Binod Timalsina
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View article: Growth hormone is required for hippocampal engram cell maturation
Growth hormone is required for hippocampal engram cell maturation Open
Memory is stored in specialized cells known as engram cells, but the molecular mechanisms underlying this process remain unclear. We discovered that the initial translation leading to growth hormone (GH) synthesis in engram cells is requir…
View article: Malignant hyperthermia in a paediatric patient; managed successfully without dantrolene: a case report
Malignant hyperthermia in a paediatric patient; managed successfully without dantrolene: a case report Open
Introduction: Malignant hyperthermia (MH) is a potentially life-threatening pharmacogenetic syndrome triggered by volatile anaesthetics, succinylcholine, and stress such as vigorous exercise. Case presentation: The authors describe a case …
View article: Differential Effects of the Processed and Unprocessed Garlic (Allium sativum L.) Ethanol Extracts on Neuritogenesis and Synaptogenesis in Rat Primary Hippocampal Neurons
Differential Effects of the Processed and Unprocessed Garlic (Allium sativum L.) Ethanol Extracts on Neuritogenesis and Synaptogenesis in Rat Primary Hippocampal Neurons Open
Garlic (Allium sativum L.) is an aromatic herb known for its culinary and medicinal uses for centuries. Both unprocessed (white) and processed (black) garlic are known to protect against the pathobiology of neurological disorders such as A…
View article: N-Acetylglucosamine Kinase–Small Nuclear Ribonucleoprotein Polypeptide N Interaction Promotes Axodendritic Branching in Neurons via Dynein-Mediated Microtubule Transport
N-Acetylglucosamine Kinase–Small Nuclear Ribonucleoprotein Polypeptide N Interaction Promotes Axodendritic Branching in Neurons via Dynein-Mediated Microtubule Transport Open
N-acetylglucosamine kinase (NAGK) has been identified as an anchor protein that facilitates neurodevelopment with its non-canonical structural role. Similarly, small nuclear ribonucleoprotein polypeptide N (SNRPN) regulates neurodevelopmen…
View article: Neuronal Differentiation and Outgrowth Effect of Thymol in Trachyspermum ammi Seed Extract via BDNF/TrkB Signaling Pathway in Prenatal Maternal Supplementation and Primary Hippocampal Culture
Neuronal Differentiation and Outgrowth Effect of Thymol in Trachyspermum ammi Seed Extract via BDNF/TrkB Signaling Pathway in Prenatal Maternal Supplementation and Primary Hippocampal Culture Open
Reviving the neuronal functions in neurodegenerative disorders requires the promotion of neurite outgrowth. Thymol, which is a principal component of Trachyspermum ammi seed extract (TASE), is reported to have neuroprotective effects. Howe…
View article: Anesthetic management of congenital epulis in a newborn: a case report
Anesthetic management of congenital epulis in a newborn: a case report Open
Introduction: The epulis of the newborn is a granular cell tumor that originates from the mucosa of the gingiva. Case presentation: The authors report a case of a 4-day-old neonate with a large mass arising from the right upper gingival ar…
View article: Functional Characterization of a Regiospecific Sugar-<i>O</i>-Methyltransferase from<i>Nocardia</i>
Functional Characterization of a Regiospecific Sugar-<i>O</i>-Methyltransferase from<i>Nocardia</i> Open
ThnM1 is a putative sugar- O -methyltransferase produced by the Nocardia sp. strain CS682 and is encoded by a gene belonging to the biosynthetic gene cluster (BGC) of 1-(α- l -(2- O -methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphth…
View article: Inhibition Mechanism of Components Isolated from Morus alba Branches on Diabetes and Diabetic Complications via Experimental and Molecular Docking Analyses
Inhibition Mechanism of Components Isolated from Morus alba Branches on Diabetes and Diabetic Complications via Experimental and Molecular Docking Analyses Open
Previously, we reported the anti-diabetic effect of Morus alba root bark and the compounds therein. In our continuous study of other parts of this plant, the ability of the branch of Morus alba to inhibit α-glucosidase, protein tyrosine ph…
View article: Multidisciplinary approaches to coping with neurodegenerative disorders amid COVID-19 pandemic
Multidisciplinary approaches to coping with neurodegenerative disorders amid COVID-19 pandemic Open
Neurodegenerative disorders, including Alzheimers and Parkinsons, are the leading causes of dementia in the elderly. In the coming days, an alarming upsurge of dementia patients is expected with increasing life expectancy. This is the scen…
View article: Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety
Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety Open
Mounting evidence support the potential benefits of functional foods or nutraceuticals for human health and diseases. Black cumin (Nigella sativa L.), a highly valued nutraceutical herb with a wide array of health benefits, has attracted g…
View article: Roles of Cannabidiol in Reversing Proteinopathies
Roles of Cannabidiol in Reversing Proteinopathies Open
Cannabidiol is a well-known non-psychotropic phytocannabinoid from Cannabis sativa, which exerts a broad range of neuropharmacological activities in the central nervous systems. Over the past years, compelling evidence from preclinical and…
View article: Correlates of Selected Biochemical Markers of Bone turnover among Post-Menopausal Women
Correlates of Selected Biochemical Markers of Bone turnover among Post-Menopausal Women Open
Introduction: Bone turnover leading to osteoporosis and poor quality of life is common during post-menopausal period. Study of bone turnover markers that contribute to non-invasive assessment of bone-metabolic disorders holds an important …
View article: Prevalence and Factors Associated with Microalbuminuria among Type 2 Diabetic Patients : A Hospital Based Study
Prevalence and Factors Associated with Microalbuminuria among Type 2 Diabetic Patients : A Hospital Based Study Open
Introduction: Microalbuminuria is the earliest clinical evidence of diabetic nephropathy. However, prevalence and associated factors with microalbuminuria among type 2 diabetic patients has been understudied area of research in Nepalese co…
View article: Effect of Maternal Socio-demographic Factors and Child Feeding Practice on Wasting Among Under Five Years Children in Slum Area of Rupandehi District in Nepal
Effect of Maternal Socio-demographic Factors and Child Feeding Practice on Wasting Among Under Five Years Children in Slum Area of Rupandehi District in Nepal Open
Introduction: Childhood wasting although well studied elsewhere, it has not been well understood about in slum area of Nepal. This study aimed to assess effect of socio-demographic factors and child feeding practice in the determination of…
View article: A Study on Pattern of Growth in Height Among Children of Dhulikhel Municipality
A Study on Pattern of Growth in Height Among Children of Dhulikhel Municipality Open
Introduction: Growth reference charts are essential to assess appropriate growth of individual children. The height of an individual is the most widely accepted method for the evaluation of growth of the children. The child's height is pri…
View article: Prevalence of the absence of Palmaris longus muscle in the students of Kathmandu University
Prevalence of the absence of Palmaris longus muscle in the students of Kathmandu University Open
Background: Palmaris longus muscle is one of the superficial muscles of flexor compartment of forearm. Its main function is to anchor the skin and fascia of the hand. It is a weak flexor of the hand at wrist and tenses the palmar aponeuro…