Qian Bian
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View article: Subacute Inhalation Exposure of Mice to Ozone Induces Damage to Various Organs
Subacute Inhalation Exposure of Mice to Ozone Induces Damage to Various Organs Open
Ambient ozone (O3) pollution, which has become a global problem, is associated with damage to various biological systems, as determined by many studies. However, there is limited experimental evidence regarding the systemic damage induced …
View article: Airborne Microplastics from Plastic Manufacturing Industry: Concentrations and Characterisation Using Py-Gc/Ms and Hyperspectral Analysis
Airborne Microplastics from Plastic Manufacturing Industry: Concentrations and Characterisation Using Py-Gc/Ms and Hyperspectral Analysis Open
View article: The cmSCOPE Model: A simple adaptation of the SCOPE model to describe the vertically stratified heterogeneity of maize growth and stress dynamics
The cmSCOPE Model: A simple adaptation of the SCOPE model to describe the vertically stratified heterogeneity of maize growth and stress dynamics Open
View article: Transgenerational Response of Germline Nuclear Hormone Receptor Genes to Nanoplastics at Predicted Environmental Doses in Caenorhabditis elegans
Transgenerational Response of Germline Nuclear Hormone Receptor Genes to Nanoplastics at Predicted Environmental Doses in Caenorhabditis elegans Open
Transgenerational nanoplastic toxicity could be detected in Caenorhabditis elegans after exposure at the parental generation (P0-G); however, the underlying mechanisms remain largely unclear. We aimed to examine the role of germline nuclea…
View article: Mechanism of circRNA_SMG6 mediating lung macrophage ECM degradation via miR-570-3p in microplastics-induced emphysema
Mechanism of circRNA_SMG6 mediating lung macrophage ECM degradation via miR-570-3p in microplastics-induced emphysema Open
Microplastics (MPs) are plastic particles < 5 mm in diameter, of which polystyrene microplastics (PS-MPs) are representative type. The extracellular matrix (ECM) degradation of macrophages is associated with the development of emphysema. A…
View article: [Child with sitosterolemia initially presenting with hemolytic anemia and thrombocytopenia: a case repore and literrature review].
[Child with sitosterolemia initially presenting with hemolytic anemia and thrombocytopenia: a case repore and literrature review]. Open
This article focuses on a case study of sitosterolemia in a child who initially presented with hemolytic anemia and thrombocytopenia. Sitosterolemia is a rare autosomal recessive lipid metabolism disorder, difficult to diagnose due to its …
View article: Genotoxicity Evaluation of Titanium Dioxide Nanoparticles In Vivo and In Vitro: A Meta-Analysis
Genotoxicity Evaluation of Titanium Dioxide Nanoparticles In Vivo and In Vitro: A Meta-Analysis Open
Background: Recent studies have raised concerns about genotoxic effects associated with titanium dioxide nanoparticles (TiO2 NPs), which are commonly used. This meta-analysis aims to investigate the potential genotoxicity of TiO2 NPs and e…
View article: Analysis of Active Components and Antioxidant Activity of Lactobacillus casei Fermented Euryales ferox Supernatant
Analysis of Active Components and Antioxidant Activity of Lactobacillus casei Fermented Euryales ferox Supernatant Open
The changes of active components and antioxidant activity of the supernatant during Lactobacillus casei fermentation were studied using Euryales ferox as raw material. The pH, titratable acid, peptide yield, molecular weight distribution o…
View article: Nanoplastic Exposure at Predicted Environmental Concentrations Induces Activation of Germline Ephrin Signal Associated with Toxicity Formation in the Caenorhabditis elegans Offspring
Nanoplastic Exposure at Predicted Environmental Concentrations Induces Activation of Germline Ephrin Signal Associated with Toxicity Formation in the Caenorhabditis elegans Offspring Open
In nematode Caenorhabditis elegans, exposure to polystyrene nanoparticles (PS-NPs) at predicted environmental concentrations can cause induction of transgenerational toxicity. However, the underlying mechanisms for toxicity formation of PS…
View article: A study on the roles of long non-coding RNA and circular RNA in the pulmonary injuries induced by polystyrene microplastics
A study on the roles of long non-coding RNA and circular RNA in the pulmonary injuries induced by polystyrene microplastics Open
Microplastics (MPs) pollution has become a global concern due to its close relation to the environment and human health. Recently, more and more studies have pointed out the existence of MPs in the air, but its potential inhalation toxicit…
View article: Nanoplastics Cause Transgenerational Toxicity Through Inhibiting Germline Microrna Mir-38 in C. Elegans
Nanoplastics Cause Transgenerational Toxicity Through Inhibiting Germline Microrna Mir-38 in C. Elegans Open
View article: A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2
A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2 Open
Mutations and transient conformational movements of receptor binding domain (RBD) that make neutralizing epitopes momentarily unavailable, present immune escape routes to SARS-CoV-2. To mitigate viral escape, we developed a cocktail of neu…
View article: A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2
A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2 Open
Mutations and transient conformational movements of receptor binding domain (RBD) that make neutralizing epitopes momentarily unavailable, present immune escape routes to SARS-CoV-2. To mitigate viral escape, we developed a cocktail of neu…
View article: [Pathogenesis and diagnosis of hereditary stomatocytosis].
[Pathogenesis and diagnosis of hereditary stomatocytosis]. Open
View article: Brevilin A, a Natural Sesquiterpene Lactone Inhibited the Growth of Triple-Negative Breast Cancer Cells via Akt/mTOR and STAT3 Signaling Pathways
Brevilin A, a Natural Sesquiterpene Lactone Inhibited the Growth of Triple-Negative Breast Cancer Cells via Akt/mTOR and STAT3 Signaling Pathways Open
Zhao Qu,1 Yushan Lin,1 Daniel Kam-Wah Mok,1,2 Qingya Bian,3 William Chi-Shing Tai,1,2,4 Sibao Chen1– 3 1State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), Shenzhen Research Institute, The Hong Kong Poly…
View article: Correction to: Particulate matter 2.5 induced arrhythmogenesis mediated by TRPC3 in human induced pluripotent stem cell-derived cardiomyocytes
Correction to: Particulate matter 2.5 induced arrhythmogenesis mediated by TRPC3 in human induced pluripotent stem cell-derived cardiomyocytes Open
View article: LncRNA MALAT1, an lncRNA acting via the miR-204/ZEB1 pathway, mediates the EMT induced by organic extract of PM<sub>2.5</sub> in lung bronchial epithelial cells
LncRNA MALAT1, an lncRNA acting via the miR-204/ZEB1 pathway, mediates the EMT induced by organic extract of PM<sub>2.5</sub> in lung bronchial epithelial cells Open
Extensive cohort studies have explored the hazards of particulate matter with aerodynamic diameter 2.5 μm or smaller (PM 2.5 ) to human respiratory health; however, the molecular mechanisms for PM 2.5 carcinogenesis are poorly understood. …
View article: Real‐world study of tenofovir disoproxil fumarate to prevent hepatitis B transmission in mothers with high viral load
Real‐world study of tenofovir disoproxil fumarate to prevent hepatitis B transmission in mothers with high viral load Open
Summary Background Data on tenofovir disoproxil fumarate (TDF) therapy for preventing vertical transmission of hepatitis B virus (HBV) in the real‐world setting are limited. Aim To investigate TDF for preventing vertical transmission of HB…
View article: Study on systemic and reproductive toxicity of acetochlor in male mice
Study on systemic and reproductive toxicity of acetochlor in male mice Open
Acetochlor is one of the three most abundant herbicides used in China, which is a pre-emergence herbicide belonging to chloroacetanilides.
View article: Exosomal microRNA-21 derived from bronchial epithelial cells is involved in aberrant epithelium-fibroblast cross-talk in COPD induced by cigarette smoking
Exosomal microRNA-21 derived from bronchial epithelial cells is involved in aberrant epithelium-fibroblast cross-talk in COPD induced by cigarette smoking Open
Rationale: Aberrant bronchial epithelium-fibroblast communication is essential for the airway remodeling that contributes to chronic obstructive pulmonary disease (COPD). Exosomes have emerged as novel mediators of intercellular com…
View article: Chinese version of the Perceived Stress Scale-10: A psychometric study in Chinese university students
Chinese version of the Perceived Stress Scale-10: A psychometric study in Chinese university students Open
Chinese university students often suffer from acute stress, which can affect their mental health. We measured and evaluated perceived stress in this population using the Simplified Chinese version of the 10-item Perceived Stress Scale (SCP…
View article: Highly pathogenic avian influenza A virus H5N1 non‑structural protein 1 is associated with apoptotic activation of the intrinsic mitochondrial pathway
Highly pathogenic avian influenza A virus H5N1 non‑structural protein 1 is associated with apoptotic activation of the intrinsic mitochondrial pathway Open
Outbreaks of avian influenza A (H5N1) virus infection have significant health and economic consequences. Non-structural protein 1 (NS1) is an essential virulence factor of the highly pathogenic H5N1 avian influenza virus and of the apoptos…
View article: Multiplex Reverse-Transcription Loop-Mediated Isothermal Amplification Coupled with Cascade Invasive Reaction and Nanoparticle Hybridization for Subtyping of Influenza A Virus
Multiplex Reverse-Transcription Loop-Mediated Isothermal Amplification Coupled with Cascade Invasive Reaction and Nanoparticle Hybridization for Subtyping of Influenza A Virus Open
View article: Feedback circuitry via let-7c between lncRNA CCAT1 and c-Myc is involved in cigarette smoke extract-induced malignant transformation of HBE cells
Feedback circuitry via let-7c between lncRNA CCAT1 and c-Myc is involved in cigarette smoke extract-induced malignant transformation of HBE cells Open
Cigarette smoking is a primary risk factor for the development of lung cancer, which is regarded as the leading cause of cancer-related deaths. The process of malignant transformation of cells, however, is complex and elusive. The present …
View article: Analysis of plasma microRNA expression profiles in a Chinese population occupationally exposed to benzene and in a population with chronic benzene poisoning
Analysis of plasma microRNA expression profiles in a Chinese population occupationally exposed to benzene and in a population with chronic benzene poisoning Open
The four indicated plasma miRNAs may be biomarkers of indicating responses to benzene exposure. Further studies are warranted to verify our findings with a large sample and to confirm the underlying mechanisms.