Bo Han
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View article: CD132 expression promotes AML aggressiveness via the JAK-STAT signaling pathway
CD132 expression promotes AML aggressiveness via the JAK-STAT signaling pathway Open
Acute myeloid leukemia (AML) is a common and challenging leukemia in adults, often accompanied by a poor prognosis. Despite the availability of diverse treatment approaches, relapse and refractory (R/R) was still the major cause of death i…
View article: Single‐Cell RNA Sequencing Reveals Macrophage–Endothelial Cell Crosstalk in Viral Myocarditis
Single‐Cell RNA Sequencing Reveals Macrophage–Endothelial Cell Crosstalk in Viral Myocarditis Open
Viral myocarditis is characterized by inflammatory cell infiltration and myocardial damage. However, the involvement of immune cells and the interaction between immune cells and stromal cells remain poorly understood. We successfully estab…
View article: MiR-425-5p intervenes in autoimmune myocarditis by regulating Treg cell differentiation through NRAS
MiR-425-5p intervenes in autoimmune myocarditis by regulating Treg cell differentiation through NRAS Open
Aim Our Previous research revealed significant differences in exosome-mediated intercellular miR-425a-5p between normal children and those with fulminant myocarditis. We sought to elucidate the molecular underpinnings and functional implic…
View article: Risk Factors and Long‐Term Outcomes of Tricuspid Regurgitation After Transcatheter Closure of Pediatric Perimembranous Ventricular Septal Defects
Risk Factors and Long‐Term Outcomes of Tricuspid Regurgitation After Transcatheter Closure of Pediatric Perimembranous Ventricular Septal Defects Open
Background Transcatheter closure of perimembranous ventricular septal defects in children is a highly effective procedure, but it can result in tricuspid regurgitation (TR). The associated risk factors and long‐term outcomes of TR followin…
View article: Multi-omics analysis reveals Jianpi formula-derived bioactive peptide-YG-22 potentially inhibited colorectal cancer via regulating epigenetic reprogram and signal pathway regulation
Multi-omics analysis reveals Jianpi formula-derived bioactive peptide-YG-22 potentially inhibited colorectal cancer via regulating epigenetic reprogram and signal pathway regulation Open
Introduction Colorectal cancer (CRC) is a prevalent malignancy worldwide, often treated with chemotherapy despite its limitations, including adverse effects and resistance. The traditional Chinese medicine (TCM) Jianpi formula has been dem…
View article: Intradermal delivery of SARS-CoV-2 RBD3-Fc mRNA vaccines via a needle-free injection system induces robust immune responses in rats
Intradermal delivery of SARS-CoV-2 RBD3-Fc mRNA vaccines via a needle-free injection system induces robust immune responses in rats Open
Introduction Needle-free injection system (NFIS) is easy to operate and can decrease needle phobia. Besides, NFIS can increase the interaction of antigens in a more dispersed manner with immune cell at local injection site, which may impro…
View article: Genotype-phenotype insights of pediatric dilated cardiomyopathy
Genotype-phenotype insights of pediatric dilated cardiomyopathy Open
Dilated cardiomyopathy (DCM) in children is a severe myocardial disease characterized by enlargement of the left ventricle or both ventricles with impaired contractile function. DCM can cause adverse consequences such as heart failure, sud…
View article: Application of machine learning in predicting postoperative arrhythmia following transcatheter closure of perimembranous ventricular septal defects
Application of machine learning in predicting postoperative arrhythmia following transcatheter closure of perimembranous ventricular septal defects Open
The machine learning model accurately predicts postoperative arrhythmias, aiding in risk stratification of pmVSD patients and guiding clinical decisions.
View article: Mechanistic insights into COVID-19 mRNA vaccine-associated myocarditis: a bioinformatics analysis
Mechanistic insights into COVID-19 mRNA vaccine-associated myocarditis: a bioinformatics analysis Open
This study implicates immune dysregulation driven by CXCR3, NKG7, and GZMH in post-vaccination myocarditis, supported by regulatory networks and therapeutic insights using a bioinformatics analysis. These findings advance mechanistic under…
View article: PCP4 inhibits the progression of prostate cancer through Ca<sup>2+</sup>/CAMKK2/AMPK/AR pathway.
PCP4 inhibits the progression of prostate cancer through Ca<sup>2+</sup>/CAMKK2/AMPK/AR pathway. Open
Our findings elucidate the molecular mechanism that PCP4 downregulation promotes PCa progression via Ca2+/CAMKK2/AMPK/AR pathway, highlighting its significance in CRPC development.
View article: Leveraging artificial intelligence for predicting spontaneous closure of perimembranous ventricular septal defect in children: a multicentre, retrospective study in China
Leveraging artificial intelligence for predicting spontaneous closure of perimembranous ventricular septal defect in children: a multicentre, retrospective study in China Open
National Natural Science Foundation of China, Shanghai Municipal Hospital Clinical Technology Project, Shanghai Municipal Health Commission, and Clinical Research Unit of XinHua Hospital.
View article: Intraoperative rapid molecular diagnosis aids glioma subtyping and guides precise surgical resection
Intraoperative rapid molecular diagnosis aids glioma subtyping and guides precise surgical resection Open
Objective The molecular era of glioma diagnosis and treatment has arrived, and a single rapid histopathology is no longer sufficient for surgery. This study sought to present an automatic integrated gene detection system (AIGS), which enab…
View article: 3D printing processes in precise drug delivery for personalized medicine
3D printing processes in precise drug delivery for personalized medicine Open
With the advent of personalized medicine, the drug delivery system will be changed significantly. The development of personalized medicine needs the support of many technologies, among which three-dimensional printing (3DP) technology is a…
View article: Procedural Efficiencies and Clinical Outcomes for Transcatheter Device Closure of Perimembranous Ventricular Septal Defects With Different Waist-Length Occluders
Procedural Efficiencies and Clinical Outcomes for Transcatheter Device Closure of Perimembranous Ventricular Septal Defects With Different Waist-Length Occluders Open
Transcatheter closure of pmVSD using a symmetrical double-disk occluder is safe and effective. Compared with a 3-mm waist symmetrical occluder, transcatheter closure with a 4-mm waist symmetrical occluder correlated with higher incidences …
View article: Planning and construction of Xiong’an New Area (city of over 5 million people): Contributions of China’s geologists and urban geology
Planning and construction of Xiong’an New Area (city of over 5 million people): Contributions of China’s geologists and urban geology Open
China established Xiong'an New Area in Hebei Province in 2017, which is planned to accommodate about 5 million people, aiming to relieve Beijing City of the functions non-essential to its role as China's capital and to expedite the coordin…
View article: Role of immune cells in the pathogenesis of myocarditis
Role of immune cells in the pathogenesis of myocarditis Open
Myocarditis is an inflammatory heart disease that mostly affects young people. Myocarditis involves a complex immune network; however, its detailed pathogenesis is currently unclear. The diversity and plasticity of immune cells, either in …
View article: Identification and functional analysis of circulating small extracellular vesicle <scp>lncRNA</scp> signatures in children with fulminant myocarditis
Identification and functional analysis of circulating small extracellular vesicle <span>lncRNA</span> signatures in children with fulminant myocarditis Open
Fulminant myocarditis (FM) is the most serious type of myocarditis. However, the molecular mechanism underlying the pathogenesis of FM has not been fully elucidated. Small extracellular vesicles (sEVs) play important roles in many diseases…
View article: Technical Recommendations for Computed Tomography Guidance of Intervention in the Right Ventricular Outflow Tract: Native RVOT, Conduits, and Bioprosthetic Valves
Technical Recommendations for Computed Tomography Guidance of Intervention in the Right Ventricular Outflow Tract: Native RVOT, Conduits, and Bioprosthetic Valves Open
This consensus document for the performance of cardiovascular computed tomography (CCT) to guide intervention in the right ventricular outflow tract (RVOT) in patients with congenital heart disease (CHD) was developed collaboratively by pe…
View article: Hsa_circ_0014784-induced YAP1 promoted the progression of pancreatic cancer by sponging miR-214-3p
Hsa_circ_0014784-induced YAP1 promoted the progression of pancreatic cancer by sponging miR-214-3p Open
Taken together, our study found that hsa_circ_0014784 downregulation decremented invasion, proliferation, EMT, and angiogenesis of PC by regulating miR-214-3p/YAP1 signaling.