Binit Kumar Singh
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View article: P-2077. Carbapenemase Resistance Detection by Direct Xpert Carba-R Assay on Flagged Blood Cultures
P-2077. Carbapenemase Resistance Detection by Direct Xpert Carba-R Assay on Flagged Blood Cultures Open
Background Early detection of carbapenem-resistant gram negative bacilli(CR-GNB) is critical in patients with sepsis. Delay in diagnosis leads to higher mortality. We evaluated the performance of the Xpert® Carba-R assay (Cepheid, Sunnyval…
View article: Evaluation of GeneNAT Real-Time Polymerase Chain Reaction Analyzer and Pre-loaded Chip-Based Mycobacterium tuberculosis and Multidrug-Resistant Tuberculosis Detection in the Diagnosis of Pulmonary Tuberculosis
Evaluation of GeneNAT Real-Time Polymerase Chain Reaction Analyzer and Pre-loaded Chip-Based Mycobacterium tuberculosis and Multidrug-Resistant Tuberculosis Detection in the Diagnosis of Pulmonary Tuberculosis Open
View article: Diagnostics Evaluation of Smart Sure™ Mycobacterium tuberculosis Screening Kit and Smart Sure™ Multidrug-resistant Tuberculosis Detection Kit on Nonsputum Specimens at a Tertiary Care Center of North India
Diagnostics Evaluation of Smart Sure™ Mycobacterium tuberculosis Screening Kit and Smart Sure™ Multidrug-resistant Tuberculosis Detection Kit on Nonsputum Specimens at a Tertiary Care Center of North India Open
Background: Tuberculosis (TB) is caused due to the infection of Mycobacterium tuberculosis (MTB) and it can infect the various parts of the human body. The disease is highly prevalent and is the second most common cause of death worldwide …
View article: Evaluation of Loop-Mediated Isothermal Amplification Assay in Diagnosing Tuberculous Meningitis
Evaluation of Loop-Mediated Isothermal Amplification Assay in Diagnosing Tuberculous Meningitis Open
View article: 1879. Paradoxical Reaction in Lymph Node Tuberculosis among HIV-negative Patients: Incidence, Predictive Factors, and Clinical Outcomes
1879. Paradoxical Reaction in Lymph Node Tuberculosis among HIV-negative Patients: Incidence, Predictive Factors, and Clinical Outcomes Open
Background The aim of this study is to evaluate the occurrence of paradoxical reactions (PRs), cytokine levels and outcome in HIV-negative lymphnode tuberculosis (TB) patients. Methods This is a prospective observational study conducted at…
View article: Evaluation of kit-based loop-mediated isothermal amplification (TB-LAMP) assay in the diagnosis of tubercular lymphadenitis
Evaluation of kit-based loop-mediated isothermal amplification (TB-LAMP) assay in the diagnosis of tubercular lymphadenitis Open
Background. The rapid and accurate diagnosis of tubercular lymphadenitis remains a challenging task today. The World Health Organization (WHO) endorsed the LoopAMP MTBC kit (TB-LAMP) as a replacement for sputum smear microscopy in the diag…
View article: Evaluation of kit-based loop-mediated isothermal amplification (TB-LAMP) assay in the diagnosis of tubercular lymphadenitis
Evaluation of kit-based loop-mediated isothermal amplification (TB-LAMP) assay in the diagnosis of tubercular lymphadenitis Open
Background: The rapid and accurate diagnosis of tubercular lymphadenitis remains a challenging task today.WHO endorsed LoopAMP™ MTBC kit (TB-LAMP) as a replacement for sputum-smear microscopy in the diagnosis of pulmonary tuberculosis (PTB…
View article: Evaluation of kit-based loop-mediated isothermal amplification (TB-LAMP) assay in the diagnosis of tubercular lymphadenitis
Evaluation of kit-based loop-mediated isothermal amplification (TB-LAMP) assay in the diagnosis of tubercular lymphadenitis Open
Background: The rapid and accurate diagnosis of tubercular lymphadenitis remains a challenging task today.WHO endorsed LoopAMP™ MTBC kit (TB-LAMP) as a replacement for sputum-smear microscopy in the diagnosis of pulmonary tuberculosis (PTB…
View article: Prevention of relapse in drug sensitive pulmonary tuberculosis patients with and without vitamin D3 supplementation: A double blinded randomized control clinical trial
Prevention of relapse in drug sensitive pulmonary tuberculosis patients with and without vitamin D3 supplementation: A double blinded randomized control clinical trial Open
Background The immunomodulatory effects of vitamin D are widely recognized and a few studies have been conducted to determine its utility in the treatment of tuberculosis, with mixed results. This study was conducted to see if vitamin D su…
View article: Prevention of relapse in Drug Sensitive Pulmonary Tuberculosis patients with and without Vitamin D3 supplementation: A double blinded randomized control clinical trial
Prevention of relapse in Drug Sensitive Pulmonary Tuberculosis patients with and without Vitamin D3 supplementation: A double blinded randomized control clinical trial Open
Background: The immunomodulatory effects of vitamin D are widely recognized and a few studies have been conducted to determine its utility in the treatment of tuberculosis, with mixed results. This study was conducted to see if vitamin D s…
View article: Species Identification of Non-tuberculous Mycobacteria (NTM) from Sputum Samples of TB Suspects in a Tertiary Care Centre from North India
Species Identification of Non-tuberculous Mycobacteria (NTM) from Sputum Samples of TB Suspects in a Tertiary Care Centre from North India Open
Purpose: Non-tuberculous Mycobacteria (NTM) infections are often misdiagnosed as tuberculosis due to the similar clinical and radiological presentations.NTM infections can be differentiated from tuberculosis only through species identifica…
View article: Comparative Performance of Line Probe Assay (Version 2) and Xpert MTB/RIF Assay for Early Diagnosis of Rifampicin-Resistant Pulmonary Tuberculosis
Comparative Performance of Line Probe Assay (Version 2) and Xpert MTB/RIF Assay for Early Diagnosis of Rifampicin-Resistant Pulmonary Tuberculosis Open
We conclude that although Xpert MTB/RIF assay is comparatively superior to LPA in detecting Mtb among AFB smear-negative pulmonary TB. However, both tests are equally efficient in early diagnosis of AFB smear-positive presumptive RR-TB pat…
View article: Choosing the therapy for neurological infection with rapidly growing mycobacteria
Choosing the therapy for neurological infection with rapidly growing mycobacteria Open
The management of neurological infections due to non-tubercular mycobacteria is extremely challenging because of scarce literature, issues with penetration, lack of easily available susceptibility platforms and adverse effects associated w…
View article: Diagnostic Evaluation of Non-Interpretable Results Associated with rpoB Gene in Genotype MTBDRplus Ver 2.0
Diagnostic Evaluation of Non-Interpretable Results Associated with rpoB Gene in Genotype MTBDRplus Ver 2.0 Open
The present study showed that the results of the Genotype MTBDRplus assay were NI in a small proportion of isolates. pDST and rpoB sequencing were useful in elucidating the cause and clinical meaning of the NI results.
View article: Gargle lavage as a viable alternative to swab for detection of SARS-CoV-2
Gargle lavage as a viable alternative to swab for detection of SARS-CoV-2 Open
Background & objectives: Nasopharyngeal and oropharyngeal swab (NPS and OPS) collection is widely accepted as the preferred method for obtaining respiratory samples. However, it has certain disadvantages which may be overcome by gargling. …
View article: Persistent Laparoscopic Port-site Discharging Sinus
Persistent Laparoscopic Port-site Discharging Sinus Open
Laparoscopic port-site infections, though infrequent, undermine the advantages provided by minimally invasive surgeries. Persistent nonhealing discharging sinuses, not responding to conventional antibiotic therapy, pose diagnostic and ther…
View article: A prospective study of non-tuberculous mycobacterial disease among tuberculosis suspects at a tertiary care centre in north India
A prospective study of non-tuberculous mycobacterial disease among tuberculosis suspects at a tertiary care centre in north India Open
Background & objectives: The burden of non-tuberculous mycobacterial (NTM) disease is increasing worldwide. The disease shares clinicoradiological features with tuberculosis (TB), Nocardia and several fungal diseases, and its diagnosis is …
View article: 2156. To Evaluate the Role of Kit-Based Loop-Mediated Isothermal Amplification (TB-LAMP) Assay in the Diagnosis of Tubercular Lymphadenitis
2156. To Evaluate the Role of Kit-Based Loop-Mediated Isothermal Amplification (TB-LAMP) Assay in the Diagnosis of Tubercular Lymphadenitis Open
Background Tuberculosis (TB) is the leading cause of death as a single infectious agent worldwide. In 2017, there were an estimated 1.3 million TB deaths among HIV-negative people and 300,000 deaths among HIV-positive people. The rapid and…
View article: Evaluation comparative study of analgesic effect of breast feeding and dextrose of the heel lance in neonates
Evaluation comparative study of analgesic effect of breast feeding and dextrose of the heel lance in neonates Open
View article: High degree of fluoroquinolone resistance among pulmonary tuberculosis patients in New Delhi, India
High degree of fluoroquinolone resistance among pulmonary tuberculosis patients in New Delhi, India Open
Background & objectives: The fluoroquinolones (FQs) group of antibiotics is the backbone drugs for the management of drug-resistant tuberculosis (TB). In routine clinical practice, drug susceptibility testing (DST) for FQs is not performed…
View article: Presence of Fluoroquinolone mono-resistance among drug-sensitive Mycobacterium tuberculosis isolates: An alarming trend and implications
Presence of Fluoroquinolone mono-resistance among drug-sensitive Mycobacterium tuberculosis isolates: An alarming trend and implications Open
View article: Impact of nicotine replacement therapy as an adjunct to anti-tuberculosis treatment and behaviour change counselling in newly diagnosed pulmonary tuberculosis patients: an open-label, randomised controlled trial
Impact of nicotine replacement therapy as an adjunct to anti-tuberculosis treatment and behaviour change counselling in newly diagnosed pulmonary tuberculosis patients: an open-label, randomised controlled trial Open
View article: Diagnostic utility of a line probe assay for multidrug resistant-TB in smear-negative pulmonary tuberculosis
Diagnostic utility of a line probe assay for multidrug resistant-TB in smear-negative pulmonary tuberculosis Open
Genotype MTBDRplus VER 2.0 is a rapid and precise diagnostic tool for detection of MTB in sputum smear-negative samples. It also facilitates accurate diagnosis of RMP and INH resistance within turn around-time.
View article: Evaluating the Diagnostic Accuracy of Xpert MTB/RIF Assay in Pulmonary Tuberculosis
Evaluating the Diagnostic Accuracy of Xpert MTB/RIF Assay in Pulmonary Tuberculosis Open
Pulmonary tuberculosis still remains a major communicable disease worldwide. In 2013, 9 million people developed TB and 1.5 million people died from the disease. India constitutes 24% of the total TB burden. Early detection of TB cases is …