Explanipedia

Dual-energy lattice-tip ablation system for persistent atrial fibrillation: a randomized trial Open

Elad Anter, Moussa Mansour, Devi G. Nair, Dinesh C Sharma, Tyler L. Taigen , et al. · 2024

Medicine

Clinical outcomes of catheter ablation for atrial fibrillation (AF) are suboptimal due, in part, to challenges in achieving durable lesions. Although focal point-by-point ablation allows for the creation of any required lesion set, this st…

Pulsed Field Ablation for the Treatment of Atrial Fibrillation: PULSED AF Pivotal Trial Open

Atul Verma, David E. Haines, Lucas V.A. Boersma, Nitesh Sood, Andrea Natale , et al. · 2023

Medicine Physics

Background: Pulsed field ablation uses electrical pulses to cause nonthermal irreversible electroporation and induce cardiac cell death. Pulsed field ablation may have effectiveness comparable to traditional catheter ablation while prevent…

Effect of contact force on pulsed field ablation lesions in porcine cardiac tissue Open

Lars M. Mattison, Atul Verma, Khaldoun G. Tarakji, Tobias Reichlin, Gerhard Hindricks , et al. · 2023

Medicine Materials science Physics

Introduction Contact force has been used to titrate lesion formation for radiofrequency ablation. Pulsed field ablation (PFA) is a field‐based ablation technology for which limited evidence on the impact of contact force on lesion size is …

Effect of Contact Force on Pulsed Field Ablation Lesions in Porcine Cardiac Tissue Open

Daniel C. Sigg, Lars M. Mattison, Atul Verma, Khaldoun G. Tarakji, Tobias Reichlin , et al. · 2022

Materials science Medicine Physics

Background: Contact force has been used to titrate lesion formation for radiofrequency ablation. Pulsed Field Ablation (PFA) is a field-based ablation technology for which limited evidence on the impact of contact force on lesion size is a…

Effects of Electrode-Tissue Proximity on Cardiac Lesion Formation Using Pulsed Field Ablation Open

Brian Howard, Atul Verma, Wendy S. Tzou, Lars M. Mattison, Bor Kos , et al. · 2022

Materials science Medicine Chemistry

Background: Pulsed field ablation (PFA) is a novel energy modality for treatment of cardiac arrhythmias. The impact of electrode-tissue proximity on lesion formation by PFA has not been conclusively assessed. The objective of this investig…

Characterization of Phrenic Nerve Response to Pulsed Field Ablation Open

Brian Howard, David E. Haines, Atul Verma, Nicole Kirchhof, Noah Barka , et al. · 2022

Medicine

Background: Phrenic nerve palsy is a well-known complication of cardiac ablation, resulting from the application of direct thermal energy. Emerging pulsed field ablation (PFA) may reduce the risk of phrenic nerve injury but has not been we…

Safety and chronic lesion characterization of pulsed field ablation in a Porcine model Open

Mark T. Stewart, David E. Haines, Damijan Miklavčič, Bor Kos, Nicole Kirchhof , et al. · 2021

Medicine

Background Pulsed field ablation (PFA) has been identified as an alternative to thermal‐based ablation systems for treatment of atrial fibrillation patients. The objective of this Good Laboratory Practice (GLP) study was to characterize th…

Reduction in Pulmonary Vein Stenosis and Collateral Damage With Pulsed Field Ablation Compared With Radiofrequency Ablation in a Canine Model Open

Brian Howard, David E. Haines, Atul Verma, Douglas L. Packer, Nicole Kirchhof , et al. · 2020

Medicine

Background: Pulmonary vein (PV) stenosis is a highly morbid condition that can result after catheter ablation for PV isolation. We hypothesized that pulsed field ablation (PFA) would reduce PV stenosis risk and collateral injury compared w…

βIV-Spectrin regulates STAT3 targeting to tune cardiac response to pressure overload Open

Sathya D. Unudurthi, Drew Nassal, Amara Greer-Short, Nehal Patel, Taylor S. Howard , et al. · 2018

Biology Medicine

Heart failure (HF) remains a major source of morbidity and mortality in the US. The multifunctional Ca2+/calmodulin-dependent kinase II (CaMKII) has emerged as a critical regulator of cardiac hypertrophy and failure, although the mechanism…

Synchronization of Pacemaking in the Sinoatrial Node: A Mathematical Modeling Study Open

Daniel Gratz, Birce Önal, Alyssa Dalic, Thomas J. Hund · 2018

Computer science Chemistry Physics

Computational studies using mathematical models of the sinoatrial node (SAN) cardiac action potential (AP) have provided important insight into the fundamental nature of cell excitability, cardiac arrhythmias, and potential therapies. Whil…

Ca2+/calmodulin-dependent kinase II-dependent regulation of atrial myocyte late Na+ current, Ca2+ cycling, and excitability: a mathematical modeling study Open

Birce Önal, Daniel Gratz, Thomas J. Hund · 2017

Chemistry Biology Medicine

Atrial fibrillation (AF) affects more than three million people per year in the United States and is associated with high morbidity and mortality. Both electrical and structural remodeling contribute to AF, but the molecular pathways under…

Two‐Pore K + Channel TREK‐1 Regulates Sinoatrial Node Membrane Excitability Open

Sathya D. Unudurthi, Xiangqiong Wu, Lan Qian, Foued Amari, Birce Önal , et al. · 2016

Chemistry Medicine Physics

Background Two‐pore K + channels have emerged as potential targets to selectively regulate cardiac cell membrane excitability; however, lack of specific inhibitors and relevant animal models has impeded the effort to understand the role of…

LongQt: A cardiac electrophysiology simulation platform Open

Birce Önal, Daniel Gratz, Thomas J. Hund · 2016

Computer science Medicine Biology

Mathematical modeling has been used for over half a century to advance our understanding of cardiac electrophysiology and arrhythmia mechanisms. Notably, computational studies using mathematical models of the cardiac action potential (AP) …

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