Binxiao Su
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View article: Effect of remimazolam besylate versus midazolam on time to extubation in critically ill, mechanically ventilated patients: a randomized controlled trial
Effect of remimazolam besylate versus midazolam on time to extubation in critically ill, mechanically ventilated patients: a randomized controlled trial Open
Background Previous studies have indicated that the administration of short-acting sedatives prior to weaning from mechanical ventilation is linked to a more rapid recovery and extubation process, in addition to lowering intensive care uni…
View article: The study on effects of acute exposure to high altitude hypoxia on cognitive function in lowlander
The study on effects of acute exposure to high altitude hypoxia on cognitive function in lowlander Open
The investigation of cognitive functions in response to high-altitude exposure has garnered increasing scientific interest. However, it remains unclear whether cognitive abilities are selectively impaired or what are the trends of the func…
View article: Neonatal sevoflurane exposures inhibits DHHC5-mediated palmitoylation of TfR1 in oligodendrocytes, leading to hypomyelination and neurological impairments
Neonatal sevoflurane exposures inhibits DHHC5-mediated palmitoylation of TfR1 in oligodendrocytes, leading to hypomyelination and neurological impairments Open
We discovered that decreased DHHC5 in oligodendrocytes promotes TfR1 associated ferroptosis, resulting in hypomyelination and initiating neuronal ferroptosis, thereby impairing cognition following neonatal sevoflurane exposures. The transi…
View article: Sequential use of midazolam and Remimazolam besylate for sedation in critically ill, mechanically ventilated patients: a randomized controlled study
Sequential use of midazolam and Remimazolam besylate for sedation in critically ill, mechanically ventilated patients: a randomized controlled study Open
Background: Previous research has indicated that the administration of short-acting sedatives prior to weaning from mechanical ventilation is linked to a more rapid recovery and extubation process, as well as to lower intensive care unit (…
View article: LncRNA RPL29P2 promotes peritoneal fibrosis and impairs peritoneal transport function via miR-1184 in peritoneal dialysis
LncRNA RPL29P2 promotes peritoneal fibrosis and impairs peritoneal transport function via miR-1184 in peritoneal dialysis Open
Peritoneal dialysis (PD), hemodialysis and kidney transplantation are the three therapies to treat uremia. However, PD is discontinued for peritoneal membrane fibrosis (PMF) and loss of peritoneal transport function (PTF) due to damage fro…
View article: Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis
Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis Open
Importance Previous research has suggested that Xuebijing injection (XBJ), an herbal-based intravenous preparation, may reduce mortality among patients with sepsis. Objective To determine the effect of XBJ vs placebo on 28-day mortality am…
View article: Electroacupuncture Alleviate Lung Injury of Sepsis Through α7nAChR and NF-κB Signaling Pathway
Electroacupuncture Alleviate Lung Injury of Sepsis Through α7nAChR and NF-κB Signaling Pathway Open
Background Sepsis is the leading cause of death in hospitalized patients in the intensive care unit (ICU). Although substantial progress has been made in studies on the treatment of sepsis, the mortality rate remains extremely high. We hav…
View article: Effects of Nalbuphine on Gastrointestinal Function in Post-Operative Critical Ill Patients Admitted to the ICU: A Multicenter Randomized Controlled Trial
Effects of Nalbuphine on Gastrointestinal Function in Post-Operative Critical Ill Patients Admitted to the ICU: A Multicenter Randomized Controlled Trial Open
Background Gastrointestinal (GI) function can be a significant problem in critically ill patients and is associated with detrimental outcomes. The administration of opioids for pain reduction is thought to contribute to GI dysfunction. We …
View article: Optimal ambulatory vital sign targets in pulmonary hypertension pregnant women via time-dependent survival analysis
Optimal ambulatory vital sign targets in pulmonary hypertension pregnant women via time-dependent survival analysis Open
Objective To investigate the safe range of vital signs of pregnant women pulmonary hypertension (PH). Study design Retrospective study. Setting The largest First-class Hospital at grade 3 in Northwestern China Population pregnant women wit…
View article: Optimal Ambulatory Vital Sign Targets in Pulmonary Hypertension Pregnant Women via Time-Dependent Survival Analysis
Optimal Ambulatory Vital Sign Targets in Pulmonary Hypertension Pregnant Women via Time-Dependent Survival Analysis Open
Background: Pulmonary hypertension (PH) can cause complications in pregnant women due to significant hemodynamic fluctuation or right heart failure as well as death during pregnancy and postpartum. Those in critical condition would be sent…
View article: Analysis of Prognostic Relevance based on Ambulatory Vital Signs Among Pregnancy with Pulmonary Hypertension in the ICU
Analysis of Prognostic Relevance based on Ambulatory Vital Signs Among Pregnancy with Pulmonary Hypertension in the ICU Open
Purpose: The study seeks to utilise the extensively monitored data to explore the prognostic information in the continuous ambulatory vital signs of the pregnant women with pulmonary hypertension in the ICU, aiming to bring insights to phy…
View article: Microglia in the Pathophysiology of Hemorrhagic Stroke and the Relationship Between Microglia and Pain After Stroke: A Narrative Review
Microglia in the Pathophysiology of Hemorrhagic Stroke and the Relationship Between Microglia and Pain After Stroke: A Narrative Review Open
View article: Microglia: A Potential Therapeutic Target for Sepsis-Associated Encephalopathy and Sepsis-Associated Chronic Pain
Microglia: A Potential Therapeutic Target for Sepsis-Associated Encephalopathy and Sepsis-Associated Chronic Pain Open
Neurological dysfunction, one of the severe manifestations of sepsis in patients, is closely related to increased mortality and long-term complications in intensive care units, including sepsis-associated encephalopathy (SAE) and chronic p…
View article: Protocol of a randomized controlled trial testing inhaled Nitric Oxide in mechanically ventilated patients with severe acute respiratory syndrome in COVID-19 (SARS-CoV-2)
Protocol of a randomized controlled trial testing inhaled Nitric Oxide in mechanically ventilated patients with severe acute respiratory syndrome in COVID-19 (SARS-CoV-2) Open
Introduction Severe acute respiratory syndrome (SARS-CoV-2) due to novel Coronavirus (2019-nCoV) related infection (COVID-19) is characterized by severe ventilation perfusion mismatch leading to refractory hypoxemia. To date, there is no s…
View article: Protocol for a randomized controlled trial testing inhaled nitric oxide therapy in spontaneously breathing patients with COVID-19
Protocol for a randomized controlled trial testing inhaled nitric oxide therapy in spontaneously breathing patients with COVID-19 Open
Introduction the current worldwide outbreak of Coronavirus disease 2019 (COVID-19) due to a novel coronavirus (SARS-CoV-2) is seriously threatening the public health. The number of infected patients is continuously increasing and the need …
View article: Male sexual dysfunction: A review of literature on its pathological mechanisms, potential risk factors, and herbal drug intervention
Male sexual dysfunction: A review of literature on its pathological mechanisms, potential risk factors, and herbal drug intervention Open
View article: Inhibiting a spinal cord signaling pathway protects against ischemia injury in rats
Inhibiting a spinal cord signaling pathway protects against ischemia injury in rats Open
View article: Neuroprotective effect of endogenous cannabinoids on ischemic brain injury induced by the excess microglia-mediated inflammation.
Neuroprotective effect of endogenous cannabinoids on ischemic brain injury induced by the excess microglia-mediated inflammation. Open
Increasing evidence has demonstrated the role of endogenous cannabinoids system (ECS) on protecting brain injury caused by ischemia (IMI). Papers reported that microglia-mediated inflammation has become one of the most pivotal mechanisms f…