Bin Wu
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View article: Translation elongation: measurements and applications
Translation elongation: measurements and applications Open
Translation converts genetic information in mRNAs into functional proteins. This process occurs in four major steps: initiation, elongation, termination and ribosome recycling; each of which profoundly impacts mRNA stability and protein yi…
View article: Correlation study between GC–MS analysis of cigarette aroma compounds and sensory evaluation
Correlation study between GC–MS analysis of cigarette aroma compounds and sensory evaluation Open
An effective complex aroma was obtained using a solvent-assisted flavor evaporation pretreatment method, and volatile flavor substances were obtained by gas chromatography–mass spectrometry (GC–MS). The nine attribute flavor characteristic…
View article: Application effect of psychological counseling intervention based on WeChat platform in chemotherapy of gastrointestinal tumors with completely implanted venous infusion ports
Application effect of psychological counseling intervention based on WeChat platform in chemotherapy of gastrointestinal tumors with completely implanted venous infusion ports Open
This study’s objective was to observe the application effect of psychological counseling intervention based on the WeChat platform for patients with gastrointestinal tumors undergoing chemotherapy with completely implanted venous infusion …
View article: Poly-GR repeats associated with ALS/FTD gene <i>C9ORF72</i> impair translation elongation and induce a ribotoxic stress response in neurons
Poly-GR repeats associated with ALS/FTD gene <i>C9ORF72</i> impair translation elongation and induce a ribotoxic stress response in neurons Open
Hexanucleotide repeat expansion in the C9ORF72 gene is the most frequent inherited cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The expansion results in multiple dipeptide repeat proteins, among which arg…
View article: A rapid inducible RNA decay system reveals fast mRNA decay in P-bodies
A rapid inducible RNA decay system reveals fast mRNA decay in P-bodies Open
RNA decay is vital for regulating mRNA abundance and gene expression. Existing technologies lack the spatiotemporal precision or transcript specificity to capture the stochastic and transient decay process. We devise a general strategy to …
View article: Bidirectional Transcription at the <scp><i>PPP2R2B</i></scp> Gene Locus in Spinocerebellar Ataxia Type 12
Bidirectional Transcription at the <span><i>PPP2R2B</i></span> Gene Locus in Spinocerebellar Ataxia Type 12 Open
Background Spinocerebellar ataxia type 12 (SCA12) is a neurodegenerative disease caused by expansion of a CAG repeat in the PPP2R2B gene. Objective In this study, we tested the hypothesis that the PPP2R2B antisense ( PPP2R2B‐AS1 ) transcri…
View article: A Rapid Inducible RNA Decay system reveals fast mRNA decay in P-bodies
A Rapid Inducible RNA Decay system reveals fast mRNA decay in P-bodies Open
RNA decay plays a crucial role in regulating mRNA abundance and gene expression. Modulation of RNA degradation is imperative to investigate an RNA’s function. However, information regarding where and how RNA decay occurs remains scarce, pa…
View article: Bidirectional transcription at the<i>PPP2R2B</i>gene locus in spinocerebellar ataxia type 12
Bidirectional transcription at the<i>PPP2R2B</i>gene locus in spinocerebellar ataxia type 12 Open
OBJECTIVE Spinocerebellar ataxia type 12 (SCA12) is a neurodegenerative disease caused by expansion of a CAG repeat in the PPP2R2B gene . Here we tested the hypothesis that the PPP2R2B antisense ( PPP2R2B-AS1 ) transcript containing a CUG …
View article: Post‐hospitalization rehabilitation alleviates long‐term immune repertoire alteration in COVID‐19 convalescent patients
Post‐hospitalization rehabilitation alleviates long‐term immune repertoire alteration in COVID‐19 convalescent patients Open
The global pandemic of Coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is an once‐in‐a‐lifetime public health crisis. Among hundreds of millions of people who have contracted with …
View article: Comparative transcriptome analyses of immune responses to LPS in peripheral blood mononuclear cells from the giant panda, human, mouse, and monkey
Comparative transcriptome analyses of immune responses to LPS in peripheral blood mononuclear cells from the giant panda, human, mouse, and monkey Open
Gram-negative bacteria are major pathogens that can cause illnesses in giant pandas. Lipopolysaccharides (LPS), components of Gram-negative bacteria, can activate immune responses in mammals (i.e., humans and mice) through recognition by t…
View article: Adipokine C1q/Tumor Necrosis Factor- Related Protein 3 (CTRP3) Attenuates Intestinal Inflammation Via Sirtuin 1/NF-κB Signaling
Adipokine C1q/Tumor Necrosis Factor- Related Protein 3 (CTRP3) Attenuates Intestinal Inflammation Via Sirtuin 1/NF-κB Signaling Open
CTRP3 expression levels correlate negatively with intestinal inflammation in acute mouse colitis models and patients with IBD. CTRP3 may attenuate intestinal inflammation via SIRT1/NF-κB signaling. The manipulation of CTRP3 signaling, incl…
View article: Role of hippocampal circKcnk9 in visceral hypersensitivity and anxiety comorbidity of irritable bowel syndrome
Role of hippocampal circKcnk9 in visceral hypersensitivity and anxiety comorbidity of irritable bowel syndrome Open
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by recurrent visceral pain and altered bowel habits (diarrhea or constipation). However, the molecular and pathological mechanisms are poorly understood. Th…
View article: Dynamin is primed at endocytic sites for ultrafast endocytosis
Dynamin is primed at endocytic sites for ultrafast endocytosis Open
Dynamin mediates fission of vesicles from the plasma membrane during endocytosis. Typically, dynamin is recruited from the cytosol to endocytic sites, requiring seconds to tens of seconds. However, ultrafast endocytosis in neurons internal…
View article: Dynamin forms liquid-like condensates at synapses to support ultrafast endocytosis
Dynamin forms liquid-like condensates at synapses to support ultrafast endocytosis Open
Summary Endocytosis at synapses is accelerated by the pre-accumulation of Dynamin 1xA at the endocytic zone by Syndapin 1. However, it is unclear how these proteins support the ultrafast kinetics of endocytosis. Here we report that these p…
View article: Methyltransferase-like 3 modulates visceral hypersensitivity through regulating the nuclear export of circKcnk9 in YTHDC1-dependent manner
Methyltransferase-like 3 modulates visceral hypersensitivity through regulating the nuclear export of circKcnk9 in YTHDC1-dependent manner Open
Background: Accumulating evidence shows that N6-methyladenosine (m 6 A) modulators contribute to the process of chronic pain. However, the exact mechanisms of m 6 A writers involved in visceral hypersensitivity of Irritable bowel syndrome …
View article: Adipokine C1q/Tumor necrosis factor-Related Protein 3 (CTRP3) Attenuates Intestinal Inflammation via Histone Deacetylase Sirtuin 1 (SIRT1)/NF-κB Signaling
Adipokine C1q/Tumor necrosis factor-Related Protein 3 (CTRP3) Attenuates Intestinal Inflammation via Histone Deacetylase Sirtuin 1 (SIRT1)/NF-κB Signaling Open
BACKGROUND & AIMS The adipokine C1q/tumor necrosis factor-related protein 3 (CTRP3) has anti-inflammatory effects in several non-intestinal disorders. Although CTRP3 is reduced in the serum of patients with inflammatory bowel disease (IBD)…
View article: Health-related quality of life among Chinese patients with Crohn’s disease: a cross-sectional survey using the EQ-5D-5L
Health-related quality of life among Chinese patients with Crohn’s disease: a cross-sectional survey using the EQ-5D-5L Open
Background Crohn’s disease (CD) is a chronic disease that may have an adverse impact on health-related quality of life (HRQoL). This study aimed to describe the HRQoL of CD patients and assess correlating factors using the EQ-5D-5L in Chin…
View article: Inhibition of Microbiota-dependent Trimethylamine N-Oxide Production Ameliorates High Salt Diet-Induced Sympathetic Excitation and Hypertension in Rats by Attenuating Central Neuroinflammation and Oxidative Stress
Inhibition of Microbiota-dependent Trimethylamine N-Oxide Production Ameliorates High Salt Diet-Induced Sympathetic Excitation and Hypertension in Rats by Attenuating Central Neuroinflammation and Oxidative Stress Open
Excessive dietary salt intake induces neuroinflammation and oxidative stress in the brain, which lead to sympathetic excitation, contributing to hypertension. However, the underlying mechanisms remain elusive. Accumulating evidence reveals…
View article: Epigenetic Landscapes of Single-Cell Chromatin Accessibility and Transcriptomic Immune Profiles of T Cells in COVID-19 Patients
Epigenetic Landscapes of Single-Cell Chromatin Accessibility and Transcriptomic Immune Profiles of T Cells in COVID-19 Patients Open
T cells play a critical role in coronavirus diseases. How they do so in COVID-19 may be revealed by analyzing the epigenetic chromatin accessibility of cis- and trans-regulatory elements and creating transcriptomic immune profiles. We perf…