Bingxue Chen
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View article: The immune system’s mediation of the protective effect of Parabacteroides against obesity: A Mendelian randomization study
The immune system’s mediation of the protective effect of Parabacteroides against obesity: A Mendelian randomization study Open
Parabacteroides , a core component of the human gut microbiota, is closely associated with various diseases. While some studies have observed a decrease in the abundance of Parabacteroides in patients with obesity, the specific relationshi…
View article: Global, regional, and national burden of nutritional deficiencies spanning from 1990 to 2021, with a focus on the impacts observed during the COVID-19 pandemic
Global, regional, and national burden of nutritional deficiencies spanning from 1990 to 2021, with a focus on the impacts observed during the COVID-19 pandemic Open
Background The United Nations has recognized nutritional deficiencies as a critical health issue that necessitates urgent eradication. This study aimed to provide a comprehensive analysis of the spatial distribution and temporal trends of …
View article: Novel therapeutic targets for metabolism-related diseases: proteomic Mendelian randomization and colocalization analyses
Novel therapeutic targets for metabolism-related diseases: proteomic Mendelian randomization and colocalization analyses Open
Background: In recent years, driven by the rapid advancement of proteomics research, numerous scholars have investigated the intricate associations between plasma proteins and various diseases. Thus, this study aimed to identify novel ther…
View article: Multi-omics investigation of prospective therapeutic targets for type 1 diabetes
Multi-omics investigation of prospective therapeutic targets for type 1 diabetes Open
Background: In recent years, the incidence of type 1 diabetes has been rising steadily, positioning its prevention and treatment as a central focus of global public health initiatives. Previous Mendelian randomization (MR) studies have inv…
View article: Associations of diet and lifestyle with new-onset diabetes and major cardiovascular events: The cardiometabolic disease and cancer cohort (4C) study and mendelian randomization
Associations of diet and lifestyle with new-onset diabetes and major cardiovascular events: The cardiometabolic disease and cancer cohort (4C) study and mendelian randomization Open
Background and Aim: At present, there is an absence of a widely accepted model for a healthy diet-lifestyle in China. Therefore, this study aims to provide novel evidence for the development of a healthier diet-lifestyle model specifically…
View article: Association of lipid-lowering drugs with the risk of type 2 diabetes and its complications: a mendelian randomized study
Association of lipid-lowering drugs with the risk of type 2 diabetes and its complications: a mendelian randomized study Open
This Mendelian randomization study suggests an association between HMGCR and the pathogenesis of type 2 diabetes mellitus, with increased genetically proxied HMGCR expression reducing the risk of type 2 diabetes mellitus, while PCSK9 and N…
View article: Potential Association Between Triglyceride-Glucose Related Indices and Type 2 Diabetes-Related Complications: Insights from the National Metabolic Management Center and MIMIC-IV 3.0 Databases
Potential Association Between Triglyceride-Glucose Related Indices and Type 2 Diabetes-Related Complications: Insights from the National Metabolic Management Center and MIMIC-IV 3.0 Databases Open
Background The triglyceride-glucose index (TyG) and its related indices are predominantly utilized for the effective assessment of insulin resistance. However, their predictive value concerning type 2 diabetes-related complications remains…
View article: Non-linear association between the plasma atherogenic index and type 2 diabetes mellitus: findings from a multicentre prospective cohort study based on the 4C study
Non-linear association between the plasma atherogenic index and type 2 diabetes mellitus: findings from a multicentre prospective cohort study based on the 4C study Open
Background Currently, the plasma atherogenic index (AIP) is mainly used to predict atherosclerosis and cardiovascular diseases, but there is still insufficient evidence to indicate its association with type 2 diabetes. Therefore, we aim to…
View article: Association between gut microbiota and adrenal disease: a two-sample Mendelian randomized study
Association between gut microbiota and adrenal disease: a two-sample Mendelian randomized study Open
Background Some observational studies and clinical experiments suggest a close association between gut microbiota and metabolic diseases. However, the causal effects of gut microbiota on adrenal diseases, including Adrenocortical insuffici…
View article: Correlation of renal function indicators and vascular damage in T2DM patients with normal renal function
Correlation of renal function indicators and vascular damage in T2DM patients with normal renal function Open
Background This study aimed to assess the correlation between renal function-related indices and vascular damages among patients with type 2 diabetes mellitus (T2DM) and normal renal function. Methods We screened a cohort of eligible patie…
View article: Correlation study of renal function indices with diabetic peripheral neuropathy and diabetic retinopathy in T2DM patients with normal renal function
Correlation study of renal function indices with diabetic peripheral neuropathy and diabetic retinopathy in T2DM patients with normal renal function Open
Background The anticipation of diabetes-related complications remains a challenge for numerous T2DM patients, as there is presently no effective method for early prediction of these complications. This study aims to investigate the associa…
View article: Study on the factors influencing the prognosis after perianal abscess surgery
Study on the factors influencing the prognosis after perianal abscess surgery Open
Objective To study the influence of clinical characteristics and diagnosis and treatment methods of perianal abscess on postoperative recurrence or formation of anal fistula to provide a basis for selecting appropriate surgical and inspect…
View article: Involvement of PGC7 and UHRF1 in the regulation of DNA methylation of the IG-DMR in the imprinted <italic>Dlk1-Dio3</italic> locus
Involvement of PGC7 and UHRF1 in the regulation of DNA methylation of the IG-DMR in the imprinted <italic>Dlk1-Dio3</italic> locus Open
The gene dosage at the imprinted Dlk1-Dio3 locus is critical for cell growth and development. A relatively high gene expression within the Dlk1-Dio3 region, especially the active expression of Gtl2, has been identified as the only reliable…
View article: Deleted in lymphocytic leukemia 2 induces retinoic acid receptor beta promoter methylation and mitogen activated kinase-like protein activation to enhance viability and mobility of colorectal cancer cells
Deleted in lymphocytic leukemia 2 induces retinoic acid receptor beta promoter methylation and mitogen activated kinase-like protein activation to enhance viability and mobility of colorectal cancer cells Open
Abnormal expression of long non-coding RNAs (lncRNAs) is frequently linked to the pathogenesis of colorectal cancer (CRC). This work explored the function of lncRNA deleted in lymphocytic leukemia 2 (DLEU2) in CRC and the epigenetic mechan…
View article: Vitamin C functions as double-edge sword on cancer progression depending on ERK activation or inhibition mediated by its receptor SVCT2
Vitamin C functions as double-edge sword on cancer progression depending on ERK activation or inhibition mediated by its receptor SVCT2 Open
The effect of Vitamin C (Vc) in oncotherapy was controversial for decades. And hyperactivation of extracellular signal-regulated kinase (ERK) drove tumorigenesis. Herein, we demonstrated that Vc activated ERK through sodium-dependent Vc tr…
View article: Deleted in lymphocytic leukemia 2 induces retinoic acid receptor beta promoter methylation and mitogen activated kinase-like protein activation to enhance viability and mobility of colorectal cancer cells
Deleted in lymphocytic leukemia 2 induces retinoic acid receptor beta promoter methylation and mitogen activated kinase-like protein activation to enhance viability and mobility of colorectal cancer cells Open
Abnormal expression of long non-coding RNAs (lncRNAs) is frequently linked to the pathogenesis of colorectal cancer (CRC). This work explored the function of lncRNA deleted in lymphocytic leukemia 2 (DLEU2) in CRC and the epigenetic mechan…
View article: [Front matter]
[Front matter] Open
On behalf of the Organising Committee, we would like to
View article: FOXC1 Downregulates Nanog Expression by Recruiting HDAC2 to Its Promoter in F9 Cells Treated by Retinoic Acid
FOXC1 Downregulates Nanog Expression by Recruiting HDAC2 to Its Promoter in F9 Cells Treated by Retinoic Acid Open
FOXC1, a transcription factor involved in cell differentiation and embryogenesis, is demonstrated to be a negative regulator of Nanog in this study. FOXC1 is up-regulated in retinoic acid-induced differentiation of F9 Embryonal Carcinoma (…
View article: The Study on the Construction of a Commercial Society Simulation Game Based on Science and Technology Innovation
The Study on the Construction of a Commercial Society Simulation Game Based on Science and Technology Innovation Open
In the early 1980s, the ERP simulation game was introduced in China and gradually was applied to the higher education. With the development of the times, however, the teaching of the stereotypical simulation game has been unable to meet th…
View article: The Design of the Operation Procedure and Rules of a Commercial Society Simulation Game
The Design of the Operation Procedure and Rules of a Commercial Society Simulation Game Open
Based on the research of prevailing ERP simulation game, this paper, which is aiming at the cultivation of innovative and entrepreneurial talents, initially elaborates the operation procedure and rules of a model of value chain—a simulat…
View article: Research on Design of the Logic and Process of an Operation Simulation System for Technological Innovation-based Manufacturing Enterprises
Research on Design of the Logic and Process of an Operation Simulation System for Technological Innovation-based Manufacturing Enterprises Open
In this paper, based on theories of management simulation and disruptive innovation in modern enterprises, we build a business operation simulation system with technological innovation-based manufacturing enterprises at the core.We prelimi…
View article: A Study on Design of an Operation Simulation System for Technological and Innovative Manufacturing Enterprises
A Study on Design of an Operation Simulation System for Technological and Innovative Manufacturing Enterprises Open
As an experiential teaching mode, business operation simulation sandbox-based training plays an important role of "entrepreneurial simulation" teaching in cultivating innovative and entrepreneurial talents.However, mainstream electronic bu…
View article: A novel method on pilot selection for sparse channel estimation in OFDM systems
A novel method on pilot selection for sparse channel estimation in OFDM systems Open
A novel pilot pattern selection method is proposed in wireless OFDM systems which can be used for sparse channel estimation. It is that cumulative coherence function is proposed to select optimal pilot patterns. This proposed method can ch…