Birendra Nath Mallick
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View article: Functional switching among dynamic neuronal hub-nodes in the brain induces maintenance/transition of cognitive states
Functional switching among dynamic neuronal hub-nodes in the brain induces maintenance/transition of cognitive states Open
The cognitive states have broadly been divided into waking, rapid eye movement sleep (REMS), and non-REMS (NREMS). The exact mechanism of cognitive state maintenance/transition is unknown to date. We have proposed that functional activatio…
View article: REM Sleep Loss-Induced Elevated Noradrenaline Plays a Significant Role in Neurodegeneration: Synthesis of Findings to Propose a Possible Mechanism of Action from Molecule to Patho-Physiological Changes
REM Sleep Loss-Induced Elevated Noradrenaline Plays a Significant Role in Neurodegeneration: Synthesis of Findings to Propose a Possible Mechanism of Action from Molecule to Patho-Physiological Changes Open
Wear and tear are natural processes for all living and non-living bodies. All living cells and organisms are metabolically active to generate energy for their routine needs, including for survival. In the process, the cells are exposed to …
View article: Where do we look for the next breakthrough in sleep research?
Where do we look for the next breakthrough in sleep research? Open
View article: Correction: In the Rat Midbrain, SG2NA and DJ-1 have Common Interactome, Including Mitochondrial Electron Transporters that are Comodulated Under Oxidative Stress
Correction: In the Rat Midbrain, SG2NA and DJ-1 have Common Interactome, Including Mitochondrial Electron Transporters that are Comodulated Under Oxidative Stress Open
View article: In the Rat Midbrain, SG2NA and DJ-1 have Common Interactome, Including Mitochondrial Electron Transporters that are Comodulated Under Oxidative Stress
In the Rat Midbrain, SG2NA and DJ-1 have Common Interactome, Including Mitochondrial Electron Transporters that are Comodulated Under Oxidative Stress Open
View article: Sleep and Neuroimmunomodulation for Maintenance of Optimum Brain Function: Role of Noradrenaline
Sleep and Neuroimmunomodulation for Maintenance of Optimum Brain Function: Role of Noradrenaline Open
Immune function and sleep are two normal physiological processes to protect the living organism from falling sick. There is hardly any disease in which they remain unaffected, though the quantum of effect may differ. Therefore, we propose …
View article: Noradrenaline induced PKC and PKA mediated translocation of Na-K ATPase α1-subunit to the plasma membrane in Neuro-2a cells
Noradrenaline induced PKC and PKA mediated translocation of Na-K ATPase α1-subunit to the plasma membrane in Neuro-2a cells Open
Rapid Eye Movement Sleep (REM) maintains brain excitability by modulating the brain Na-K ATPase activity. Earlier, It was reported that REMS deprivation (REMSD) associated elevated NA increases the expression of Na-K ATPase subunit as well…
View article: REM sleep loss–induced elevated noradrenaline could predispose an individual to psychosomatic disorders: a review focused on proposal for prediction, prevention, and personalized treatment
REM sleep loss–induced elevated noradrenaline could predispose an individual to psychosomatic disorders: a review focused on proposal for prediction, prevention, and personalized treatment Open
View article: Noradrenaline Acting on Alpha1 Adrenoceptor as well as by Chelating Iron Reduces Oxidative Burden on the Brain: Implications With Rapid Eye Movement Sleep
Noradrenaline Acting on Alpha1 Adrenoceptor as well as by Chelating Iron Reduces Oxidative Burden on the Brain: Implications With Rapid Eye Movement Sleep Open
The noradrenaline (NA) level in the brain is reduced during rapid eye movement sleep (REMS). However, upon REMS deprivation (REMSD) its level is elevated, which induces apoptosis and the degeneration of neurons in the brain. In contrast, i…
View article: Relevance of deprivation studies in understanding rapid eye movement sleep
Relevance of deprivation studies in understanding rapid eye movement sleep Open
Rapid eye movement sleep (REMS) is a unique phenomenon essential for maintaining normal physiological processes and is expressed at least in species higher in the evolution. The basic scaffold of the neuronal network responsible for REMS r…
View article: Noradrenergic β-Adrenoceptor-Mediated Intracellular Molecular Mechanism of Na–K ATPase Subunit Expression in C6 Cells
Noradrenergic β-Adrenoceptor-Mediated Intracellular Molecular Mechanism of Na–K ATPase Subunit Expression in C6 Cells Open
View article: Transcriptome Analysis Reveals Altered Expression of Memory and Neurotransmission Associated Genes in the REM Sleep Deprived Rat Brain
Transcriptome Analysis Reveals Altered Expression of Memory and Neurotransmission Associated Genes in the REM Sleep Deprived Rat Brain Open
Sleep disorders are associated with cognitive impairment. Selective rapid eye movement sleep (REMS) deprivation (REMSD) alters several physiological processes and behaviors. By employing NGS platform we carried out transcriptomic analysis …
View article: Disciplined sleep for healthy living: Role of noradrenaline
Disciplined sleep for healthy living: Role of noradrenaline Open
View article: Noradrenaline from Locus Coeruleus Neurons Acts on Pedunculo-Pontine Neurons to Prevent REM Sleep and Induces Its Loss-Associated Effects in Rats
Noradrenaline from Locus Coeruleus Neurons Acts on Pedunculo-Pontine Neurons to Prevent REM Sleep and Induces Its Loss-Associated Effects in Rats Open
Normally, rapid eye movement sleep (REMS) does not appear during waking or non-REMS. Isolated, independent studies showed that elevated noradrenaline (NA) levels inhibit REMS and induce REMS loss-associated cytomolecular, cytomorphological…
View article: Rapid Eye Movement Sleep Deprivation Induces Neuronal Apoptosis by Noradrenaline Acting on Alpha1 Adrenoceptor and by Triggering Mitochondrial Intrinsic Pathway
Rapid Eye Movement Sleep Deprivation Induces Neuronal Apoptosis by Noradrenaline Acting on Alpha1 Adrenoceptor and by Triggering Mitochondrial Intrinsic Pathway Open
Many neurodegenerative disorders are associated with rapid eye movement sleep (REMS) loss; however, the mechanism was unknown. As REMS loss elevates noradrenaline (NA) level in the brain as well as induces neuronal apoptosis and degenerati…
View article: Editorial (Thematic Issue: Epigenetics and Neuro-behavioral Modulations)
Editorial (Thematic Issue: Epigenetics and Neuro-behavioral Modulations) Open
One of the distinct characteristics of the living organisms, in addition to the ability to retain parental characters and qualities, is their flexibility to cope with and adapt to external as well as internal needs. For that the organisms …
View article: REM sleep and its Loss-Associated Epigenetic Regulation with Reference to Noradrenaline in Particular
REM sleep and its Loss-Associated Epigenetic Regulation with Reference to Noradrenaline in Particular Open
Sleep, an essential physiological process, has been divided into rapid eye movement sleep (REMS) and non-REMS (NREMS) in higher animals. REMS is a unique phenomenon that unlike other sleep-waking states is not under voluntary control. Dire…
View article: Targeting modulation of noradrenalin release in the brain for amelioration of REMS loss-associated effects
Targeting modulation of noradrenalin release in the brain for amelioration of REMS loss-associated effects Open
Rapid eye movement sleep (REMS) loss affects most of the physiological processes, and it has been proposed that REMS maintains normal physiological processes. Changes in cultural, social, personal traits and life-style severely affect the …