Bin Wu
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View article: Case Report: Adenosine-induced atrioventricular dissociation: unmasking monomorphic tachycardia as a diagnostic challenge in a neonate
Case Report: Adenosine-induced atrioventricular dissociation: unmasking monomorphic tachycardia as a diagnostic challenge in a neonate Open
Background Neonatal monomorphic tachycardia poses a diagnostic challenge. This report demonstrates how adenosine-induced AV dissociation confirmed ventricular tachycardia. Case A 3-day-old preterm neonate (34 + 2 weeks) presented with refr…
View article: The growth-promoting role of the intestinal microbiota in Opsariichthys bidens: implications for selective breeding
The growth-promoting role of the intestinal microbiota in Opsariichthys bidens: implications for selective breeding Open
Differences in growth rates are commonly observed within cultured populations of the Opsariichthys bidens . In this study, we investigated the role of the intestinal microbiota in the growth and development of O. bidens by comparing two po…
View article: Risk Factors Associated With Venous Thromboembolism in Individuals With COPD: A Systematic Review and Meta-analysis
Risk Factors Associated With Venous Thromboembolism in Individuals With COPD: A Systematic Review and Meta-analysis Open
Objective Currently, no comprehensive analysis of the risk factors for venous thromboembolism (VTE) in chronic obstructive pulmonary disease (COPD) patients has been reported. We aimed to explore the risk factors for VTE among individuals …
View article: Integrated Metabolomic and Transcriptomic Analysis Identifies Candidate Regulatory Networks in Bone Metabolic Dysregulation of Osteoarthritis
Integrated Metabolomic and Transcriptomic Analysis Identifies Candidate Regulatory Networks in Bone Metabolic Dysregulation of Osteoarthritis Open
Osteoarthritis (OA) represents a prevalent articular condition characterized by significant disturbances in bone metabolic balance, yet the molecular pathways governing these skeletal alterations remain inadequately defined.This study cond…
View article: Baseline characteristics of patients in the Chinese Bronchiectasis Registry (BE-China): a multicentre prospective cohort study
Baseline characteristics of patients in the Chinese Bronchiectasis Registry (BE-China): a multicentre prospective cohort study Open
For the Chinese translation of the abstract see Supplementary Materials section.
View article: Neuromuscular and balance adaptations following acute stretching exercise: a randomized control trial
Neuromuscular and balance adaptations following acute stretching exercise: a randomized control trial Open
Purpose This study aimed to examine the acute effects of static stretching (SS) and dynamic stretching (DS) on neuromuscular function and balance in recreationally active men. Method Sixty participants were randomly assigned to SS, DS, or …
View article: The malic acid inhibiting inflammation in ankylosing spondylitis by interfering M1 macrophage polarization
The malic acid inhibiting inflammation in ankylosing spondylitis by interfering M1 macrophage polarization Open
Ankylosing spondylitis (AS) is a motor system immune disease with significant genetic characteristics, resulting in joint fusion, deformity, rigidity, seriously affecting the quality of life of patients. Inflammatory bowel disease (IBD), c…
View article: Benthic Microbes on the Shore of Southern Lake Taihu Exhibit Ecological Significance and Toxin-Producing Potential Through Comparison with Planktonic Microbes
Benthic Microbes on the Shore of Southern Lake Taihu Exhibit Ecological Significance and Toxin-Producing Potential Through Comparison with Planktonic Microbes Open
Water quality and aquatic ecosystems along lakeshores are vital for ecological balance and human well-being. However, research has primarily focused on plankton, with benthic niches being largely overlooked. To enhance understanding of ben…
View article: Five states of reduction in OTA/AO A1.3 intertrochanteric fractures of the femur a biomechanical study
Five states of reduction in OTA/AO A1.3 intertrochanteric fractures of the femur a biomechanical study Open
Positive support of the medial cortex can be regarded as the best reduction state for OTA/AO 31A1.3 intertrochanteric fractures, suggesting that this approach should be preferred during surgery to enhance mechanical stability and improve c…
View article: Muscular toxicity of colchicine combined with statins: a real-world study based on the FDA adverse event reporting system database from 2004–2023
Muscular toxicity of colchicine combined with statins: a real-world study based on the FDA adverse event reporting system database from 2004–2023 Open
Background Through an analysis of the Food and Drug Administration Adverse Event Reporting System (FAERS), we explored the signal strength of adverse reactions (ADRs) related to myopathy caused by the combination of colchicine and statins …
View article: Gut microbiota composition and functional classification in preschool children with allergic rhinitis and functional constipation
Gut microbiota composition and functional classification in preschool children with allergic rhinitis and functional constipation Open
Objective Studies suggest that functional constipation (FC) is more common in preschool children with allergic rhinitis (AR) compared to those without. FC can significantly impact a child's quality of life. This study investigated the rela…
View article: Bioinformatics analysis and experimental validation of key genes associated with lumbar disc degeneration and biomechanics
Bioinformatics analysis and experimental validation of key genes associated with lumbar disc degeneration and biomechanics Open
This study presented a new approach to investigate the correlation between biomechanical mechanisms and LDD. The deterioration of the biomechanical environment may cause LDD through the TGF-β signaling pathway. TGFB1 and SMAD3 are importan…
View article: Contribution of serum level of CCL28 in the diagnosis and evaluation of Sjögren’s syndrome
Contribution of serum level of CCL28 in the diagnosis and evaluation of Sjögren’s syndrome Open
Through the detection of changes in serum CCL28 content in Sjögren's syndrome (SS), we explored the significance of CCL28 in disease diagnosis and evaluation. Serum samples were collected from patients with SS, rheumatoid arthritis (RA), a…
View article: A 6-week, phase IIb, randomized, double-blind, placebo-controlled trial of Anyu Peibo capsules for the treatment of major depressive disorder in adults
A 6-week, phase IIb, randomized, double-blind, placebo-controlled trial of Anyu Peibo capsules for the treatment of major depressive disorder in adults Open
Background: Almost one-third of patients with major depressive disorder (MDD) do not respond to conventional antidepressants, and new treatments for MDD are urgently needed. Objectives: This phase IIb clinical trial was designed to evaluat…
View article: The potential of Chinese medicines in the treatment of hyperuricemia.
The potential of Chinese medicines in the treatment of hyperuricemia. Open
The annual incidence of gout is increasing along with lifestyle and dietary changes. Accumulation of urate crystals in joints and tissues when the amount of uric acid exceeds its saturation concentration causes acute inflammation that lead…
View article: Orai1 overexpression improves sepsis-induced T-lymphocyte immunosuppression and acute organ dysfunction in mice
Orai1 overexpression improves sepsis-induced T-lymphocyte immunosuppression and acute organ dysfunction in mice Open
Immune paralysis induced by sepsis, especially dysfunction of CD4+ T cells, leads to an increased risk of infection. In sepsis, abnormal differentiation of T lymphocytes is associated with multiorgan dysfunction syndrome. In T lymphocytes,…
View article: Detecting potential mechanism of vitamin D in treating rheumatoid arthritis based on network pharmacology and molecular docking
Detecting potential mechanism of vitamin D in treating rheumatoid arthritis based on network pharmacology and molecular docking Open
Aim: Vitamin D plays a vital role in Rheumatoid arthritis (RA). However, the mechanism of vitamin D and rheumatism is still unclear. Therefore, a strategy based on network pharmacology and molecular docking was used to explore the mechanis…
View article: Expression and regulatory characteristics of peripheral blood immune cells in primary Sjögren’s syndrome patients using single-cell transcriptomic
Expression and regulatory characteristics of peripheral blood immune cells in primary Sjögren’s syndrome patients using single-cell transcriptomic Open
Immune cell subgroups in peripheral blood mononuclear cells (PBMCs) in primary Sjogren's syndrome (pSS) are thought to regulate immune responses, but the nature and functions of these subgroups remain unclear. Here we performed single-cell…
View article: The bridge of the gut–joint axis: Gut microbial metabolites in rheumatoid arthritis
The bridge of the gut–joint axis: Gut microbial metabolites in rheumatoid arthritis Open
Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint destruction, synovitis, and pannus formation. Gut microbiota dysbiosis may exert direct pathogenic effects on gut homeostasis. It may trigger the host’s innate immun…
View article: Decoding the Mechanism of CheReCunJin Formula in Treating Sjögren’s Syndrome Based on Network Pharmacology and Molecular Docking
Decoding the Mechanism of CheReCunJin Formula in Treating Sjögren’s Syndrome Based on Network Pharmacology and Molecular Docking Open
Background. Sjögren’s syndrome (SS) is a chronic autoimmune disease characterized by progressive oral and ocular dryness that correlates poorly with autoimmune damage to the glands. CheReCunJin (CRCJ) formula is a prescription formulated a…
View article: Medication Rules in Herbal Medicine for Mild Cognitive Impairment: A Network Pharmacology and Data Mining Study
Medication Rules in Herbal Medicine for Mild Cognitive Impairment: A Network Pharmacology and Data Mining Study Open
Background. Although traditional Chinese medicine (TCM) has good efficacy in the treatment of mild cognitive impairment (MCI), especially memory improvement and safety, its substance basis and intervention mechanism are particularly comple…
View article: Study on spatial diversity and influencing factors of Tunpu settlement in Qianzhong
Study on spatial diversity and influencing factors of Tunpu settlement in Qianzhong Open
The Qianzhong Tunpu settlement in China is a historical product of the co-evolution and development of the military defense policies of the Ming Dynasty (1368-1644 AD) such as the station troops and station farms and the unique geographica…
View article: Systemic lupus erythematosus after delivery and myasthenia gravis with COL6A1 gene mutation: A case report
Systemic lupus erythematosus after delivery and myasthenia gravis with COL6A1 gene mutation: A case report Open
The coexistence of systemic lupus erythematosus (SLE) and myasthenia gravis (MG) is rarely reported, especially the appearance of SLE before MG. In addition to the production of autoantibodies after thymectomy, gene mutation may be an impo…
View article: Effect of Electroacupuncture on Gut Microbiota in Participants With Knee Osteoarthritis
Effect of Electroacupuncture on Gut Microbiota in Participants With Knee Osteoarthritis Open
A close relationship between knee osteoarthritis (KOA) and gut microbiota has recently been described. Herein, we aim to investigate the effect of electroacupuncture (EA) on gut microbiota in participants with KOA. We conducted a study of …
View article: Association of antibiotics use in preschool age with atopic and allergic skin diseases in young adulthood: a population-based retrospective cohort study
Association of antibiotics use in preschool age with atopic and allergic skin diseases in young adulthood: a population-based retrospective cohort study Open
Background Overuse and misuse of antibiotics is a public health problem in low-income and middle-income countries. Although the association of antibiotics with atopic and allergic diseases has been established, most studies focused on pren…