Bingyu Pang
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View article: Targeting the Galectin‐7/<scp>TRPM2</scp>/Zn<sup>2+</sup>/<scp>DRP</scp>‐1 Signaling Pathway: A Potential Therapeutic Intervention in the Pathogenesis of <scp>SJS</scp>/<scp>TEN</scp>
Targeting the Galectin‐7/<span>TRPM2</span>/Zn<sup>2+</sup>/<span>DRP</span>‐1 Signaling Pathway: A Potential Therapeutic Intervention in the Pathogenesis of <span>SJS</span>/<span>TEN</span> Open
Background Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) represent a spectrum of severe drug‐induced cutaneous reactions. These conditions are characterized by widespread and confluent keratinocyte apoptosis, which di…
View article: Exosomal <i>miR-375-3p</i> mediated lipid metabolism, ferritinophagy and CoQ-dependent pathway contributes to the ferroptosis of keratinocyte in SJS/TEN
Exosomal <i>miR-375-3p</i> mediated lipid metabolism, ferritinophagy and CoQ-dependent pathway contributes to the ferroptosis of keratinocyte in SJS/TEN Open
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) manifest life-threatening cutaneous adverse drug reactions characterized by keratinocyte death. Previous studies have indicated that apoptosis and necroptosis are implicat…
View article: Keratin 17 covalently binds to alpha-enolase and exacerbates proliferation of keratinocytes in psoriasis
Keratin 17 covalently binds to alpha-enolase and exacerbates proliferation of keratinocytes in psoriasis Open
Dysregulated glucose metabolism is an important characteristic of psoriasis. Cytoskeletal protein keratin 17 (K17) is highly expressed in the psoriatic epidermis and contributes to psoriasis pathogenesis. However, whether K17 is involved i…
View article: Keratin 17 Is Required for Lipid Metabolism in Keratinocytes and Benefits Epidermal Permeability Barrier Homeostasis
Keratin 17 Is Required for Lipid Metabolism in Keratinocytes and Benefits Epidermal Permeability Barrier Homeostasis Open
The epidermal barrier refers to the stratum corneum, the uppermost layer of the skin, and constitutes the first line of defense against invasion by potentially harmful pathogens, diminishes trans -epidermal water loss, and plays a crucial …