine hepatoblastomas Open
Hepatoblastoma (HB), the most common childhood liver cancer and the simplest of human neoplasms molecularly, commonly deregulates Wnt/β-catenin (B), Hippo/YAP (Y) and/or NFE2/NRF2 (N) signaling. Murine HBs that closely resemble human tumor…
View article: MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read‐Through Transcription, and Intragenic Contacts
MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read‐Through Transcription, and Intragenic Contacts Open
The MYC oncoprotein regulates numerous genes involved in processes such as cell cycle control and mitochondrial and ribosomal structure and function. This requires heterodimerization with its partner, MAX, and binding to specific promoter …
View article: Gas1-Mediated Suppression of Hepatoblastoma Tumorigenesis
Gas1-Mediated Suppression of Hepatoblastoma Tumorigenesis Open
Background and Aims Hepatoblastoma (HB), the most common pediatric liver cancer, often dysregulates the Wnt/β-catenin, Hippo and NFE2L2/NRF2 pathways. Pairwise combinations of oncogenically active forms of the terminal transcription factor…
View article: MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read-Through Transcription and Intragenic Contacts
MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read-Through Transcription and Intragenic Contacts Open
Summary The MYC oncoprotein regulates numerous genes involved in cellular processes such as cell cycle and mitochondrial and ribosomal structure and function. This requires heterodimerization with its partner, MAX, and binding to specific …
View article: A prognostic nomogram integrating carcinoembryonic antigen levels for predicting overall survival in elderly patients with stage II–III colorectal cancer
A prognostic nomogram integrating carcinoembryonic antigen levels for predicting overall survival in elderly patients with stage II–III colorectal cancer Open
We constructed a prediction nomogram for stage II-III elderly CRC patients by combining pre-treatment carcinoembryonic antigen (CEA) levels, which can accurately predict patient survival. This facilitates clinicians to accurately assess pa…
View article: Identification of a novel immune-related transcriptional regulatory network in sarcopenia
Identification of a novel immune-related transcriptional regulatory network in sarcopenia Open
Background Sarcopenia is highly prevalent in elderly individuals and has a significant adverse effect on their physical health and quality of life, but the mechanisms remain unclear. Studies have indicated that transcription factors (TFs) …
View article: High glucose promotes the progression of colorectal cancer by activating the BMP4 signaling and inhibited by glucagon-like peptide-1 receptor agonist
High glucose promotes the progression of colorectal cancer by activating the BMP4 signaling and inhibited by glucagon-like peptide-1 receptor agonist Open
Background The detailed molecular mechanism between type 2 diabetes mellitus (T2DM) and colorectal cancer (CRC) is still uncertain. Bone morphogenetic protein 4 (BMP4) dysregulation is implicated in T2DM and CRC, respectively. This study a…
View article: Premature Aging and Reduced Cancer Incidence Associated with Near-Complete Body-Wide<i>Myc</i>Inactivation
Premature Aging and Reduced Cancer Incidence Associated with Near-Complete Body-Wide<i>Myc</i>Inactivation Open
Summary MYC proto-oncogene dysregulation alters metabolism, translation and other functions in ways that support tumor induction and maintenance. Although Myc+/- mice are healthier and longer-lived than control mice, the long-term ramifica…
View article: Additional file 9 of Identification of a novel immune-related transcriptional regulatory network in sarcopenia
Additional file 9 of Identification of a novel immune-related transcriptional regulatory network in sarcopenia Open
Additional file 9. Results of C-Map database.
View article: Additional file 1 of Identification of a novel immune-related transcriptional regulatory network in sarcopenia
Additional file 1 of Identification of a novel immune-related transcriptional regulatory network in sarcopenia Open
Additional file 1. Primers of DETFs and final DEGs.
View article: Additional file 2 of Identification of a novel immune-related transcriptional regulatory network in sarcopenia
Additional file 2 of Identification of a novel immune-related transcriptional regulatory network in sarcopenia Open
Additional file 2. Results of DEGs.
View article: Additional file 7 of Identification of a novel immune-related transcriptional regulatory network in sarcopenia
Additional file 7 of Identification of a novel immune-related transcriptional regulatory network in sarcopenia Open
Additional file 7. Results of DEIGSs.
View article: Additional file 4 of Identification of a novel immune-related transcriptional regulatory network in sarcopenia
Additional file 4 of Identification of a novel immune-related transcriptional regulatory network in sarcopenia Open
Additional file 4. Results of ORA.
View article: Additional file 3 of Identification of a novel immune-related transcriptional regulatory network in sarcopenia
Additional file 3 of Identification of a novel immune-related transcriptional regulatory network in sarcopenia Open
Additional file 3. Functional enrichment analysis.
View article: Additional file 8 of Identification of a novel immune-related transcriptional regulatory network in sarcopenia
Additional file 8 of Identification of a novel immune-related transcriptional regulatory network in sarcopenia Open
Additional file 8. Results of co-analysis.
View article: Additional file 10 of Identification of a novel immune-related transcriptional regulatory network in sarcopenia
Additional file 10 of Identification of a novel immune-related transcriptional regulatory network in sarcopenia Open
Additional file 10. Clinical characterization of patients.
View article: Additional file 5 of Identification of a novel immune-related transcriptional regulatory network in sarcopenia
Additional file 5 of Identification of a novel immune-related transcriptional regulatory network in sarcopenia Open
Additional file 5. Results of DEPs.
View article: Additional file 6 of Identification of a novel immune-related transcriptional regulatory network in sarcopenia
Additional file 6 of Identification of a novel immune-related transcriptional regulatory network in sarcopenia Open
Additional file 6. Results of ssGSEA.
View article: Identification of novel immune related transcriptional regulatory network in sarcopenia
Identification of novel immune related transcriptional regulatory network in sarcopenia Open
Background: Sarcopenia is highly prevalent in elderly and has a significant adverse effect on their physical health and quality of life, but the mechanisms remain unclear. Studies have indicated that transcription factors (TFs) and immune …
View article: Iron metabolism mediates the relationship between Vitamin C and hepatic steatosis and fibrosis in NAFLD
Iron metabolism mediates the relationship between Vitamin C and hepatic steatosis and fibrosis in NAFLD Open
Vitamin C (Vit C) and iron metabolism are closely related to metabolic disorders. However, the relation between iron storage protein ferritin and Vit C has not been elucidated. We aimed to investigate the crosstalk between Vit C and ferrit…
View article: Association Between Abdominal Adipose Tissue Distribution and Obstructive Sleep Apnea in Chinese Obese Patients
Association Between Abdominal Adipose Tissue Distribution and Obstructive Sleep Apnea in Chinese Obese Patients Open
Purpose Factors related to the occurrence of obstructive sleep apnea syndrome (OSAS) in obesity have not been fully clarified. The aim of this study was to identify the association between OSAS and abdominal fat distribution in a cohort of…
View article: Relationship of Vitamin A and Thyroid Function in Individuals With Obesity and After Laparoscopic Sleeve Gastrectomy
Relationship of Vitamin A and Thyroid Function in Individuals With Obesity and After Laparoscopic Sleeve Gastrectomy Open
Vitamin A deficiency (VAD) occurs in obesity and may be associated with thyroid dysfunction. We aimed to investigate the association of VA with thyroid function in obesity and after laparoscopic sleeve gastrectomy (LSG). Nine hundred and s…
View article: Epithelial-Mesenchymal Transformation Related Genomic Analysis Reveals Prognostic And Immunogenic Significance In Colorectal Cancer
Epithelial-Mesenchymal Transformation Related Genomic Analysis Reveals Prognostic And Immunogenic Significance In Colorectal Cancer Open
Background : Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. Epithelial-mesenchymal transition (EMT) has been viewed to play a vital role in immune regulation and treatment response shaping. EMT is associated…
View article: Potential Functions of the BMP Family in Bone, Obesity, and Glucose Metabolism
Potential Functions of the BMP Family in Bone, Obesity, and Glucose Metabolism Open
Characteristic bone metabolism was observed in obesity and diabetes with controversial conclusions. Type 2 diabetes (T2DM) and obesity may manifest increased bone mineral density. Also, obesity is more easily to occur in T2DM. Therefore, w…
View article: Glucagon-like Peptide-1 Improves Fatty Liver and Enhances Thermogenesis in Brown Adipose Tissue via Inhibiting BMP4-Related Signaling Pathway in High-Fat-Diet-Induced Obese Mice
Glucagon-like Peptide-1 Improves Fatty Liver and Enhances Thermogenesis in Brown Adipose Tissue via Inhibiting BMP4-Related Signaling Pathway in High-Fat-Diet-Induced Obese Mice Open
Objective. Glucagon-like peptide-1 (GLP-1) receptor agonist is effective in decreasing blood glucose and body weight. It could improve fatty liver with unclear mechanisms. Hence, we aimed to explore whether GLP-1 could improve fatty liver …
View article: Hepatic Steatosis Is Associated with Elevated Serum Iron in Patients with Obesity and Improves after Laparoscopic Sleeve Gastrectomy
Hepatic Steatosis Is Associated with Elevated Serum Iron in Patients with Obesity and Improves after Laparoscopic Sleeve Gastrectomy Open
Background: Iron is closely related to metabolism. However, the relationship between iron and hepatic steatosis has not been fully elucidated. Objective: We aimed to investigate the triangular relationship between iron and hepatic steatosi…