Bipinesh Sansar
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View article: Triple Oral Metronomic Chemotherapy Versus Chemotherapy of Physician Discretion After Failure of Platinum-Based Therapy in Advanced Head and Neck Cancer: A Phase III Randomized Study (METRO-CHASE Study)
Triple Oral Metronomic Chemotherapy Versus Chemotherapy of Physician Discretion After Failure of Platinum-Based Therapy in Advanced Head and Neck Cancer: A Phase III Randomized Study (METRO-CHASE Study) Open
PURPOSE Platinum-refractory advanced head and neck squamous cell carcinoma (HNSCC) has poor outcomes and limited treatment options, especially in resource-constrained settings. Triple oral metronomic chemotherapy (OMCT), involving low-dose…
View article: Navigating the Genetic Frontier: Establishing Genetic Clinics for Comprehensive Hereditary Cancer Management in Resource-Limited Settings
Navigating the Genetic Frontier: Establishing Genetic Clinics for Comprehensive Hereditary Cancer Management in Resource-Limited Settings Open
This review article explores the vital role of genetic clinics in the management of hereditary cancers, emphasizing their significance in early detection, tailored treatment, and family screening. It presents analysis of the prevalence of …
View article: 159eTiP Impact of on-demand training & audio-visual aids to improve referral rates for genetic counselling and/ testing at tertiary cancer centres (mainstreaming study)
159eTiP Impact of on-demand training & audio-visual aids to improve referral rates for genetic counselling and/ testing at tertiary cancer centres (mainstreaming study) Open
View article: 63eP Exploring endometrial stromal tumors: Diagnostic dilemmas and treatment paradigm
63eP Exploring endometrial stromal tumors: Diagnostic dilemmas and treatment paradigm Open
View article: Real-world data on trastuzumab emtansine (TDM1) efficacy and safety: Results of a single-centre retrospective study of HER2-positive metastatic breast cancer patients
Real-world data on trastuzumab emtansine (TDM1) efficacy and safety: Results of a single-centre retrospective study of HER2-positive metastatic breast cancer patients Open
View article: 79P Relevance of combined positive score (CPS) & low-dose immune checkpoint inhibitors (ICIs) in microsatellite stable (MSS) advanced gastric adenocarcinoma (GC): A multi-institution analysis
79P Relevance of combined positive score (CPS) & low-dose immune checkpoint inhibitors (ICIs) in microsatellite stable (MSS) advanced gastric adenocarcinoma (GC): A multi-institution analysis Open
View article: Unravelling Eribulin’s role in metastatic breast cancer: evaluating benefits for both triple negative and non-triple negative patients in real-world scenarios in resource-constrained settings
Unravelling Eribulin’s role in metastatic breast cancer: evaluating benefits for both triple negative and non-triple negative patients in real-world scenarios in resource-constrained settings Open
Eribulin is a viable and safe option for treating heavily pre-treated MBC in real-world settings. The study found comparable efficacy in both TNBC and non-TNBC patients.
View article: A physiotherapists perspective of geriatric clinic in a tertiary oncology centre
A physiotherapists perspective of geriatric clinic in a tertiary oncology centre Open
Commonly deranged domains included fatigue (97%), risk of fall (80%), reduced aerobic capacity (75%) and comorbidities (73%). The correlation between SPPB and POMA was assessed using Spearman's rank correlation method which obtained…
View article: Olanzapine as Antiemetic Prophylaxis in Moderately Emetogenic Chemotherapy
Olanzapine as Antiemetic Prophylaxis in Moderately Emetogenic Chemotherapy Open
Importance The role of olanzapine has not been adequately evaluated in moderately emetogenic chemotherapy (MEC) regimens with or without neurokinin-1 receptor antagonists. Objective To evaluate whether addition of olanzapine to an MEC regi…
View article: Docetaxel-oxaliplatin-capecitabine/5-fluorouracil (DOX/F) followed by docetaxel versus oxaliplatin-capecitabine/5-fluorouracil (CAPOX/FOLFOX) in HER2-negative advanced gastric cancers
Docetaxel-oxaliplatin-capecitabine/5-fluorouracil (DOX/F) followed by docetaxel versus oxaliplatin-capecitabine/5-fluorouracil (CAPOX/FOLFOX) in HER2-negative advanced gastric cancers Open
Background We evaluated whether the addition of docetaxel (D) to a combination comprising 5-fluorouracil/leucovorin (5-FU/LV) or capecitabine (C) plus oxaliplatin (O) (DOF/DOX) improved overall survival (OS) compared with 6 months of 5-flu…
View article: At Crossroads: The Challenges for Geriatric Oncology in India
At Crossroads: The Challenges for Geriatric Oncology in India Open
A larger percentage of our population is aging healthily and living on to a ripe old age. 60 years of age is taken as cut-off for identifying geriatric population for the purpose of specialized healthcare. The incidence of cancer is increa…
View article: Breast lymphomas: Clinical and pathological insights from a tertiary cancer care center in India
Breast lymphomas: Clinical and pathological insights from a tertiary cancer care center in India Open
Background: Breast lymphomas are a rare group of malignancies that are further subdivided into primary and secondary. AIMS: To study the pathological and clinical course of breast lymphomas. Materials and Methods: This is a retrospective a…
View article: An audit of metastatic tumors to the liver highlighting the spectrum of differential diagnosis: A retrospective study from a tertiary cancer center in North India
An audit of metastatic tumors to the liver highlighting the spectrum of differential diagnosis: A retrospective study from a tertiary cancer center in North India Open
Background: Space-occupying lesions of the liver can broadly be divided into benign and malignant and further as primary and metastatic lesions. Among the malignant lesions of the liver, metastatic lesions of unknown primary origin present…
View article: Molecular oncology and the role of artificial intelligence in advancing cancer treatment
Molecular oncology and the role of artificial intelligence in advancing cancer treatment Open
Artificial intelligence (AI) holds significant promise for advancing molecular oncology and improving personalized cancer care. This review highlights the numerous benefits of AI integration in various aspects of molecular oncology, from d…
View article: Incurable advanced salivary gland tumours: a retrospective analysis and peek into the perplexing clinical and molecular intricacies from a tertiary care centre in India
Incurable advanced salivary gland tumours: a retrospective analysis and peek into the perplexing clinical and molecular intricacies from a tertiary care centre in India Open
Our analysis highlights the variable disease biology of advanced salivary gland tumours and throws light on the various possible treatment targets and strategies. Molecular profiling and advancement in targeted therapies are expected to in…
View article: Pattern of Care and Outcomes of Gallbladder Cancer Patients: Retrospective Study from a High Incidence Region in India
Pattern of Care and Outcomes of Gallbladder Cancer Patients: Retrospective Study from a High Incidence Region in India Open
Introduction Gallbladder cancer (GBC) is the 20th most common cancer in India with a crude incidence rate of 2.3 per 100,000 persons. Of note, it is relatively common in states which fall in the Gangetic plains. Patients often present in t…
View article: Gestational Trophoblastic Neoplasia—A Retrospective Analysis of Patients Treated at a Tertiary Care Oncology Center in North India
Gestational Trophoblastic Neoplasia—A Retrospective Analysis of Patients Treated at a Tertiary Care Oncology Center in North India Open
Objectives The aim of this study was to do a retrospective analysis of patients of gestational trophoblastic neoplasia (GTN) treated at our center concerning their clinical features and treatment outcomes. Materials and Methods Patients di…
View article: Molecular Oncology and the Role of Artificial Intelligence in Advancing Cancer Treatment
Molecular Oncology and the Role of Artificial Intelligence in Advancing Cancer Treatment Open
View article: Neoadjuvant chemotherapy in technically unresectable head and neck cancers: a retrospective audit
Neoadjuvant chemotherapy in technically unresectable head and neck cancers: a retrospective audit Open
Our study shows that neoadjuvant chemotherapy in technically unresectable HNC patients can make the disease resectable in around one-third of the patients. The patients who could undergo surgery after neoadjuvant chemotherapy had significa…
View article: Lenvatinib
Lenvatinib Open
View article: A Pilot Study on the Addition of Tramadol or Eutectic Mixture of Local Anesthetics (Prilocaine Plus Lignocaine) to Local Lignocaine Infiltration for Prevention of Bone Marrow Aspiration/Biopsy Associated Pain
A Pilot Study on the Addition of Tramadol or Eutectic Mixture of Local Anesthetics (Prilocaine Plus Lignocaine) to Local Lignocaine Infiltration for Prevention of Bone Marrow Aspiration/Biopsy Associated Pain Open
Objectives Bone marrow aspiration although being a common procedure is associated with significant pain and its reduction remains an unmet need. We evaluated the use of tramadol and eutectic mixture of local anesthetics (prilocaine plus li…
View article: Evolving immunotherapy approaches and their efficacy based on gender of the patient
Evolving immunotherapy approaches and their efficacy based on gender of the patient Open
We read with interest the article titled, "Impact of sex of the patient on efficacy and safety of cancer immunotherapy: A retrospective audit,"[1] and the editorial by Khaddar and Mishra.[2] In this study, the authors explored a possible a…
View article: Follicular Lymphoma in Young Adults: Study from a Regional Cancer Center in South India
Follicular Lymphoma in Young Adults: Study from a Regional Cancer Center in South India Open
Objective Follicular lymphoma (FL) is a disease of the elderly. It is postulated that younger patients have distinct tumor biology and treatment outcomes. Various lymphoma groups across the world have studied this to understand if young ad…
View article: JAK-STAT inhibitor as a potential therapeutic opportunity in AML patients resistant to cytarabine and epigenetic therapy
JAK-STAT inhibitor as a potential therapeutic opportunity in AML patients resistant to cytarabine and epigenetic therapy Open
The prognosis of AML is generally poor, with 5-year survival rate of 25%. There has been substantial progress in identification of new therapeutic targets, along with approval of at least three targeted therapies for AML in recent years. N…
View article: Differences in disease characteristics and survival outcomes of follicular lymphoma in young adults and older population: An institutional analysis
Differences in disease characteristics and survival outcomes of follicular lymphoma in young adults and older population: An institutional analysis Open
View article: A pilot study on comparative efficacy of tramadol or eutectic mixture of local anaesthetics (prilocaine plus lignocaine) in preventing bone marrow aspiration associated pain
A pilot study on comparative efficacy of tramadol or eutectic mixture of local anaesthetics (prilocaine plus lignocaine) in preventing bone marrow aspiration associated pain Open