Explanipedia

STAT3 regulates the generation of astroglia in human brain organoids with high mTORC1 activity Open

Bipan Kumar Deb, Thomas L. Li, John D. Blair, Dirk Hockemeyer, Helen S. Bateup · 2023

During brain development, neural progenitor cells first produce neurons, then astrocytes and other glial cell types, which provide important trophic support and shape neuronal development and function. Intrinsic genetic programs interact w…

Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2+ Open

Pragnya Chakraborty, Bipan Kumar Deb, Vikas Arige, Thasneem Musthafa, Sundeep Malik , et al. · 2023

Loss of endoplasmic reticular (ER) Ca 2+ activates store-operated Ca 2+ entry (SOCE) by causing the ER localized Ca 2+ sensor STIM to unfurl domains that activate Orai channels in the plasma membrane at membrane contact sites (MCS). Here, …

Author response: Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2+ Open

Pragnya Chakraborty, Bipan Kumar Deb, Vikas Arige, Thasneem Musthafa, Sundeep Malik , et al. · 2022

Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Loss of…

Regulation of Store-Operated Ca 2+ Entry by IP 3 Receptors Independent of Their Ability to Release Ca 2+ Open

Pragnya Chakraborty, Bipan Kumar Deb, Vikas Arige, Thasneem Musthafa, Sundeep Malik , et al. · 2022

Loss of endoplasmic reticular (ER) Ca 2+ activates store-operated Ca 2+ entry (SOCE) by causing the ER localized Ca 2+ sensor STIM to unfurl domains that activate Orai channels in the plasma membrane at membrane contact sites (MCS). Here w…

Modeling Somatic Mutations Associated With Neurodevelopmental Disorders in Human Brain Organoids Open

Bipan Kumar Deb, Helen S. Bateup · 2022

Neurodevelopmental disorders (NDDs) are a collection of diseases with early life onset that often present with developmental delay, cognitive deficits, and behavioral conditions. In some cases, severe outcomes such as brain malformations a…

Regulation of Store-Operated Ca 2+ Entry by IP 3 Receptors Independent of Their Ability to Release Ca 2+ Open

Pragnya Chakraborty, Bipan Kumar Deb, Colin W. Taylor, Gaiti Hasan · 2021

A Multicomponent Neuronal Response Encodes the Larval Decision to Pupariate upon Amino Acid Starvation Open

Siddharth Jayakumar, Shlesha Richhariya, Bipan Kumar Deb, Gaiti Hasan · 2018

Organisms need to coordinate growth with development, particularly in the context of nutrient availability. Thus, multiple ways have evolved to survive extrinsic nutrient deprivation during development. In Drosophila , growth occurs during…

Correction: Publisher Correction: Store-independent modulation of Ca2+ entry through Orai by Septin 7 Open

Bipan Kumar Deb, Trayambak Pathak, Gaiti Hasan · 2018

Stable STIM1 Knockdown in Self-Renewing Human Neural Precursors Promotes Premature Neural Differentiation Open

Renjitha Gopurappilly, Bipan Kumar Deb, Pragnya Chakraborty, Gaiti Hasan · 2018

Ca²⁺ signaling plays a significant role in the development of the vertebrate nervous system where it regulates neurite growth as well as synapse and neurotransmitter specification. Elucidating the role of Ca²⁺ signali…

Regulation of Store-Operated Ca2+ Entry by Septins Open

Bipan Kumar Deb, Gaiti Hasan · 2016

The mechanism of store-operated Ca²⁺ entry (SOCE) brings extracellular Ca²⁺ into cells after depletion of intracellular Ca²⁺ stores. Regulation of Ca²⁺ homeostasis by SOCE helps control various i…

Mutant IP3 receptors attenuate store-operated Ca2+ entry by destabilizing STIM–Orai interactions in Drosophila neurons Open

Sumita Chakraborty, Bipan Kumar Deb, Tetyana Chorna, Vera Konieczny, Colin W. Taylor , et al. · 2016

Store-operated Ca2+ entry (SOCE) occurs when loss of Ca2+ from the endoplasmic reticulum (ER) stimulates the Ca2+ sensor, STIM, to cluster and activate the plasma membrane Ca2+ channel Orai (encoded by Olf186-F in flies). Inositol 1,4,5-tr…

Store-independent modulation of Ca2+ entry through Orai by Septin 7 Open

Bipan Kumar Deb, Trayambak Pathak, Gaiti Hasan · 2016

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