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View article: KLF13 promotes ferroptosis and chemosensitivity in lung adenocarcinoma
KLF13 promotes ferroptosis and chemosensitivity in lung adenocarcinoma Open
Our study reveals that KLF13 promotes ferroptosis in LUAD by inhibiting GPX4, thereby enhancing sensitivity to chemotherapy drugs. Overall, targeting KLF13 may contribute to developing new therapeutic strategies for LUAD.
View article: ZNF146 accelerates lung adenocarcinoma progression through MDM2/p53 and PHGDH/ferroptosis
ZNF146 accelerates lung adenocarcinoma progression through MDM2/p53 and PHGDH/ferroptosis Open
Background Lung adenocarcinoma (LUAD) remains a significant contributor to cancer incidence and mortality, with transcription factors playing pivotal roles in its progression and serving as potential therapeutic targets. Results Through an…
View article: NDRG1‐Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment
NDRG1‐Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment Open
Lung adenocarcinoma (LUAD) is a leading cause of cancer‐related mortality, with the tumor microenvironment (TME) playing a critical role in its progression. Metabolic reprogramming, particularly lactate accumulation, drives immune suppress…
View article: Sarcosine sensitizes lung adenocarcinoma to chemotherapy by dual activation of ferroptosis via PDK4/PDHA1 signaling and NMDAR-mediated iron export
Sarcosine sensitizes lung adenocarcinoma to chemotherapy by dual activation of ferroptosis via PDK4/PDHA1 signaling and NMDAR-mediated iron export Open
Background Ferroptosis, a regulated cell death driven by iron-dependent lipid peroxidation, is associated with chemoresistance in lung adenocarcinoma (LUAD). This study aims to investigate the role of sarcosine in ferroptosis and its under…
View article: <scp>miR</scp>‐30c‐5p inhibits esophageal squamous cell carcinoma progression by repressing the <scp>PI3K</scp>/<scp>AKT</scp> signaling pathway
<span>miR</span>‐30c‐5p inhibits esophageal squamous cell carcinoma progression by repressing the <span>PI3K</span>/<span>AKT</span> signaling pathway Open
Background Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors, with high incidence and poor prognosis. Revealing mechanisms of ESCC progression and developing new therapeutic targets remains crucial. The a…
View article: The associations between dysregulation of human blood metabolites and lung cancer risk: evidence from genetic data
The associations between dysregulation of human blood metabolites and lung cancer risk: evidence from genetic data Open
Background Metabolic dysregulation is recognized as a significant hallmark of cancer progression. Although numerous studies have linked specific metabolic pathways to cancer incidence, the causal relationship between blood metabolites and …
View article: NSUN5/TET2-directed chromatin-associated RNA modification of 5-methylcytosine to 5-hydroxymethylcytosine governs glioma immune evasion
NSUN5/TET2-directed chromatin-associated RNA modification of 5-methylcytosine to 5-hydroxymethylcytosine governs glioma immune evasion Open
Malignant glioma exhibits immune evasion characterized by highly expressing the immune checkpoint CD47. RNA 5-methylcytosine(m5C) modification plays a pivotal role in tumor pathogenesis. However, the mechanism underlying m5C-modified RNA m…
View article: Epidemiological characteristics and therapeutic advances of <scp>EGFR</scp> exon 20 insertion mutations in non‐small cell lung cancer
Epidemiological characteristics and therapeutic advances of <span>EGFR</span> exon 20 insertion mutations in non‐small cell lung cancer Open
The third most prevalent type of epidermal growth factor receptor ( EGFR ) mutation, EGFR exon 20 insertions (EGFRex20ins), involves 2%–12% of all cases of EGFR‐positive non‐small cell lung cancer (NSCLC). Approximately 90% of the mutation…